Can a targeted pill boost Chemo's power against a rare blood cancer?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years old,regardless of gender; 2. Centrally confirmed histopathological/cytologic diagnosis of PTCL with the following subtypes:Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS);Follicular helper T (TFH) cell lymphoma of lymph nodes, including angioimmunoblastic, follicular, NOS; Enteropathy-associated T-cell lymphoma(EATL); Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)and any other PTCL subtypes deemed by the investigator to be eligible for inclusion. 3. No prior anti-tumor therapy. 4. There must be at least one measurable or evaluable lesion that meets the Lugano 2014 criteria for lymphoma: Measurable lesion: Nodal lesions with major diameter greater than 1.5cm and minor diameter greater than 1.0cm as assessed by PET/CT or Computed Tomography (CT) and/or Magnetic Resonance Imaging (MRI); Or the length of extranodal lesions \>1.0cm; 2)Evaluable lesions: PET-CT showed increased uptake in lymph nodes or extranodal regions (higher than liver) and imaging features consistent with lymphoma; 5. ECOG performance status score: 0-2; 6. Expected survival time ≥3 months; 7. Have adequate organ and bone marrow functiont; 8. No concurrent hemophagocytic lymphohistiocytosis (HLH). If a patient has clinically diagnosed HLH, enrollment eligibility will be determined by the investigator based on an evaluation of the patient's general physical condition following targeted anti-HLH therapy. 9. Women of childbearing potential must have a negative serum pregnancy test within 7 days before the first dose of medication; Effective contraception should be used from the time of informed consent until 6 months after the last dose of study drug. 10. Capable of understanding the study procedures and voluntarily signing a written informed consent form (ICF).; Exclusion Criteria: 1. Prior treatment with epigenetic agents before enrollment; 2. Patients with a history of severe cardiac disease, history of radiation therapy to the mediastinal/pericardial region, cumulative anthracycline dose \> 550 mg (doxorubicin equivalent), prior use of mitoxantrone, baseline left ventricular ejection fraction (LVEF) \< 50%, or history of exposure to other cardiotoxic drugs; 3. History of other primary aggressive malignancies that are not in remission, or have been in remission for less than 3 years; 4. Primary central nervous system (CNS) lymphoma or secondary CNS involvement. 5. Known allergy or hypersensitivity to the study drugs or their related metabolites; 6. Currently participating in another clinical study, or less than 4 weeks elapsed from the end of treatment in a previous clinical study to the planned start of study treatment; 7. Pregnant or lactating women; 8. Active infections; 9. Medical History and Concurrent Conditions; 10. History of Human Immunodeficiency Virus (HIV) infection and/or Acquired Immunodeficiency Syndrome (AIDS); 11. Patients with mental disorders or those unable to provide informed consent 12. Any other condition deemed by the investigator to be unsuitable for study enrollment;