Disease by etiologic mechanism

This phase 2 trial tests whether giving patients their own tumor-specific immune cells, along with a dendritic cell vaccine, can help fight recurrent medulloblastoma or primitive neuroectodermal tumors. Participants receive these treatments after high-dose chemotherapy and a stem…

This early-stage trial is testing a new vaccine called PCV24, designed to protect children against 24 types of pneumococcal bacteria. The study involves 230 healthy children aged 6 weeks to 17 years and will check for side effects and measure immune response. The vaccine is given…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This early-stage trial tests a new malaria vaccine called PfSPZ-LARC2 in up to 22 healthy adults who have never had malaria. The vaccine uses live but genetically weakened malaria parasites that stop developing late in the liver, aiming to trigger a stronger immune response than …

This phase 2 trial tests whether a vaccine made from immune cell-derived exosomes can slow cancer growth in people with advanced non-small cell lung cancer who have responded to initial chemotherapy. Participants receive low-dose cyclophosphamide followed by weekly injections of …

This phase II trial tests a new 24-valent pneumococcal conjugate vaccine (PCV24) in 992 adults aged 18 and older. The study aims to check the vaccine's safety and how well it triggers an immune response compared to an existing 23-valent vaccine. Participants receive one dose of e…

This trial is testing whether a single injection of an experimental chikungunya vaccine, VLA1553, is safe and triggers a protective immune response in healthy children aged 1 to 11 years. About 300 children will receive either a full dose, a half dose, or a control vaccine. The s…

This early-stage trial is testing whether a new vaccine can safely train the immune system to fight Epstein-Barr virus (EBV), which causes infectious mononucleosis and is linked to several cancers. Healthy adults aged 18 to 29, both with and without prior EBV infection, will rece…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

This trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with early-stage non-small cell lung cancer. The study includes adults with stage IB to IIIA (non-N2) disease who are eligible for surgery. Participants receive one dose of ate…

This study tests an experimental vaginal insert (ABI-2280) to see if it can safely clear persistent high-risk human papillomavirus (HPV) infection in women aged 25 to 55. Participants must have had HPV for at least a year with no serious cervical changes. The study compares diffe…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This trial is testing several different targeted drug combinations in people with mesothelioma that has returned after initial treatment. The goal is to see which therapies can control the disease and potentially improve survival. Participants are assigned to a treatment based on…

This trial asks men with advanced prostate cancer which of two oral medications they prefer: the experimental drug ODM-201 or the approved drug enzalutamide. Both work by blocking male hormones that fuel cancer growth. Participants will take each drug for a period and then answer…

This trial asks whether giving extra albumin—a key protein in the blood—can lower inflammation and oxidative stress in people with sepsis, a severe infection that can cause organ failure. Adults in intensive care with sepsis and low albumin levels are randomly assigned to receive…

This study tests whether two lab-made antibodies can safely control HIV in people who stop their regular antiretroviral therapy for a short time. Thirty-two adults in Sub-Saharan Africa who are currently on HIV treatment will receive either the antibodies or a placebo. The goal i…

This trial is testing whether adding anakinra, a drug used for arthritis, to standard chemoradiotherapy is safe for people with rectal cancer. The study will include about 12 patients and will use a dose-escalation design to find the highest tolerable dose of capecitabine when co…

This trial tests whether online group dialectical behavioral therapy (DBT) is as effective as traditional face-to-face group DBT for women with bulimia nervosa. Participants will be randomly assigned to either 12 weeks of online or in-person group therapy, and researchers will co…

This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly ass…

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger …

This study tests whether a pharmacist-led education program can help women with hypothyroidism and low vitamin D levels improve their vitamin D levels and medication habits. Sixty women will be split into two groups: one receives standard care, the other gets counseling, brochure…

This study looked at whether tiny plastic particles (microplastics) we encounter daily might contribute to obesity and gut problems. Researchers gave 96 overweight or obese adults either a probiotic supplement or a placebo to see if the probiotic could reduce the harmful effects …

This study tested a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 61 people with advanced melanoma or other solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drugs could s…

This Phase 3 trial tests whether TAS-205, an oral drug, can improve movement and safety in people with Duchenne muscular dystrophy. It includes 104 participants, both those who can walk and those who cannot. The study compares TAS-205 to a placebo over 52 weeks.

This study tested a gene transfer treatment for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and affects movement, breathing, and other functions. Fourteen people aged 3 and older received a single injection of the treatment into the fluid around the …

This pilot trial is investigating whether giving two immunotherapy drugs, nivolumab and ipilimumab, along with radiation therapy before surgery can safely help treat soft tissue sarcoma. The study enrolls adults with resectable, intermediate-to-high grade sarcomas larger than 5 c…

This phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This trial tests whether using 3D on-board imaging before each radiation session improves accuracy and outcomes for men with prostate cancer compared to standard imaging. The study tracks disease-free survival, side effects, and costs over 2 to 5 years. It aims to find the best i…

This study tests whether aerobic exercise in simulated altitude (normobaric hypoxia) can improve body composition and metabolism in people with MASLD, a type of fatty liver disease. Twenty sedentary adults with MASLD will walk on a treadmill for 8 weeks, either in mild altitude o…

This study tested a combination of two drugs, ramucirumab and pembrolizumab, in 43 people with head and neck cancer that had spread or come back. The goal was to first find a safe dose and then see if the combination could shrink tumors. The approach aims to block blood vessel gr…

This study looks at the Bonebridge BCI 602, a bone conduction implant designed to help people with certain types of hearing loss. The trial will measure how well the device improves hearing and speech understanding one year after implantation, compared to not using it. It also tr…

This trial tests whether giving oral antibiotics alongside a therapeutic food improves recovery in young children with severe acute malnutrition (kwashiorkor or marasmus). Children aged 6 months to 5 years who qualify for home-based feeding will receive either amoxicillin, cefdin…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This study is testing a single dose of the antibiotic Vabomere in 39 children from birth to under 18 years old who have serious bacterial infections. The goal is to find the right dose and check how safe and tolerable the drug is. All children are hospitalized and receiving other…

This early-phase trial tested the drug everolimus (RAD001) alongside radiation therapy in 26 people with advanced non-small cell lung cancer that could not be surgically removed. The goal was to find a safe dose and check for side effects. Participants received everolimus weekly …

This trial compares two surgical techniques for removing a pterygium, a fleshy growth on the eye's surface that can distort vision. Researchers are testing whether using a piece of the patient's own conjunctiva (the clear tissue covering the eye) or a preserved amniotic membrane …

