Diabetes mellitus

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study looks at whether allowing a slightly higher blood sugar range (70-110 mg/dL) during labor in mothers with diabetes can reduce the number of newborns with low blood sugar. Researchers will compare this approach to standard care in 169 pregnant women planning a vaginal d…

This study tests whether a new tablet formulation of semaglutide (oral semaglutide D) works as well as the approved version in Japanese adults with type 2 diabetes. About 264 participants will take either the new or approved tablet once daily for 27 weeks. Researchers will compar…

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This trial tests a digital health program designed to help young adults with type 1 diabetes improve their blood sugar control. Participants use the SweetGoals app to set and track behavioral goals, and some also receive financial incentives for meeting those goals or access to w…

This study will follow about 470 adults with type 2 diabetes who are starting oral semaglutide as part of their normal care. Researchers will track changes in blood sugar (HbA1c) and body weight over 5 to 7 months. The goal is to see how well the medication works when prescribed …

This study tested a new medicine called NNC0487-0111 in 448 adults with type 2 diabetes. Participants received either a once-weekly injection, a daily pill, or a placebo for about 43 weeks. The goal was to see how well different doses lower blood sugar and body weight.

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

This phase 2 trial tests whether adding nicorandil, a drug typically used for heart conditions, can improve blood sugar control and reduce body weight in obese people with type 2 diabetes who are already taking sulfonylureas. About 46 adults with a BMI over 30 will receive nicora…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This Phase 3 trial tested whether HTD1801 (berberine ursodeoxycholate) can help people with type 2 diabetes who aren't well controlled on metformin alone. Over 500 participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug lowered blood …

This trial tests whether inhaled insulin (Exubera) can control blood sugar as well as insulin glargine (Lantus) injections in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants will receive either inhaled insulin before meals or …

This trial tests whether an inhaled form of insulin (Exubera) can control blood sugar as effectively as a daily insulin injection (Lantus) in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants are randomly assigned to add either …

This study tests whether a mobile app can help people with type 1 diabetes adjust their insulin doses better than standard care. About 50 participants over age 15 will use the app or receive usual care for 3 months. The main goal is to see if the app improves blood sugar control,…

This trial is testing an investigational drug called OPT101 in adults with type 1 diabetes. The goal is to see if it is safe and how it affects the immune system. Participants will receive multiple doses of the drug, and researchers will monitor for side effects and measure drug …

This completed study compared the effectiveness of once-daily oral semaglutide (Rybelsus) to other oral diabetes medications in 1020 adults with type 2 diabetes who were already taking metformin. Participants were randomly assigned to receive either Rybelsus or another diabetes p…

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This pilot study tests whether having older Black men with diabetes lead support groups can help other older Black men better manage their type 2 diabetes. All 48 participants receive standard diabetes education, and half also get 6 months of monthly peer-led support sessions. Th…

This study tests whether a peer-supported self-care program can improve quality of life and diabetes management in adults aged 60 and older with type 2 diabetes. Participants in the intervention group will join weekly video calls with trained peer supporters and receive support v…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This study tests whether wearing a continuous glucose monitor (CGM) alongside lifestyle changes can improve insulin sensitivity in teens aged 10-17 with prediabetes. Fifteen overweight or obese participants will use the Dexcom G7 device to see real-time glucose data, aiming to bo…

This trial tests whether time-limited eating—consuming all food and drinks within an 8-hour period and fasting for the remaining 16 hours—can improve blood sugar control, insulin function, and body fat in adolescents with type 2 diabetes. Participants aged 12 to 21 will follow th…

This study tests a newly developed mobile app designed for adults with type 2 diabetes who are starting insulin for the first time. The app aims to improve how people perceive insulin use and how well they manage their own care. Over one month, participants will use the app and h…

This trial explores whether a gluten-free diet can ease digestive symptoms and improve blood sugar control in people with type 2 diabetes who have non-celiac gluten sensitivity. Participants first follow a gluten-free diet for six weeks. Those who feel better then take part in a …

This study compares two bowel cleansing solutions, Golytely and SUPREP, for colon cancer screening in people with diabetes. Researchers want to see which one cleans the colon better and is easier to tolerate. About 80 participants will be randomly assigned to one of the two preps…

This early study tests a herbal effervescent tablet taken twice daily before meals in 14 adults with type 2 diabetes. The goal is to see if it safely helps lower blood sugar levels (HbA1c, fasting, and after meals). Participants include those managing diabetes with diet or supple…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This study tests whether three diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 participants will take one of the drugs for 48 weeks, with an …

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This study looks at whether involving family members can help people with type 2 diabetes in rural Kentucky eat healthier and exercise more. Researchers will work with 75 participants and their families to create a personalized nutrition and physical activity plan for 6 months. T…

This trial tests whether a smart insulin pen called DIA:CONN P8 can help people with type 1, type 2, or pancreatogenic diabetes better control their blood sugar. Participants use the pen for 12 weeks, and the pen automatically calculates bolus insulin doses based on meal informat…

This trial tests whether a 'food as medicine' program can help people with diabetes better control their blood sugar. Participants receive weekly medically tailored meals, nutrition classes led by dietitians, and vouchers for fresh produce. The study will measure changes in HbA1c…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tested a new drug called HTD1801 (berberine ursodeoxycholate) against the standard diabetes drug dapagliflozin in 367 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. The main goal was to see how well HTD1801 lowers blood sugar …

