Agnosia

This study tests a telemonitoring device called ANTALGEEK® that helps people manage acute pain at home after outpatient surgery. The device tracks pain levels and guides medication use, aiming to improve recovery and lower the risk of chronic pain. About 150 adults having surgery…

This study looks at whether adding lidocaine to standard sedation during radiofrequency ablation for liver cancer can reduce inflammation and lower the chance of the cancer returning. The researchers focus on a process called NETosis, which is linked to tumor growth and spread. O…

This study combines two treatments—laser heat to destroy tumors near the spinal cord and precise radiation—to better control spine tumors that have spread from other cancers. About 60 adults with solid tumors will receive both therapies. The goal is to improve tumor control, redu…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study looks at whether a special brain wave monitor (EEG) can help doctors choose the right amount of sedation medicine for children who need a brain MRI. About 50 children under 5 years old (or older children who have trouble staying still) will receive a standard low dose …

This study compares two types of nerve blocks (paravertebral block and external oblique intercostal block) to standard pain medicine for people having gallbladder removal surgery. About 147 adults will be randomly assigned to one of three groups to see which approach reduces pain…

This study investigates whether wearing a virtual reality headset during epidural injections can lower pain and anxiety in people with nerve root pain (radiculopathy). Participants receive two injections, each with the headset, and researchers measure anxiety levels and pain scor…

This trial tests whether adding either dexmedetomidine or magnesium sulphate to the standard numbing medicine bupivacaine improves pain control after chest surgery. About 60 adults with cancer undergoing thoracotomy will receive one of three nerve-block combinations. The main goa…

This study compares two types of nerve blocks for pain relief in women undergoing breast cancer surgery. One group receives a single-level block, while another receives a two-level block, with some patients also getting the medication dexmedetomidine. The goal is to see which app…

This trial tests whether giving the painkiller parecoxib before a CT-guided wire placement can reduce pain during lung nodule localization for surgery. About 150 adults with lung cancer scheduled for video-assisted thoracoscopic surgery will receive either parecoxib or a placebo …

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This study compares buprenorphine to a standard opioid (hydromorphone) for pain relief in adults aged 65 and older who come to the emergency department with a broken bone. Researchers want to see if buprenorphine works just as well but causes fewer side effects like nausea, confu…

This study tests whether freezing certain nerves during minimally invasive lung surgery can help patients recover faster with less pain. 150 adults having lung surgery will either get standard pain management or standard care plus nerve freezing. The goal is to see if the freezin…

This study tests whether motivational interviews led by midwives can lower stress and alexithymia (trouble identifying feelings) in pregnant women and their partners. About 140 couples will be split into two groups: one gets the motivational sessions, the other does not. Research…

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests a new nerve block called the External Oblique Intercostal Plane Block (EOIB) to see if it reduces pain and the need for opioids after major upper abdominal surgery. 78 adults having laparoscopic surgery on the stomach, liver, gallbladder, or pancreas will be rand…

This study tests whether a continuous nerve block (erector spinae plane block) can reduce pain and morphine use after coronary artery bypass surgery. 78 adults with good heart function will receive either the nerve block with ropivacaine or standard painkillers. The goal is to se…

This study tests two different ultrasound-guided nerve blocks to see which provides better pain relief for children aged 6 to 12 after chest surgery. Seventy-five children will receive either a subtransverse process interligamentary plane block or a rhomboid intercostal block com…

This study compares a lighter 'ambulatory' epidural to a standard one during childbirth, measuring how satisfied women feel about their labor and delivery. About 126 women with healthy, full-term pregnancies will fill out a questionnaire 2 days and 4 weeks after giving birth. The…

This study compares two drug combinations (ketamine with propofol vs. dexmedetomidine with propofol) for sedating children aged 2-12 during a heart catheterization to close simple heart defects. The goal is to see which approach causes fewer breathing problems and provides smooth…

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This study compares two types of nerve blocks—coeliac plexus block and splanchnic nerve block—to see which one reduces pain better in adults with upper abdominal cancer. Forty-four participants will receive one of the procedures and be monitored for pain, opioid use, and quality …

This pilot study tests if patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) using a pump, instead of waiting for a nurse to bring pills. About 24 adults will be enrolled, and researchers will measure how many agree…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests if a safe, non-invasive nerve stimulation on the ear can lower pain and the need for strong painkillers after abdominal or urologic surgery. 174 adults will receive either real stimulation at different frequencies or a sham (fake) treatment before and after surge…

This study compares two remote training programs for 300 people who have had a mild traumatic brain injury (concussion) and struggle with emotional awareness and regulation. One program teaches participants to recognize and label their emotions, while the other focuses on general…

