Agnosia

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery helps elderly patients (65-90 years) live longer. 1,500 participants were randomly assigned to receive either morphine alone or morphine plus dexmedetomidine for three days a…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tested whether a custom-made acrylic palatal stent (like a mouth guard) can reduce pain and bleeding after gum graft surgery. 44 adults who needed a gum graft from the roof of their mouth either received the stent or standard care. The stent aims to protect the healing…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This completed phase 2 trial tested whether oxytocin, given as a nasal spray or through an IV, can reduce pain from heat in healthy adults. Twenty-four participants rated their pain on a 0-10 scale after skin heating. The study also looked at whether age, weight, or sex affect ho…

This study tested three methods to reduce pain and fear in 166 children aged 5-9 during dental numbing injections: a device that cools and vibrates, gentle tapping near the injection site, and a thinner needle. Researchers measured pain scores, heart rate, and cooperation. The go…

This trial compares two types of nerve blocks—femoral nerve block and adductor canal block—for controlling pain after anterior cruciate ligament (ACL) reconstruction. Participants receive one of the two blocks before surgery, and researchers track their pain levels and painkiller…

This phase 3 trial tests whether intravenous arginine, an amino acid, can shorten painful episodes in children with sickle cell disease. Participants aged 3 to 21 receive either arginine or a placebo alongside standard pain treatment. The study measures how quickly the crisis res…

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tested two ways to numb the shoulder during surgery: the standard interscalene block done by anesthesiologists, and a newer shoulder field block done by surgeons. 64 adults having shoulder surgery were randomly assigned to one method. The goal was to see if the field b…

This study tested a new approach that combines a minimally invasive spine-stabilizing procedure (kyphoplasty) with a single dose of targeted radiation given during surgery. The goal was to see if this combination could better control pain from cancer that has spread to the spine.…

This study tested whether a gas called MEOPA (laughing gas) can help elderly people manage pain during physiotherapy for stiff hips or knees. Six patients aged 65 or older received three sessions of physiotherapy with MEOPA or standard care. The goal was to see if the gas improve…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested whether a specific nerve block (SPSIP block) can reduce pain during and after surgery to implant a pacemaker or defibrillator. Sixty adults were randomly assigned to receive either the nerve block with numbing medicine or a sham injection. Researchers measured p…

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested a new medicine called HTX-034 to see if it can control pain after bunion surgery better than the standard local anesthetic. 78 adults having bunion surgery received either HTX-034 or the standard treatment. The goal was to measure pain levels and safety over the…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study compared two types of nerve blocks for pain control after breast surgery: the serratus posterior superior intercostal plane block and the PECS II block. One hundred adults aged 21 to 70 were enrolled. Researchers measured how much morphine patients needed in the first …

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This completed study tested whether an ultrasound-guided nerve block (TAP block) provides better pain relief after C-section than standard pain medicine. 100 women aged 20-50 who had a C-section took part. Researchers measured pain scores to see which method worked better.

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study compared two types of nerve blocks (serratus posterior superior intercostal plane block and deep serratus anterior plane block) to see which provides better pain relief after breast surgery. Sixty-two adults having a mastectomy received one of the two blocks with bupiv…

This study tested whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in patients undergoing a procedure called ERCP. Seventy adults were randomly assigned to either learn the breathing technique or receive standard care. The techni…

This study tested two different nerve blocks to manage pain after shoulder surgery. 60 adults were randomly assigned to receive either an interscalene block or an infraspinatus-teres minor block. The goal was to see which block reduces the need for strong painkillers and causes f…

This completed trial tested whether giving dexmedetomidine or lidocaine continuously during gallbladder surgery can control pain afterward and reduce the need for opioids. 64 adults undergoing laparoscopic cholecystectomy were randomly assigned to receive one of the two drugs. Th…

This study compared two ultrasound-guided nerve blocks—external oblique intercostal block and erector spinae plane block—for pain after laparoscopic gallbladder removal. Sixty adults received one of the blocks before surgery, and researchers measured their opioid use and pain sco…

This study looked at 82 adults who had hip surgery and received a nerve block (PENG block) for pain. One group got the pain medicine as a manual injection every 4 hours, while the other got it through a pump continuously. Researchers compared pain levels, opioid use, and recovery…