This study looks at whether bariatric (weight-loss) surgery can reduce the risk of heart attacks, strokes, heart failure, and death in people who have both type 2 diabetes and obesity. It compares people who had the surgery with those who received usual diabetes care. The goal is…

This Phase 3 trial tested whether HTD1801, a new drug made from a modified natural compound, can lower blood sugar in people with type 2 diabetes who struggle to control it with diet and exercise alone. The study enrolled 408 adults and compared the drug to a placebo over 24 week…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This clinical trial is testing an investigational drug called HTD1801 (berberine ursodeoxycholate) to see if it can improve blood sugar control in adults with type 2 diabetes that is not well managed by diet and exercise alone. The study will compare the drug against a placebo ov…

This trial tests whether a specially designed mealtime insulin, HDV-insulin lispro, can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will use continuous glucose monitors and work with doctors to adjust doses. One group receives the …

This phase 3 trial compares an experimental once-weekly injection, HRS9531, to the established drug semaglutide in adults with type 2 diabetes that is not well controlled by metformin alone or with SGLT2 inhibitors. The study will measure changes in blood sugar levels and body we…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This trial tests whether using a continuous glucose monitor (CGM) before and after major surgery can reduce complications in adults with diabetes or impaired glucose tolerance. Participants wear the device for at least 6 hours before surgery and up to 7 days after, while a compar…

This trial tests whether adding supervised exercise to standard care can improve wound healing in people with diabetic foot ulcers. Participants are randomly assigned to aerobic exercise, a structured exercise protocol, or standard care alone for 12 weeks. Researchers track ulcer…

This study investigates whether continuous glucose monitor (CGM) data can pinpoint the time of day when a person with prediabetes experiences the largest blood sugar spikes after eating. Participants wear a CGM and activity tracker for 10 days to identify their personal 'vulnerab…

This trial investigates whether a once-weekly injection of semaglutide can improve blood sugar control and reduce body weight in adults with type 2 diabetes and obesity who have not achieved adequate control with standard therapy. Participants receive semaglutide for 16 weeks, st…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial tests whether a mobile health system that sends real-time text messages—prompting users to take a walk or stand up after sitting too long—can increase physical activity in people with prediabetes or type 2 diabetes. Participants receive a Fitbit tracker and brief advic…

This study looks at whether offering financial rewards, along with nurse coaching and home monitoring, helps adults with type 2 diabetes improve their blood sugar control. About 450 participants will be randomly assigned to receive either nurse coaching and home monitoring alone,…

This trial tests whether adding lactulose—a type of sugar syrup—to the standard bowel-cleansing drink (PEG-ELS) can improve colonoscopy preparation in people with type 2 diabetes. Diabetic patients often have poor bowel cleansing, which can reduce the quality of the exam. The stu…

This study tested whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes control their blood sugar better than traditional finger-prick testing. About 600 participants from two community health centers in China wore a CGM device for three 2-week period…

This trial investigates whether drinking fig leaf tea twice a day for 8 weeks, along with a low-glycemic diet, can help protect kidney function in adults with type 2 diabetes and stage 2 chronic kidney disease. Researchers will measure changes in blood sugar, cholesterol, and kid…

This study tests whether an advanced hybrid closed loop insulin pump (MiniMed 780G) can improve blood sugar control, quality of life, thinking skills, and physical abilities in people over 60 with type 1 diabetes. Participants are randomly assigned to either continue their usual …

This study investigates whether reducing iron levels in the body through blood donation can improve insulin sensitivity and liver function in people with type 2 diabetes and non-alcoholic fatty liver disease. Participants will undergo phlebotomy until their iron stores are deplet…

This study tests whether a connected smartphone app called Health2Sync helps adults with type 2 diabetes who use basal insulin achieve better blood sugar control. The app syncs blood glucose readings and shares them with doctors, who can then adjust insulin doses. Researchers com…

This study tests whether treating low blood sugar (hypoglycemia) at a slightly lower threshold of 65 mg/dL, instead of the standard 70 mg/dL, can prevent rebound high blood sugar in children with type 1 diabetes. Each child undergoes both approaches in a crossover design, receivi…

This study tests how different amounts of dietary carbohydrates affect insulin needs and blood sugar control in adults with type 1 diabetes. Participants are randomly assigned to one of three diets: a traditional diet with 50-60% of calories from carbs, a moderately low-carb diet…

This study tests whether a structured Diabetes Healthcare Program can help adults with type 2 diabetes improve their blood sugar control and feel more confident managing their condition. Participants attend six biweekly training sessions covering diet, exercise, medication, and s…

This study investigates whether a 12-week program combining aerobic and resistance exercise can improve blood sugar control and cognitive function in adults aged 65-79 with type 2 diabetes and mild memory issues. Participants follow a supervised exercise routine that gradually in…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study tests two approaches to help people with diabetic neuropathy improve their balance. One group uses textured insoles in their shoes, while the other group does a series of quick stretches and compressions called Rood's facilitatory technique. Both groups also receive co…

This study tests an experimental oral drug called LY3502970 in Japanese adults with type 2 diabetes. The main goal is to check for side effects and see how the body processes the drug. Participants take either the drug or a placebo and are monitored over up to 24 weeks with blood…

