Genentech, Inc.

This study tests an experimental drug called XmAb24306, given alone or with another cancer drug (atezolizumab), in adults with advanced solid tumors that cannot be cured. The main goal is to check safety and how the drug moves through the body. About 195 participants will take pa…

This study tests a new drug combination (giredestrant plus everolimus) against standard hormone therapy plus everolimus in people with a common type of advanced breast cancer (ER+/HER2-). The goal is to see if the new combo can delay cancer growth longer. About 373 adults who hav…

This early-stage trial tests a new drug called cevostamab, alone or with other medicines, in about 126 people whose multiple myeloma has returned or stopped responding to treatment. The main goal is to find the safest dose and check for side effects. Researchers will also see if …

This study tests an experimental drug called GDC-9545, alone or with other medicines, in people with advanced estrogen receptor-positive breast cancer that has spread. The main goals are to check the drug's safety and find the best dose. About 181 participants will take part in t…

This early-stage study tests a new experimental drug (RO7496353) combined with an immunotherapy drug, with or without standard chemotherapy, in people with advanced lung, stomach, or pancreatic cancer. The main goal is to check safety and find the right dose. About 102 participan…

This study tests a new medicine called RO7446603 for people with diabetic macular edema, a condition that causes vision loss due to swelling in the back of the eye. The trial has two parts: first, checking safety of the drug alone or with other eye injections; second, comparing a…

This early-stage study tests a new drug (XmAb24306) combined with another drug (cevostamab) in about 90 people whose multiple myeloma has returned or stopped responding after at least three prior treatments. The main goal is to check safety and find the best dose. Researchers wil…

This study looks at whether adding the drug venetoclax to standard BTKi therapy can help people with chronic lymphocytic leukemia (CLL) reach very deep remission. The goal is to allow patients to stop treatment for a period. About 118 adults who have been on BTKi therapy for at l…

This study compares two different devices for giving trastuzumab as a shot under the skin. It involves 312 healthy men to see if the drug levels in the body are similar between the devices. The goal is to check safety and how the body handles the drug, not to treat any disease.