This study tests a program called Fit Together that combines standard medical care with community activity sessions for children with obesity. About 400 children aged 5-12 will receive a referral to local park programs offering exercise, sports, and nutrition activities. Research…

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This pilot study explores whether adding a cognitive training game called PolyRules! to the WW (formerly Weight Watchers) online program can help adults with overweight or obesity lose more weight. Participants will either follow the WW program alone or combine it with the brain-…

This trial is testing two different ways of delivering a second course of radiation to people whose head or neck cancer has come back after prior radiation. One approach uses a single daily dose of radiation combined with two chemotherapy drugs given every other week over 11 week…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial is testing whether a radioactive tracer, technetium Tc 99m sulfur colloid, can accurately locate sentinel lymph nodes in women with early-stage breast cancer. The sentinel node is the first lymph node cancer is likely to spread to, and finding it helps guide surgery. T…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This pilot study is testing whether a dietary supplement made from the tinder fungus can safely ease gut symptoms in adults with mild-to-moderate ulcerative colitis or Crohn's disease. Participants will drink the supplement and be monitored for changes in symptoms, inflammation m…

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This trial asks whether taking magnesium oxide for three months before the fertility drug letrozole can improve ovulation rates in women with insulin-resistant polycystic ovary syndrome (PCOS). About 60 subfertile women aged 18–35 will either receive magnesium oxide followed by l…

This phase 2 study tested a combination of three drugs in 46 people with a specific type of lung cancer (EGFR-mutated) that had spread to the lining of the brain and spinal cord (meningeal metastasis). The treatment included a high-dose targeted pill (furmonertinib), an intraveno…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This study is testing a postbiotic supplement called resM™ GLP-1 Postbiotic to see if it helps overweight adults lose weight and improve their metabolic health. The supplement contains vitamins, minerals, and plant extracts. Researchers will measure changes in weight, BMI, food c…

This trial is testing an investigational drug called PF-06741086, given as a once-weekly injection under the skin, to see if it can reduce the number of bleeding episodes in people with severe hemophilia A or moderately severe to severe hemophilia B. The study includes both peopl…

This study tested a new way of giving radiation therapy combined with immunotherapy for people with advanced non-small cell lung cancer that does not have certain genetic mutations. The goal was to see if mixing high-dose and low-dose radiation could help the immune system fight …

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This trial tests a program called PD_Pal, where a specially trained nurse helps people with Parkinson's and their family caregivers create a personalized care plan. The plan covers current care, future needs, and end-of-life preferences, aiming to ensure that care matches what th…

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This phase II trial is testing whether the immunotherapy drug tislelizumab can help control locally advanced non-small cell lung cancer when given after radiation therapy or sequential chemoradiation. The study enrolls people with stage III lung cancer who cannot tolerate the sta…

This phase 3 trial is testing an investigational drug called DKF-MA102 (leuprorelin acetate) in men with advanced prostate cancer. The goal is to see if two injections, given 12 weeks apart, can safely lower testosterone levels to a target range, which may help control the cancer…

This study tests whether pulsed electromagnetic field therapy (PEMT) can improve swallowing function in people with cervicogenic dysphagia, a swallowing disorder caused by neck problems. Forty adults aged 50-60 with this condition will receive either real or placebo PEMT, along w…

This phase II trial tested the drug Minnelide in 16 adults with a rare and aggressive form of pancreatic cancer called adenosquamous carcinoma of the pancreas (ASCP) that had not responded to prior treatments. Participants took Minnelide by mouth daily for 21 days of each 28-day …

This study looks at whether the antiviral medication Paxlovid can reduce the risk of severe illness, death, and loss of daily functioning in older adults living in long-term care hospitals in Korea. Researchers will compare health outcomes of residents aged 60 and older who recei…

This trial is testing whether adding targeted radiation (SBRT) to two immunotherapy drugs, durvalumab and tremelimumab, can better control metastatic head and neck cancer. The study includes adults with this cancer that has spread, and the radiation is given between cycles of the…

This early-phase study tests a new oral drug, furmonertinib, in 30 people with advanced non-small cell lung cancer that has a specific EGFR exon 20 insertion mutation. Some participants have already tried other treatments, while others are newly diagnosed. The goal is to see if t…

This trial compares the antibiotic rifapentine against the standard drug rifampin during the first 8 weeks of treatment for pulmonary tuberculosis. About 334 adults with TB bacteria in their sputum are randomly assigned to receive either the standard regimen or one with rifapenti…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy can help control gastroesophageal cancer that cannot be removed by surgery. The study includes 16 participants and primarily looks at safety and whether the cancer …

This early-phase trial tested an experimental drug called BMS-986408, alone or combined with the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy), in 68 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to chec…

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This trial tests a new way to personalize the dose of levothyroxine, a thyroid hormone medication, for people who have had surgery for thyroid cancer. Using mathematical and statistical models, the approach aims to predict the best dose for each individual, potentially reducing s…

This study follows about 140 people in Korea who have steroid-refractory graft-versus-host disease (GvHD) — a serious complication after a stem cell transplant where donor immune cells attack the recipient's body. Researchers are tracking how well the drug ruxolitinib (Jakavi) wo…

This study tested a new combination of drugs for people with Hodgkin lymphoma that either returned after treatment or didn't respond. The goal was to find the safest dose of a targeted drug (brentuximab vedotin) when added to standard chemotherapy. 45 adults took part, and the st…

This phase II trial is testing whether combining brentuximab vedotin, a targeted antibody-drug conjugate, with lenalidomide, a chemotherapy drug, can shrink tumors in people with T-cell lymphoma that has relapsed or not responded to earlier treatment. The study enrolls adults wit…

This trial tests whether giving radiation to the nipple and areola after a nipple-sparing mastectomy is safe and feasible for women with early-stage breast cancer. The goal is to see if this extra radiation can reduce the risk of cancer returning in the preserved nipple area, all…

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This trial is testing a procedure called HIPEC, where a heated chemotherapy drug (cisplatin) is delivered directly into the abdomen after surgery to remove visible cancer. The goal is to find the safest dose that can be used in patients with advanced ovarian, fallopian tube, or p…

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This study tested a new type of artificial lens, called the AT ELANA 841P, for people having cataract surgery. 284 adults with cataracts in both eyes received either the new lens or a standard lens. Researchers measured how well patients could see at different distances and check…

This phase II trial is investigating whether giving the drug bevacizumab directly into the liver's main artery, alongside standard chemotherapy, can shrink liver tumors in people with colorectal cancer that has spread only to the liver. The study enrolls patients whose cancer pro…

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This small safety trial tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area linked to Parkinson's motor symptoms. Seven people with advanced Parkinson's took part to see if the procedure is safe and might improve movement. The go…

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This phase 2 trial tests a treatment called Lete-Cel, which uses a patient's own immune cells that have been specially trained to attack cancer cells. It is for people with advanced synovial sarcoma or myxoid/round cell liposarcoma whose tumors have a specific marker (NY-ESO-1) a…

This study tests a drug called hydronidone in 300 adults with liver scarring (fibrosis or cirrhosis) from chronic hepatitis B. Participants take the drug three times daily for 28 days to see if it is safe. The main goal is to track any side effects.

