Diabetes mellitus

This early-stage trial tests a small, soft implant that holds donor insulin-making cells (islets) and protects them from the immune system. The goal is to see if the device is safe and keeps the cells alive and working in adults with type 1 diabetes. Some participants are also on…

This study tests whether people with type 2 diabetes can switch from a weekly injection of dulaglutide to a once-monthly shot called PG-102. The trial involves 60 adults whose blood sugar is well-controlled on dulaglutide. Researchers will compare blood sugar levels and safety ov…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This study tests whether helping people with diabetes find local resources (like food or housing help) and pairing them with a peer supporter can improve blood sugar and blood pressure. About 694 adults with diabetes who have trouble controlling their condition will be randomly a…

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This study tests a new, long-acting form of semaglutide (a diabetes drug) that is given once every four weeks instead of weekly. The goal is to see if it is safe and works well for controlling blood sugar and weight in 24 adults with type 2 diabetes. Participants must already be …

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This study tests whether giving people with type 2 diabetes and food insecurity monthly vouchers for fruits and vegetables can improve blood sugar control. Participants receive $100 per month in produce-only gift cards along with dietary education for five months, then switch to …

This study investigates whether regular blood tests can detect liver cancer earlier in people with type 2 diabetes who also have significant liver scarring. Participants are randomly assigned to either a surveillance group receiving specialized blood tests every six months or a s…

This study tests a 10-week virtual program called Acceptance Based Coping (ABaCo) for Hispanic/Latinx military patients with type 2 diabetes. The program, delivered by a bilingual health coach, teaches skills to cope with diabetes-related stress and improve self-care. Researchers…

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This study will test whether a 4-month digital coaching program (Noom) helps adults who recently started GLP-1 medications improve their diet and physical activity. About 220 participants will use the app to track food and exercise, get coaching, and learn about managing challeng…

This early-stage study tests how the body processes HRS9531 tablets under different dosing conditions. It involves 100 healthy adults aged 18-55 with a BMI between 23 and 35. The goal is to measure drug levels and safety, not yet to treat weight or diabetes.

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

The HARVEST study is testing whether eating a special low-glycemic, high-protein rice instead of regular white rice can improve blood sugar control in people with prediabetes or type 2 diabetes. Over 16 weeks, 225 adults in Singapore will replace their usual rice with one of thre…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the first part of the small intestine (duodenum) in people recently diagnosed with type 2 diabetes. The goal is to see if this can help control blood sugar levels without needi…

This phase 3 study tests whether a new oral drug called elecoglipron can help adults with type 2 diabetes better manage their blood sugar when added to their current insulin and other diabetes medications. About 600 participants will receive either elecoglipron or a placebo daily…

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 we…

This study tests an experimental drug called elecoglipron, taken alone or together with the existing medication dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled. About 800 participants will receive either the new drug, a placebo, or a combina…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests a new, simpler weight training program called D-STORM for adults with type 2 diabetes. The program uses easier exercises to build muscle and improve blood sugar control. Over 12 weeks, 56 participants will either do the training plus usual care or just usual care…

This study will test whether replacing breakfast and a snack with a diabetes-specific nutritional drink (Glucerna) helps people with type 2 diabetes and obesity keep their blood sugar in a healthy range more often. About 198 adults will be randomly assigned to either the drink-ba…

This study tests whether a personalized online lifestyle program, with or without a virtual AI coach, can help people with type 2 diabetes improve their blood sugar control. 160 adults will use continuous glucose monitors and attend online group sessions over 12 months, with foll…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This phase 3 study tests whether taking two diabetes medications together—elecoglipron and dapagliflozin—works better than either drug alone for controlling blood sugar in adults with type 2 diabetes. The trial enrolls about 2,000 people whose diabetes is not well managed by life…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This study tests a new medicine called UBT251, given as a weekly shot, in 300 adults with type 2 diabetes. Some participants will get UBT251, others will get a placebo or an existing drug (semaglutide). The goal is to see if UBT251 can safely lower blood sugar and help with weigh…

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the duodenum (the first part of the small intestine). The goal is to improve blood sugar control and reduce fat buildup in the liver for people with type 2 diabetes and fatty l…

This phase 3 study tests a new oral drug, elecoglipron, against the approved pill semaglutide in adults with type 2 diabetes who also have increased heart risk. The goal is to see which works better for lowering blood sugar and body weight over about a year. Participants take one…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests whether two low-calorie versions of the MIND-HK diet can improve blood sugar and heart health in adults with type 2 diabetes. 180 participants aged 40-70 will be split into three groups: one following a low-calorie diet, one a very low-calorie diet, and a control…

This Phase 3 trial tests a new injection called UBT251 in 360 adults with type 2 diabetes who have not been able to control their blood sugar with diet and exercise alone. Participants will receive either a weekly shot of UBT251 (at different doses) or a placebo for several weeks…

This study looks at how well a new once-weekly insulin, called insulin icodec, works for people with type 2 diabetes who are switching from a daily insulin. Researchers will track blood sugar control, treatment satisfaction, and how well patients stick to the new regimen over abo…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This phase 3 study compares an experimental weekly injection called UBT251 to the approved drug semaglutide in adults with type 2 diabetes whose blood sugar is not well controlled by oral medications like metformin. The main goal is to see if UBT251 is at least as effective as se…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study will test whether adding a probiotic supplement to standard diabetes medications (metformin or insulin) improves blood sugar control and reduces inflammation in pregnant women with gestational diabetes. Two hundred women diagnosed between 18-26 weeks of pregnancy will …

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study tests a new automated insulin delivery system for people with type 1 or type 2 diabetes in a hospital setting. Six participants will have their blood sugar controlled by the system for 24 hours while eating standard meals. The goal is to see if the system can keep bloo…

This study tests whether an interactive educational video, added to standard diabetes education, helps children aged 8 to 14 with type 1 diabetes improve their blood sugar control. The video lets kids make decisions in everyday situations and see the results. Researchers will mea…

This study tests whether a mild electrical stimulation applied to the ear (via a small device) can improve memory and thinking in people with type 2 diabetes who also have mild cognitive impairment. The trial will involve 38 participants who will either receive the active stimula…

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works better for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be randomly assi…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study looks at whether structured nutrition counseling helps pregnant women with gestational diabetes improve their diet quality and reduce harmful substances called advanced glycation end products. About 48 first-time pregnant women aged 18-35 will be assigned to either cou…

