Agnosia

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This study will test whether a 4-week daily music therapy app can reduce chronic pain and improve quality of life in 25 youth with sickle cell disease. Participants will either use the app or receive standard educational materials. Researchers will also look at changes in immune …

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether giving patients a printed opioid prescription instead of sending it directly to the pharmacy can reduce opioid use after total hip replacement. About 100 adults will be randomly assigned to receive either the standard pain regimen with automatic pharmacy …

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This pilot study will test whether oral ketamine can control pain as well as oxycodone in emergency department patients who need extra pain medication. Sixty adults with certain types of pain will be randomly assigned to receive either drug. Researchers will measure changes in pa…

This study compares two types of nerve blocks—quadro-iliac plane block and supra-inguinal fascia iliaca compartment block—for pain after total hip replacement. Sixty adults scheduled for hip surgery will receive one of the blocks along with spinal anesthesia. Researchers will mea…

This study tests whether giving scheduled morphine alongside patient-controlled pain relief can prevent the intense 'rebound pain' that often occurs when a nerve block wears off after orthopaedic surgery. About 100 adults having arm or leg surgery will be randomly assigned to rec…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study compares two ways to manage pain after open inguinal hernia repair: an ultrasound-guided nerve block (TFPB) versus surgical wound infiltration with local anesthetic. About 104 adults will be randomly assigned to one method. The goal is to see which reduces opioid use a…

This study compares two types of nerve blocks used to manage pain after total hip replacement. Sixty adults having hip replacement will receive either a quadro-iliac plane block or a PENG block combined with a lateral femoral cutaneous nerve block. Researchers will measure pain s…

This study tests whether a numbing injection called a superficial parasternal intercostal plane block (SPIPB) can widen the internal thoracic artery, making it easier for surgeons to harvest during coronary artery bypass grafting (CABG). The trial involves 50 adults aged 22 to 65…

This study tests whether giving scheduled morphine doses alongside on-demand pain relief can prevent the severe 'rebound pain' that often occurs when a nerve block wears off after orthopedic surgery. One hundred adults having arm or leg surgery will be randomly assigned to receiv…

This study looks at whether giving a nerve block (serratus anterior plane block) before or after mastectomy surgery leads to better recovery and less pain. Eighty women having a mastectomy will be randomly assigned to receive the block either before the surgeon makes the first cu…

This clinical trial will compare Sahrmann exercises and McGill exercises in 42 adults with non-specific low back pain. Participants will be randomly assigned to one of the two exercise programs, alongside standard physical therapy. The study aims to see which approach better redu…

This study tests whether a special ultrasound-guided nerve block can lower the amount of strong painkillers (opioids) needed after breast reduction surgery. About 80 women will be randomly assigned to receive either standard pain treatment alone or standard treatment plus the ner…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure tota…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests a special anesthesia method that uses fewer opioids during spine surgery in people aged 65 and older. The goal is to see if it lowers pain and the need for strong painkillers after surgery. Half the participants will get this opioid-sparing anesthesia, and the ot…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) can reduce pain and the need for strong opioid painkillers after lung transplant surgery. 88 adults receiving a double lung transplant will get an intercostal nerve block either wi…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This trial tests whether a combined nerve block can improve pain relief after total knee replacement while preserving leg strength. 240 adults scheduled for knee surgery will receive either the combined block or a standard saphenous nerve block. Researchers will measure opioid us…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This small study tests a wearable device called Octane Aether that sends magnetic pulses to the lower back. 24 adults with chronic low back pain will use the device at home for 60 minutes daily over 10 weeks. The goal is to see if it reduces pain compared to a sham (inactive) dev…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study explores whether giving only pain medicine (remifentanil) without sedatives is safe and feasible for adults in the ICU after brain surgery. The goal is to avoid side effects of sedatives, like confusion or hiding signs of brain problems. Sixty-five participants will be…

This study tests whether injecting a long-lasting numbing medicine (Exparel mixed with bupivacaine) into the penis before placing an inflatable penile implant can reduce post-surgery pain and the need for opioid painkillers. One hundred men with erectile dysfunction who are getti…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study looks at three different ways to give methadone during heart surgery to find the best dose for controlling pain afterward. About 69 adults having planned heart surgery will take part. Researchers will measure methadone levels in the blood and ask about pain to see whic…

