New hope for advanced breast cancer: drug combo trial launches
NCT ID NCT05508906
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 28 times
Summary
This early-phase study tests a new drug called OP-1250 combined with other targeted therapies (ribociclib, alpelisib, everolimus, or atirmociclib) in adults with advanced or metastatic ER-positive, HER2-negative breast cancer. The main goals are to find safe doses and check for side effects. About 190 participants will join, and researchers will also look for early signs that the tumors shrink or stop growing.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Advent Health Hematology and Oncology
RECRUITINGOrlando, Florida, 32804, United States
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Atrium Health Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28204, United States
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Banner MD Anderson Cancer Center
RECRUITINGGilbert, Arizona, 85234, United States
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Breast Cancer Research Center- Western Australia
RECRUITINGNedlands, Western Australia, 6009, Australia
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48126, United States
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Henry-Joyce Cancer Clinic, The Vanderbilt Clinic
RECRUITINGNashville, Tennessee, 37232, United States
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Ichan School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Macquarie Health
RECRUITINGSydney, New South Wales, 2109, Australia
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Northwest Medical Specialties
RECRUITINGTacoma, Washington, 98405, United States
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Regents of the University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of California San Francisco Health
RECRUITINGSan Francisco, California, 94158, United States
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University of Colorado Cancer Center
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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Washington University, School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Conditions
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