This study tests a special exercise program (neuromuscular re-education) against standard therapy for people with cervical radiculopathy, a condition causing neck pain, numbness, and weakness in one arm. Researchers will measure pain, neck movement, and daily function in 52 adult…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests whether relaxation and breathing exercises guided by an AI system can reduce pain and improve quality of life in postmenopausal women with chronic muscle and joint pain. About 48 women aged 45 to 65 will either work with a physiotherapist, use an AI-assisted prog…

This study compares two ultrasound-guided nerve blocks—recto-intercostal fascial plane block (RIFPB) and transversus abdominis plane block (TAPB)—for pain control after laparoscopic gallbladder removal. 90 adults undergoing elective surgery will receive one of the two blocks. The…

This study tests two different methods of patient-controlled pain pumps to see which one reduces opioid use and improves pain relief after surgery. About 1170 adults having various surgeries will be randomly assigned to one of two pump settings. The goal is to find a smarter way …

This study tests whether giving the anti-inflammatory drug dexketoprofen through a vein can prevent or lessen the severe pain that often occurs when a nerve block wears off after shoulder surgery. About 66 adults having arthroscopic shoulder surgery will be randomly assigned to r…

This study tests whether watching a video that guides you to imagine acupuncture can reduce pain and the need for painkillers after spinal surgery. 120 adults will either watch the imagery video or an education video daily for a week after surgery. Researchers will compare pain s…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study compares two types of nerve blocks—erector spinae plane block and modified thoracoabdominal nerve block—for pain control after laparoscopic gallbladder removal. Fifty adults aged 30-65 will receive one of the two blocks with bupivacaine. Researchers will measure how lo…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This study compares two ultrasound-guided nerve block techniques—Quadro-iliac Plane Block and Transversus Abdominis Plane Block—for pain control after inguinal hernia repair. About 60 adults aged 18-65 will be enrolled to see which method provides better pain relief and recovery.…

This study tests whether adding a new nerve block (BiFeS) to the standard adductor canal block provides better pain relief after knee surgery for torn cartilage. About 135 adults aged 18-65 will be enrolled. Researchers will measure pain scores and morphine use in the first 24 ho…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study is testing two holistic, non-drug programs to help military members manage chronic musculoskeletal pain. About 608 participants will be randomly assigned to either a single-session class called Empowered Relief, a multi-session program called Move to Health, or usual c…

This study tests if a special nerve block given before gallbladder surgery can lower the amount of painkillers and anesthesia needed during the operation. It also looks at whether it helps with pain and nausea after surgery. About 64 adults having gallbladder removal are being re…

This study tests whether a 15mg dose of the painkiller ketorolac works as well as a 30mg dose for relieving kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over several hours.…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce opioid prescriptions and pain after breast conserving surgery. 260 breast cancer patients will be randomly assigned to receive either the ERAS protocol or standard care. The ERAS protocol inclu…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study tests whether using virtual reality for mindfulness therapy can help adults with long-term low back pain feel better and move easier. About 214 people aged 20-70 will either get 8 weeks of VR mindfulness sessions plus usual care, or just usual care. The goal is to see …

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study tests whether a robotic baby seal named PARO can reduce pain and anxiety in children aged 1 to 7 during a common but stressful procedure: placing an IV line. About 120 children will either receive standard care alone or standard care plus the robot. Researchers will me…

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, get information, and communicate with their care team from home. Researchers want to see if using the app improves quality of life, reduces anxiety, and cuts…

This study tests whether a numbing injection (TAP block) given before heart procedures done through the groin can reduce pain and improve patient and doctor satisfaction. About 100 adults having planned heart catheterization or stent placement will be randomly assigned to receive…

This study tests a new long-acting painkiller called ALX006 for pain after bunion surgery. About 60 adults will receive a single nerve block shot of either ALX006 or a standard painkiller. The goal is to see if ALX006 provides longer pain relief with fewer side effects.

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study tests whether adding dexamethasone (a steroid) to a standard numbing medication (bupivacaine) in a nerve block can extend pain relief for people undergoing upper limb vascular surgery. Eighty adult patients will receive the block before surgery, and researchers will me…

This study is testing whether adding ketamine to a standard nerve block can reduce pain after upper arm surgery. About 80 adults having arm surgery will receive the nerve block with or without ketamine, and their pain levels will be measured. The goal is to see if ketamine improv…

This study tests whether adding a specific nerve block (PIFB) to standard pain management helps patients recover faster after open-heart surgery. It compares two types of nerve blocks in 123 adults undergoing elective heart surgery. The goal is to see if one block is at least as …

This study tests a coaching program called OPTIONS that helps veterans with chronic pain learn non-medication strategies. Around 296 veterans with musculoskeletal pain will work with a coach to align pain management with their personal values and goals. The main goal is to see if…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study compares two ways to manage pain after video-assisted lung surgery: a nerve block injected near the ribs and a small dose of morphine given into the spinal fluid. Sixty adults having elective lung surgery will be randomly assigned to one of the two methods before anest…

This Mayo Clinic study tests whether using a virtual reality (VR) headset can reduce pain and the need for opioid painkillers in 100 adults hospitalized with a broken bone. Participants will use a VR program while in the hospital, and researchers will track their pain medication …

This study tests whether using a virtual reality (VR) headset showing calming nature videos can reduce pain and anxiety during a first-trimester procedural abortion. Seventy-two adults will either receive usual care (pain medication and local anesthetic) or usual care plus the VR…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain and improve satisfaction. About 106 women in labor will either listen to music or not. They will rate their anxiety and pain levels and answer questions about their care.

