A Self-Applied numbing cream might take the sting out of IUD insertion

NCT ID NCT07768059

NEW Not yet recruiting Symptom relief Sponsor: Mount Sinai Hospital, Canada Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial tests whether a numbing cream containing lidocaine and prilocaine, applied at home before the procedure, can reduce pain during IUD insertion or endometrial biopsy. Participants are randomly assigned to receive either the active cream or a placebo, and they rate their pain at several points during the procedure. The goal is to see if this simple approach offers meaningful pain relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A topical cream containing lidocaine and prilocaine, self-applied vaginally before the procedure
What this could lead to: If effective, this could offer a simple, at-home way to reduce pain during IUD insertion or endometrial biopsy, improving comfort for many people.
What could go wrong: The trial is relatively small and early, and the cream may not reduce pain enough to be noticeable. There is also a small risk of allergic reactions or side effects from the numbing medication.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL BIOPSY IUD

Contacts and locations

Locations

Ontario Power Generation Building

Toronto, Ontario, M5G1Z5, Canada

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