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This study tests a drug called hydronidone in 200 adults with liver fibrosis caused by chronic hepatitis B or fatty liver disease. Participants take three capsules three times daily for 28 days. The main goal is to check for side effects, not to measure how well the drug works.

This study is testing whether upadacitinib, an oral medication, can safely and effectively manage Crohn's disease over the long term. Participants who completed a previous year-long study will continue taking the drug and be monitored for up to a year. The goal is to see if the d…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This trial tests whether giving a fluorescent dye called indocyanine green during endoscopic surgery helps surgeons remove non-functioning pituitary macroadenomas more completely. About 34 adults with these tumors will be randomly assigned to receive the dye or not during surgery…

This study tested whether taking extra leucine, a natural amino acid, helps preserve muscle during a 4-week alternate-day fasting program in overweight young men. Participants were randomly assigned to one of four doses of leucine. Researchers measured body composition, blood mar…

This study tested a gel called SGX302, which is activated by visible light, on 15 people with mild-to-moderate plaque psoriasis. The goal was to see if it could clear or nearly clear skin lesions over 18 weeks. The treatment is applied to the skin and then exposed to light, aimin…

This virtual trial tests whether a daily prebiotic and probiotic supplement can relieve symptoms of bacterial vaginosis and yeast infections, such as itching, odor, and abnormal discharge. Women aged 25 and older with these concerns will take two capsules daily for 30 days. The s…

This study tests a drug called hydronidone in 150 adults with liver scarring caused by chronic hepatitis B. Participants take the capsules three times daily for 28 days. The main goal is to check for side effects and ensure the drug is safe. This is an early-phase trial, so it fo…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This study tests whether doing a gum graft at the same time as placing a dental implant works as well as the traditional two-step approach. The goal is to increase the width of keratinized gum tissue around implants, which helps prevent inflammation and implant failure. Twenty-tw…

This early-phase trial tested a combination of four drugs (romidepsin, CC-486, dexamethasone, and lenalidomide) in 26 adults with T-cell cancers that had returned or stopped responding to prior treatments. The main goal was to find a safe dose and check for side effects. While th…

This phase 1 trial is testing whether adding the antiviral drug Vistide (cidofovir) to the standard combination of radiation and chemotherapy can improve outcomes for people with HPV-positive cervical cancer. The idea is that Vistide may make cancer cells more sensitive to radiat…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This study tested a combination of the targeted drug brentuximab vedotin (ADCETRIS) plus standard CHP chemotherapy in 82 people with newly diagnosed peripheral T-cell lymphoma (PTCL) that has low CD30 levels. The goal was to see how many patients' tumors shrank or disappeared. Re…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This trial tests whether a dye called indocyanine green, viewed with near-infrared imaging, can help surgeons spot pelvic lymph nodes during robot-assisted prostate removal in men with stage II prostate cancer. The dye is injected into the prostate, and the imaging system is used…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This trial tests whether a specialized three-dimensional corrective exercise program can slow or stop the progression of mild-to-moderate idiopathic scoliosis in children and teens aged 8–16. Participants are split into two groups: one performs the 3D corrective exercises (with a…

This trial is testing whether a piece of the patient's own eye tissue, called Tenon's capsule, can help close large or recurrent macular holes—tears in the center of the retina that can blur or distort vision. During standard vitrectomy surgery, the tissue is harvested and placed…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This phase II study tests the targeted therapy regorafenib (Stivarga) in 8 people with metastatic medullary thyroid cancer that has progressed after prior treatment. The drug aims to block cancer growth by targeting specific proteins. Researchers are measuring how long participan…

This trial tests whether eating oat-based porridge daily, alongside standard prenatal calcium and vitamin D supplements, can improve calcium and vitamin D levels in pregnant women with mild to moderate hypocalcemia. Researchers will measure blood levels at weeks 8 and 33 of pregn…

This trial is testing whether a higher dose of the fertility drug letrozole (10 mg) works better than the standard lower dose (5 mg) for stimulating ovulation in infertile women with polycystic ovary syndrome (PCOS). About 86 women aged 18-35 with PCOS will take one of the two do…

This phase I trial is testing a combination of drugs—avelumab, utomilumab, rituximab, ibrutinib, and chemotherapy—in people with diffuse large B-cell lymphoma or mantle cell lymphoma that has returned or not responded to treatment. The goal is to find the safest dose and see how …

This Phase 2 trial tests whether adding chemotherapy (carboplatin and pemetrexed) to the targeted drug osimertinib works better than osimertinib alone for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The study enrolls 80 patients w…

This phase II trial is testing an oral drug called RAD001 (everolimus) in people with advanced thyroid cancer that no longer responds to radioactive iodine treatment. The drug works by blocking a key growth pathway (mTOR) in cancer cells. The study aims to see if RAD001 can slow …

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This study compares a new treatment called TheraSphere (tiny radioactive beads) to standard chemoembolization for people with liver cancer that cannot be removed by surgery. About 92 Chinese adults with early-to-mid stage liver cancer will be randomly assigned to one of the two t…

This trial investigates whether the method of inserting orthodontic miniscrews (self-drilling vs. self-tapping), along with patient sex and jaw location, influences the risk of complications like inflammation, pain, root damage, or screw failure. The study involves adults aged 20…

This trial is testing whether an experimental drug called JS015, when combined with standard chemotherapy or immunotherapy, is safe and effective for people with advanced solid tumors that have not responded to prior treatment. The study includes patients with certain cancers lik…

This trial follows women with polycystic ovary syndrome (PCOS) who take metformin, a standard diabetes medication, for six months. Researchers track changes in insulin resistance, iron levels, erythropoietin, cholesterol, and blood counts at three and six months. The goal is to s…