This phase 3 trial tests whether an experimental injectable drug called HRS9531 can help adults with type 2 diabetes achieve better blood sugar control when diet and exercise alone are not enough. Participants receive either HRS9531 or a placebo for 36 weeks. The main goal is to …

This trial investigates a surgical procedure for people with type 2 diabetes and mild obesity (grade 1). The surgery combines three steps: rerouting part of the small intestine, reducing the stomach size, and cutting certain abdominal nerves. The goal is to see if this approach c…

This study investigates whether adding foxtail millet muffins to the diet can help manage blood sugar and improve metabolic health in obese adults with type 2 diabetes. Over 10 weeks, participants eat either a wheat muffin or one or two foxtail millet muffins daily, alongside a l…

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This study tests whether a low-carbohydrate diet (under 75 grams per day) can help adults with type 1 diabetes preserve their remaining insulin production. The idea is that the diet might calm the immune attack on insulin-making cells. Participants will follow the diet for a peri…

This study tests a four-week virtual program designed to help teens aged 12-21 with type 1 diabetes use technology like insulin pumps and continuous glucose monitors. Participants complete surveys and interviews about their diabetes management and technology use. The goal is to u…

This study tests whether a personalized nutrition program—where meals are tailored to each person's calorie needs based on age, sex, weight, height, and activity level—can improve blood sugar, weight, and blood pressure in adults with type 2 diabetes. Participants receive either …

This study tracks 300 adults with type 1 diabetes who use the Omnipod 5, an automated insulin delivery system, as part of their routine care. Researchers will compare blood sugar control—measured by time in target range and HbA1c levels—before starting the system and at 6, 12, an…

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This study tracks the long-term safety of dorzagliatin, a drug for type 2 diabetes, in over 2,000 patients over 52 weeks. Researchers monitor side effects and how well the drug controls blood sugar. The goal is to ensure the drug remains safe for everyday use.

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests whether walking with a wearable hip exoskeleton can improve blood sugar control after meals in people with type 2 diabetes. Participants walk for 30 minutes after a meal, either without assistance or wearing the exoskeleton in two different support modes. The goa…

This study tests whether using a continuous glucose monitor (CGM) — a small sensor that tracks blood sugar levels in real time — helps teens and young adults (ages 14 to under 25) with type 1 diabetes improve their blood sugar control compared to standard fingerstick testing. Par…

This trial compares a generic extended-release tablet containing empagliflozin and metformin to the brand-name Synjardy XR. Healthy adults aged 18 to 45 receive a single dose of each version in random order, and researchers measure drug levels in the blood to see if the generic w…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This trial compares a generic extended-release tablet containing three diabetes drugs (empagliflozin, linagliptin, and metformin) to the brand-name Trijardy XR. The study involves 36 healthy adults who take a single dose of each version under fed conditions to see if the generic …

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This trial investigates whether a generic tablet containing imeglimin hydrochloride works the same way in the body as the brand-name diabetes drug Twymeeg. Healthy adults aged 18 to 45 take a single dose of each version under fasting conditions, and researchers compare how much d…

This study investigates whether giving endocrinologists (diabetes specialists) a one-week intensive training program helps them manage type 2 diabetes more effectively. The training includes a hospital stay experience and hands-on patient management. Researchers will compare bloo…

This study tests whether regular video or phone calls with a nurse (tele-nursing) can help teenagers with type 1 diabetes improve their blood sugar control, feel more confident managing their condition, and reduce anxiety. Participants aged 12–18 receive diabetes education both i…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study tests an experimental drug, JP-2266, in adults with type 2 diabetes. The drug works by blocking two proteins (SGLT1 and SGLT2) to help lower blood sugar. Participants receive either JP-2266 or a placebo for 12 weeks, and researchers measure changes in HbA1c, a key bloo…

This study tests a software upgrade for an automated insulin pump system (Control-IQ) in adults with type 1 diabetes. The upgrade adds an adaptive biobehavioral control module that learns from the user's patterns to improve blood sugar management. Participants use the standard sy…

This study tests PS1, a new tablet designed to help control blood sugar in people with type 2 diabetes. It is the first time PS1 is given to humans, so the main goal is to check its safety and how the body handles it. The trial includes healthy volunteers and people with type 2 d…

This study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This study tests whether an extract from the earthworm Lumbricus rubellus (DLBS1033) can reduce inflammation and improve quality of life in people with type 2 diabetes. Sixty adults on standard diabetes therapy will receive either a low or high dose of the extract or continue sta…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This trial investigates whether eating 100 grams of curd cheese daily as part of a personalized diet for 8 weeks can improve cholesterol levels, blood sugar, and body measurements in overweight adults aged 40 to 64. Participants are randomly assigned to either a curd cheese-suppl…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This pilot study tests whether dialectical behavioural therapy (DBT) — a type of talk therapy that teaches skills like mindfulness and emotion regulation — can help Indigenous youth with type 2 diabetes improve their quality of life and diabetes control. The study enrolls 20 yout…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This trial tests whether giving intravenous thiamine (vitamin B1) alongside standard treatment helps people with diabetic ketoacidosis recover faster. Diabetic ketoacidosis is a serious condition where the blood becomes too acidic. The study includes adults hospitalized with this…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This study tested an updated version of the Control-IQ system, which automatically adjusts insulin delivery for people with type 1 diabetes. Sixty-six adults and adolescents used the new software along with a continuous glucose monitor for several weeks. The main goal was to see …