This pilot study tests a device called the NOL monitor, which measures pain levels during spine surgery. Doctors use it to decide when to give more pain medicine. The goal is to see if this approach reduces the amount of opioids needed during and after surgery, and helps patients…

This study tests a new ultrasound-guided pain block for high-risk children (ages not specified) having anal or penile surgery. The goal is to see if this block can delay or replace strong pain medicines that can cause breathing or heart problems. Sixty children will be enrolled, …

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study compares a web-based exercise program to traditional home exercises for people with non-specific low back pain. Thirty adults aged 18-45 with moderate pain will follow an 8-week program using an app. Researchers will measure changes in pain, function, and quality of li…

This study compares two types of nerve blocks (rectus sheath block and transversus abdominis plane block) to see which provides better pain relief after laparoscopic weight-loss surgery. About 96 adults aged 20-60 will be randomly assigned to receive one of the blocks after gener…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study tests whether training the sense of touch can reduce pain and improve daily function in people with chronic low back pain. 66 adults aged 25-45 with persistent pain will be split into three groups: device-based training, manual training, or standard physical therapy. T…

This study tests whether injecting tramadol, with or without dexamethasone, into the knee joint after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a …

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study tests whether giving lidocaine through a vein during and after liver surgery can reduce side effects like nausea, vomiting, and breathing problems caused by opioid painkillers. About 312 adults having planned open liver surgery will be randomly assigned to receive eith…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can reduce pain during a prostate biopsy. About 140 men will get either a real TENS device or a fake one, along with standard numbing medicine. The goal is to see if TENS makes the p…

This study tests whether a four-week physiotherapy program and a meditation app can reduce headache pain and improve quality of life in 78 adults with frequent or chronic tension-type headaches. Participants will be split into groups receiving physiotherapy, meditation, or both. …

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether cognitive functional therapy (CFT) can reduce disability in people with chronic low back pain after spinal surgery. 90 adults aged 18-75 who have had surgery at least 3 months ago and still have pain will receive either CFT or a sham treatment. The main g…

This study tests two common painkillers, indomethacin and paracetamol, given before egg retrieval in IVF. 177 women aged 18-45 will rate their pain after the procedure. The goal is to find a better way to manage pain during this common fertility treatment.

This study aims to find the best dose of morphine given with spinal anesthesia to control pain after a cesarean section. Researchers will compare four different doses in 180 women to see which provides the longest pain relief with the fewest side effects like nausea and itching. …

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to r…

This study will test whether a video game that guides children through breathing exercises can reduce pain, fear, and anxiety during a routine blood draw. About 60 children aged 7 to 12 will be randomly assigned to either play the breathing game during the procedure or receive st…

This study compares two types of pain-relieving injections for people having knee replacement surgery. One uses a long-acting drug called liposomal bupivacaine, and the other uses a mix of five different medications. The goal is to see which approach provides better pain control …

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests two different drugs—dexmedetomidine and low-dose ketamine—given during weight-loss surgery to see which one reduces pain and the need for morphine afterward. Ninety adults having bariatric surgery will be randomly assigned to one of the two drugs or a placebo. Th…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether using a virtual reality headset or a smartphone during burn dressing changes can lower pain and anxiety. 99 adults with second-degree burns will be randomly assigned to VR, smartphone, or standard care. Pain and anxiety are measured right after the dressi…

This study tests whether an AI-powered app can improve follow-up for patients recovering from surgery with a continuous nerve block for pain. 166 adults will use either the AI app or a standard automated messaging system. The goal is to see if the AI reduces the number of times p…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether lactoferrin, a natural protein found in milk, can help manage pain after a cesarean section. Ninety women having planned C-sections will receive either lactoferrin or a placebo before and after surgery, alongside standard painkillers. The goal is to see i…

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug …

This study tests whether a procedure called sacroplasty can help older adults recover faster from sacral fractures. Sacroplasty involves injecting cement into the broken bone to stabilize it. The trial will compare this procedure to standard care like pain medication and physical…