This study tested a drug called sonelokimab, given as a shot under the skin, in 422 adults with moderate to severe hidradenitis suppurativa (a painful skin condition causing boils and abscesses). Participants were randomly assigned to receive either the drug or a placebo for up t…

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This early-phase trial tests the safety and tolerability of a new drug called GRT6019 in 24 healthy men. Participants receive multiple doses over 4 weeks and are monitored for side effects and how the drug moves through the body. The goal is to see if GRT6019 is safe enough to st…

This study tests whether restricting carbohydrates on two consecutive days per week or after 4pm each day can improve metabolic health and energy balance in adults with abdominal overweight or obesity. Over four weeks, participants follow one of these eating patterns or their usu…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests whether a web-based program called PATH can help adults with obesity become more physically active and stick to recommended exercise levels. Participants are randomly assigned to either the PATH program, which includes personalized coaching and online resources, …

This early-stage trial is testing whether an immunotherapy drug called tislelizumab can be given as a simple injection under the skin instead of through an IV drip for people with advanced non-small cell lung cancer. The study will compare how well the body absorbs the drug in bo…

This pilot trial asks whether removing a wider margin of brain tissue around a high-grade glioma—beyond the standard visible tumor boundary—can improve survival without causing more neurological harm. It enrolls adults with a first-time diagnosis of high-grade glioma in a surgica…

This phase III trial is investigating whether adding lapatinib to the standard combination of paclitaxel and trastuzumab before surgery can improve outcomes for patients with HER2-positive stage II or III breast cancer. The study aims to see if the three-drug regimen leads to a h…

This early-stage trial tests a new drug called SG301, given as an injection under the skin every two weeks, for systemic lupus erythematosus (SLE). The study first gives a single dose to healthy volunteers to check safety, then gives multiple doses to people with lupus. The main …

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This study tests a gene therapy (PF-06838435) for people with severe hemophilia B, a bleeding disorder. The therapy uses a harmless virus to deliver a working gene for clotting factor IX. Researchers are following 21 participants long-term to see if it is safe and reduces bleedin…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This study looks at whether giving less radiation after surgery for HPV-positive throat cancer can still prevent the cancer from coming back while causing fewer long-term side effects. About 83 adults with HPV-positive oropharyngeal cancer will receive either a standard or reduce…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare genetic mutations not currently approved for this treatment. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin …

This trial is testing whether a compound called sodium pentaborate pentahydrate can help people with overweight or obesity lose weight and improve their blood sugar. Participants will receive either the compound or a placebo, and researchers will track changes in body weight, wai…

This pilot study looks at whether a daily low-dose iron supplement (27 mg for three months) can improve iron status, gut health, and endurance in young female elite football players. Researchers will track diet, blood markers like hemoglobin and ferritin, gut leakage indicators, …

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This early-phase trial is testing whether adding an experimental drug called alisertib to the standard treatment osimertinib can help people with stage IV EGFR-mutant lung cancer. The study aims to find the safest dose of alisertib when given with osimertinib and to see how the c…

This early-phase study tested a new drug called BAY 2862789 in 45 people with advanced solid tumors, including non-small cell lung cancer. The drug works by activating immune cells to fight cancer. The main goals were to check safety, find the best dose, and see how the drug move…

This study tested whether the antibiotic tigecycline works better than the standard drug doxycycline for scrub typhus, a bacterial infection spread by mites. Thirty-one hospitalized patients were randomly assigned to receive either tigecycline or doxycycline. Researchers measured…

This phase 2 trial is testing the drug ibrutinib in 18 people with stage IV melanoma that has not responded to previous treatments. Ibrutinib works by blocking certain enzymes that help cancer cells grow. The study aims to see if the drug can shrink tumors and how long it keeps t…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This trial tests whether giving goserelin, a hormone-blocking drug, alongside chemotherapy can help preserve ovarian function and fertility in premenopausal women with breast cancer. Participants receive either chemotherapy plus goserelin or chemotherapy alone. Researchers will m…

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This phase II trial is testing whether combining the targeted drug ixazomib with two chemotherapy drugs (gemcitabine and doxorubicin) can shrink tumors or stop them from growing in patients with a rare and aggressive kidney cancer called renal medullary carcinoma. The study enrol…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This trial tests whether adding the immunotherapy drug toripalimab to a standard chemotherapy regimen (FLOT) before surgery can improve outcomes for people with locally advanced gastric cancer. Participants receive four cycles of the combination, then undergo surgery, and are fol…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This early-stage trial is testing whether combining two experimental immunotherapy drugs, zalifrelimab and balstilimab, can help shrink or control advanced solid tumors, including cervical cancer. The drugs are designed to block different 'brakes' on the immune system, potentiall…

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This trial tests whether eating dairy products can improve how the body uses insulin in overweight and obese adults with prediabetes. Participants will be randomly assigned to eat either limited dairy (1 serving or less per day), reduced-fat dairy, or regular-fat dairy for 12 wee…

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This Phase 2 trial tests whether drinking three cups of ArtemiCoffee (made from the Artemisia annua plant) daily for 24 weeks can lower PSA levels in 20 men whose prostate cancer has returned after initial treatment. The goal is to see if at least half of the men experience a 50%…

This trial tests whether a simple clip-and-floss traction device can speed up the removal of large colon polyps using a technique called endoscopic submucosal dissection (ESD). About 280 people scheduled for ESD will be randomly assigned to receive either the traction device or s…

This trial tests whether obinutuzumab, a next-generation antibody, can help people with membranous nephropathy—a kidney disease that causes protein leakage and swelling—who haven't responded well to the standard drug rituximab or who can't take it due to allergic reactions. About…

This trial is testing an experimental drug called brincidofovir, given intravenously, in people aged 2 months and older who have an adenovirus or cytomegalovirus infection. The study aims to see how safe and tolerable different doses are, and whether the drug can reduce the amoun…

This trial tests whether a vaginal self-sampling device can accurately detect high-risk human papillomavirus (HPV) compared to samples collected by a clinician. About 1,000 women aged 30-64, either regular screening attendees or those who haven't been screened in 3+ years, will p…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study is testing whether a new urine analysis device, the Sysmex UF-5000, can accurately measure inflammation markers in healthy men. The goal is to establish a baseline for what's normal, which could help develop a quick, non-invasive test for urethritis, a common infection…

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This study compares two visual field tests used to monitor glaucoma: the current standard Humphrey Visual Field Analyzer and the newer iCare COMPASS. About 28 people with glaucoma or related eye conditions will take both tests in the same visit, with the order alternating between…