This study compared two types of nerve blocks—ISPB and ESPB—for pain relief after elective posterior cervical spine surgery. 102 adults received one of the blocks with bupivacaine, and researchers measured how much opioid painkiller they needed during and after surgery. The goal …

This study looked at 60 women having planned cesarean deliveries to compare two pain relief methods: giving morphine through the spinal needle versus a numbing injection near the belly muscles. The main goal was to see how many women needed extra pain medicine in the first 24 hou…

This study tested two treatments for neck pain caused by muscle knots (myofascial pain syndrome). Forty adults received either high-intensity laser therapy or shockwave therapy, plus standard physical therapy, over 4 weeks. The goal was to see which treatment better reduces pain …

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested whether adding nalbuphine to the standard spinal anesthetic levobupivacaine helps control pain after total hip replacement. Sixty adults were split into two groups: one received levobupivacaine alone, the other received levobupivacaine plus nalbuphine. Researche…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested whether a quick, inexpensive cooling spray can reduce pain during routine finger-prick blood sugar tests in emergency room patients. 80 adults each received both the spray and a placebo before separate tests, then rated their pain. The goal is to find a simple w…

This study tested whether a parent-child mandala painting activity during chemotherapy could reduce fear and pain in children with cancer and ease the burden on their caregivers. 108 children aged 5-12 and their parents took part, with half doing six 30-minute painting sessions o…

This study looked at 80 adults having elective lower back surgery to see which pain relief method works better: injecting local anesthetic near the surgical site or a nerve block called ESP. The goal was to improve recovery quality and reduce the need for strong painkillers in th…

This study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…

This study tested whether giving acetaminophen (Tylenol) through an IV works better than pills for pain after lumbar spine surgery. 166 adults having a specific type of back fusion surgery were randomly assigned to receive either IV or oral acetaminophen. The goal was to see if t…

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measure…

This study tested whether injecting a long-lasting numbing medicine (bupivacaine) into surgical sites just before waking up from anesthesia could reduce pain and the need for strong painkillers after jaw surgery. 102 adults having jaw surgery took part. Researchers measured pain …

This study tested whether listening to personally chosen music can reduce pain and anxiety during dental drilling. Thirty adults picked a relaxing song and had their heart rate, blood pressure, and pain levels measured with and without music. The goal is to see if music can be a …

This study looked at whether adding breathing training to a standard exercise program can help adults with long-term back or neck pain. 183 people took part in a 12-week program. One group did only exercise, another added breathing exercises with biofeedback, and a third got gene…

This study tested whether a single dose of S-ketamine, given during surgery, could lower the amount of morphine patients needed for pain in the first 24 hours after laparoscopic gynecologic surgery. 53 relatively healthy adults took part. The goal was to see if S-ketamine could i…

This pilot study tested a portable TENS device for reducing menstrual pain in 34 women with primary dysmenorrhea. Participants used the device on their lower abdomen during pain episodes for up to three cycles. The goal was to see if this drug-free approach could ease pain and im…

This study looked at whether adding a nerve block (called ESP block) to general anesthesia helps people undergoing lower back surgery. 50 adults were split into two groups: one got the nerve block plus anesthesia, the other got anesthesia alone. The goal was to see if the nerve b…

This study tested whether listening to different types of music can reduce pain and anxiety from a cold water challenge in 40 healthy young adults. Participants immersed their hand in cold water while in silence or while listening to music with different emotional tones and rhyth…

This study tested whether using virtual reality goggles or squeezing a stress ball can help reduce pain during episiotomy repair (stitches after childbirth). 112 women were randomly assigned to use VR, a stress ball, both, or standard care. The goal was to see which method works …

This study tested two ways of giving epidurals to 102 pregnant women in labor: a standard method and a newer one called dural puncture epidural (DPE). The goal was to see which provides faster pain relief and better satisfaction. Results help doctors choose the best option for ma…

This completed Phase 4 trial tested whether a turmeric extract (curcumin) can reduce pain after total laparoscopic hysterectomy. 126 participants took either liposomal curcumin or a placebo before and after surgery. The main goal was to measure pain levels 24 hours after the oper…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This study tested if freezing the nerves between the ribs (cryoablation) could reduce hospital stay compared to standard epidural pain medicine in 50 young people aged 12-24 having Nuss surgery for pectus excavatum (sunken chest). The goal was to see which method controls pain be…

