New daily pill could help teens manage type 2 diabetes

NCT ID NCT07668336

Not yet recruiting Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: orforglipron (oral pill)
What this could lead to: If it works, this could offer a convenient once-daily pill option for teens with type 2 diabetes, potentially improving blood sugar control and weight management.
What could go wrong: This is a phase 3 trial, but it's still early for this age group. The drug may not work better than existing options, and side effects like nausea or hypoglycemia are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

Advantage Clinical Trials

The Bronx, New York, 10467, United States
Alder Hey Children's Hospital

Liverpool, L14 5AB, United Kingdom
All India Institute of Medical Sciences

Bhubaneswar, 751019, India
All India Institute of Medical Sciences

New Delhi, 110029, India
Avron Hospitals

Ahmedabad, 380013, India
Azienda Ospedaliera Universitaria Di Messina G. Martino

Messina, 98125, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

Verona, 37126, Italy
Azienda Ospedaliera Universitaria Meyer IRCCS

Florence, 50139, Italy
CenExel iResearch, LLC

Decatur, Georgia, 30030, United States
Cendi - Endocrinologia e Diabetes

Goiânia, 74230-035, Brazil
Central States Research

Tulsa, Oklahoma, 74136, United States
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.

Ciudad Madero, 89440, Mexico
Centro de Investigacion Medica de Occidente, S.C.

Guadalajara, 44260, Mexico
Centro de Pesquisa Sao Lucas

Campinas, 13060-803, Brazil
Centro de investigación y control metabólico

Monterrey, 66465, Mexico
Chang Gung Medical Foundation-Linkou Branch

Taoyuan, 333, Taiwan
Children's Healthcare of Atlanta - Center for Advanced Pediatrics (CAP)

Atlanta, Georgia, 30329, United States
China Medical University Hospital

Taichung, 404332, Taiwan
Chungnam national university hospital

Junggu, 35015, South Korea
Cliniques universitaires Saint-Luc

Brussels, 1200, Belgium
Clínica García Flores SC

Monterrey, 64610, Mexico
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, 66606, United States
Driscoll Children's Hospital

Corpus Christi, Texas, 78411, United States
Endolife Speciality Hospitals

Guntur, 522001, India
Frontier Clinical Research, LLC

Smithfield, Pennsylvania, 15478, United States
Fukuoka Children's Hospital

Fukuoka, 813-0017, Japan
Gadolin Research

Beaumont, Texas, 77702, United States
Gujarat Endocrin Pvt Ltd

Ahmedabad, 380052, India
H.R.U Málaga - Hospital General

Málaga, 29011, Spain
Harmony Health Hub

Nashik, 422002, India
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain
Hull Royal Infirmary

Hull, HU3 2JZ, United Kingdom
IBTED - Tecnologia e Educação em Diabetes

São Paulo, 04038-032, Brazil
IRCCS Istituto Giannina Gaslini

Genova, 16147, Italy
Instituto Méderi de Pesquisa e Saúde

Passo Fundo, 99010-120, Brazil
Instituto da Crianca com Diabetes

Porto Alegre, 91350-250, Brazil
Instituto de Pesquisa Clinica

São Paulo, 01223-001, Brazil
Instituto de Pesquisa clinica de Campinas

Campinas, 13060-080, Brazil
Jawaharlal Nehru Medical College

Aligarh, 202002, India
Juntendo University Urayasu Hospital

Urayasu, 279-0021, Japan
King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College

Mumbai, 400012, India
Kyungpook National University Chilgok Hospital

Deagu, 41404, South Korea
Medical Research Partners

Ammon, Idaho, 83406, United States
Nihon University Hospital

Chiyoda-ku, 101-8309, Japan
Niigata University Medical & Dental Hospital

Niigata, 951-8520, Japan
Osaka City General Hospital

Osaka, 534-0021, Japan
Ospedale Pediatrico Salesi

Ancona, 60123, Italy
Ospedale San Raffaele

Milan, 20132, Italy
Proactive Clinical Research LLC

Edinburg, Texas, 78539, United States
Rady Children's Hospital

San Diego, California, 92123, United States
Royal London Hospital

London, E1 1BB, United Kingdom
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Saitama City Hospital

Saitama, 336-8522, Japan
Saitama Medical University Hospital

Iruma, 350-0495, Japan
Sendai City Hospital - Asutonagamachi

Sendai, 982-8502, Japan
Seoul National University Bundang Hospital

Seongnam, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Shiga General Hospital

Moriyama, 524-8524, Japan
Shizuoka Children's Hospital

Shizuoka, 420-8660, Japan
Soon Chun Hyang University Bucheon Hospital

Bucheon-si, 14584, South Korea
Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States
Sutter Valley Medical Foundation (SVMF) Pediatric Endocrinology

Sacramento, California, 95821, United States
UBAM Unidad Biomedica Avanzada Monterrey

Monterrey, 64460, Mexico
UZ Gent

Ghent, 9000, Belgium
UZ Leuven

Leuven, 3000, Belgium
University of Naples Federico II

Naples, 80131, Italy
Urakami Pediatric Endocrinology and Diabetes Clinic

Tokyo, 101-0062, Japan
Vanderbilt Health One Hundred Oaks

Nashville, Tennessee, 37204, United States
Victoria Clinical Research Group

Victoria, Texas, 77901, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.