Agnosia

This study tested a nasal spray containing a strong painkiller (sufentanil) for adults with sickle cell disease experiencing a painful crisis. The goal was to see if it could provide faster relief than the standard gas mixture (EMONO) before giving morphine through an IV. The tri…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …

This study aimed to see if a combination of pain medicines (multimodal analgesia) works better than standard care for pain after lower back fusion surgery. It included 50 adults aged 18 to 70. The study was stopped early, so results are limited.

This study aimed to find the ideal dose of a spinal pain medicine (hydromorphone) for children undergoing back surgery for scoliosis. Researchers tested several doses in 31 patients to balance good pain control with fewer side effects. The trial was stopped early, so the results …

This study looked at whether adding guanfacine to opioid painkillers could reverse the extra pain sensitivity that long-term opioid use can cause. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was terminated early, so results are l…

This study looked at whether adding guanfacine (a blood pressure medicine) to morphine could reduce pain sensitivity and tolerance in people with chronic neck or back pain. The study planned to enroll 137 adults who had not taken opioids recently. However, the study was terminate…

This study tested whether synthetic cannabidiol (CBD) could help people living with HIV who have a condition called alexithymia, which makes it hard to recognize and describe emotions. Participants took either CBD or a placebo for 4 weeks. The goal was to see if CBD could improve…

This study tested whether adding baclofen (a muscle relaxant) to buprenorphine (a painkiller) could improve pain relief in 19 healthy volunteers. Participants received either a placebo or baclofen alongside buprenorphine and then underwent heat-based pain tests. The trial was ter…

This study tested whether low level laser therapy (LLLT) could reduce pain and improve hand function in people with hand osteoarthritis. About 83 military members and their families received either real or sham laser treatment weekly for six weeks. The trial was terminated early,…

This phase 2 trial tested whether adding MR-guided radiation to standard chemotherapy could reduce pain in people with metastatic pancreatic cancer. Only 9 participants were enrolled before the study was terminated early. The main goal was to track pain scores over time, but the …

This study tested a system that combines virtual reality (VR) with brain training (neurofeedback) to help people manage chronic back pain without using opioid drugs. Eleven adults with severe back pain took part in up to 20 sessions. Researchers measured how well patients tolerat…

This study looked at why a common numbing shot for knee surgery works so well. Doctors used ultrasound to see if the medicine spreads to nerves behind the knee. The goal was to measure how often this spread happens in 30 adults having knee surgery. The study was stopped early, bu…