Can removing ovaries prevent cancer in High-Risk women? new study investigates
NCT ID NCT00043472
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 4 times
Summary
This study followed 40 women at high genetic risk for ovarian cancer due to BRCA mutations or strong family history. One group chose to have their ovaries and fallopian tubes removed to prevent cancer, while the other group opted for regular CA-125 blood tests every 3 months to catch cancer early. Researchers tracked cancer rates, quality of life, and decision-making to see which approach works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- surgical removal of ovaries and fallopian tubes (prophylactic salpingo-oophorectomy)
- What this could lead to
- If successful, this could confirm that preventive surgery reduces ovarian cancer risk in high-risk women, and that regular CA-125 blood tests can catch cancers early in those who avoid surgery.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't prove cause and effect. Results may not apply to all women, and surgery carries risks like menopause and surgical complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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