This study tests whether an erector spinae plane block (ESPB) — an injection of the anesthetic ropivacaine into back muscles — can reduce pain and the need for pain medication in children undergoing posterior spinal fusion for scoliosis. About 42 children with adolescent idiopath…

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedu…

This study looks at two ways of giving the pain medicine ketorolac to children after heart surgery: as a steady drip or as shots every few hours. The goal is to see if the steady drip reduces the need for stronger opioid pain medicines. About 166 children aged 3 months to 5 years…

This study tests whether a nerve block called transversalis fascia plane block can reduce pain after kidney transplant surgery. Fifty adults will receive either the nerve block plus standard painkillers or standard painkillers alone. The goal is to see if the block lowers pain sc…

This study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …

This study tests a 30-microgram sublingual sufentanil tablet for treating moderate to severe pain from a single injury in the emergency department. 300 adults with pain scores of 4 or higher on a 0-10 scale will receive either the tablet or standard pain treatment. The goal is to…

This study looks at two common methods of giving extra opioids (strong painkillers) to patients recovering from open abdominal surgery who already have an epidural. Researchers want to see if adding opioids to the epidural fluid works as well as giving them through an IV, and whe…

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study looks at two ways to manage pain during weight-loss surgery (sleeve gastrectomy) in 70 adults. One group gets standard opioid painkillers, the other gets a mix of non-opioid drugs. The goal is to see if the opioid-free approach can reduce opioid use and still control p…

This pilot study is testing whether CBD oil can help reduce pain and nerve damage in people with diabetic peripheral neuropathy (DPN). About 20 adults with mild to moderate DPN will receive either CBD or a placebo for 6 weeks. The goal is to see if CBD is safe and effective, and …

This study tests a new nerve block called BiFeS against the standard iPACK block for pain after knee replacement surgery. 88 adults having a knee replacement will be randomly assigned to receive one of the two blocks. The goal is to see which provides better pain relief and helps…

This study compares two sedatives—remimazolam and midazolam—in 440 critically ill patients on breathing machines. The goal is to see if remimazolam helps patients come off the ventilator faster. Participants are randomly assigned to one drug, and researchers track how long they n…

This study tests whether a pain management plan that limits opioids can help adults who need hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior total hip replacement will be randomly assigned to either the opioid-sparing …

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study tests whether battlefield acupuncture can reduce pain and the need for pain medication in people hospitalized for exertional rhabdomyolysis, a condition where muscle breaks down after extreme exercise. About 36 adults who choose the treatment will have their pain level…

This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned…

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This study is testing whether a drug called aniracetamfen can safely reduce pain and help people recover faster after a major pancreatic surgery called pancreaticoduodenectomy. About 35 adults who are having this surgery will receive the drug, and researchers will track their pai…

This study looks at two different methods for using a patient-controlled pain pump after surgery. The goal is to see if a new, time-based method can reduce the amount of opioids needed while still controlling pain effectively. About 450 adults having various surgeries will take p…

This study compares two common steroids, dexamethasone and methylprednisolone, to see which one better reduces swelling and pain after surgery for a broken lower jaw. About 72 adults aged 18 to 40 with a recent, isolated jaw fracture will receive one of the two drugs during surge…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests whether a special nerve block called Quadro-Iliac Plane (QIP) block can reduce pain and the need for opioids after hip replacement surgery. 100 adults scheduled for hip replacement will be randomly assigned to receive either the QIP block with numbing medicine or…

This study tests three treatments—a nerve block (SPB), Botox, and capsaicin—to see which works best for chronic nerve pain after mastectomy. 123 women whose pain is not controlled by standard medicines will be randomly assigned to one of the three groups. The main goal is to meas…

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study tests whether focused shock wave therapy can reduce pain and improve jaw function in people with temporomandibular disorders (TMD) of muscular origin. One hundred adults with moderate to severe jaw pain for at least 3 months will receive either shock wave therapy or a …

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain taper off them before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two group…

This study tests whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce opioid use and pain after pancreatoduodenectomy (a major pancreatic surgery). About 93 adults will be randomly assigned to receive nefopam, lidocaine, or standard epidural pain relief. …

This study compares two common conservative treatments for De Quervain's tenosynovitis, a painful thumb tendon condition: a static hand-wrist splint versus home-based exercise therapy. Forty adults with acute or subacute pain will be tracked for changes in pain, wrist function, a…