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested whether a smartphone app that lets people log their blood sugar readings at home can improve diabetes control. One hundred adults with poorly controlled type 2 diabetes used the app or continued usual care for 3 months. Researchers measured changes in HbA1c, a k…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested whether an educational mobile game could help children aged 7 to 14 with type 1 diabetes better manage their blood sugar. 76 children played the game alongside their usual care. Researchers measured changes in HbA1c (a long-term blood sugar marker) and how satis…

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This completed Phase 3 study tested whether adding semaglutide to a new once-weekly insulin (insulin icodec) improves blood sugar control in 148 adults with type 2 diabetes. Participants first received insulin icodec alone for 26 weeks; those with still-high blood sugar then adde…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This study looked at whether eating more dairy products (full-fat or low-fat) helps people with type 2 diabetes manage their blood sugar, weight, and heart health. 112 adults with type 2 diabetes who ate fewer than 3 servings of dairy per day were assigned to add either full-fat …

This study tested whether adding a smart, AI-powered insulin boost before meals could improve blood sugar control in adults with type 1 diabetes. Nineteen participants used either a standard automated insulin system or the same system with the AI boost during hotel stays and at h…

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This study looked at whether a dietary fiber called OptiFibre can help people with type 2 diabetes control their blood sugar and lose weight. About 80 adults with diabetes were observed for 3 months. The goal was to see if adding this fiber to their routine improved blood sugar l…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This early-stage study tested an oral drug called LY3502970 in 68 adults with type 2 diabetes. The main goal was to check safety and side effects, while also measuring how the drug moves through the body and affects blood sugar. Participants took the drug or a placebo for up to 1…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This study tested whether verapamil, a drug usually used for high blood pressure, can help preserve insulin-making cells in adults newly diagnosed with type 1 diabetes. 136 participants received either verapamil or a placebo for 12 months. The main goal was to see if verapamil co…

This study tested whether oat flakes containing β-glucan, a type of fiber, could help adolescents aged 12–18 with type 1 diabetes improve their blood sugar control, pancreatic function, and cholesterol levels. Sixty participants were randomly assigned to eat the oat flakes or a c…

This study tested whether taking a melatonin supplement (3 mg each night for 6 months) could improve sleep, thinking skills, and blood sugar control in 70 adolescents with type 1 diabetes. Half received melatonin and half received a placebo. The researchers measured changes in bl…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study looked at whether a daily prebiotic supplement (Molkosan®) could improve blood sugar and other health markers in people with type 2 diabetes. Twelve adults took a low dose (20 ml per day) for 12 weeks. Researchers measured changes in glucose tolerance, insulin levels, …

This study looked at whether giving underserved patients with type 2 diabetes a continuous glucose monitor (CGM) plus monthly telehealth visits with a pharmacist helps them manage their blood sugar better. 46 adults with uncontrolled diabetes took part. Researchers compared those…

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This study compared insulin injections and metformin pills in 60 pregnant women with gestational diabetes to see which is safer and more effective. Participants were randomly assigned to receive either insulin or metformin, and researchers monitored blood sugar levels and newborn…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a smartphone app called T2.coach that tracks diet, blood sugar, activity, and sleep, then uses machine learning to give personalized behavioral goals. About 280 adults with type 2 diabetes and high blood sugar used the app for 6 months alongside standard diabete…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested a phone-based program for 100 African Americans aged 50+ with poorly controlled type 2 diabetes. The program combined diabetes education and help with social needs like food or housing. Results aim to show if this approach improves blood sugar control and qualit…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether giving insulin as an extended bolus (over time) instead of all at once helps control blood sugar after high-fat, high-protein meals in teens with type 1 diabetes. Thirty teens using a closed-loop insulin pump ate a standardized breakfast and received eit…

This study tested whether an enhanced continuous glucose monitor (eCGM) linked to a decision-support system can help older adults (65+) with type 1 diabetes manage their blood sugar. The system automatically uploads glucose, insulin, and activity data to give personalized insulin…

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study looked at whether giving diabetes patients who are at risk for food insecurity money to buy fruits and vegetables, along with nutrition education, can improve their blood sugar control and reduce emergency room visits. Over 2,000 adults participated, with one group rec…

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This study tested a visual injection site map to help people with diabetes rotate where they inject insulin. The goal was to reduce lipohypertrophy—lumpy fatty tissue caused by repeated shots in the same spot—and improve blood sugar control. 170 adults on insulin for at least six…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study tested whether eccentric training (a type of exercise that lengthens muscles) done in a low-oxygen (hypoxic) chamber or with creatine supplements could improve blood sugar control, muscle strength, and fitness in people with type 1 diabetes. 28 adults with type 1 diabe…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This small pilot study tested whether a remote digital care program (TELEDUC-DIAB) could help 10 teens aged 12-17 with poorly controlled type 1 diabetes. Participants used a monitoring platform and educational app alongside their usual care. The main goal was to see if their bloo…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This study tested an artificial pancreas system that learns a person's exercise patterns to prevent low blood sugar (hypoglycemia) during and after moderate exercise. Fifteen adults with type 1 diabetes used the system for about 4 months, comparing it to a standard version. The g…