This study tests whether a combination of three diabetes drugs (tirzepatide, empagliflozin, and pioglitazone) can help people newly diagnosed with type 2 diabetes achieve remission—meaning their blood sugar stays normal even after stopping medication. About 296 adults will take e…

This study looks at how well a new insulin called icodec controls blood sugar in adults with type 2 diabetes who are switching from their current daily insulin. About 214 participants in Italy will use icodec as prescribed by their doctor for 22 to 30 weeks. Researchers will meas…

This study tests whether a mobile app (MOM-HD) can help pregnant women with high blood pressure or diabetes monitor their blood pressure and blood sugar at home. About 864 women in Nepal will either use the app plus standard care or standard care alone. The goal is to see if home…

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This study tests a new medicine called bofanglutide (GZR18) for adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. Bofanglutide is given as a shot under the skin every two weeks, and researchers compare it to semaglutide, a weekly injection…

This early-stage trial tests a single injection of UBT38006 in 43 healthy adult men to see if it is safe and how the body processes it. Participants receive either the drug, a placebo, or an active comparator (insulin degludec). The goal is to gather safety data and measure drug …

This study gives 400 adults with diabetes or high blood pressure free home-delivered produce boxes and vouchers for 6 months, plus nutrition education and self-management classes. The goal is to see if this helps them eat more fruits and vegetables, feel less food insecure, and i…

This study tests a new injectable drug called SRSD384 in 78 overweight or obese adults. In the first part, participants receive a single dose of SRSD384 alone. In the second part, they receive SRSD384 combined with another weight-loss drug, tirzepatide. The main goal is to check …

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

This study tests a modified oral rehydration salts (ORS) drink designed for diabetic pilgrims at risk of heat stress and dehydration during the Hajj. The modified ORS has adjusted electrolytes and carbohydrates to avoid raising blood sugar. Researchers will compare it to standard…

This study tests whether starting treatment with two experimental drugs together (DWP16001 and DWC202518) works better than either drug alone for people with type 2 diabetes. About 510 adults will take the combo or a single drug for 24 weeks, and researchers will measure changes …

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This study tests a once-weekly injection called CagriSema (a mix of cagrilintide and semaglutide) in 80 children and adolescents with type 2 diabetes. The goal is to see if it lowers blood sugar and body weight better than a placebo. The trial lasts about 15 months, with everyone…

This study tests whether a device that emits light (biophoton therapy) can help control type 2 diabetes. About 46 adults with diabetes will either receive the real device or a placebo for 4 weeks, then everyone gets the real device for 8 more weeks. Researchers will measure blood…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This study tests a new way to deliver insulin for type 2 diabetes: a spray applied to the skin instead of an injection. Thirty adults who already use insulin will try the spray for 21 days. Researchers will check if it keeps blood sugar in a safe range and causes less skin irrita…

This study tests a new tool called the Snouda Metabolic Score (SMS) that helps doctors identify the specific metabolic problems driving Type 2 Diabetes in each patient. 150 adults will follow a personalized 24-week lifestyle and nutrition plan based on their SMS results. The goal…

This study tests whether empagliflozin (Jardiance), a drug used for type 2 diabetes, can improve blood sugar control in people who have had an islet transplant and still have partial islet function. About 40 adults will receive either a placebo, 10 mg, or 25 mg of empagliflozin d…

This study looks at whether combining peer support with remote patient monitoring can help Black adults with uncontrolled type 2 diabetes improve their blood sugar levels. About 200 participants from Alabama will use the program for 6 months. The goal is to see if this approach l…

This study compares two drugs, ATG and teplizumab, to see if they can delay or prevent type 1 diabetes in people who are at high risk. About 60 participants aged 4 to 35 will receive either two infusions of ATG or 14 daily infusions of teplizumab. Researchers will monitor them fo…

This study will test an automated insulin delivery system (the Medtronic 780G pump with continuous glucose monitoring) in 20 pregnant women with type 2 diabetes. Participants join before 16 weeks of pregnancy and use the device until delivery. The main goal is to see how much tim…

This study tests whether adding fecal microbiota transplantation (FMT) to a calorie-restricted diet and a diabetes drug (semaglutide) helps people with obesity and type 2 diabetes lose more weight and improve metabolism. Twenty adults aged 18-60 with a BMI of 30-40 and diabetes f…

This study tests whether a 3-month support program, led by a nurse and a community health worker and guided by an AI tool called MEDBRIDGE, can help people with type 2 diabetes manage their medications after leaving the hospital. The program aims to reduce confusion about medicat…

This Phase 2 trial tests whether HRS9531 tablets can improve blood sugar control in people with type 2 diabetes who haven't achieved good control with lifestyle changes or metformin alone. About 240 participants will receive either the drug or a placebo for 20 weeks. The main goa…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study compares two glucose monitoring methods—continuous glucose monitors (CGM) and traditional finger-prick tests—in adults with type 2 diabetes who are taking the drug dapagliflozin. The 120 participants will be split into two groups and followed for 12 weeks to see which …

This study will adapt a community health worker-led program to include mental health and digital tools for South Asians with type 2 diabetes who are at risk for depression. Researchers will test whether the program is feasible and acceptable to participants. The study involves 10…

This study will test whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and nutrition. About 80 participants will be randomly assigned to CGM-guided care or stand…

This study tests whether a structured nutrition education program can help adults with type 2 diabetes who are not meeting blood sugar goals. About 253 participants will either receive a nutrition booklet alone or the booklet plus four monthly group lessons. The main goal is to s…

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This phase 2 trial tests whether a drink called A1Cantus can lower blood sugar levels (HbA1c) in adults with type 2 diabetes. About 50 participants will drink either the active supplement or a placebo twice daily for 3 months. The study is double-blind, meaning neither participan…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This early-phase trial tests whether specially modified immune cells, called CD6-CAR Tregs, can safely control type 1 diabetes. The cells are made from the patient's own blood and designed to stop the immune system from attacking insulin-producing cells. Six adults with stage 3 t…

This study will give 12 families of children with type 1 diabetes and food insecurity either weekly boxes of fresh produce or semi-prepared meal kits, plus nutrition coaching. The goal is to see if these programs are practical and improve diet quality and blood sugar stability. I…

This study tests whether montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in 50 teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking harmful inflammatory chemicals linked to diabetes complications. Researchers…

This study will test whether an artificial intelligence (AI) system can help community doctors better manage patients who have high blood pressure along with diabetes or high cholesterol. About 6,800 adults will be split into two groups: one where doctors use the AI tool to guide…

This study looks at whether adding pioglitazone (a type 2 diabetes drug) to dapagliflozin (an SGLT2 inhibitor) can reduce the liver's glucose production, fat breakdown, and ketone production in people with type 1 diabetes. These effects from dapagliflozin can raise the risk of ke…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

This study will test a program based on WHO guidelines to improve diabetes screening and care in 10 primary health centers in Nigeria. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if the program helps more people get diagnosed and treated.