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study compares continuous regional anaesthesia (a numbing medicine delivered through a tiny tube near the nerves) with standard pain management for people who have war-related leg injuries. About 150 adults will take part, and researchers will measure pain levels and opioid …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study tests whether neurofeedback — a type of brain training using real-time brainwave feedback — can reduce musculoskeletal pain in people with chronic inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will be randomly assigned to either 8 session…

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether using a smartwatch and mobile app, along with standard care, can help adults with chronic low back pain manage their symptoms better. Eighty adults will be split into two groups: one gets standard treatment alone, the other also uses a smartwatch and app …

This study tests whether adding low-dose ketamine to standard morphine pain pumps helps teens use less morphine after scoliosis surgery. About 114 patients aged 10-18 will be randomly assigned to get either the combo or morphine alone. The goal is to see if the combo reduces opio…

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from nerve damage (neuroma) after limb injury or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 weeks. The…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests whether adding neostigmine to a standard numbing medicine (bupivacaine) in a belly-wall nerve block can improve pain control after cesarean delivery. About 58 women having planned C-sections will receive either the combo or the standard block alone. The goal is t…

This study tests whether using a cold spray or a Buzzy device (a vibrating cold pack) can reduce pain and fear during penicillin injections. Ninety adults receiving intramuscular penicillin will be randomly assigned to one of three groups: cold spray, Buzzy device, or standard ca…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study tests a combination of two pain-relief methods—a sedative drug called dexmedetomidine and a local anesthetic injected into the scalp—for people undergoing brain tumor surgery. The goal is to see if this approach reduces the need for strong opioid painkillers after surg…

This study tests if giving the numbing drug bupivacaine through a chest tube can reduce pain after minimally invasive lung surgery. About 249 adults having video-assisted thoracoscopic surgery will receive either a low or high dose of bupivacaine, or a placebo. The main goal is t…

This study will test whether teaching patients to mindfully listen to jazz music for 15 minutes can lower their pain while they wait in the emergency department. The researchers will enroll 60 adults with neck or back pain and compare the music approach to a standard mindful pain…

Frozen shoulder causes pain and stiffness. A common treatment called hydrodistension injects fluid into the shoulder joint to stretch it, but it can be painful. This study tests whether giving a nerve block first can reduce that pain and improve results. Fifty adults with frozen …

This trial tests two different nerve block methods to control pain after laparoscopic gallbladder removal. Sixty adults undergoing elective surgery will receive either a newer single-puncture block or an external oblique intercostal plane block, while a control group gets only st…

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will receive either the gas plus standard numbing medicine or a sham mask plus standard care. Participa…

This study compares opioid-free anesthesia to standard opioid-based anesthesia for people having laparoscopic pancreatic surgery. The goal is to see if avoiding opioids leads to less pain and lower opioid use after surgery. Two hundred adults aged 18-80 will take part, and resear…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. Thirty patients will be randomly assigned to either the Medstrom device or standard monitoring. The goal is to see if the device …

This study compares opioid-free anesthesia to standard opioid anesthesia in 200 adults undergoing pancreatic surgery. The goal is to see if avoiding opioids during surgery can still control pain well and reduce the need for painkillers afterward. Participants will have their pain…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can improve pain control and reduce the need for strong painkillers after laparoscopic appendix removal. 180 adults aged 18-65 undergoing this surgery will receive either NAC, AL…

This study compares two nerve block techniques—dual external oblique fascial plane block and erector spinae plane block—for pain control after percutaneous nephrolithotomy (PCNL), a surgery to remove large kidney stones. Ninety adults will be randomly assigned to receive one of t…

This study tests whether adding a painkiller (ketorolac) to a standard sedative (midazolam) makes flexible bronchoscopy more comfortable and safer for patients. Flexible bronchoscopy is a procedure where a thin tube is inserted into the lungs to diagnose or treat problems, but it…

This study tests whether wearing virtual reality (VR) glasses during needle insertion can reduce pain and anxiety in hemodialysis patients. 150 adults with end-stage kidney disease will either receive standard care or watch a calming 360-degree underwater video through VR goggles…