This study tested whether helping people with type 2 diabetes address unmet basic needs—like food, housing, and safety—can improve their blood sugar control. About 473 adults on Medicaid received either a 6-month navigation program or usual care. The goal was to see if this suppo…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infect…

This early study tested a single dose of the drug rongliflozin in 32 Chinese adults with type 2 diabetes who had normal, mildly, or moderately reduced kidney function. Researchers measured how the drug moved through the body and how it affected blood sugar and urine glucose. The …

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This early study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Only 3 patients took part, and they stayed on anti-rejection drugs. The goal was to see if the procedure was safe and could reduce …

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested whether eating more protein (1.5 grams per kilogram of body weight daily, instead of the usual 0.8 grams) could help older adults with type 2 diabetes prevent muscle loss and improve muscle function. Twenty-five participants followed either a high-protein or sta…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested a program designed to help women with type 2 diabetes become more physically active. 86 women aged 30-65 took part. The program included a video, a pamphlet, and regular check-ins to encourage exercise. The goal was to see if this approach could increase daily a…

This study tested three different diabetes treatments in 186 overweight or obese adults newly diagnosed with type 2 diabetes. Participants received either empagliflozin plus metformin, sitagliptin plus metformin, or metformin alone for 12 weeks. Researchers measured changes in bl…

This completed trial tested whether providing free, healthy food boxes every two weeks for six months could improve blood sugar control and health behaviors in adults with type 2 diabetes living in a low-income community. 405 participants were randomly assigned to receive the foo…

This study tested the safety and effectiveness of the MiniMed 780G automated insulin pump in 574 adults with type 2 diabetes who need insulin. Participants used the system at home for about 135 days. The goal was to see if the pump improved blood sugar control without causing saf…

This study tested whether the Omnipod 5, a tubeless automated insulin pump, works better than multiple daily insulin injections for managing type 1 diabetes. 189 children and adults participated. The main goal was to see if the pump improved blood sugar control (HbA1c) over 13 we…

This study tested a mobile health lifestyle program for 200 overweight or obese pregnant women in China. Participants used a WeChat account and a Huawei wristband to track diet, exercise, and weight, and received personalized feedback. The goal was to see if this approach could h…

This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether adding the drug liraglutide to standard care could reduce new heart problems like heart attacks, strokes, and hospitalizations. The goal was to see if this appr…

This study tested whether a six-week empowerment-based health education program could improve self-management in 50 adults with type 2 diabetes. Participants learned about diabetes, diet, and physical activity through group activities and discussions. The goal was to see if this …

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study looked at how safe and effective Fiasp, a faster-acting mealtime insulin, is for people with type 1 or type 2 diabetes in everyday life. 42 adults used Fiasp as prescribed by their doctor for about 6 months. Researchers tracked side effects and blood sugar control to s…

This study tested whether using a continuous glucose monitor (CGM) in the hospital right after childbirth could better detect low blood sugar (hypoglycemia) in women with type 1 or type 2 diabetes, compared to standard finger-stick tests. Thirty-nine women in their third trimeste…

This study looked at how sitagliptin (Januvia) affects levels of anti-rejection drugs and blood sugar in 16 people who had a kidney transplant and have type 2 diabetes. Participants took sitagliptin daily for 3 months. The goal was to see if it is safe and works well in this grou…

This study tested whether a nurse-led mobile app could improve diabetes management in 112 adults with type 2 diabetes. The intervention group received structured education and reminders via the app for 6 months, while the control group got standard care. The main goal was to see …

This study looked at whether a class of diabetes drugs called SGLT2 inhibitors can improve fatty liver disease in people with type 2 diabetes. 150 adults took the drugs for 6 months, and researchers measured changes in liver stiffness, fat levels, and blood sugar control. The goa…

This Phase 3 trial tested a new weekly injection called TG103, combined with the common diabetes pill metformin, in 632 adults with type 2 diabetes. The goal was to see if TG103 could lower blood sugar better than an existing weekly shot (dulaglutide) over 28 weeks. Participants …

This early study tested a new approach called Stem Cell Educator therapy in 13 adults with type 1 diabetes. The treatment involves taking a patient's own blood cells, processing them with stem cells, and returning them to the body. The main goal was to see if it is safe and feasi…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested whether a diet rich in slowly digestible starch (SDS) could improve blood sugar control and reduce inflammation in people with type 2 diabetes. Fifty-three adults with type 2 diabetes followed either a high-SDS or low-SDS diet for three months. Researchers measu…

This study tested a personalized dietary program for 30 adults with type 2 diabetes. The program was designed to help participants better manage their blood sugar and potentially achieve remission. Researchers measured changes in HbA1c and other health markers to see if the diet …

This study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…

This small pilot study tested whether transplanting pancreatic islets together with parathyroid glands into the muscle could help people with type 1 diabetes stop using insulin. The 4 participants already had a functioning kidney or liver transplant and were on lifelong immunosup…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study looked at whether a 1-hour glucose test (using 50 grams of sugar) can accurately diagnose gestational diabetes, so pregnant women might not need the longer 3-hour test. Researchers analyzed results from 351 women with singleton pregnancies who had already completed bot…

This study tested a new rapid blood test (LumiraDx HbA1c) to see how well it measures blood sugar control in people with diabetes. Researchers compared it to a standard lab method in 177 adults. The goal was to see if the quick test is accurate enough for routine diabetes monitor…