This study looks at adding a drug called Chiglitazar to standard SGLT-2 inhibitor treatment for adults with type 2 diabetes whose blood sugar is not well controlled. Researchers will track changes in blood sugar, heart, kidney, and liver health over time. About 3550 participants …

This early-stage study tests a new treatment called SR-02 for adults with type 1 diabetes who experience dangerously low blood sugar. The treatment involves implanting insulin-producing cells into the belly lining. Nine participants will receive the implant and must take lifelong…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a community-to-facility care model to help control type 2 diabetes in Bangladesh. Researchers will compare the new integrated approach with usual care in 20 city wards involving 5,000 adults. The goal is to see if linking community health workers with clinics imp…

This study tests whether adding the drug cofrogliptin to standard treatment (metformin, insulin, and vitamin D3) can help preserve beta-cell function in adults with latent autoimmune diabetes (LADA). Over 52 weeks, 84 participants will take either cofrogliptin or a placebo, and r…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This early study tests whether adding an experimental drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo …

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests whether high-protein drinks during labor can keep blood sugar in a healthier range for pregnant women with insulin-treated diabetes. Sixty women will be randomly assigned to drink either a high-protein beverage or standard clear liquids every four hours during la…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This study tests a special education program designed to boost confidence in managing type 2 diabetes. About 400 adults will either receive this program or standard care. The goal is to see if the program improves blood sugar monitoring, diabetes knowledge, and quality of life.

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether an AI-powered lifestyle program can help adults with type 2 diabetes maintain weight loss as well as continuing the drug tirzepatide. All 400 participants first take tirzepatide for 20 weeks to lose weight. Then, those who meet goals are randomly assigned…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study tests whether giving people with diabetes a continuous glucose monitor (CGM) when they leave the hospital helps them control their blood sugar better than traditional finger-stick testing. 120 participants will be randomly assigned to use either a CGM or finger sticks …

This study looks at whether a 12-week Mediterranean diet can lower oxidative stress and improve blood sugar control in girls aged 10-18 with type 1 diabetes who have high HbA1c levels. Researchers will measure changes in blood markers and glucose levels. The goal is to see if thi…

This study compares a new oral diabetes medication, QLG1091, to the existing drug Rybelsus, both taken alongside metformin. About 478 adults with type 2 diabetes will take one of the two pills daily for 26 weeks. The goal is to see if QLG1091 controls blood sugar (HbA1c) as well …

This study tests whether a 3-month video-based lifestyle program works better when delivered by a patient's own primary care doctor versus an unfamiliar doctor. The program covers healthy eating, physical activity, and behavior change. Researchers will measure blood sugar control…

This study tests whether five virtual sessions with a trained pharmacist can improve blood sugar, diabetes knowledge, medication adherence, and quality of life in adults with uncontrolled type 2 diabetes. Participants are randomly assigned to receive the tele-education program pl…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This early-stage trial tests a microneedle patch called DWRX5003 that delivers semaglutide, a drug used for obesity and type 2 diabetes. The study involves 72 healthy adults to check safety and how well the drug enters the body compared to standard injections. It is not yet testi…

This study will see if a program led by community health workers (CHWs) can help people with type 2 diabetes in rural and low-income clinics. About 200 Spanish-speaking Hispanic adults will attend monthly diabetes classes and get weekly check-ins from CHWs. The goal is to see if …

This study tests whether providing free, medically tailored meals to children with Type 1 Diabetes who face food insecurity can improve their health. Fifty kids will either receive standard care or standard care plus 10 healthy meals per week for 6 months. Researchers will track …

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study will test whether sending reminders by text, email, or secure patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults who have not refilled their statin in the last 3 months will receive one of these me…

This study tests a new injectable medicine, GZR101-80, for people with type 2 diabetes that is not well controlled by current pills or basal insulin. About 345 adults will receive the drug for 16 weeks to see if it lowers blood sugar and HbA1c safely. The goal is better daily con…

This study tests a new way of managing care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes. About 960 people from rural community health centers will either receive the new integrated care package or continue with standard care. The goal is to…

This study will test whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau foods can improve metabolic health in 40 obese adults. Participants will follow a diet based on coconut milk dishes for a period, and researchers will measure ch…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This study tests a 12-week home exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early muscle weakness. The goal is to see if short, regular workouts can improve physical activity levels and muscle strength. About 73 parti…

This study tests whether a mobile app can help people with diabetes better manage their condition after leaving the hospital. The app provides education, reminders, and monitoring tools for 90 days. Researchers will compare self-care behaviors, blood sugar control, and hospital r…

This study tests whether adding artificial intelligence to an automated insulin delivery system can improve blood sugar control for people with type 1 diabetes. The AI learns each person's meal patterns and automatically gives insulin boluses without requiring them to announce me…

This study looks at whether a probiotic called Lactobacillus paracasei LC19 can help control blood sugar in people recently diagnosed with type 2 diabetes. About 70 adults who have not taken diabetes medication will take the probiotic daily for 12 weeks. Researchers will measure …

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This study compares two ways to manage diabetes after hospital discharge: using a continuous glucose monitor (CGM) versus standard fingerstick checks. About 64 adults with type 2 or steroid-induced diabetes who need insulin after leaving the hospital will wear a sensor for 28 day…

This study tests whether tributyrin, a dietary supplement that turns into butyrate in the body, can improve blood sugar control, reduce inflammation, and lower heart disease risk in people with type 2 diabetes. Sixty participants at high risk for heart problems will receive eithe…