This study evaluates Thyroscan, a genomic test that analyzes genetic material from thyroid nodule samples, to see if it can accurately distinguish benign from malignant nodules. The trial involves 250 adults with suspicious thyroid nodules who are scheduled for surgery or have st…

This study evaluates a disposable, at-home PCR test that detects chlamydia and gonorrhea from a urine sample. Men aged 14 and older collect their own sample and use the test with app or written instructions. The goal is to see if the test works accurately outside a clinic, potent…

This trial tests whether a new PET/CT tracer, 64Cu-SAR-bisPSMA, can find more sites of prostate cancer recurrence than the standard 68Ga PSMA-11 scan in men whose PSA rises after prostate removal. Fifty men will receive both scans, and researchers will compare how many lesions ea…

This study tests whether tissue taken during routine carpal tunnel release surgery can help diagnose amyloidosis, a condition where abnormal proteins build up in organs. People with bilateral carpal tunnel syndrome and certain risk factors—like age, heart issues, or family histor…

This study investigates whether a liquid biopsy taken from the airways during a bronchoscopy can help diagnose lung cancer and identify genetic mutations. The approach aims to be less invasive and faster than traditional tissue biopsies. Researchers will compare the accuracy of t…

This study tests a special dye that makes prostate cancer cells glow during surgery. About 22 men with aggressive prostate cancer will receive the dye before their prostate removal surgery. Surgeons will use a special camera to see the glowing cancer, helping them remove more of …

This study tested a special PET/MRI scan that uses a radioactive tracer to find liver cancer cells. The goal was to see if this scan can detect liver cancer earlier and more accurately than standard scans. 52 adults with liver cancer took part, and researchers compared the new sc…

This study tested an artificial intelligence (AI) system called Vision-LSTM to see if it could accurately diagnose a specific type of thyroid nodule (TI-RADS 4b) from ultrasound images. Researchers used images from 401 patients and compared the AI's performance to that of junior …

This study tested whether a fast diagnostic test (FilmArray) plus expert antibiotic advice improves care for patients who develop pneumonia in the hospital. 116 adults with hospital-acquired pneumonia were randomly assigned to get either standard care with expert advice or the sa…

This study tests whether intestinal ultrasound can accurately detect pouchitis—inflammation of the internal pouch created after ulcerative colitis surgery. Adults who have had this surgery will receive an ultrasound, and the results will be compared to the standard pouchoscopy wi…

This pilot study explores whether a PCR-based test can deliver faster results for diagnosing invasive candidiasis in intensive care patients. The trial compares the time to results using this new strategy against standard methods, with the hope of enabling earlier, more targeted …

This trial evaluates a new blood test (ELISPOT) that looks for immune cells in a newborn's cord blood that produce antibodies against the Toxoplasma parasite. The goal is to see if this test can diagnose congenital toxoplasmosis—an infection passed from mother to baby during preg…

This trial explores whether specially trained dogs can identify high-risk prostate cancer by smelling urine samples. Men with suspected prostate cancer will provide urine samples, which six dogs will sniff. The study will compare the dogs' accuracy against MRI results and biopsy …

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This trial tests whether sending reminder messages to older adults before a doctor's appointment can increase the number who get the shingles vaccine. The study will compare different message styles to see which is most effective. Participants are adults aged 50 and older who hav…

This trial tests whether adding a low-dose propofol infusion during general anesthesia can prevent post-operative nausea and vomiting (PONV) in adults with a history of PONV or motion sickness. Participants receive either a hybrid approach (propofol plus sevoflurane) or propofol …

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This trial tests a cancer prevention program delivered by trained Chinese American community health workers to Chinese American adults in Texas. The program uses family health history to provide personalized education on breast, colorectal, gastric, liver, and lung cancers, along…

This study looks at whether US women at risk for HIV can and will take Truvada, a daily pill that prevents HIV infection. Researchers will measure how well women stick to the pill regimen over 24 weeks and explore their attitudes toward this prevention method. The goal is to see …

This study followed 40 women at high genetic risk for ovarian cancer due to BRCA mutations or strong family history. One group chose to have their ovaries and fallopian tubes removed to prevent cancer, while the other group opted for regular CA-125 blood tests every 3 months to c…

This trial is testing the safety of the Menhycia® vaccine in about 3,000 healthy 3-month-old infants who have not yet received any epidemic meningitis vaccine. The infants will receive three doses of the vaccine at least one month apart, with an optional booster at 12 months of a…

This study tests whether a brief self-affirmation exercise, where people reflect on a proud moment, can make health messages more acceptable and increase the uptake of COVID-19 rapid tests. Researchers are working with community health workers and the Mexican Consulate to reach L…

This study tested whether taking a specific probiotic (Lactobacillus crispatus M247) along with another probiotic blend could help prevent repeat urinary tract infections (UTIs) in women. 84 women with a history of frequent UTIs took either the probiotic combo or a standard probi…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This study looks at how to best help childcare centers use proven methods to improve kids' diets, like hands-on activities with fruits and vegetables. About 1,850 teachers and staff from Arkansas and Louisiana will take part. The goal is to see if giving extra support to centers …

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This trial tests whether a brief online game can help Canadian adults better identify COVID-19 vaccine misinformation. Participants judge true/false statements and get instant feedback in a game-like format, compared to reading the same information as a blog post or doing nothing…

This trial tests whether a brief online game can help adults better identify COVID-19 and vaccine misinformation. Participants judge true or false statements and get instant corrections in a game-like format. The study compares this approach to reading the same information as pla…

This study looks at whether online psychotherapy, a physical activity program, or a combination of both can reduce fatigue in people with Post-COVID syndrome. 195 adults with fatigue will be assigned to one of three groups for 3 months of treatment. The goal is to find which appr…

This phase 2 trial tests whether inhaling a blend of peppermint and lemon essential oils can reduce nausea and vomiting in people receiving their first chemotherapy for a solid tumor. Participants will inhale the oils four times daily and whenever nausea strikes, with symptoms tr…

This study tested a structured physiotherapy program for 60 people who had lung cancer surgery. The program included breathing exercises, early walking, and posture training during their hospital stay. Researchers measured how long people stayed in the hospital and checked vital …

This trial tests whether TECAR therapy, a non-invasive device that delivers energy to painful areas, can reduce pain in people with fibromyalgia. About 46 adults with fibromyalgia will receive either real or sham TECAR sessions twice a week for three weeks. Researchers will measu…