This study tests if watching relaxing virtual reality (VR) scenes before an egg retrieval procedure can lower pain. One hundred women having elective egg freezing will either get standard care or standard care plus a VR relaxation session. Pain levels are measured with a simple 0…

This study compares two treatments—kinesiotaping (a special tape) and peloidotherapy (mud therapy)—plus home exercises, against exercises alone for people with mild-to-moderate carpal tunnel syndrome. 90 adults will be randomly assigned to one of three groups. The goal is to see …

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study tests whether giving morphine during coronary artery bypass surgery can improve pain control and reduce side effects like nausea after the operation. Sixty adults scheduled for elective heart surgery will be randomly assigned to receive either morphine or no additional…

This study compares two regional anesthesia techniques to manage pain in 50 adults undergoing heart surgery via a chest incision. One group receives an Erector Spinae Plane Block, while the other gets a combination of Superficial Parasternal Intercostal Plane Block and Serratus A…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults having the procedure will be randomly assigned to either listen to music or not. Afterward, they will rate their pain on a 0–10 scale. If music helps, it cou…

This study tests a telehealth program called ENGAGE for people with stage IV breast, prostate, lung, or colorectal cancer. The program helps manage symptoms like pain, fatigue, and distress that interfere with daily life. About 190 participants will be randomly assigned to ENGAGE…

This study tests whether a nerve block (injecting numbing medicine near a nerve in the ear) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having ear surgery will be randomly assigned to get the nerve block or standard care. The main…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study tests if a long-lasting painkiller called Exparel can reduce pain and the need for strong narcotic pain pills in children aged 13 and older after knee surgery. About 100 participants will receive either Exparel plus a standard painkiller or the standard painkiller alon…

This study is testing whether a low dose of ketamine, given alongside standard pain medicine, can better control severe pain from sickle cell disease in children and young adults aged 5 to 20. Participants will receive either ketamine or a placebo infusion, and researchers will m…

This study tests whether interventional radiologists can safely give deep sedation using ketamine, fentanyl, and midazolam for procedures that normally require general anesthesia. Up to 40 adults will participate. The main goal is to see if the procedure can be completed without …

This study tests a new ultrasound-guided nerve block called the Quadro-Iliac Plane Block to manage pain after lumbar spine surgery. Researchers will enroll 80 adults undergoing elective back surgery to see if the block reduces opioid use and improves recovery quality. The goal is…

This study tests whether shining bright blue light on adults with painful rib fractures can reduce pain and inflammation. 75 hospitalized patients will be randomly assigned to receive blue light, white light, or standard hospital lighting for 4 hours each morning for up to 3 days…

This study tests whether a long-lasting numbing drug (liposomal bupivacaine) combined with a standard numbing drug can improve pain control after lung surgery. About 134 adults having keyhole lung surgery will receive either the combination or standard care. The goal is to see if…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study tests whether a long-acting numbing drug called liposomal bupivacaine, when added to a standard painkiller, provides better pain relief after video-assisted lung surgery. About 100 adults having lung surgery will receive either the combination or the standard drug alon…

This study tests a new way to manage pain after a double lung transplant. Instead of relying only on strong pain medicines, doctors will use a cold-therapy probe during surgery to numb the nerves near the incision. The goal is to see if this method reduces the need for opioids an…

This study tests whether a long-acting numbing drug called liposomal bupivacaine can control pain for up to 72 hours after hemorrhoid surgery better than standard numbing medicine. About 156 adults having hemorrhoid surgery will receive either the long-acting drug or regular bupi…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after upper abdominal surgery. About 146 adults having open surgery will receive one of the two drugs injected into the belly lining before the incision is…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of opioids patients need after surgery. 70 adults with facial fractures will be randomly assigned to receive either the nerve block or a placebo. The goal is to se…

This study tests whether giving ketamine during laparoscopic gastric sleeve surgery can lower the chance and severity of shoulder pain after the operation. About 50 adults having the surgery will be split into two groups: one gets ketamine as part of anesthesia, the other does no…

This study tests whether adding an extra nerve block (IPACK) to a standard one (adductor canal block) can better control pain and reduce opioid use after knee realignment surgery. About 100 adults undergoing specific knee osteotomies will be randomly assigned to receive either th…

This study tests whether placing the numbing drug bupivacaine into the abdomen during open appendix surgery can reduce pain afterward. Sixty adults having open appendectomy will receive either bupivacaine or a saltwater placebo. Researchers will measure pain levels and how often …

This study compares two nerve block techniques—ESPB and PIFB—for pain control and breathing recovery in 80 adults having open-heart surgery. Both blocks use the numbing drug ropivacaine. The goal is to see which method reduces opioid use and improves recovery.