This study looks at whether starting an automated insulin delivery (AID) system within two weeks of a type 1 diabetes diagnosis helps young patients manage their blood sugar more easily. Sixteen youth newly diagnosed with type 1 diabetes will be offered the system and followed fo…

This study tests whether a supplement called HMB, combined with exercise, can improve muscle mass, strength, and insulin resistance in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to receive HMB, exercise, both, or pla…

This study tests a new medicine called CagriSema, which combines two drugs to lower blood sugar in people with type 2 diabetes. About 400 adults aged 18-64 will receive either CagriSema or a placebo using one of two injection devices. The main goal is to see how well it reduces H…

This study tests whether an investigational drug called HTD1801 can slow the worsening of kidney disease in adults who have both type 2 diabetes and chronic kidney disease. About 75 participants will take either HTD1801 or a placebo twice daily for 12 weeks. Researchers will meas…

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This phase 4 trial will test whether adding alogliptin to a standard two-drug regimen (pioglitazone and metformin) improves blood sugar control and liver health in 80 adults with type 2 diabetes and fatty liver disease. Participants must not have used diabetes medications in the …

This study tests a new drug called IMC-S118AI in people with type 1 diabetes who have a specific genetic marker (HLA-A*02:01). The main goal is to check if the drug is safe and how it works in the body. Researchers will also look at whether it can help preserve the cells that mak…

This study will test the safety and effectiveness of tirzepatide, a once-weekly injection, in 300 adults with obesity or overweight plus related health problems. Participants will receive increasing doses over 12 months while doctors track side effects, weight loss, and improveme…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a contr…

This study will test two ways of controlling blood sugar during heart surgery in 3000 elderly patients with type 2 diabetes. One group will have tight control (blood sugar between 5-8 mmol/L) and the other liberal control (11-14 mmol/L). The goal is to see which approach leads to…

This study looks at whether starting automated insulin delivery (AID) early in children aged 7–16 with type 1 diabetes improves blood sugar control, reduces stress for patients and families, and prevents long-term complications compared to standard insulin injections. One hundred…

This study follows 40 adults with type 1 diabetes who previously used an automated insulin delivery system. Researchers want to see if the system's benefits, like better blood sugar control, last for years. They will also check if long-term use leads to weight gain.

This study tests a new treatment for diabetes using lab-grown cells that produce insulin. About 30 adults with diabetes who have used insulin for over 5 years will receive an infusion of these cells. The goal is to see if the cells are safe and can improve blood sugar control, po…

This study will test whether a natural fiber called oligofructose, found in foods like onions and bananas, can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. A total of 100 people (50 with diabetes and 50 without) will take either th…

This study tests whether eating 3 dates daily for 8 weeks can improve blood sugar control and reduce oxidative stress in 130 adults with well-controlled type 2 diabetes. Participants replace a carbohydrate portion with dates to keep calories steady. The goal is to see if this sim…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study looks at whether a GLP-1 receptor agonist, a drug already used for diabetes and obesity, can improve fat buildup in the liver and blood in people with MASLD. Researchers will measure changes in fats, proteins, and genes in 30 participants who already take the drug. The…

This study tests a procedure that uses radiofrequency energy to disable certain nerves near the kidneys and abdomen. The goal is to see if this can safely lower blood pressure and improve blood sugar control in 20 adults with resistant hypertension and type 2 diabetes who have no…

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This study compares two diabetes medications—imeglimin and metformin—in 176 adults newly diagnosed with type 2 diabetes. Participants will take one of the two drugs for 12 weeks. The main goal is to see which drug better improves mitochondrial function, measured by a blood test c…

This study tests whether group care—where patients meet together with health workers for education and check-ups—can improve control of high blood pressure and diabetes in Nepal. Over 1,100 adults from 37 health facilities will be assigned to standard care, low-intensity group ca…

This study tests a new once-daily tablet that combines three diabetes drugs (henagliflozin, retagliptin, and metformin) in Chinese adults with type 2 diabetes. About 300 participants will take the pill for 24 weeks to see how well it lowers blood sugar and check for side effects.…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This early study tests whether semaglutide, a drug already used for type 2 diabetes, can protect the body's insulin-producing cells in people with stage 1 type 1 diabetes. The goal is to see if it can delay or prevent the disease from progressing to the next stage. Fifteen adults…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests a new approach to managing type 2 diabetes that combines an AI smartphone app with support from family doctors. About 1200 adults in China will use the app to track their meals and get personalized feedback, while also receiving regular check-ins from their docto…

This study tests whether a home-based vibrating calf device can help adults with type-2 diabetes improve blood sugar control. 305 participants in Saudi Arabia will be assigned to active vibration, a sham device, or usual care for 12 weeks. The main goal is to see if vibration-ass…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether regular phone calls from a nurse can help adults with diabetes in Ethiopia improve their blood sugar control, take medications correctly, and learn more about their condition. About 320 participants will either receive usual care or get structured phone c…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study tests whether a new drug, HDM1005, works better than another drug called mazdutide at controlling blood sugar in people with type 2 diabetes. About 912 adults whose diabetes is not well controlled with metformin (alone or with another diabetes pill) will receive one of…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This phase 2 trial tests whether the cancer drug sorafenib can help people newly diagnosed with type 1 diabetes keep making their own insulin. Ten adults aged 18-60 will receive either sorafenib or a placebo daily, along with their usual insulin. The study measures changes in ins…

This study tests whether personalized diet and physical activity guidance from a nurse can help pregnant women with gestational diabetes control their blood sugar and reduce complications for their babies. Sixty-six women will be randomly assigned to either receive this extra sup…

This study tests whether a special vacuum dressing (negative pressure wound therapy) placed on the closed surgical wound can prevent infections in diabetic patients who have emergency abdominal surgery. About 110 high-risk adults with diabetes will be randomly assigned to get eit…

This study enrolls 324 adults with type 2 diabetes whose blood sugar is not well controlled on oral medications. All participants will first receive short-term intensive insulin therapy in the hospital. Then, they will be randomly assigned to one of three insulin-based regimens f…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This study tests whether taking melatonin daily can help pregnant women with gestational diabetes better control their blood sugar. Researchers will compare melatonin to a placebo in 150 women. Participants take the supplement or placebo from diagnosis until delivery and have reg…