This study tested a new device called LabPatch, a small patch worn on the arm that measures blood sugar levels continuously. Researchers compared its accuracy to standard lab tests and two commercial glucose meters. The study involved 30 adults with type 1 or type 2 diabetes to s…

This completed study tested whether a special laser technique called surface-enhanced Raman spectroscopy (SERS) can diagnose diabetes from a blood sample. Researchers analyzed blood from 52 people (healthy and diabetic) to see if the laser could tell them apart. The goal is to de…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study looked at two different exercise programs in 24 adults with prediabetes (higher than normal blood sugar but not yet diabetes). One group did short bursts of intense exercise (HIIT), the other did steady moderate exercise. Researchers measured changes in blood sugar, ch…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a diabetes prevention program adapted for American Indian men living on the Colville reservation. Overweight and obese men without diabetes took part in a culturally informed program aimed at weight loss and reducing diabetes risk. The trial enrolled 113 men and…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study looked at whether telling overweight East Asians their genetic risk for type 2 diabetes, combined with using a Fitbit, could encourage them to be more active. 355 participants aged 40-60 were split into groups: some got just a Fitbit, others got their genetic risk plus…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study looked at whether taking vitamin D or fish oil supplements every day can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.

This study tested whether a habit-formation smartphone app could help adults with prediabetes stay engaged in the National Diabetes Prevention Program. Researchers compared how many classes people attended and how long they stayed in the program between those who used the app and…

This study tests whether a gel made from a patient's own blood platelets can help diabetic individuals heal faster after tooth removal. Twelve adults with diabetes who need two similar-sized tooth extractions will receive the gel in one socket and standard care in the other. Rese…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This trial tests a set of conversation cards, called QBSafe, designed to help people with type 2 diabetes talk with their doctors about what matters most in their daily lives. The goal is to see if these conversations can reduce the burden of living with diabetes and improve well…

This trial tests whether a quick cold spray on the skin before a subcutaneous insulin injection can reduce pain compared to a placebo spray. Adults in the emergency department who need at least two insulin injections receive both sprays in random order, rating their pain after ea…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tested two local anesthesia techniques—intraseptal and periodontal ligament—in 120 adults with controlled type 2 diabetes who needed a tooth pulled. The goal was to see which method numbs better and how it affects blood pressure and heart rate. Results help dentists ch…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested custom 3D printed insoles for people with diabetes who are at risk of foot ulcers. Thirty participants wore different types of insoles in a lab to see which ones best reduced pressure on the bottom of the feet. The goal was to improve foot health and mobility.

This study tested a program called PREP-DC that teaches teens and young adults with type 1 diabetes how to communicate better with their doctors and get ready for adult diabetes care. 52 participants aged 17-23 were split into two groups: one received the program, the other got s…

This study tested a program called T1DES designed to help Black young adults aged 18-30 with type 1 diabetes feel less stressed about their condition. Researchers wanted to see if the program was practical and could improve blood sugar levels and emotional well-being. The study i…

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This pilot study tested a culturally tailored mindfulness program for 18 low-income, Spanish-speaking Latina pregnant women. The goal was to see if the program could reduce stress and improve markers of inflammation and blood sugar control. Participants were split into two groups…

This study tested a smart technology platform with a serious game for 200 adolescents with type 1 diabetes. The game was designed to help them build emotional and social skills, cope with their condition, and improve quality of life. Researchers measured changes in well-being, em…

This study tested a new insulin dosing calculator for adults with type 2 diabetes when they are admitted to the hospital. The goal was to see if the calculator helps control blood sugar without causing dangerously low levels. Thirty-eight participants received their initial insul…

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested a 7-session anti-stigma psychoeducation program for adults with Type 1 diabetes. The goal was to see if it could reduce feelings of stigma and improve quality of life. 36 participants completed the program and were compared to a group that did not receive it. Re…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested whether personalized text messages could help young adults with type 1 diabetes feel more confident managing their condition as they moved from pediatric to adult care. 234 participants received either usual care or usual care plus a text messaging program. The …

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …

This study tested a video-based telemedicine program called REDCHiP for parents of young children (ages 2-6) with type 1 diabetes. The program uses education, behavior training, and therapy to reduce parents' fear of hypoglycemia (low blood sugar). 396 families participated, comp…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study used ultrasound to measure how much fluid remains in the stomach after standard preoperative fasting in 592 adults scheduled for elective surgery. Researchers compared diabetic and non-diabetic patients to see if diabetes affects stomach emptying. The goal is to help t…

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This study looks at how the body processes arginine, a natural nutrient, in teenagers with type 2 diabetes. Researchers will give participants arginine and measure its effect on insulin production. The goal is to better understand the disease and see if arginine could be a safe, …

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study investigates the link between gut bacteria and diabetic kidney disease, a common complication of type 2 diabetes. Researchers will analyze blood, urine, and stool samples from 556 adults with the condition to look for bacterial and metabolic markers. The goal is to und…

This study tests whether teaching Latino patients with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. 84 adults will receive either one-on-one digital training or standard care. The main goal is to se…

This early-stage trial is testing an experimental drug called HTD4010, a synthetic version of a natural peptide that may help the pancreas regenerate insulin-producing cells. The study enrolls healthy, non-diabetic volunteers to receive single ascending doses of the drug or a pla…