This study tests whether a simple questionnaire-based pain calculator can help doctors choose the right pain medication for women undergoing in-office gynecologic procedures like IUD insertion or biopsy. About 200 participants will either get pain meds based on the calculator or …

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This study tests whether a device that gently stimulates a nerve in the ear can help reduce the amount of strong painkillers (opioids) needed after major abdominal surgery. About 108 adults will receive either the real stimulation or a sham version while in the intensive care uni…

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in sedated patients in the intensive care unit (ICU). Forty adults on ventilators and receiving morphine will receive either real or fake tDCS. The goal is to see if tDCS can lower pai…

This Phase 2 trial tests a topical anesthetic marker applied to the skin to reduce pain from needle pricks. Twenty adults will have the marker applied to their forearm, and pain will be measured every 10 minutes for 40 minutes compared to untreated skin. The goal is to see how we…

This study tests whether a 20-minute hot water foot bath can reduce pain and help patients pass gas sooner after laparoscopic gallbladder removal. 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to see if this simple, drug-free method im…

This study tests a new pain management system for people recovering from incarcerated mixed hemorrhoid surgery. The system includes pain medicine before surgery, traditional Chinese medicine treatments, and personalized nursing. Researchers want to see if it reduces pain and comp…

This study looks at different ways to manage pain after a type of kidney stone surgery called PCNL. Researchers will track how much opioid pain medicine patients need and their pain levels. The goal is to find which method works best to reduce pain and limit opioid use.

This study tests two quick, drug-free mental techniques—body-scan mindfulness and guided imagery—to see if they can lower acute pain in adults staying in short-stay hospital wards. 160 participants will be randomly assigned to one of these techniques or a brief educational sessio…

This study will test whether rinsing with cold water (15-20°C) reduces mouth soreness and improves comfort compared to room-temperature water in 200 head and neck cancer patients undergoing radiotherapy. Participants will rinse four times daily for six weeks. The goal is to see i…

This study compares three common pain relief methods for people having laparoscopic gallbladder surgery: numbing the surgical area with bupivacaine, a nerve block in the back (ESP block), or a small dose of morphine into the spinal fluid. The goal is to see which method reduces p…

This study tests two different ultrasound-guided nerve blocks to see which one provides better pain relief after breast cancer surgery. 70 adults aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce the need for strong painkillers and impro…

This study will observe 120 adults undergoing video-assisted thoracoscopic surgery (VATS) to compare three pain management approaches: a nerve block (SPSIPB), an epidural, and standard opioid painkillers. Researchers will measure pain scores and how much extra pain medicine patie…

This study looks at whether giving a scalp nerve block before a craniotomy (brain surgery) can lower pain after surgery and reduce the need for strong painkillers. Researchers will compare giving the block before the first cut versus after. The study plans to enroll 64 adults age…

This study tests whether listening to music during a transperineal prostate biopsy can lower pain and anxiety. About 78 men over age 50 with suspected prostate cancer will be randomly assigned to have music or no music during the procedure. The goal is to see if music helps patie…

This study compares three types of physical therapy for adults aged 20-60 with prolonged shoulder pain. Participants are randomly assigned to routine therapy, tendon-specific exercises, or therapy that also addresses psychological factors. The goal is to see which approach best h…

This study tests whether watching an educational video before surgery, plus using virtual reality (a relaxing forest walk) or listening to music during the procedure, can lower anxiety and pain for people having ingrown toenail surgery. About 175 adults will be split into three g…

This study tests whether a long-acting form of the painkiller bupivacaine (called liposomal bupivacaine) can reduce the need for opioid pain medicine after laparoscopic liver, gallbladder, or pancreas surgery. Sixty adults aged 18–80 will receive either the long-acting painkiller…

This study tests whether small changes—like playing calming music, showing a relaxing video, or giving numbing gel at the right time—can reduce pain and anxiety during a bladder cancer exam or treatment. About 378 adults with bladder cancer will be randomly assigned to receive on…