This study tests whether a daily probiotic called LP-LDL® can improve cholesterol, blood sugar, inflammation, and memory in 210 adults with prediabetes, type 1, or type 2 diabetes who also have high cholesterol or triglycerides. Participants take either the probiotic or a placebo…

This study compares two different drug combinations for people with type 2 diabetes whose blood sugar is not well controlled with metformin and sitagliptin. About 200 adults will receive either empagliflozin or glimepiride added to their current treatment. The goal is to see whic…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study tests a web-based education program for teens with type 1 diabetes and their mothers. The goal is to see if the program helps improve eating habits, blood sugar control, and self-management. About 72 teens and their moms will take part, with some teens getting the prog…

This study looks at whether two common diabetes drugs, GLP-1 analogs and SGLT2 inhibitors, can reduce osteoarthritis symptoms like joint pain and stiffness in people with type 2 diabetes. Researchers will follow 390 adults over 50 who have been on one of these drugs for at least …

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This study tests a 12-week digital program led by a nurse to help young adults (ages 18-45) with type 2 diabetes better manage their condition. Participants use a web or mobile app for education, goal-setting, and direct messaging with a nurse. The goal is to see if this approach…

This study looks at two common diabetes pills—henagliflozin and metformin—to see how they affect muscle mass and blood sugar in older adults (ages 60-85) who are newly diagnosed with type 2 diabetes. About 116 participants will take one of the two medicines daily for 24 weeks. Th…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This observational study in Jakarta will test whether a smartphone facial scan can accurately estimate blood sugar and HbA1c levels without needles. Researchers will compare the scan results with standard lab blood tests in 300 adults, with or without diabetes. If accurate, this …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study will screen about 2,200 children aged 2-10 for autoantibodies that signal early type 1 diabetes. The goal is to find the disease before symptoms appear and test if educational programs help families. Researchers will also check if this screening is practical and cost-e…

This study checks if a cheap thermal camera (about 200 euros) works as well as a professional one for spotting early signs of foot problems in people with diabetes. 130 adults with diabetes will have both cameras take pictures of the bottom of their feet. The goal is to see if th…

This study tests a new way to detect early damage in the feet of people with diabetes by measuring how the skin responds to pressure. Researchers will compare 200 people with and without diabetes to see if skin stiffness and stretchiness can predict ulcer risk. The goal is to pre…

This study compares several non-invasive methods to measure foot calluses (plantar hyperkeratosis) in 50 people, half with diabetes and half without. The goal is to find the most reliable technique for assessing callus hardness and stiffness, which could help prevent foot ulcers …

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This study investigates whether drinking kefir, a fermented dairy drink rich in live bacteria and yeasts, from around 14 weeks of pregnancy until routine diabetes screening can improve blood sugar control and reduce the risk of gestational diabetes. Pregnant individuals are rando…

This study tests whether a digital health program with personalized support helps adults at risk for type 2 diabetes build healthy habits faster than standard lifestyle education. 222 participants will be followed for 24 weeks. The main goal is to see how quickly they can achieve…

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study tests a special foot care program (DiaFOOTCare) for people with type 2 diabetes who are at risk of developing foot ulcers. About 78 participants will be split into two groups: one receives the program, the other gets standard care. The goal is to see if the program imp…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study tests whether an enhanced diabetes prevention program that provides healthy food deliveries, exercise classes, and community resources helps African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income commun…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests a mobile health app designed to help young adults (ages 20-35) reduce their risk of type 2 diabetes. The app provides guidance on nutrition, physical activity, sleep, and stress management. Researchers will compare changes in quality of life and blood sugar level…

This early-phase trial will test whether giving a salbutamol inhaler during surgery can prevent atelectasis (partial lung collapse) in diabetic patients. Atelectasis is a common complication after chest, belly, or spine surgery. The study plans to enroll 80 adults aged 18-70 who …

This study tests whether a smartphone app called "Better Pregnancy" can help prevent gestational diabetes in pregnant women at high risk. About 400 women will either use the app plus get standard prenatal care, or receive standard care alone. The app provides personalized diet, a…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests whether combining continuous glucose monitors (CGMs) with group lifestyle sessions can help people with prediabetes lower their blood sugar and prevent type 2 diabetes. Twenty adults with prediabetes will attend regular group meetings on diet, exercise, and stres…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study tests a digital health program that uses patient data to identify pregnant women at high risk for gestational diabetes. High-risk participants will receive online education, lifestyle coaching, and self-management tools to prevent the condition. The goal is to reduce d…

This study tests whether wearing a continuous glucose monitor (CGM) can motivate people with prediabetes to be more physically active. Fifty adults with prediabetes will wear a CGM for 20 days and receive education on their blood sugar readings. The goal is to see if seeing real-…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study tests a 12-session virtual program to help adults with prediabetes in the UAE prevent type 2 diabetes. The program covers diet, physical activity, sleep, and stress management, and is led by a health coach from the same cultural background. Thirty participants will att…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

This study tests whether a virtual health community can help people with prediabetes improve blood sugar control and prevent type 2 diabetes. Participants will receive lifestyle support through a digital platform, including education, guidance, and group interaction. The trial wi…

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests whether an activity book called 'Think-Find-Solve' can improve insulin self-management in children aged 8-12 with type 1 diabetes. Forty children and their parents will take part, with one group using the book for three months. The goal is to see if the book help…

This study tests whether taking taurine and beetroot supplements can improve how people with type 2 diabetes regulate their body temperature during extreme heat. Researchers will measure sweating and core temperature in 18 adults during a heat exposure session. The goal is to fin…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study tests whether adding Eroxon gel to the standard pill tadalafil can improve erections in men aged 18 to 40 with type 2 diabetes. Thirty men who already take tadalafil will use the gel before sex and report changes in erectile function. The goal is to see if the combinat…

This study tests whether an 8-week arts-based storytelling workshop can improve social connection, identity, and emotional well-being in adolescents and young adults with diabetes. Ten participants aged 16-25 will attend weekly sessions involving writing, drawing, and group discu…

This study looks at whether morning or evening exercise is better for controlling blood sugar in men with type 2 diabetes. Sixty men aged 40-60 will do high-intensity interval and resistance training for 12 weeks, either in the morning or evening. Researchers will measure changes…

This study will test a mindfulness-based education program for adults with type 2 diabetes. The goal is to see if it reduces diabetes-related distress and helps people feel more empowered to manage their condition. 70 participants will take part in group sessions that combine min…

