New shot into breast tumors aims to wake up immune system before surgery
NCT ID NCT07319195
First seen Jan 10, 2026 · Last updated May 24, 2026 · Updated 22 times
Summary
This study tests whether injecting a drug that activates immune cells (CD40 agonist) directly into breast tumors, alone or with another immune-boosting drug (PD-1 inhibitor), is safe and can be done before planned surgery. About 32 adults with early-stage or recurrent breast cancer that can be removed will get one injection at least 7 days before surgery. Researchers will check for side effects, whether surgery is delayed, and if the treatment boosts immune activity in the tumor.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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