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study compares two numbing medicines given as nerve blocks before total ankle replacement surgery. One is EXPAREL, a long-acting form of bupivacaine, and the other is standard bupivacaine. Researchers want to see if EXPAREL provides better pain relief and reduces the need fo…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to rece…

This study tests if giving acetazolamide (Diamox) before laparoscopic hysterectomy can lessen pain after surgery, especially pain from the gas used in the abdomen. About 100 women having the surgery will receive either the drug or a placebo. Their pain levels and painkiller use w…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This study looks at whether numbing the upper and lower jaw nerves before surgery can lower pain and the need for extra pain medicine after jaw surgery. About 60 adults having planned jaw surgery will take part. The goal is to see if this nerve block helps control pain better tha…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests whether adding a special nerve block (BAP) to a standard abdominal wall block (TAP) can better control pain and reduce the need for strong painkillers after minimally invasive left-sided colorectal surgery. About 140 adults having elective laparoscopic surgery wi…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This study tests two methods of giving the numbing drug bupivacaine to reduce pain after keyhole gallbladder removal. One method sprays the drug inside the belly, the other injects it into the skin around the small cuts. The trial will enroll 100 adults and measure pain scores an…

This study tests whether a mild electrical device called TENS can reduce pain during labor in first-time mothers. 132 women will receive both real TENS and a sham (inactive) device at different times to compare pain levels. The goal is to see if TENS offers a safe, non-drug optio…

This study tests two methods of giving epidural pain medicine during labor: continuous drip versus small, timed bursts. 60 women giving birth will be randomly assigned to one method, and researchers will measure pain levels, total medicine used, and satisfaction. The goal is to f…

This study tests two minimally invasive treatments for people with long-lasting hip pain (Greater Trochanteric Pain Syndrome). Participants will receive either a targeted artery treatment (TAME) or a platelet-rich plasma (PRP) injection. The goal is to see which one reduces pain …

This study tests whether a nerve block called the transversalis fascia plane block can reduce pain and opioid use after hand-assisted laparoscopic donor nephrectomy. Fifty living kidney donors will be randomly assigned to receive either standard anesthesia alone or standard anest…

This study tests a special nursing program based on Snyder Hope Theory for people aged 60 and older who recently had hip fracture surgery. The program includes counseling, goal setting, and rehab training to improve hope, reduce pain and anxiety, and help patients regain function…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief with faster recovery. About 128 adults undergoing elec…

This study tests whether adding two nerve blocks (iPACK and adductor canal block) to standard pain control helps people recover better after arthroscopic knee surgery. About 64 adults aged 18-50 will be enrolled. The main goal is to see if these blocks improve overall recovery qu…

This study compares two ways of giving morphine after a planned C-section: through a shot in the spine (intrathecal) or through a small tube near the spine (epidural). The goal is to find which method provides better pain relief with fewer side effects like nausea or itching. Abo…

This study tests whether a nerve block called a parasternal plane block can better control pain during heart surgery in children aged 6 months to 7 years. The block is given after anesthesia and uses a numbing medicine (bupivacaine). Researchers will measure pain using a special …

This study aims to see if offering a menu of pain control options before getting an IUD helps patients feel more in control, satisfied, and less pain. About 200 people getting an IUD will answer surveys before and after the menu is introduced. The goal is to improve the IUD inser…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests whether taking melatonin before a planned C-section can lower pain afterward. Sixty women will receive either 5 mg, 10 mg, or a placebo pill one hour before surgery. Researchers will track pain levels, how soon they need extra pain relief, and any side effects ov…

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It include…

This study tests whether taking two dietary supplements (PEA and Scutellaria) along with a structured exercise program can reduce nerve pain and damage caused by chemotherapy. About 40 adult cancer survivors who have nerve pain will be followed for 60 days. The goal is to see if …

This phase 3 trial tests whether a combination of four drugs (R.E.C.K) controls pain after robotic kidney surgery as well as the more expensive drug Exparel. About 170 adults having robotic partial or total kidney removal will be randomly assigned to receive one of the two inject…

This study looks at whether wrist-ankle acupuncture can reduce pain after perianal surgery. About 58 adults with moderate to severe pain will receive this acupuncture along with standard care. Researchers will measure pain relief and how often extra pain medicine is needed.

This study compares an herbal extract called Aescin (Reparil®) to the common painkiller ibuprofen for managing pain, swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers w…

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing medicine (bupivacaine) can improve pain control after thyroid removal. Sixty adults undergoing total thyroidectomy will receive one of the two combinations via an ultrasound-guided nerve block.…

This study tests whether giving a single dose of paracetamol or ibuprofen before septorhinoplasty (nose surgery) can reduce the amount of strong opioid painkillers needed during and after the operation. Fifty-four adults having nose surgery will receive one of the two drugs befor…

This study looks at which pain control method works best after rotator cuff repair surgery. Researchers will compare different combinations of pain medicines to see which reduces the need for strong narcotics like oxycodone. About 130 adults having shoulder surgery will take part…