This study tests whether short, frequent exercise sessions—called 'exercise snacks'—can improve health in sedentary adults with diabetes or prediabetes. Participants will do 3-5 minute bouts of simple exercises like squats or brisk walking several times a day for 12 weeks. The go…

This study looks at whether eating a small handful of almonds (about 18 grams) 30 minutes before a meal can reduce the rise in blood sugar after eating. Researchers will test 25 adults with prediabetes, comparing blood sugar levels after meals with and without almonds. They also …

This pilot study will test whether a remotely delivered mindfulness-based diabetes education program, combined with home blood sugar monitoring, is feasible and acceptable for rural Black adults with type 2 diabetes and high diabetes distress. The program is compared to standard …

This pilot study tests an 8-week program called DREAM that uses AI-powered text messages to encourage physical activity in adults with type 2 diabetes. Twenty participants will receive twice-weekly messaging and set weekly activity goals. The study focuses on whether the program …

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This study tests an 8-week mindfulness program for people with type 1 or type 2 diabetes who have trouble sensing when their blood sugar drops too low. The program teaches body awareness techniques like mindful eating and body scanning to help patients catch early warning signs. …

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This pilot study tests a virtual program called STRIDE, designed for adults aged 21-44 who have type 2 diabetes and are raising children. The program includes three online sessions focused on self-care, healthy eating, and family activity. Researchers will measure changes in diab…

This study aims to find a better colonoscopy preparation method for people with diabetes. Current prep methods can cause low blood sugar and poor bowel cleaning. The new approach uses a low-fiber diet the day before and same-day preparation to reduce risks. About 40 adults with d…

This pilot study will test whether a 6-week program of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and blood sugar control in 30 adults aged 40+ with type 2 diabetes and chronic insomnia. Participants are randomly assigned to CBT-I or usual care, and outco…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether a color-coded rotation training program helps people with diabetes improve their insulin self-management skills. Researchers will teach 112 participants how to rotate injection sites and change needles using a colorful chart and a mannequin. The goal is t…

This study compares high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in 28 adults with type 2 diabetes. Over 12 weeks, researchers will measure how each exercise affects functional mobility, muscle strength, and quality of life. The goal i…

This study compares pain after root canal therapy done in one visit versus two visits for people with diabetes. 200 patients aged 12-60 with a single-rooted tooth needing root canal will be randomly assigned to either a single session or two sessions. The main goal is to see whic…

This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…

This study will test a virtual reality program called 'Health for My Feet' for people with type 2 diabetes. The program aims to teach foot care through VR goggles and includes weekly reminder messages. Researchers will compare foot care knowledge, self-care habits, and foot healt…

This study tests a single injection of CIL001 (Paliroden) into the ear to repair nerve damage that causes hearing problems in people with type 2 diabetes. The trial includes 135 adults aged 45-75 with diabetes for at least 5 years. Researchers will check safety and whether the in…

This pilot study tests a device called CRAD ULCER X-01 that uses pulsating electromagnetic fields (PEMF) to help heal diabetic foot ulcers. 32 people with chronic, non-healing ulcers will be split into groups receiving standard wound care plus either a placebo or 1-3 hours of PEM…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study will test whether resistance training and breathing exercises can reduce depression and improve sleep and quality of life in women with type 1 diabetes. About 78 women with good blood sugar control and mild to moderate depression will take part. The exercises target ma…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This study looks at whether a common diabetes medication (GLP-1 RA) can improve muscle strength and bone health in women over 65 with type 2 diabetes. About 20 participants will take the drug as part of their regular care and undergo tests like grip strength and bone density scan…

This pilot study looks at whether it is safe and practical for pregnant women with type 1 or type 2 diabetes to continue using their insulin pump during labor, instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to keep using it whil…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study tests whether acupressure, a technique that applies gentle pressure to specific points on the body, can lower blood sugar and reduce anxiety in people aged 65 and older with diabetes. Forty-eight participants will receive either real acupressure or a sham version for 6…

This study tests whether watching interactive videos that teach diabetes self-care skills can help adults with type 2 diabetes improve their blood sugar control and feel more empowered. Sixty participants will be randomly assigned to either receive the video education or standard…

This study tests whether a single, one-on-one session focused on depression can help teens with type 1 diabetes feel better and improve their blood sugar levels. Eighty teens aged 11-18 with mild depression will either get the special session or standard diabetes education. Resea…

This global registry study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitor (CGM). Researchers will track changes in HbA1c, a key measure of blood sugar control, over time. The goal is to understand how CGM use affects diabetes management in real-wor…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study looks at how menopause and poor sleep change heart structure and function in women aged 48-58 with type 2 diabetes. Researchers will use heart ultrasounds to measure early signs of heart strain. No treatment is given; the goal is to better understand these risks.

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study tests how well the adhesive parts of a future patch pump stick to the skin of children aged 7 to 17 who need insulin for diabetes. The device is a dummy—it has no electronics and just mimics the shape and weight of a real pump. Researchers will see if the patch stays a…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This early-stage trial will check whether two different ways of making the experimental drug GZR4 produce the same levels in the blood. About 64 healthy men will receive a single shot of one version or the other. The study is not designed to treat diabetes, but to ensure future b…

This study will test how well the Dexcom G7 continuous glucose monitor works in 100 adults undergoing heart surgery with cardiopulmonary bypass. The device's readings will be compared to standard blood glucose checks during and after surgery. The goal is to see if the monitor sta…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This study will track 750 adults with prediabetes who are scheduled for non-cardiac surgery. Researchers will measure their blood sugar levels before, during, and after surgery to see how often high blood sugar occurs. They will also check if high blood sugar is linked to more co…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study looks at whether a painless ultrasound scan of the sciatic nerve and a blood test for a specific protein can help detect diabetic peripheral neuropathy (nerve damage) earlier than current methods. Researchers will measure nerve size and blood flow in 120 people with ty…

This study will follow 200 people with colorectal cancer and healthy controls to explore how genes, blood sugar, and immune responses are connected. Researchers will analyze blood and tissue samples to find shared genetic factors that may influence both cancer and diabetes. The g…

This study will test whether a continuous glucose monitor (CGM) worn for 14 days after childbirth can predict which women with a history of gestational diabetes are at risk for developing type 2 diabetes. Fifty participants will wear a blinded CGM device and then take a standard …