This study tests a new type of lens implant (extended depth of focus IOL) for people with age-related cataracts. The lens is designed to provide clear vision at multiple distances, potentially reducing the need for glasses after surgery. About 220 adults will be randomly assigned…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study tests whether brief, one-minute exercise breaks—called 'exercise snacks'—can improve fitness and health in adults with obesity. Eighty inactive participants aged 35-64 will use a phone app to do personalized movement breaks throughout the day for 12 weeks. The goal is …

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice …

This trial compares two exercise programs—stabilization exercises and corrective exercises—to see which better reduces pain, improves breathing, and corrects posture in office workers with upper cross syndrome. About 50 adults aged 24–40 who work long hours at computers will be r…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This trial tests whether a nurse-led group programme called ViaMente can help reduce burnout and improve psychological well-being in mental health professionals. The programme consists of five weekly sessions focusing on recognizing and managing burnout, organizing time, reducing…

This study looks at whether cooling the mouth with popsicles during chemotherapy can reduce taste changes in prostate cancer patients. About 60 people starting a type of chemo called taxane will be asked to suck on popsicles during their infusion. The goal is to see if this simpl…

This study compared two types of ultrasound-guided nerve blocks (caudal block and dorsal penile block) to control pain after hypospadias repair in 62 boys aged 1-6 years. The main goal was to see how long it took before children needed extra pain medicine. The results could help …

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

This study is testing whether computerized brain-training exercises can help older adults (age 60+) who have Long COVID with thinking problems, mood, and daily life. Researchers will check if the program is easy to use and if people stick with it. The goal is to gather early evid…

This trial tests whether an ultrasound-guided injection of alcohol and a numbing agent around the celiac ganglia can relieve pain in people newly diagnosed with inoperable pancreatic cancer. Participants receive either the nerve block or a sham procedure, alongside standard pain …

This study is testing a new probiotic called CLB101TM in healthy but overweight adults who have digestive issues like bloating or stomach pain. The probiotic is designed to produce a natural substance called butyrate, which may help strengthen the gut lining and support immune he…

This study explores whether engaging in positive activities can improve emotional well-being and quality of life for Asian American cancer patients and their caregivers. Participants, who are within a year of a cancer diagnosis and undergoing treatment, along with their caregiver…

This trial tests whether children and teenagers who have just had surgery for idiopathic scoliosis can safely stand up within 6 hours after the operation. Participants will be helped by a physiotherapist to stand in an upright position, as part of an enhanced recovery program. Th…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests whether giving trigger point injections—small amounts of numbing medication into tender neck muscles—shortly after anterior cervical surgery can reduce pain and the need for opioid painkillers. Patients undergoing elective anterior neck surgery are randomly assig…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This trial tests whether a specialized amino acid supplement designed for people with Parkinson's disease can improve nutrition without interfering with their dopamine medication. Researchers will compare this supplement to a store-bought whey protein supplement and an inactive p…

This study tests whether a single injection of nanofat—made from a person's own fat—can improve the appearance of atrophic scars caused by burns or trauma. Each participant has two similar scars: one gets the nanofat injection plus silicone gel, and the other gets only silicone g…

This trial tests whether adding DIR/Floortime™—a play-based, relationship-focused therapy—to standard care can improve emotional development and everyday skills in children aged 4-12 with mild to moderate intellectual developmental disorder. Over 10 weeks, some children receive t…

This study compares two non-invasive treatments—high-power laser and pulsed electromagnetic therapy—for reducing pain and improving nerve function in people with lumbar radiculopathy (sciatica from a herniated disc). Sixty participants aged 55-68 will receive one of the therapies…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This completed Phase 3 study tested whether BOTOX injections can safely reduce the appearance of a widened lower face caused by prominent masseter (chewing) muscles. About 207 adults with moderate-to-severe muscle prominence received either BOTOX or a placebo in both sides of the…

This trial tests whether watching a 30-40 minute augmented-reality animation that shows a child's journey through surgery can reduce anxiety in children aged 3-12 before adenotonsillectomy. Half the children will watch the animation before surgery, while the other half receives s…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This study compared two types of nerve blocks (serratus anterior plane block and serratus posterior superior intercostal plane block) for pain after video-assisted lung surgery. 60 adults aged 18-65 were enrolled. Researchers measured pain levels and patient satisfaction to see w…

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tests whether a CT-guided nerve block called celiac plexus neurolysis can relieve severe abdominal pain in people with upper gastrointestinal cancer better than standard pain medication. About 110 adults with biopsy-proven upper GI cancer and severe pain will be random…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This study evaluates a new dermocosmetic cream containing 15% azelaic acid in people with mild-to-moderate acne. Researchers will observe how well the cream reduces acne lesions and improves skin discoloration, and how well it is tolerated, compared to standard treatments like or…

This study tested whether online occupational therapy-based parent coaching could improve feeding problems in children aged 3-6 who were born prematurely. 39 mothers participated, with some receiving coaching and others not. The coaching aimed to teach mothers better feeding stra…

This study looks at a breast reconstruction method that uses only a small part of a back muscle, aiming to reduce shoulder pain and stiffness. Researchers will compare this technique to standard implant reconstruction in about 190 women. The goal is to see which approach gives be…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This pilot study tests whether a daily herbal supplement made from Lindera obtusiloba can improve quality of life for people with non-small cell lung cancer who are receiving PD-1 or PD-L1 inhibitor immunotherapy. About 20 adults will take the supplement for 8 weeks alongside the…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether a heavy lifting strength training program is safe and helpful for people who have finished treatment for head and neck cancer at least one year ago. Researchers want to see if it improves muscle strength, physical function, fatigue, and quality of life co…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This trial tests whether a phone-based positive psychology program can improve mood, quality of life, and daily functioning in adults who have just undergone a stem cell transplant for blood cancer. Participants receive weekly calls and complete exercises focused on gratitude, pe…

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (tTIS) to see if it can improve motor symptoms in people with Parkinson's disease. 90 participants will be randomly assigned to receive either real stimulation targeting specifi…

This study tests whether a wearable exoskeleton—a supportive device worn around the torso—can reduce physical effort and pain for nursing home staff who regularly lift, turn, and bathe residents in bed. Over 11 weeks, 35 care workers across five French nursing homes will wear the…

This trial tests whether balance exercises on an unstable bubble cushion can improve postural control in children with Down syndrome. Twenty-two children aged 6-9 will perform supervised seated and standing exercises three times a week for 8 weeks. Researchers will measure change…

