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Hormone combo may cut breast cancer risk in menopausal women

NCT ID NCT04821141

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 32 times

Summary

This study looks at whether a combination of two hormones (bazedoxifene and conjugated estrogens) can reduce breast cancer risk in women going through menopause who also have hot flashes. About 120 women at higher risk for breast cancer will either receive the treatment for 6 months or be placed on a waiting list. Researchers will check changes in breast density and cell growth, which are linked to cancer risk.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Northwestern Medical Center

    Chicago, Illinois, 60601, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University of California San Francisco

    San Francisco, California, 94115, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

Conditions

Explore the condition pages connected to this study.