This study compares two muscle techniques—post-isometric relaxation and post-isometric stretching—for reducing chronic neck pain. Forty adults with neck pain will receive standard treatments (TENS and heat) plus one of the techniques over five sessions. Researchers will measure p…

This study tests whether a single dose of magnesium sulfate given during gallbladder surgery can lower the amount of morphine patients need afterward. 106 adults having laparoscopic gallbladder removal will be randomly assigned to receive either magnesium or a placebo. The goal i…

This study tests if a home-based program of laughter and fun yoga can lower pain in children aged 2-10 with acute lymphoblastic leukemia who are receiving chemotherapy. Sixty participants will be randomly assigned to either the laughter and yoga program plus usual care, or usual …

This study tests whether a special insole that vibrates can reduce phantom limb pain in people with leg amputations. Twenty participants will wear the device daily for three weeks and report their pain levels. The goal is to offer a simple, drug-free option for chronic pain relie…

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without a peer health coach, can reduce pain and opioid use in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants use an app to track pain and mood,…

This study compares three doses of a medicine called dexmedetomidine, added to the numbing drugs used for nerve blocks during arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free for longer. About 69 adults having surgery below the elbow will take par…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This study tests whether controlled breathing exercises can control pain during joint injections as well as local anesthesia. 136 participants will be randomly assigned to either receive lidocaine (standard care) or practice 5-minute breathing cycles. The goal is to see if the br…

This study compares two types of nerve blocks—M-TAPA and TAP block—for pain relief after open inguinal hernia repair. Sixty adults undergoing elective surgery will receive one of the two blocks with the same numbing medicine. Researchers will measure pain scores and patient satis…

This study is for children under 6 years old who need heart surgery. It tests a pain medicine called EXPAREL to see if it works well and is safe compared to a standard painkiller. The medicine is given near the surgery area to help with pain after the operation. About 48 children…

This study compares two types of nerve blocks to control pain after chest surgery (thoracotomy). The goal is to see if a newer block (SPSIP) works as well as the standard block (paravertebral) in reducing pain and the need for opioids. About 80 adults scheduled for thoracotomy wi…

This study tests whether a technique called acu-TENS, which uses mild electrical pulses on acupuncture points, can reduce pain and stress during transvaginal egg retrieval for IVF. 144 women will be randomly assigned to receive real acu-TENS or a sham version. The main goal is to…

This study compares two ultrasound-guided methods (conventional vs. retroclavicular) for numbing the arm in 60 obese patients undergoing forearm or hand surgery. Both approaches use the same local anesthetics (bupivacaine and lidocaine). The goal is to see which technique is fast…

This study tests whether doing breathing exercises every hour after a transplant can reduce pain and improve how well patients recover. Sixty adults having their first transplant will be split into two groups: one will do the breathing exercises, the other will get usual care. Re…

This study compares two ultrasound-guided nerve blocks for pain after video-assisted lung surgery. 90 adults will receive either an erector spinae plane block or a serratus posterior superior intercostal plane block. Researchers will measure opioid use and pain scores for 24 hour…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approa…

This study tests whether a combination of two medicines given through an IV (tramadol and paracetamol) works better and causes fewer side effects than a standard shot of pethidine for managing pain during the first stage of labor. About 140 women in early labor will be randomly a…

This study compares two ways to numb people for tympanoplasty (eardrum repair): traditional general anesthesia (being fully asleep) versus a targeted nerve block that keeps the patient awake. Researchers will enroll 128 adults to see which method allows faster discharge from the …

This study looks at two types of anesthesia for replacing the battery of a deep brain stimulator in people with Parkinson's disease. Researchers want to see which method—general anesthesia or regional anesthesia with sedation—provides better pain control and patient satisfaction …

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during weight-loss surgery can reduce pain, inflammation, and cell stress afterward. About 104 adults having laparoscopic bariatric surgery will receive either the combo, one drug alone, or…

This study tests whether a nerve block called the erector spinae plane block can reduce abdominal pain in people with gastrointestinal cancer. Researchers will compare opioid use and hospital stay length between 25 patients who get the block and a matched group who received stand…

This study tests whether intravenous magnesium sulfate can quickly reduce severe period pain in women visiting the emergency room. Sixty women with acute dysmenorrhea will receive either magnesium or a standard painkiller (dexketoprofen). Pain levels are measured before and one h…

This study looks at whether a supervised program of moderate walking and strength training can safely reduce pain in breast cancer survivors who still have pain after treatment. Ten women who finished cancer therapy at least six months ago will participate. The goal is to see if …

This study tests whether adding a 6-week online telerehabilitation program to standard medical care can improve function and reduce pain in adults with chronic low back pain. Two hundred participants will either receive usual care alone or usual care plus the digital program, whi…

This study tests if oral ketamine can help control severe pain from sickle-cell crises in teens and young adults (ages 12–24). Participants receive the drug every 8 hours for 48 hours alongside standard pain care. The goal is to find better ways to manage pain and reduce the need…

