New drug duo aims to control advanced breast cancer
NCT ID NCT05548127
First seen Oct 31, 2025 · Last updated May 22, 2026 · Updated 29 times
Summary
This study tests a new oral drug, vepdegestrant, combined with abemaciclib in people with advanced or metastatic ER+ breast cancer that no longer responds to previous treatments. About 37 adults will take both pills at home daily until their cancer worsens or side effects become too severe. The goal is to see if the combination is safe and can shrink or control the cancer.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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BC Cancer Vancouver
Vancouver, British Columbia, V5Z 1H7, Canada
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BC Cancer Vancouver
Vancouver, British Columbia, V5Z 4E6, Canada
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, G7H 5H6, Canada
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Clinica Universidad de Navarra
Madrid, Madrid, Comunidad de, 28027, Spain
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Clinica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
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Clínica Universidad de Navarra
Madrid, Madrid, Comunidad de, 28027, Spain
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Rome, Lazio, 00168, Italy
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Hospital Universitari Dexeus
Barcelona, Catalunya [cataluña], 08028, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, Torino, 10060, Italy
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Memorial Hospital
Shiloh, Illinois, 62269, United States
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Moffitt Cancer Center - International Plaza
Tampa, Florida, 33607, United States
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Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
Tampa, Florida, 33612, United States
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Moffitt McKinley Hospital
Tampa, Florida, 33612, United States
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Northwest Medical Specialties, PLLC
Bonney Lake, Washington, 98391, United States
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Northwest Medical Specialties, PLLC
Federal Way, Washington, 98003, United States
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Northwest Medical Specialties, PLLC
Gig Harbor, Washington, 98332, United States
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Northwest Medical Specialties, PLLC
Puyallup, Washington, 98373, United States
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Northwest Medical Specialties, PLLC
Tacoma, Washington, 98405, United States
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Siteman Cancer Center
St Louis, Missouri, 63108, United States
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - Shiloh
Shiloh, Illinois, 62269, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - WUPI
Shiloh, Illinois, 62269, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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Stanford Women's Cancer Center
Palo Alto, California, 94304, United States
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Sunnybrook Research Institute
Toronto, Ontario, M4N 3M5, Canada
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The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
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U.T. MD Anderson Cancer Center
Houston, Texas, 77030, United States
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U.T. MD Anderson Cancer Center, Investigational Pharmacy Services - Unit 376
Houston, Texas, 77030, United States
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UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.