Could new scans and duct wash detect breast cancer earlier in High-Risk women?

NCT ID NCT00006421

Completed Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 10 times

Summary

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three years with annual exams and imaging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 2-Fluorodeoxyglucose
What this could lead to: If successful, this could lead to better early detection methods for breast cancer in high-risk women, potentially improving survival rates.
What could go wrong: This is an observational study focused on screening methods, not a treatment trial. It may not directly improve outcomes, and the small sample size limits generalizability.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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