New drug combo targets hard-to-treat breast cancer before surgery

NCT ID NCT07054190

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 31 times

Summary

This study tests a new drug called inavolisib, given with other medicines, to people with a specific type of early-stage breast cancer (PIK3CA-mutated, ER-positive, HER2-negative). About 60 participants will receive the treatment before surgery to see if it safely shrinks or eliminates tumors. The goal is to improve outcomes for this genetic subtype of breast cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Asan Medical Center.
RECRUITING

Seoul, 05505, South Korea
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C2, Canada
Centro Médico Fleischer
RECRUITING

Buenos Aires, C1414, Argentina
Centro Oncologico Korben
RECRUITING

Ciudad Autonoma Buenos Aires, C1426AGE, Argentina
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
RECRUITING

São Paulo, São Paulo, 01317-000, Brazil
Community Clinical Trials
RECRUITING

Orange, California, 92868, United States
Das Brustzentrum
RECRUITING

Berlin, 12623, Germany
HELIOS Klinikum Berlin-Buch
RECRUITING

Berlin, 13125, Germany
HELIOS Klinikum Schwerin
RECRUITING

Schwerin, 19055, Germany
Hospital Aleman de Buenos Aires
RECRUITING

Buenos Aires, C1118AAT, Argentina
Hospital Araujo Jorge
RECRUITING

Goiânia, Goiás, 74605-070, Brazil
Hospital Clinic Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital do Cancer de Pernambuco - HCP
RECRUITING

Recife, Pernambuco, 50040-000, Brazil
Irmandade Da Santa Casa de Misericordia de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T1E2, Canada
Kliniken Essen-Mitte
RECRUITING

Essen, 45136, Germany
McGill University Health Center
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise
RECRUITING

Paderborn, 33098, Germany
Sunnybrook Odette Cancer Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
RECRUITING

Barcelona, 08035, Spain

Conditions

Explore the condition pages connected to this study.

BREAST CANCER