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study uses the FreeStyle Libre 2, a small sensor worn on the arm, to track blood sugar changes in 120 people with rare forms of diabetes, including monogenic diabetes and hyperinsulinemia. Researchers will compare these patterns with data from healthy people and those with t…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study looks at whether it's possible to screen children for type 1 diabetes during their regular well-child visits. Researchers will ask parents and doctors about their experience with the screening and track how many families complete the test. The goal is to find the best …

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study will ask 75 people with diabetes and their healthcare providers about their experience using the Instara-1 continuous glucose monitor. Participants will wear the device and answer questionnaires about comfort, ease of use, and how it helps manage their diabetes. The go…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study will follow about 579 adults who need surgery to remove part or all of their pancreas but do not have diabetes before the operation. Researchers want to see how often new diabetes develops after surgery and whether the amount of pancreas removed changes that risk. The …

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This early-stage trial will test a new tablet that combines two common drugs—one for type 2 diabetes and one for high blood pressure—in healthy volunteers. The goal is to see if the single pill works the same in the body as taking the two drugs separately. Thirty-six healthy adul…

This study looks at how losing sleep and having a disrupted body clock (like shift workers) can make the body less responsive to insulin, a key step toward obesity and type 2 diabetes. Researchers will test 48 healthy adults aged 18-45 to see how the timing of the stress hormone …

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This observational study will check if diathermy, a tool used during surgery to stop bleeding, affects the accuracy of continuous glucose monitors in people with Type 1 Diabetes. About 126 adults and children will have their glucose readings compared before and after diathermy us…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study looks at whether the way health information is presented can help people with diabetes better understand their risk of developing foot ulcers. Researchers will compare two types of messages—one focusing on the benefits of good foot care, the other on the risks of negle…

This study follows 2,500 adults in Mexico aged 18 to 65 who do not yet have type 2 diabetes or high blood pressure. Over five years, researchers will track their health through yearly check-ups, blood tests, and lifestyle questionnaires. The goal is to identify what factors incre…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes…

This study looks at how certain natural chemicals (endocannabinoids) influence the development of fat cells from stem cells found in belly fat. Researchers will take small fat samples from 30 people undergoing abdominal surgery, including healthy controls, people with obesity, an…

This early study tests a new device: a small patch with tiny, painless needles that sits on the skin and measures glucose and ketone levels continuously. Ten people with type 1 diabetes will wear the patch for 4 hours while briefly stopping their insulin pumps. Researchers will c…

This study looks at whether wearing a continuous glucose monitor (CGM) and receiving education can help teenagers with prediabetes improve their blood sugar levels and adopt healthier behaviors. Twenty-five teens aged 13-17 will take part in a 20-week program, first receiving sta…

This observational study aims to understand if toxins from gut bacteria are linked to early signs of diabetes in lean people with prediabetes. Researchers will measure blood markers of gut toxins and insulin-producing cell function in 120 participants. The goal is to find new way…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This pilot study looks at how sleep, physical activity, and meal timing in early pregnancy relate to blood sugar patterns and the risk of gestational diabetes. Researchers will track 140 pregnant women using wearable devices and an AI food-logging app. The goal is to see if real-…

This study looks at whether certain autoantibodies (proteins that mistakenly attack the body) are more common in people with obesity and if they are linked to related health problems like type 2 diabetes. Researchers will study 160 adults with a BMI over 30. The goal is to better…

This early-stage trial tests a new experimental pill called UI087, which combines three diabetes drugs into one. Researchers want to see if it is safe and how the body processes it compared to taking the three drugs separately. The study involves 44 healthy adults and is not yet …

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study investigates why women with type 1 diabetes (T1D) frequently develop polycystic ovary syndrome (PCOS), a condition of high androgen levels. Researchers will compare five groups of 12 participants each, including women with T1D and PCOS, women with T1D alone, men with T…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides personalized advice on side effects and dose adjustments. The study is in its early stages, with only 16 participants, and is…

This study tests whether giving primary care doctors detailed feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and type 2 diabetes. Researchers will enroll 324 healthcare providers in Nepal, Mozambique, Tanzania, and Chi…

This early-stage trial will test a new tablet called AD-123 in 50 healthy adults. Researchers want to see if taking one AD-123 pill works similarly to taking two separate pills (AD-1231 and AD-1232) together. The study focuses on safety and how the drug moves through the body, no…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This registry study will follow 10,000 Chinese adults with obesity or overweight across 50 hospitals. Researchers will collect data on weight, lab tests, and liver health over 6 and 12 months. The goal is to understand current treatment patterns and outcomes in real-world clinica…

This early-stage study tests a new medicine called efsubaglutide alfa (YN-011) in 48 healthy adults in Brazil. The goal is to check the drug's safety, how the body processes it, and its effects. Participants receive a single injection of either the drug or a placebo and are monit…

The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predi…

This study tests whether a new single pill that combines two diabetes drugs (chiglitazar and metformin) works the same as taking them separately. It involves 64 healthy adults who will take both versions and have their blood levels measured. The goal is to see if the combo pill i…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This early-phase trial in 28 healthy Chinese adults tests a new fixed-dose combination pill for type 2 diabetes. One part checks whether a high-fat meal changes how much drug gets into the blood. The other part looks at drug levels after taking the pill daily for 10 days. The goa…

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study tests a companion mobile app that wirelessly collects real-time glucose readings from Dexcom G7 continuous glucose monitors (CGMs) used by children with diabetes in the hospital. The app sends the data to a central hospital database, making it accessible to care teams …

This study works with 35 primary care clinics to help them screen patients for physical inactivity and refer them to community-based exercise programs. The goal is to see if this approach can be smoothly integrated into routine care and whether it leads to better health outcomes …

This study aims to detect and measure microplastics in pancreas tissue from 10 patients having pancreatic surgery. Researchers will also check fat tissue and blood samples. The goal is to see if microplastics are present and whether they might be linked to metabolic problems or c…

This study looks at people with autoimmune thyroid disease (like Hashimoto's or Graves') to see if they have hidden signs of type 1 diabetes risk. Researchers will test blood for diabetes-related antibodies and use genetic data to build a risk model. The goal is to better underst…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study looks at whether a new tool helps young adults (ages 18-30) with type 1 diabetes and their doctors work together better to make care plans that fit daily life. Researchers will compare usual doctor visits with visits using the tool, and interview participants afterward…

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study will use ultrasound to measure stomach volume after standard fasting in 220 diabetic and non-diabetic patients scheduled for surgery. The goal is to see if current fasting guidelines are safe for people with diabetes, who may have slower stomach emptying. Results could…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This observational study looks at how having type 2 diabetes impacts quality of life in cancer patients receiving immunotherapy. Researchers will compare changes in well-being over six months between patients with and without diabetes. About 920 adults with solid tumors will fill…

This study will check if low vitamin D levels are linked to higher insulin resistance in 165 adults with type 2 diabetes. Researchers will use a simple blood test called the triglyceride-glucose index. The goal is to better understand how vitamin D might affect diabetes control.