This study is testing whether a special nerve block (PENG block) given before hip replacement surgery can help reduce pain, lower the need for strong painkillers, and help patients get moving sooner. About 60 adults aged 40-85 who are having hip replacement will take part. The go…

This study tests whether adding a nerve block to a steroid injection works better than a steroid injection alone for people with frozen shoulder (adhesive capsulitis). About 50 adults aged 41-65 with persistent shoulder pain will be enrolled. The goal is to see which approach pro…

This study tests whether giving sedation before ultrasound-guided spinal anesthesia can lower the chance of back pain after surgery. Spinal anesthesia is common for lower body surgeries, but some people develop discomfort or long-lasting back pain. The researchers will compare st…

This study tests whether virtual reality therapy can reduce phantom limb pain in people who have lost an arm. Twenty participants will either receive six sessions of VR therapy or just fill out surveys. The goal is to see if VR can lower pain and improve well-being.

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot can reduce pain during office hysteroscopy, a procedure to look inside the uterus. Sixty women with abnormal bleeding will be randomly assigned to get either the combo or lidoc…

This study tests whether adding a short course of the steroid methylprednisolone to standard pain treatment can lower pain and reduce the need for opioids after ACL repair. About 90 people aged 13 to 50 having ACL surgery will take part. The goal is to find a safer way to manage …

This study tests a device called NeuroCuple™ that uses no drugs to manage pain after cesarean delivery. Researchers want to see if it reduces pain and the need for opioid painkillers. The study will include 180 women having a C-section. Half will get the real device, and the othe…

This study tests two lighter pain control methods for children aged 3 to 17 who need a wrist fracture reduction. One method uses a numbing injection (hematoma block) with a low dose of ketamine, and the other uses the same block with fentanyl nasal spray. These are compared to th…

This study tests whether giving a specific nerve block (ESP block) within 6 hours of a severe chest injury can reduce the number of days patients need a ventilator. The block numbs the chest wall to ease pain and improve breathing. 400 adults with at least 3 rib fractures will be…

This study looks at whether a special numbing method called intra-osseous anesthesia can reduce pain and side effects in children after having a permanent molar removed under general anesthesia. About 80 children aged 6 to 12 will be randomly assigned to receive either this numbi…

This study tests whether a low dose of ketorolac, an NSAID, can safely reduce pain and the need for opiates in critically ill ICU patients. Thirty adults with pain will receive either ketorolac or a placebo for up to three days. The main goal is to see if this approach is feasibl…

This study tests whether having a daily check-in with a physician, in addition to standard physical therapy, helps people with low back pain more than therapy alone. 74 adults aged 18-65 with subacute or chronic mechanical low back pain will be split into two groups. Both groups …

This study compares three routine pain control methods used during minimally invasive cancer surgery: a nerve block plus local anesthetic, nerve block alone, or local anesthetic alone. About 48 adults having surgery for various cancers will be randomly assigned to one of the thre…

This study compares different nerve block techniques to manage pain after gender-affirming surgery in transgender adults. The goal is to find which method reduces pain and opioid use while minimizing side effects like nausea and urinary problems. Researchers will track pain level…

This study tests whether warming the local anesthetic used in epidural pain relief to body temperature (37°C) can lower the chance of fever during labor. About 424 women from two hospitals will take part. Half will get the warmed solution, half will get room-temperature solution.…

This study compares two hands-on techniques—SNAG (a gentle spinal glide) and sciatic nerve mobilization exercises—for easing non-specific sciatica pain. Thirty adults with pain lasting over 12 weeks will try both methods in a crossover design, with each session separated by 10 da…

This study compares two types of nerve blocks—rectus sheath block and caudal epidural block—for pain relief in children aged 1 to 8 years undergoing hernia repair. Both blocks use the numbing medicine bupivacaine. Researchers will measure pain scores, nausea, and how quickly chil…

This study tests whether a special heat wrap can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19 to 69 will wear the wrap for 8 hours a day over 7 days. Researchers will measure pain changes after 3 days using a simple pain scale.

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study compares two ways to manage pain after video-assisted lung surgery (VATS). One group gets a single nerve block, the other gets that plus a continuous nerve block with a numbing medicine. The goal is to see if the combination improves recovery quality in the first 24 ho…

This study tests whether a TENS pain-relief device, combined with video coaching sessions from a physiotherapist, can help people with leg pain from peripheral artery disease (PAD) become more active. Forty-eight participants will either get the TENS device plus coaching or usual…

This study is trying to figure out what counts as a meaningful improvement in pain after major orthopedic surgeries like hip, knee, shoulder, or spine procedures. Researchers will ask 300 adults to rate their pain and recovery before and after surgery. The goal is to set clear be…

This study looks at whether epidural pain relief given to mothers during childbirth has any effect on their child's brain development up to 24 months of age. Researchers will follow thousands of first-time mothers and their babies, comparing those who received epidural analgesia …