This study tests whether a home-based telerehabilitation program can improve functional capacity and quality of life for patients recovering from colorectal cancer surgery. Fifty-four participants will either follow the digital program or receive a standard booklet. The goal is t…

This study tests two different home exercise programs designed to prevent falls in people with Parkinson's disease. Thirty participants will do one of the programs for six weeks, and researchers will measure changes in balance, walking, and fear of falling. The goal is to find ou…

This study tests a drug called bezisterim (NE3107) in 60 people with early Parkinson's disease who have not yet started standard treatment. The goal is to see if it can improve movement symptoms like stiffness and slowness. Participants take the drug or a placebo twice daily for …

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study tests whether adding whole-body vibration exercises to mineral bath therapy (balneotherapy) helps people with chronic low back pain feel better, move easier, and sleep more soundly. Sixty adults aged 18 to 65 with long-lasting back pain will be split into two groups: o…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This trial tests whether a computer-based brain training program, alone or combined with other techniques, can improve thinking and memory in people with long COVID. Participants will be randomly assigned to different training approaches, including a placebo-like activity. The go…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This trial tests whether two different kinesio taping techniques, combined with exercise, can reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. Participants will receive one of the taping methods or serve as a control, with measurements…

This study looked at how being in different temperatures (from about 61°F to 88°F) affects how many calories healthy adults burn. Researchers also checked for brown fat activity, a type of fat that burns energy to keep you warm. 104 healthy men and women stayed in a hospital unit…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This early-stage study tests a single dose of the experimental drug PF-08653944 in 54 overweight or obese adults. Researchers want to see how the drug is absorbed when injected into the abdomen, thigh, or upper arm. The study also monitors safety through blood tests and vital sig…

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will ask about 50 participants to use the app and give feedback on how easy and helpful it is. The goal is to se…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study looks at whether natural variations in immune-related genes affect how well children with a rare type of lymphoma (ALCL) respond to treatment. By analyzing blood samples from 185 patients, researchers hope to find genetic markers linked to longer periods without the di…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…

This trial explores whether a blood test measuring reticulocyte hemoglobin content (RET-He) can predict how well cancer patients with anemia will respond to intravenous iron treatment. The study involves adults with solid tumors who have functional iron deficiency. By checking RE…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study is testing whether certain markers in the blood can predict how well the drug trastuzumab shrinks tumors in women with early HER2-positive breast cancer. Participants receive trastuzumab before breast-conserving surgery, and researchers compare blood marker levels with…

This trial tests whether adding a virtual reality (VR) simulation to standard hand hygiene training helps nurses learn and apply better handwashing practices. Nurses in the study either receive standard training alone or standard training plus an immersive VR experience where the…

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This study reviewed medical records of 730 people who had bone marrow transplants between 2010 and 2015. Researchers wanted to learn how often viral infections happen after transplant and what factors make them more likely. No new treatments were tested; instead, the goal was to …

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study asks whether common antacids or multivitamins change how the body absorbs raltegravir, an HIV medication. Healthy adult volunteers will take raltegravir alone and alongside different antacids or a multivitamin, with blood samples measuring drug levels over 12 hours. Th…

This study tested whether full-body suits made with far-infrared (FIR) emitting fibers affect body temperature, heart rate, oxygen use, and power output in young competitive cyclists. Nine cyclists rode a stationary bike for 40 minutes at a steady pace, then did a 5-second sprint…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This study is watching nearly 3,000 people newly diagnosed with breast cancer in Latin America. It does not test a new treatment but instead collects information on how the cancer is diagnosed, what treatments are used, and how patients do over time. The goal is to better underst…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This trial is testing whether using whole-body PET/CT scans and liquid biopsies (blood tests that detect cancer DNA) can improve the follow-up care of people who have completed treatment for early-stage non-small cell lung cancer. The goal is to see if these advanced tools can fi…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This study is building an international registry of people with GNE myopathy, an ultra-rare muscle disease that causes progressive weakness and often leads to wheelchair use. Participants will complete online questionnaires about their symptoms, medical history, quality of life, …

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study looks at whether a specific blood protein, apolipoprotein, can predict how much weight people lose after sleeve gastrectomy surgery for severe obesity. Researchers will measure protein levels before surgery and track weight loss for 8 months in 110 adults. The goal is …

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study aims to understand why some people gain or lose weight more easily than others. Researchers will measure how the body's energy use changes during overeating and dieting in 83 healthy adults. Participants will stay in the hospital for 10 weeks, undergoing tests like met…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study aims to find substances in blood or urine that can signal when a transplanted heart is being rejected. By analyzing samples from 188 heart transplant patients and healthy volunteers, researchers hope to develop a simple test for early detection. The goal is to catch re…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looks back at medical records to see how ribociclib, a CDK4/6 inhibitor used for hormone receptor-positive, HER2-negative metastatic breast cancer, is prescribed and tolerated in older adults (65 and over) and Black/African American patients. These groups are often und…

This study looks at whether having a patient navigator—a person who helps guide you through the healthcare system—can help women get timely follow-up care after an abnormal mammogram. The COVID-19 pandemic caused many delays in cancer diagnosis, especially for at-risk groups. Res…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at how the antibiotic ceftazidime behaves in children with sepsis who are in the intensive care unit (ICU). Sepsis changes the body rapidly, which can affect drug levels. The goal is to see if current dosing keeps enough antibiotic in the blood to fight bacteria …

This study looks at how often sleep disorders—like poor sleep quality, sleep apnea, and restless legs syndrome—occur in people with fibromyalgia. Researchers will use questionnaires to screen patients in specialized pain clinics across France. They will also ask doctors how they …

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This large observational study across multiple African sites tracks pregnant women who use antimalarial drugs, especially in the first trimester. The goal is to assess whether these medications are linked to miscarriage, stillbirth, or major birth defects. By following thousands …

This study looked at whether adding folic acid and vitamin B12 to locally made cereals can improve the nutrition, thinking skills, and mood of teenage girls in rural Ethiopia. About 472 girls aged 13-19 took part. The goal was to see if small-scale food fortification can help pre…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study investigates whether using a lower, more natural eye pressure during cataract surgery reduces trauma to the cornea compared to traditional high-pressure methods. The Active Sentry device helps maintain stable pressure by sensing changes in the eye. Researchers will mea…

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This early-stage trial will test a new drug called hydronidone, which is being developed for liver fibrosis caused by hepatitis B. Since patients often need to take antiviral drugs for hepatitis B, researchers want to see if hydronidone can be taken safely alongside four common a…