This study looks at whether people with type 2 diabetes who eat more dairy products (like milk, cheese, and yogurt) during an intensive lifestyle program have better blood sugar control and weight maintenance. Researchers will track changes in A1C, weight, and cholesterol in abou…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This Phase 1 trial tests two experimental drugs (L03RD1 and L03RD2) in 48 healthy adults to see how safe they are and how the body processes them. Participants take the drugs alone or together in a single dose. The study does not aim to treat diabetes, but to gather information f…

This study looks at how type 1 diabetes affects the heart, lungs, and overall fitness of children aged 6 to 17. It also measures their physical activity levels and quality of life. Researchers will compare these results with those of healthy children of the same age. The goal is …

This study investigates how specific fat molecules called diacylglycerols and sphingolipids inside muscle cells influence insulin resistance. Researchers will measure these lipids in different parts of muscle cells before and after weight loss or exercise in people with obesity, …

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This study investigates how women with type 1 diabetes manually adjust their automated insulin delivery (AID) systems to manage blood sugar changes during their menstrual cycle. Researchers will interview 69 women to catalog strategies like entering fake carbohydrates or changing…

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study tested whether an online diabetes self-management program could help newly diagnosed adults with type 2 diabetes learn about their condition and improve health measures. 123 participants were split into online education, face-to-face education, or a no-education contro…

This study tests different ways to invite adults with diabetes who struggle to take their medications as prescribed. Researchers will compare letters and phone call strategies to see which approach gets more people to schedule and attend a pharmacist appointment. The goal is to f…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This study investigates whether exercising in the morning versus the afternoon changes how the body handles blood sugar and burns fat in people with type 1 diabetes. Twelve adults with type 1 diabetes will do one hour of moderate exercise at 9 AM and another session at 4 PM on se…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This completed study at Northwestern University brought together 35 patients, caregivers, and healthcare providers to discuss how to improve the identification and management of high blood sugar (hyperglycemia) and diabetes during hospital stays and when moving between care setti…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study checked how well two continuous glucose monitors (Dexcom G6 and FreeStyle Libre) work when oxygen levels are low. Thirty people with type 1 or type 2 diabetes took part. Researchers compared sensor readings to blood tests during controlled low-oxygen conditions to see …

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study follows up on 370 mothers and their children who were part of a larger trial testing metformin for gestational diabetes. Researchers want to see if taking metformin during pregnancy reduces the risk of diabetes, obesity, and heart problems in mothers up to 10 years lat…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study analyzed health records from nearly 195,000 people in Denmark, Sweden, and Norway to see if semaglutide (the drug in Ozempic and Rybelsus) is linked to a higher risk of pancreatic cancer. Researchers compared new users of semaglutide to new users of other diabetes medi…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This completed study followed over 1,000 children with newly diagnosed type 1 diabetes and their healthy siblings for up to three years. Researchers collected genetic information, measured diabetes-related antibodies, and asked about environmental exposures. The goal was to build…

This study analyzed health records from nearly 75,000 people with type 2 diabetes in Hungary to see if different diabetes medications are linked to cancer risk. Researchers compared various drugs, including metformin, and adjusted for age, gender, and other health factors. The go…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study tested whether an educational video and action plan, called 'Prepare for Your Diabetes Care,' could help older adults (75+) with type 2 diabetes reduce their risk of dangerously low blood sugar. Over 12 months, 669 participants were randomly assigned to receive the int…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This study looked at how different ways of taking a blood sample from a finger affect blood sugar readings in people with diabetes. Researchers compared the first and second drops of blood, and also tested with and without squeezing the finger. The goal was to find the most accur…

This study looked at whether a 15-20 minute educational program helps pregnant women decide to take a glucose test for gestational diabetes. 199 women between 24-28 weeks of pregnancy took part. Half got standard advice, the other half got a structured video and guidebook. The re…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This completed study looked at 238 people who received a pancreas and kidney transplant for type 1 diabetes. The goal was to understand why diabetes sometimes returns even after a new pancreas is working. Researchers checked for immune system markers, like antibodies and T cells,…

This completed study tested a 4-week group program designed to boost confidence (self-efficacy) in managing type 2 diabetes. Sixteen adults from primary health centers in Indonesia took part. Researchers measured changes in self-care behaviors and self-efficacy using questionnair…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at 295 adults with type 2 diabetes in Kharga City, Egypt, to see how many also had other conditions like high blood pressure, heart disease, kidney disease, or eye problems. Researchers used blood tests, urine tests, and heart tracings to check for these issues.…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This early-stage trial tested the safety and how the body processes a new drug called HR011408 in 62 healthy adults. Participants received two different versions of the drug to compare them. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study looked at whether people with severe, long-term uncontrolled type 1 diabetes would accept and benefit from a closed-loop insulin delivery system (an 'artificial pancreas'). Researchers followed 66 adults with very high blood sugar levels over several years. The goal wa…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This study looked at 100 pregnant women with gestational diabetes to see if they were taking the recommended amount of iodine. Iodine is important for both mother and baby, and health authorities suggest supplements during pregnancy. The goal was simply to find out if these women…

This completed study tested a new biosensor designed to measure blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor uses microdialysis to sample interstitial fluid and was compared to standard continuous glucose monitors (CGM) during …