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This early-stage study tests two ways to give fentanyl without needles: a face mask and a nasal spray. Twenty healthy volunteers will receive small doses to see how well the drug enters the body. The goal is to find a faster, easier way to manage pain in emergency rooms without n…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at whether a device that measures pupil reactions can help identify children at risk for opioid-induced respiratory depression after tonsillectomy. About 300 children will have their pupils measured before, during, and after surgery. The goal is to see if pupil p…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This trial tests two types of opioid-free anesthesia in 70 people having weight-loss surgery. One method uses a gas called desflurane, the other uses intravenous drugs. Researchers will measure stress hormones in the blood to see which approach causes less stress on the body. The…

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This study watches 254 adults after elective surgery to see what factors—like age, type of surgery, or anesthesia—affect how much pain medicine they need in the recovery room. No new treatments are given; researchers just collect data from normal care. The goal is to help doctors…

This study is working on a tool to objectively measure pain and how well pain treatments work, especially for children and teens who may have trouble describing their pain. Researchers will use pupil responses to see how pain relievers affect nerve sensitivity. The study involves…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at how two common anesthesia drugs, propofol and alfentanil, change brain activity during a procedure called ERCP (a scope exam of the bile ducts). Researchers will monitor 20 patients' brain waves and pain signals to better understand how these drugs work togeth…

This study aims to understand why some children develop sleep issues, anxiety, or aggression for up to two weeks after being sedated for medical procedures. Researchers will follow over 2,000 children aged 1-17 in emergency rooms and dental clinics. By identifying risk factors li…

This study looks at how common central sensitization (a condition where the nervous system is overly sensitive to pain) is in adults with autism who do not have intellectual disabilities. Researchers will ask 100 participants to fill out a questionnaire about pain and sensitivity…

This study looks at two different nerve blocks used to manage pain after gallbladder removal surgery. Researchers will map where on the skin each block causes numbness and see which one covers the surgical cuts better. The goal is to learn more about these blocks to improve pain …

This study compares cannabis users and non-users during wisdom tooth removal under IV sedation. Researchers will measure how much sedative medication is needed and track vital signs like heart rate and blood pressure. The goal is to understand if cannabis use changes how people r…

This study tests whether the CONOX monitor, which measures brain waves, can detect pain in 120 adults undergoing urological procedures like cystoscopy under sedation. Researchers will compare the monitor's readings to traditional signs like heart rate and blood pressure. The goal…

This study looks at whether oxytocin, a natural hormone, can change how nerves react to light touch and painful pressure after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve signals…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults to see how pain levels and recovery are linked to patient details and treatments. The goal is to find patterns that could h…

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This study looks at how metamizole (Optalgin), a common painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug concentrations at several time points in 30 adults. The goal is to understand if metamizole interfe…

This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separa…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see which genetic variations are linked to pain levels and painkiller use. The goal is to better understand and personalize p…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This observational study looks at different ways to manage pain and sedation for adults with broken bones or dislocations in the emergency department. Researchers will compare standard care with various sedation and pain relief methods to see which one patients prefer and which p…

This study reviews medical records of 2,450 women who had C-sections at a French hospital to find out why some still feel pain despite spinal anesthesia. Researchers aim to identify risk factors and improve pain management. No new treatments are tested—just learning from past cas…

This study in 136 healthy adults tests whether a 30-minute nerve stimulation on the ear (tAN) reduces pain by releasing the body's natural opioids. Half the participants get a drug (naloxone) that blocks opioid effects, while the other half get a placebo. By comparing pain thresh…

This study tests whether transcutaneous electrical nerve stimulation (TENS) applied to specific acupoints can change how the brain processes pain signals. Thirty-five healthy adults will receive TENS on their hands while researchers measure brain activity using EEG. The goal is t…

This study watches 90 adults having open heart surgery to compare three standard pain relief methods: IV drugs, an epidural, or a nerve block. The main goal is to see which method best prevents chronic pain 3 months later. Researchers will also track pain levels, recovery speed, …

This study looks at how morphine, given alone or with midazolam, works in newborns who need breathing machines in intensive care. Researchers will monitor 180 infants to find the dose that provides comfort without over-sedation. The goal is to improve pain management for these fr…

This study looks at whether teaching families skills to support young adults with psychosis can reduce stress for caregivers and help patients stay stable. About 113 family members will attend 9 weekly classes led by experts. Researchers will measure family burden, patient sympto…

This study looks at how having control over a virtual environment changes how people feel pain and anxiety. Twenty healthy adults will experience mild pain and anxiety in different virtual settings—some they can control, some they cannot. The goal is to understand how the brain a…

This study looks at how often pain occurs in intensive care unit (ICU) patients who are on mechanical ventilators (breathing machines). Researchers will observe 370 adults, using special pain scales to measure pain on the second day of ventilation and when they first wake up. The…