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

This study looks at whether using a continuous glucose monitor (CGM) can help find and manage low blood sugar in newborns whose mothers had insulin-treated gestational diabetes. About 120 babies will be monitored for the first 72 hours after birth. The goal is to see if CGM catch…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study aims to create an AI-based warning system that helps people with diabetes detect early signs of foot ulcers returning. Researchers will follow 200 adults with healed diabetic foot ulcers, using a home monitoring tool and personalized follow-up plans. The goal is to cat…

This study looks at whether it's practical to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will have blood tests and answer questionnaires. If they show early markers, they will be monitored either by the resea…

This study will look at 3000 young Asians in Singapore who do not have diabetes yet. Researchers will use blood tests, glucose monitors, food diaries, and body measurements to find better ways to detect diabetes early. The goal is to create new risk tools to identify young people…

This study aims to create an artificial intelligence (AI) system that can combine medical images (like CT and MRI scans) with patient records and lab results to help doctors more accurately diagnose diseases of the liver, gallbladder, and pancreas. The researchers will use data f…

This study looks at whether a moldable silicone toe divider (Otoform) can help people with diabetes who have had a lesser toe amputated. Researchers want to see if it is possible to run a larger trial by testing how well patients accept the device and how it affects walking and f…

This study aims to understand how insulin deprivation and high blood sugar affect protein synthesis in muscles and blood of people with type 1 diabetes. Researchers will use muscle biopsies and special amino acid labels to track protein production. The study involves 70 participa…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young people aged 15-24 with type 1 diabetes. Researchers will measure blood vessel function before and after drinking a sweetened sports drink. The goal is to under…

This study tests a wrist-worn device that uses light sensors and AI to estimate blood sugar without piercing the skin. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. P…

This study looks at how fear of low blood sugar (hypoglycemia) affects how well people with diabetes follow their diet and take their medication. Researchers will measure fear levels, medication adherence, and diet adherence in 100 adults with diabetes who have had at least one l…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study will look back at medical records of 500 Chinese adults with type 1 diabetes to see if adding glucose-lowering pills to insulin helps control blood sugar better than insulin alone. The main goal is to check changes in HbA1c (average blood sugar over 2-3 months) and how…

This study will give 10 overweight men a daily pill called ATR-258 for 8 weeks to see how it changes signaling pathways in their muscles. Researchers will take small muscle samples and measure blood sugar control and body composition. The goal is to understand the biology, not to…

This pilot study tests whether fecal microbiota transplantation (FMT) can change the gut microbiome in 30 people with type 2 diabetes and stable coronary artery disease. Participants receive processed stool from healthy donors via colonoscopy. The goal is to see if this alters gu…

This pilot study will test whether a new fixed-dose combination tablet containing Chiglitazar and Metformin works the same in the body as taking the two drugs separately. Twenty-four healthy adults will receive both versions under fed conditions, and researchers will measure drug…

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study tests whether a special breathing exercise, called intermittent inspiratory muscle training, can have an immediate effect on blood sugar, heart rate, and blood vessel stiffness. Researchers will compare this breathing workout to normal breathing in 48 healthy, obese, a…

This observational study will look at how cognitive functions—like attention and mental flexibility—relate to balance, fear of falling, and quality of life in 80 adults with type 2 diabetes. Participants will complete thinking tests, balance assessments, and questionnaires. No tr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study looks at how fasting during Ramadan impacts treatment adherence, emotional well-being, and blood sugar levels in adults with type 2 diabetes. Researchers will compare those who fast and those who do not, using surveys and HbA1c tests before and after Ramadan. The goal …

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at how a common genetic change (the T allele at rs7903146) affects the pancreas's own production of GLP-1, a hormone that helps control blood sugar. Researchers will give 80 healthy adults a drug that blocks GLP-1 receptors to see how their insulin and glucagon l…

This early-stage study looks at how three popular statins (atorvastatin, rosuvastatin, simvastatin) affect blood sugar levels in 100 healthy volunteers. Participants will take the medicine for two days, and researchers will measure changes in blood glucose, insulin, and C-peptide…

This study will follow 154 older adults with type 2 diabetes who are scheduled for liver tumor surgery. Researchers will measure brain glucose metabolism using a PET scan before surgery and then check for delirium (sudden confusion) for a week after. The goal is to see if lower b…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study compares blood test results from 200 adults with type 2 diabetes to healthy people to see if platelet size and activity are different. Researchers will also check if these changes are linked to inflammation markers and blood sugar control. No treatments or extra proced…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will test a new screening program for 3,000 people turning 50 in the Ascoli Piceno province of Italy. Participants will fill out questionnaires and get a blood test to check their risk of developing type 2 diabetes and cardiovascular disease. The goal is to see if this…

This study looks at how well university students with type 1 diabetes can estimate carbohydrates in their meals and whether that affects their blood sugar control. Researchers will give a one-time educational session on carb counting and insulin adjustment, then check blood sugar…

This study will give 50 women who had gestational diabetes a continuous glucose monitor (Stelo) to wear after giving birth. The goal is to learn how their blood sugar levels change during daily life and how well the device works. Participants will use the monitor for up to 6 week…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will measure levels of a thyroid antibody called anti-thyroglobulin in 112 adults with diabetes. The goal is to see how common these antibodies are in diabetic patients, since diabetes and autoimmune thyroid disease often occur together. Participants will provide a blo…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This study will design and test web-based decision aids for parents in Canada considering screening their children for type 1 diabetes. Researchers will work with parents and experts to create the tools, then test them in online studies with 350 participants. The goal is to see i…