This early-stage study looks at how a drug called Flonoltinib maleate (being developed for a bone marrow condition) is processed and removed from the body. Six healthy adult men will take a single dose, and researchers will measure the drug and its breakdown products in blood, ur…

This study looks at whether a simple score calculated from routine blood tests—measuring hemoglobin, albumin, lymphocytes, and platelets (the HALP score)—can help predict complications after surgery to remove esophageal cancer. Researchers will track how this score changes before…

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study observed over 2,400 women in Russia with advanced HR+/HER2- breast cancer to see how well different treatments work in everyday medical practice. Researchers tracked how long patients stayed on their therapy before it stopped working or caused side effects. The goal wa…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is …

This study examines national data from Switzerland to understand trends in early-onset colorectal cancer, which affects people under 50. By analyzing surgical cases from 2003 to 2022, researchers aim to see how common this cancer is, where it occurs, and what short-term outcomes …

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study will give 100 migrant women in Turkey three structured training sessions on sexually transmitted infections, self-efficacy, and reproductive autonomy. Researchers will measure changes in knowledge, confidence, and decision-making compared to a control group. The goal i…

This study followed 775 healthy children aged 2-9 in Cambodia over three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples every wet and dry season to check for past or current infections. The goal was to understand why young children g…

This study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…

This study uses advanced MRI scans to see if bariatric surgery (weight-loss surgery) can improve the health of the pancreas in people with severe obesity. Researchers will scan the pancreas before surgery and again six months after, measuring fat content, tissue stiffness, and ot…

This study follows 1,200 people in China newly diagnosed with advanced non-small-cell lung cancer (stage IIIB/IV) that cannot be removed by surgery. Researchers will collect information from medical records and follow patients over time to see what treatments they receive, how lo…

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study investigates whether zinc oxide nanoparticles can inhibit the growth and biofilm formation of Acinetobacter baumannii, a bacterium that causes severe hospital-acquired infections like pneumonia and bloodstream infections. Researchers will collect samples from 150 patie…

This study analyzed data from 414 esophageal cancer patients who received chemoimmunotherapy before surgery. Researchers developed a new 'bio-anatomical' staging system that combines tumor characteristics and immune response to better predict survival and guide post-surgery treat…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study looked at nearly 5000 adults having planned abdominal surgery. Researchers checked their nutrition before the operation and tracked infections and recovery. The goal was to see if better nutrition before surgery leads to fewer complications.

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The specific purpose, who can join, and how the device works are not publicly available. Because key details are withheld, it is not possible to describe the expected benefits o…

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study tested a new imaging technique using a special substance (hyperpolarized carbon-13 alpha-ketoglutarate) to see how active brain tumors are in people with IDH mutant glioma. Twelve adults with this type of brain tumor received an injection and then had an MRI scan. The …

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This study will test whether 3D-printed or milled occlusal splints are more comfortable and stable for healthy adults. Twenty-four participants will try both types and report how they feel. Dentists will also evaluate the fit. The goal is to learn which method works best for futu…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study looks at how lipoproteins, like HDL (good cholesterol) and LDL (bad cholesterol), change in patients with severe COVID-19 in the intensive care unit. Researchers will measure specific proteins on these particles to see if they can predict which patients are at higher r…

This study is testing a set of cognitive assessments for children and adults with Down syndrome. The goal is to see if these tests are reliable, valid, and sensitive enough to detect changes in attention, memory, and other thinking skills. Participants aged 6 to 35 will complete …

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This trial asks whether the barbell back squat or the barbell hip thrust is better for building glute muscle and strength. About 39 young, untrained adults will train twice a week for nine weeks with one of the two exercises. Researchers will measure muscle size with MRI and stre…

This observational study looks at whether muscle loss, measured on routine CT scans, is linked to 28-day survival in adults with cancer who are admitted to the intensive care unit (ICU). Researchers will compare muscle quality and nutritional scores between patients who survive a…

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This study aims to understand how ultra-processed foods affect energy metabolism compared to unprocessed foods. Healthy adults aged 18-60 will stay at a research center for four weeks, eating different diets each week. Researchers will measure how much they eat, their metabolic r…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study tests whether sending text message reminders to patients and alerts to doctors can increase the number of women who get their recommended mammograms. About 8,490 women aged 40-74 who are overdue for screening will take part. The goal is to see if these simple 'nudges' …

This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation fr…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This study tests whether analyzing a patient's tumor alongside a sample of their normal tissue can help doctors select a more effective treatment for advanced cancer. The approach aims to provide a personalized therapy choice for every participant, even those without known geneti…

This study reviews medical records of 360 Japanese patients with advanced bladder cancer who received avelumab as a maintenance treatment after initial chemotherapy. The goal is to understand patient characteristics, treatment patterns, and outcomes like survival and tumor respon…

This study looked at whether certain blood markers of inflammation and vitamin B12 levels are linked to carpal tunnel syndrome. Researchers compared 70 people with and without the condition. The goal was to see if these markers could help explain why some cases are more severe.

This pilot study aims to test the feasibility of creating a large-scale cohort of tuberculosis (TB) patients in northern Paris, an area with high TB rates. Researchers will collect blood samples and clinical data from 30 participants over the course of their treatment to understa…

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…

This study will use artificial intelligence to analyze data from 400 COVID-19 patients treated in intensive care units. The goal is to see if machine learning models, including deep learning, can predict which patients are most likely to die from the disease. The AI's performance…

This study collects information from about 889 people with inherited retinal diseases (IRDs) to understand how vision changes over time. Participants have their eyesight and visual field tested regularly. The goal is to learn more about the natural course of these rare eye condit…

This trial investigates whether the shape of the gum flap lifted during wisdom tooth removal affects blood flow to the nearby tooth and gum tissue. Participants are healthy adults aged 18 to 40 with one impacted lower wisdom tooth. They are assigned to one of two flap designs: a …

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study is testing whether an artificial intelligence system can more accurately classify small bowel Crohn's disease and predict how patients will fare over the next year. Researchers will analyze existing CT or MRI scans from 437 patients, combining imaging features with cli…

This study looks at how IgA nephropathy, a kidney disease, is actually treated in the United States. By analyzing medical records from thousands of patients, researchers aim to understand which therapies are used, in what order, and for how long. The goal is to see how current tr…

This trial tests whether an online training course, called MelaMEd, can improve primary care doctors' ability to detect and manage melanoma, the most serious form of skin cancer. Participants—general practitioners, trainees, and pediatricians—answer questions and review skin lesi…