Finding the right dose: how morphine and midazolam affect ventilated newborns

NCT ID NCT05371886

Recruiting now Knowledge-focused Sponsor: Centre Hospitalier Intercommunal Creteil Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how morphine, given alone or with midazolam, works in newborns who need breathing machines in intensive care. Researchers will monitor 180 infants to find the dose that provides comfort without over-sedation. The goal is to improve pain management for these fragile patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: morphine and midazolam
What this could lead to: If successful, this could help doctors determine the safest and most effective doses of these sedatives for newborns on breathing machines.
What could go wrong: This is an observational study, not a treatment trial. It aims to gather data, not test a new therapy, so direct patient benefits are uncertain.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MECHANICAL VENTILATION IN NEONATES SEDATION COMPLICATION

Contacts and locations

Locations

CH SUD Francilien
RECRUITING

Corbeil-Essonnes, 91100, France
CHI Créteil
RECRUITING

Créteil, 94000, France
CHRU Morvan
RECRUITING

Brest, 29609, France
CHU Lille
RECRUITING

Lille, France
CHU Tours
RECRUITING

Tours, France

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