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New study tests if proton radiation can spare breast cancer Patients' hearts

NCT ID NCT02603341

First seen Nov 06, 2025 · Last updated May 23, 2026 · Updated 28 times

Summary

This study compares two types of radiation therapy for people with breast cancer that hasn't spread. The goal is to see if proton therapy is better than standard photon therapy at reducing heart problems while still controlling the cancer. Over 1,200 participants were randomly assigned to one of the two treatments and are being followed for years to track heart health, quality of life, and cancer outcomes.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Abramson Cancer Center at Penn Medicine

    Philadelphia, Pennsylvania, 19104, United States

  • Cancer Institute of NJ

    New Brunswick, New Jersey, 08903, United States

  • Chester County Hospital

    West Chester, Pennsylvania, 19380, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Inova Schar Cancer Institute

    Fairfax, Virginia, 22031, United States

  • Johns Hopkins

    Baltimore, Maryland, 21287, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mass General/North Shore Cancer Center

    Danvers, Massachusetts, 01923, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic-Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic-Rochester

    Rochester, Minnesota, 55905, United States

  • McLaren Proton Therapy

    Flint, Michigan, 48532, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Miami Cancer Insititute

    Miami, Florida, 33176, United States

  • New York Proton Center

    New York, New York, 10035, United States

  • Northwestern Medicine Proton Center

    Chicago, Illinois, 60190, United States

  • Oklahoma University - Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • Orlando Health

    Orlando, Florida, 32806, United States

  • Pinnacle Health Cancer Institute

    Harrisburg, Pennsylvania, 17109, United States

  • ProCure Proton Therapy Center

    Somerset, New Jersey, 07728, United States

  • RWJ University Hospital Hamilton

    Hamilton, New Jersey, 08690, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98133, United States

  • Texas Center for Proton Therapy

    Irving, Texas, 75063, United States

  • Thompson Proton Center

    Knoxville, Tennessee, 37909, United States

  • UC San Diego

    San Diego, California, 92121, United States

  • University Hospitals, Case Medical Center

    Cleveland, Ohio, 44106, United States

  • University Pointe, University of Cincinnati

    West Chester, Ohio, 45069, United States

  • University of Alabama

    Birmingham, Alabama, 35233, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45267, United States

  • University of Florida Health

    Gainesville, Florida, 32610, United States

  • University of Florida Health Proton Therapy Institute

    Jacksonville, Florida, 32206, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Miami Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Miami Sylvester Cancer Center - Deerfield

    Deerfield Beach, Florida, 33442, United States

  • University of Miami Sylvester Cancer Center at Coral Gables

    Coral Gables, Florida, 33146, United States

  • University of Washington

    Seattle, Washington, 98195, United States

  • Washington University, St. Louis

    St Louis, Missouri, 63110, United States

  • William Beaumont

    Royal Oak, Michigan, 48073, United States

  • Willis Knighton

    Shreveport, Louisiana, 71103, United States

Conditions

Explore the condition pages connected to this study.