Could a simple antacid sabotage HIV treatment?

NCT ID NCT01784302

NEW Completed Knowledge-focused Sponsor: Helen Reynolds Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This study asks whether common antacids or multivitamins change how the body absorbs raltegravir, an HIV medication. Healthy adult volunteers will take raltegravir alone and alongside different antacids or a multivitamin, with blood samples measuring drug levels over 12 hours. The goal is to see if these everyday products interfere with the drug, which could help optimize dosing for people living with HIV.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Raltegravir, an HIV medication, given with or without antacids (Maalox Plus, sodium bicarbonate) or multivitamins
What this could lead to: If it works, this could lead to better dosing guidance for people with HIV who need antacids or multivitamins, ensuring their medication works effectively.
What could go wrong: This is a small, early-stage study in healthy volunteers, not people with HIV. Results may not reflect real-world use, and the interaction may be minimal or vary by individual.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV

Contacts and locations

Locations

Royal Liverpool University Hospital

Liverpool, L7 8XP, United Kingdom

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