Genentech, Inc.

This early-stage study tests a new drug, enzelkitug, given alone or with standard immunotherapy drugs, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety and find the right dose. About 450 adults with cancers like lung, …

This study tests a new medicine called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo to see if it can bring the disease into remission within 12 wee…

This study tests an experimental drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. Participants will receive either selnoflast or a placebo on top of their usual heart medications. The goal is to see i…

This study tests a cell therapy called OpRegen in 60 people with geographic atrophy, a severe form of dry age-related macular degeneration that causes blind spots. The goal is to see if surgeons can safely deliver the cells to the right spot in the eye and if the treatment can im…

This study tests several different drug combinations in people with early-stage non-small cell lung cancer that can be removed with surgery. Participants receive treatment before and after surgery based on specific biomarkers in their tumor. The goal is to see if these targeted t…

This study is for people with advanced liver cancer (hepatocellular carcinoma) who also have moderate cirrhosis (Child-Pugh B7 or B8). It tests the safety of two drugs, atezolizumab and bevacizumab, given together or alone as a first treatment. The goal is to see if these drugs a…

This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that worsened after prior treatment. About 285 participants will be randomly assigned to receive either the new combo or a standard combo (abemaciclib…

This early-stage study tests an experimental drug called vixarelimab in 24 people with moderate to severe ulcerative colitis. The goal is to see how the drug affects inflammation in the gut and how safe it is. Participants must have tried other treatments without success.

This early-stage trial tests a new drug called RO7656594 in people with advanced or metastatic prostate cancer. The goal is to check its safety, find the right dose, and see if it can help control the disease. About 210 participants will take part in this study.

This study is for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The trial tests a new drug, GDC-7035, given alone or with other cancer treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tum…

This study tests an experimental drug called GDC-0587, alone or with another drug (giredestrant), in people with a certain type of advanced breast cancer (ER-positive, HER2-negative) that has gotten worse after previous treatment. The goal is to find a safe dose and see if the dr…

This early-stage study tests a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants must be adults with a healthy weight and no serious medical conditions. The study does not aim to treat any disease, but to gather im…

This study looks at how the body handles a single dose of the drug inavolisib in people with moderate or severe liver problems compared to healthy people. About 32 adults will take part to measure drug levels and safety. The goal is to understand if liver impairment changes how t…