New hope for advanced breast cancer: drug combo trial launches
NCT ID NCT07100106
First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 25 times
Summary
This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that worsened after prior treatment. About 285 participants will be randomly assigned to receive either the new combo or a standard combo (abemaciclib + giredestrant). The goal is to see if the new combo is safer and works better at controlling the cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia
RECRUITINGBrescia, Lombardy, 25123, Italy
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Asan Medical Center.
RECRUITINGSeoul, 05505, South Korea
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Barbara Ann Karmanos Cancer Institute
RECRUITINGDetroit, Maine, 48201-2013, United States
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Cancer Research SA
RECRUITINGAdelaide, South Australia, 5000, Australia
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Centre Eugene Marquis
RECRUITINGRennes, 35042, France
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Centre Francois Baclesse
RECRUITINGCaen, 14076, France
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Centre Oscar Lambret
RECRUITINGLille, 59020, France
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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City of Hope - Orange County Lennar Foundation Cancer Center
RECRUITINGIrvine, California, 92618, United States
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City of Hope® Cancer Center Chicago
RECRUITINGZion, Illinois, 60099, United States
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Gangnam Severance Hospital, Yonsei University Health System
RECRUITINGSeoul, Seoul Teugbyeolsi, 6273, South Korea
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Gustave Roussy
RECRUITINGVillejuif, Val-de-Marne, 94805, France
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Hospital Beata Maria Ana
RECRUITINGMadrid, 28007, Spain
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Hospital Clinico Universitario de Valencia
RECRUITINGValencia, 46010, Spain
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Hospital General Universitario Gregorio Maranon
RECRUITINGMadrid, 28007, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital de Clinicas de Porto Alegre (HCPA) - PPDS
RECRUITINGPorto Alegre, Rio Grande do Sul, 90560-030, Brazil
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Hospital do Cancer de Pernambuco - HCP
RECRUITINGRecife, Pernambuco, 50040-000, Brazil
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Institut Jean Godinot
RECRUITINGReims, Champagne-Ardenne, 51100, France
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Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
RECRUITINGBarcelona, 08035, Spain
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Irmandade Da Santa Casa de Misericordia de Porto Alegre
RECRUITINGPorto Alegre, Rio Grande do Sul, 90035-074, Brazil
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KEM - Evang. Huyssens-Stiftung Essen-Huttrop
RECRUITINGEssen, North Rhine-Westphalia, 45136, Germany
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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New York Cancer & Blood Specialists
RECRUITINGEast Patchogue, New York, 11772, United States
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Princess Margaret Hospital
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08901-1914, United States
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, 13620, South Korea
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Severance Hospital, Yonsei University Health System
RECRUITINGSeoul, 3722, South Korea
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St Vincent's Hospital Sydney
RECRUITINGDarlinghurst, New South Wales, 2010, Australia
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Texas Oncology (Worth) - USOR
RECRUITINGDallas, Texas, 75246-2003, United States
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The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITINGSeoul, 06591, South Korea
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093-1503, United States
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UCSF Helen Diller Family CCC
RECRUITINGSan Francisco, California, 94158, United States
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UPMC - Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15213-3108, United States
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University of Pennsylvania - Abramson Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Vanderbilt Breast Center at One Hundred Oaks
RECRUITINGNashville, Tennessee, 37204-3609, United States
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Virginia Oncology Associates (Norfolk) - USOR
RECRUITINGNorfolk, Virginia, 23502-2800, United States
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Washington University Siteman Cancer Center
RECRUITINGSt Louis, Missouri, 63110-1010, United States
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Winship Cancer Institute of Emory University
RECRUITINGAtlanta, Georgia, 30322-1013, United States
Conditions
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