New combo shows promise against Tough-to-Treat lymphoma
NCT ID NCT04569032
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study tested a combination of the targeted drug brentuximab vedotin (ADCETRIS) plus standard CHP chemotherapy in 82 people with newly diagnosed peripheral T-cell lymphoma (PTCL) that has low CD30 levels. The goal was to see how many patients' tumors shrank or disappeared. Results showed that many patients responded to the treatment, but side effects were common. This early-phase trial suggests the combo may be an option for this hard-to-treat cancer, but more research is needed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- brentuximab vedotin (ADCETRIS) plus CHP chemotherapy (cyclophosphamide, doxorubicin, prednisone)
- What this could lead to
- If successful, this combination could become a new frontline treatment option for certain types of PTCL that have low CD30 expression, potentially improving response rates.
- What could go wrong
- This is a small, early-phase (Phase 2) study with no control group, so results are preliminary. Side effects from chemotherapy and brentuximab vedotin can be serious, and long-term benefits are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Azienda Ospedaliera Universitaria Integrata Verona Policlinico G.B. Rossi
Verona, 37134, Italy
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Azienda Ospedaliero Universitaria di Bologna - IRCCS
Bologna, Emilia-Romagna, 40138, Italy
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CHU Grenoble Alpes
Tronche, Auvergne-Rhône-Alpes, 38700, France
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Cetir Centre Medic
Barcelona, 08029, Spain
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Cleveland Clinic taussig Cancer Center Investigational Pharmacy
Cleveland, Ohio, 44106, United States
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Cleveland Clinic, The
Cleveland, Ohio, 44195, United States
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Lombardy, 20122, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, Lombardy, 27100, Italy
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Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS Candiolo - Oncologia Medica
Candiolo, Turin, 10060, Italy
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Hammersmith Hospital
London, W12 0HS, United Kingdom
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Hopital Emile Muller
Mulhouse, 68070, France
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Hospital Clinico Universitario de Salamanca
Salamanca, 37007, Spain
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Hospital Duran I Reynals - Institut Catala d'Oncologia
Barcelona, 08908, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario De La Paz
Madrid, Other, 28046, Spain
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Höpital Haut Levéque - CHU Bordeaux Service d'hématologie clinique et thérapie cellulaire
Pessac, 33604, France
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IEC Trials, Hospital La Milagrosa.
Madrid, Other, 28010, Spain
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IRCCS Ospedale Policlinico San Martino
Genova, Other, 16132, Italy
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MACMILLIAN Cancer Centre
London, WC1E 6AG, United Kingdom
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Massey Cancer Center Clinical & Translational Research Lab
Richmond, Virginia, 23298, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center David H. Koch Center for Cancer Care
New York, New York, 10021, United States
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Oxford University Hospitals
Headington, Oxford, OX3 7LE, United Kingdom
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Rocky Mountain Cancer centers, LLP
Aurora, Colorado, 80012, United States
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Rocky Mountain Cancer centers, LLP
Boulder, Colorado, 80303, United States
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Rocky Mountain Cancer centers, LLP
Colorado Springs, Colorado, 80907, United States
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Rocky Mountain Cancer centers, LLP
Denver, Colorado, 80218, United States
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Rocky Mountain Cancer centers, LLP
Denver, Colorado, 80220, United States
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Rocky Mountain Cancer centers, LLP
Lakewood, Colorado, 80228, United States
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Rocky Mountain Cancer centers, LLP
Littleton, Colorado, 80120, United States
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Rocky Mountain Cancer centers, LLP
Lone Tree, Colorado, 80124, United States
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Rocky Mountain Cancer centers, LLP
Longmont, Colorado, 80504, United States
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Rocky Mountain Cancer centers, LLP
Pueblo, Colorado, 81003, United States
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Rocky Mountain Cancer centers, LLP
Thornton, Colorado, 80260, United States
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Stanford Cancer Center
Stanford, California, 94305, United States
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Stanford Hospital and Clinics, Investigational Drug Services
Stanford, California, 94305, United States
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Texas Oncology - Central South (Balcones Dr)
Austin, Texas, 78731, United States
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Texas Oncology - Central South (James Casey)
Austin, Texas, 78745, United States
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Texas Oncology - Central/South Texas
Austin, Texas, 78705, United States
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Texas Oncology-Northeast Texas
Longview, Texas, 75601, United States
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Texas Oncology-Northeast Texas
Palestine, Texas, 75801, United States
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Texas Oncology-Northeast Texas
Paris, Texas, 75460, United States
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Texas Oncology-Northeast Texas
Tyler, Texas, 75702, United States
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Tulane Cancer Center
New Orleans, Louisiana, 70112, United States
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Tulane Medical Center
New Orleans, Louisiana, 70112, United States
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UCLH Hospitals
London, NWI 2BG, United Kingdom
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US Oncology Investigational Products Center (IPC)
Irving, Texas, 75063, United States
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US Oncology Investigational Products Center(IPC)
Irving, Texas, 75063, United States
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US Oncology lnvestigational Products Center (IPC)
Irving, Texas, 75063, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35249, United States
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VCU Massey Cancer Center-Radiation Oncology
Richmond, Virginia, 23219, United States
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VCU Medical Center -InPatient
Richmond, Virginia, 23219, United States
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VCU Medical Center Critical Care Hospital
Richmond, Virginia, 23219, United States
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VCU at Stony Point
Richmond, Virginia, 23235, United States
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Virginia Commonwealth University
Richmond, Virginia, 23219, United States
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Virginia Oncology Associates
Chesapeake, Virginia, 23320, United States
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Virginia Oncology Associates
Hampton, Virginia, 23666, United States
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Virginia Oncology Associates
Newport News, Virginia, 23606, United States
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Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
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Virginia Oncology Associates
Virginia Beach, Virginia, 23456, United States
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