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Can a powerful combo of drugs and stem cell transplant beat tough lymphomas in kids?

NCT ID NCT03719105

NEW Recruiting now ⭐️ CURE ⭐️ Sponsor: New York Medical College Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This trial is testing a two-step approach for children, teens, and young adults with advanced T-cell or NK-cell lymphoma or leukemia. First, patients receive a combination of chemotherapy and immunotherapy drugs to shrink the cancer. Then, those who respond go on to receive a stem cell transplant from a donor, which aims to replace the diseased immune system with a healthy one. The goal is to see how well this plan works at controlling the disease and improving long-term survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
A combination of chemotherapy drugs (methotrexate, ifosfamide, dexamethasone, etoposide, pegaspargase, pralatrexate, cyclophosphamide, doxorubicin, prednisone) and immunotherapy (pembrolizumab, brentuximab vedotin), followed by an allogeneic stem cell transplant.
What this could lead to
If successful, this approach could offer a path to long-term remission or even a cure for aggressive T/NK lymphomas and leukemias in young patients.
What could go wrong
This is an early-phase pilot with a small number of patients, so results may not be conclusive. The treatment is intensive and carries risks like infection, graft-versus-host disease, and organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aggressive NK-cell leukemia angioimmunoblastic T-cell lymphoma enteropathy-associated T-cell lymphoma extranodal nasal NK/T cell lymphoma hepatosplenic T-cell lymphoma Leukemia, Large Granular Lymphocytic mature T-cell and NK-cell non-Hodgkin lymphoma peripheral T-cell lymphoma, not otherwise specified

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NK-CELL LEUKEMIA NK-CELL LYMPHOMA PERIPHERAL T CELL LYMPHOMA

Contacts and locations

Locations

  • Children's Hospital Orange County

    RECRUITING

    Orange, California, 92968, United States

  • Helen De Vos

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • New York Medical College

    RECRUITING

    Valhalla, New York, 10595, United States

  • University of Alabama

    RECRUITING

    Birmingham, Alabama, 35223, United States

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact Email: •••••@•••••

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