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood su…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 people with and without diabetes to understand why fitness levels may be lower in those with high blood …

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen women with gestational diabetes wore a continuous glucose monitor and ate two test meals. The goal was to see if …

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This study looked at whether taking vitamin C (and vitamin E) supplements for 8 weeks can make red blood cells more flexible in people with type 2 diabetes. Stiff red blood cells can lead to tiny blood vessel damage. Researchers measured red blood cell flexibility before and afte…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study tested a Turkish version of a questionnaire that helps people with diabetes take better care of their feet to prevent ulcers. Researchers interviewed 202 adults with diabetes to see if the tool was accurate and reliable. The tool covers daily foot care, checking for ea…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study looked at how short periods of low oxygen (from holding your breath) affect blood sugar levels after drinking a sugary drink. Researchers tested 20 healthy adults, people with prediabetes, and people with type 2 diabetes. The goal was to learn more about how oxygen lev…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study looked at whether cutting basal insulin by half before exercise helps keep blood sugar stable in people with type 1 diabetes. Eighteen active adults using insulin pumps completed two treadmill sessions—one with the insulin reduction and one without. Researchers measure…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study looked at 142 people who had a sinus lift procedure using cow bone mineral before getting dental implants. Researchers measured how much bone was left around the implants years later, and checked if the original jawbone height, implant type, smoking, or diabetes played…

This study followed 99 people who had both an operable pancreatic tumor and diabetes for one year after surgery. Researchers tracked their fatigue, blood sugar control, diabetes self-care, and quality of life to understand how these factors change over time. The goal was to learn…

This study looked at how the nervous system helps control blood sugar in people with type 1 diabetes who had islet cell transplants. Nine participants received drugs that block nerve signals or a placebo during controlled low blood sugar experiments. The goal was to learn whether…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…

This early-stage study looked at how two different tablet versions of the experimental diabetes drug HRS-7535 are absorbed in the body, and whether food changes that. It involved 24 healthy adults who took the tablets under fasting and fed conditions. The goal was to compare the …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This study looked at how two drugs, metformin and HRS-7535, behave in the bodies of 18 healthy men aged 18-50. The goal was to measure drug levels and safety, not to treat any disease. Results will help guide future diabetes research.

This completed Phase 1 trial tested how four diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other's levels in the body. Twenty-four healthy men took the drugs in a fixed order, and researchers measured drug concentrations and side effects. The…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed study in 130 adults with type 2 diabetes and fatty liver disease tested whether a blood marker called adiponectin can predict how well certain diabetes drugs reduce liver fat. Participants received either an SGLT2 inhibitor, a GLP-1 receptor agonist, or both for si…

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared the effects in normal-weight and overweight/obese South Asian adu…

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This pilot study looked at whether removing oxysterols (harmful compounds in cooked animal foods) from the diet could improve insulin production in African Americans with prediabetes or early type 2 diabetes. Twelve participants ate a plant-based diet free of oxysterols for a per…

This completed study followed over 1,100 pregnant women in Guangzhou to see how their diet and nutrition during and after pregnancy relate to blood sugar problems like gestational diabetes. Researchers also tracked the children's growth, brain development, and allergies up to age…

This study examined how conditions like diabetes, smoking, heart disease, and osteoporosis affect the health of dental implants. Researchers looked at 93 people with 314 implants that had been in place for at least three years. They found that these systemic factors can influence…

This study looked at how eating disorders, like anorexia or bulimia, impact blood sugar levels in women with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders. The goal was to better understand these risks and improve screening …

This study followed over 2,000 pregnant women to measure their blood sugar levels throughout pregnancy. The goal was to see how glucose patterns relate to gestational diabetes and whether the baby is born larger than normal. Researchers used continuous glucose monitors and standa…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study looked at how eating a high fat diet for just 5 days changes the way muscles handle sugar and fat. Researchers fed 11 healthy men a diet with 50-60% fat and measured muscle flexibility and gut health. The goal was to understand why muscles in people with diabetes becom…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study tested a new insulin called insulin icodec in 18 children and teenagers (ages 10 to 17) with type 2 diabetes. Each participant received a single injection based on their body weight, and researchers measured how the insulin moved through their blood over time. The goal…

This study looked at whether giving metoclopramide, a drug that speeds up stomach emptying, helps diabetic patients have less stomach fluid before surgery. 60 adults having elective surgery were checked with ultrasound to measure stomach contents. The goal was to see if the drug …

This completed study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers collected blood samples and performed metabolic tests to identify genetic defects. The goal was to better understand these genetic forms of diabetes and possibl…

This study looked at whether a blood test can measure beta cell death in people with cystic fibrosis, which may help predict diabetes. About 40 participants with cystic fibrosis and healthy controls gave blood samples to check for a specific DNA marker. The goal was to understand…

This completed phase 1 study tested how different levels of kidney function affect the processing of a single dose of the experimental drug NNC0519-0130. Thirty-six adults with type 2 diabetes and varying kidney function (normal to severely impaired) received one injection. Resea…

This study looked at how the drug finerenone affects kidney blood vessels and stress levels in people with type 2 diabetes. Researchers measured blood flow and oxidative stress in the kidneys of 91 adults. The goal was to understand how finerenone works, not to test a cure or tre…