Can a simple painkiller before nose surgery cut opioid use?

NCT ID NCT07337629

Recruiting now Symptom relief Sponsor: Samsun University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a single dose of paracetamol or ibuprofen before septorhinoplasty (nose surgery) can reduce the amount of strong opioid painkillers needed during and after the operation. Fifty-four adults having nose surgery will receive one of the two drugs beforehand, and researchers will track their pain levels and total opioid use over 24 hours. The goal is to find a safer way to manage pain with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paracetamol and ibuprofen
What this could lead to: If successful, this could show that a single dose of paracetamol or ibuprofen before surgery reduces the need for stronger painkillers like opioids afterward.
What could go wrong: This is a small, early-stage trial with only 54 participants, so results may not apply to everyone. The drugs may not significantly reduce opioid use or could cause side effects like stomach upset or allergic reactions.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA

Contacts and locations

Locations

Samsun University Samsun Training and Research Hospital
RECRUITING

Samsun, Turkey (Türkiye)

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