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Scientists hunt for diabetes genes in caribbean populations

NCT ID NCT07576374

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de la Guadeloupe Source: ClinicalTrials.gov ↗

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This trial is taking on new participants right now.
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Paused for now. It may or may not start again.
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The trial has finished. Results may not be published yet.
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Cancelled
Cancelled before anyone took part.

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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes linked to how the body handles sugar and insulin.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 118 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

subjects of African and Indian ancestry with atypical forms of non autoimmune diabetes.

Ages

18 to 47 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Phenotypic criteria : Subjects from Indian or African Ancestry self-declared Age criteria at diagnosis: Early onset of diabetes: patient aged between 18 and 47 years at the time of diagnosis of diabetes Clinical criteria: at least 2 criteria Labeled type 2 diabetic Patient hospitalized for: Ketoacid decompensation Significant weight loss (more than 10% in less than 6 months) without obvious etiology Lipodystrophic / lipoatrophic appearance Presence of an associated myopathy or deafness Presence of early inaugural nephropathy or within 3 years after diagnosis Presence of early inaugural heart disease or within 3 years after diagnosis Poor response to non-insulin treatments despite good adherence Biological criteria: Absent T1D autoantibodies: Anti-islet antibodies (ICA) Anti-IA2 antibodies Anti-insulin antibodies Anti-ZnT8 antibodies Anti-GAD antibodies Other criteria: Informed consent signed by the patient Exclusion Criteria: Type 1 diabetes (T1D) Presence of T1D antibodies Secondary diabetes (pancreas diseases, endocrine diseases, drug intake, infection) Other associated autoimmune pathologies Pregnancy Refusal to participate

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease Ketosis metabolic disease monogenic diabetes type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus, type 2 Genetic profile Genetic variation Glucose metabolism disorders Metabolic diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Centre Hospitalier Universitaire de la Guadeloupe

    Les Abymes, Guadeloupe, 97159, Guadeloupe

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