New study tracks 300 people at risk for type 1 diabetes over 10 years
NCT ID NCT07503366
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predict who will develop diabetes and to reduce dangerous complications at diagnosis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could improve how doctors predict and detect type 1 diabetes early, potentially reducing severe complications at diagnosis.
- What could go wrong
- This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and results depend on long-term follow-up over 10 years.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ambulatorio di Diabetologia Pediatrica, UOC Pediatria/Neonatologia Ospedale San Paolo
Bari, Italy
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Azienda Ospedale-Università Padova
Padova, Italy
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Azienda Ospedaliero Integrata di Verona
Verona, Italy
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Centro Provinciale di Diabetologia Pediatrica - SOC di Pediatria - Ospedale "S. Giovanni di Dio"
Crotone, Italy
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Centro Regionale di Diabetologia Pediatrica, UOC Pediatria Specialistica, Dipartimento ad Attività Integrata Materno Infantile, AOU Federico II
Naples, Italy
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Centro di Diabetologia Pediatrica Grande Ospedale Metropolitano
Reggio Calabria, Italy
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Centro diabetologico aziendale - UOS Diabetologia pediatrica; ASL Viterbo
Viterbo, Italy
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Department of Pediatrics, Hospital of Bolzano (SABES-ASDAA),Teaching Hospital of Paracelsus Medical University
Bolzano, Italy
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IRCCS "Ospedale Infantile" Burlo Garofolo
Trieste, Italy
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IRCCS Policlinico San Matteo, SS Pediatria 2 - Malattie Endocrine / Ambulatorio di Diabetologia Pediatrica
Pavia, Italy
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Ospedale G.Di Cristina - ARNAS Civico di Cristina Benfratelli
Palermo, Italy
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Ospedale Maggiore della Carità di Novara
Novara, Italy
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Ospedale Pediatrico Bambino Gesù
Roma, Italy
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Ospedale S. Raffaele
Milan, Italy
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Ospedale S.M. del Ca' Foncello, Treviso, AULSS2 Marca Trevigiana
Treviso, Italy
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Ospedale di Santa Chiara Azienda USL
Trento, Italy
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S.C. Pediatria, P.O.C SS. Annunziata
Taranto, Italy
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SOC Diabetologia ed Endocrinologia, AOU Meyer IRCCS
Florence, Italy
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SOD Diabetologia Pediatrica - Azienda Ospedaliero Universitaria delle Marche
Ancona, Italy
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UOC Endocrinologia e Malattie del Metabolismo AOU di Parma
Parma, Italy
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UOC Pediatria, Azienza Ospedaliero-Universitaria "Renato Dulbecco"
Catanzaro, Italy
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UOC Pediatria, Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy
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UOS Diabetologia ed Endocrinologia pediatrica, AORN Sant'Anna e San Sebastiano
Caserta, Italy
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Università degli Studi dell'Aquila - UO Pediatria e PSP, Ospedale San Salvatore
L’Aquila, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a breath test replace finger pricks for diabetes?
- Immune cell study may unlock kidney protection in type 1 diabetes