This study looks at whether watching a virtual reality (VR) video can help children aged 7 to 12 feel less pain and fear when getting an IV. About 150 kids having day surgery will be randomly placed into one of three groups: watching an aquarium video, a kaleidoscope video, or ge…

This study compares a new non-opioid drug called suzetrigine (Journavx) to the opioid Norco for pain after wisdom tooth removal or jaw surgery. It involves 76 adults aged 18-45. The goal is to see if suzetrigine controls pain just as well without the risk of addiction or breathin…

This study tests whether using a virtual reality (VR) headset can reduce anxiety before total knee replacement surgery and lessen pain afterward. 64 patients will watch educational videos about the operating room before surgery and relaxing nature videos after surgery. The goal i…

This study tests whether a single injection of the numbing drug ropivacaine around nerves can reduce pain and the need for narcotic pain pills in children and teens after ACL knee surgery. About 160 participants aged 13 and older will either receive the nerve block or not during …

This study tests two different nose sprays—dexmedetomidine and ketamine—to see which one better calms children aged 2 to 6 before surgery. Sixty kids will receive one of the two sprays, and researchers will measure how sleepy they get and how easily they separate from their paren…

This study tests whether injecting a local anesthetic (mepivacaine) into the ligaments around the cervix can reduce pain during an outpatient hysteroscopy. About 70 women who have never had a hysteroscopy will be randomly assigned to receive either the anesthetic or a placebo. Th…

This study tests whether Su Jok therapy—a technique using hand massage and seeds on specific points—can lower pain in newborns during a heel lance blood test. Sixty-six full-term babies will be randomly assigned to receive the therapy or standard care. Pain will be measured using…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This study compares a computer-controlled anesthetic device (SleeperOne) to a traditional syringe for numbing kids' teeth before extraction. 28 children aged 3-5 will be randomly assigned to one method. Pain, anxiety, and heart rate will be measured to see if the device makes the…

This study tests whether letting children watch cartoons or giving them a gentle foot massage before surgery can reduce their nausea, pain, and anxiety. About 105 children aged 4 to 6 will be assigned to one of three groups: watching a cartoon, receiving reflexology, or standard …

This study looks at whether people who better understand the risks and steps of their upcoming lung procedure (endobronchial ultrasound) need less propofol, a sedative. Researchers will ask participants questions about what they understood from the consent process and measure the…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study surveys 300 primary care professionals in Spain to understand their knowledge and beliefs about musculoskeletal pain. Researchers want to see if healthcare workers unintentionally reinforce fear and disability in patients with chronic pain. The results will help design…

This study tests whether using ChatGPT alongside traditional bedside training helps nursing students learn pain management better. 156 students will be randomly assigned to either AI-assisted or standard teaching. Researchers will measure changes in knowledge, attitudes, competen…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treat…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the ne…

This study will test a new ultrasound device called Accuro 3S that provides live guidance during epidural or spinal needle placement. Researchers want to see if it reduces the number of needle attempts and improves accuracy compared to standard methods. The trial will enroll 50 p…

This study will observe 50 adults undergoing total knee replacement to see how different anesthesia methods affect pain and painkiller use in the first 48 hours after surgery. Participants receive either general anesthesia with a nerve block, spinal anesthesia with a nerve block,…

This study will test whether a low power LASER, used for pain relief, can also change heart rate and the body's automatic nervous system. Researchers will monitor 45 healthy volunteers before, during, and after LASER treatment. They will also use a numbing gel to see if the effec…

This study looks at how mental health issues, like depression or anxiety, affect people with mild cognitive impairment (MCI). Researchers will study 118 adults aged 50-72 to see how these issues impact their awareness of memory problems, social life, and work. The goal is to bett…

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study looks at two types of nerve blocks—TAP and rectus sheath—used to manage pain after a hysterectomy through a bikini-line cut. Researchers will measure how much of the incision each block numbs and compare pain scores and morphine use. About 30 women having planned surge…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study looks at how opioid painkillers affect the success of immunotherapy in 100 people with advanced lung cancer who have moderate to severe pain. Researchers want to see if better pain control helps immunotherapy work better, and whether opioids themselves change the treat…