This study tested whether playing a xylophone during an IV insertion can help hospitalized children aged 3 to 6 feel less pain and fear. 64 children were randomly assigned to either play the toy with a nurse or receive standard care. Researchers measured pain, fear, and parent sa…

This study compared two types of pain blocks given before surgery to children aged 6 months to 12 years having lower belly or groin surgery. The blocks use numbing medicine to reduce pain after the operation. Researchers measured how much extra pain medicine the children needed a…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study tested whether a gel (LAT gel) applied to cuts can numb them as well as the standard numbing shots (lidocaine) before getting stitches. 70 adults with simple cuts in the emergency department took part. The goal was to see if the gel causes less pain during application …

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This study tested whether adding ketoprofen to standard paracetamol (acetaminophen) can better control pain in patients receiving brachytherapy for cervical or upper airway/digestive tract cancers. Sixty-eight adults were randomly assigned to receive either paracetamol alone or p…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain levels to nurses and learn about pain management. Researchers wanted to see if using the app could reduce pain intensity. The st…

This study tested two non-drug treatments for long-lasting low back pain: muscle energy techniques (gentle muscle stretches) and Pilates exercises. 72 adults aged 20-50 with pain lasting at least 2-3 months did 60-minute sessions four times a week for six weeks. The goal was to s…

This study tested whether using a stress ball during active labor can reduce pain and improve comfort. 78 pregnant women were split into two groups: one used a stress ball during contractions, the other received standard care. Researchers measured pain, comfort, and self-efficacy…

This study compared two types of nerve blocks (serratus anterior plane block and serratus posterior superior intercostal plane block) for pain after video-assisted lung surgery. 60 adults aged 18-65 were enrolled. Researchers measured pain levels and patient satisfaction to see w…

This study tested whether placing full-term newborns in a soft, supportive "nest" of pillows before, during, and after a heel prick blood test reduces their pain. 59 healthy newborns participated; 29 were nested and 30 received standard care. Pain was measured using the Neonatal …

This study tested whether a 15-minute talk with a clinical pharmacist helps people manage pain after getting a pacemaker. The pharmacist gave personalized advice on medications, side effects, and when to take pills. 60 adults who had pacemaker surgery took part. The study looked …

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete,…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested a special stitching technique during C-sections to see if it reduces pain and helps women get out of bed sooner. 60 women having their first C-section took part. The new method aims to put less tension on the tissue, which may lead to less pain and faster recove…

This study looked at 120 adults having gallbladder surgery to see if the position they are in when getting a nerve block (called an ESP block) affects pain after surgery. Patients were placed on their side, stomach, or sitting up during the block. The goal was to find which posit…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study tested an experimental pain medication called HTX-011 in 430 adults recovering from bunion surgery. The goal was to see if it reduces pain better than standard treatments. Participants received the drug locally at the surgery site, and pain levels were tracked for 24 h…

This study looked at 51 women in labor who wanted an epidural for pain relief. Researchers compared two standard ways of numbing the skin (injecting lidocaine under the skin or into the skin) before inserting the epidural needle. The goal was to see which method caused less pain …

This study tested whether injecting the numbing drug bupivacaine into the vaginal cuff during vaginal hysterectomy reduces pain after surgery. Forty-eight women were randomly assigned to receive either the injection or standard care. Pain levels were measured over 24 hours using …

This study compared two types of nerve blocks—serratus posterior superior intercostal plane block and thoracic paravertebral block—for pain relief after mastectomy. Sixty women received one of the blocks along with standard painkillers. Researchers measured pain scores and opioid…

This study looked at whether adding a nerve block near the breastbone to a standard chest wall block could reduce painkiller use after breast reduction surgery. 90 women were split into three groups: one got no nerve block, one got a standard block, and one got both blocks. Resea…

This study tested a medical device that automatically gives the pain drug remifentanil during surgery, based on heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could reduce the total amount of pain medicine …

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial inclu…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested whether adding pain neuroscience education (PNE) to standard physiotherapy helps people with myofascial pain syndrome, a condition causing muscle knots and pain. Forty adults aged 18-50 were split into two groups: one got only physiotherapy, the other also recei…

This study looked at two types of nerve blocks (TFP and QLB) to see which one works better for pain after lower belly surgery in children aged 3 to 7. The goal was to reduce pain and the need for extra pain medicine. 66 children took part, and researchers measured their pain scor…

This study tested whether adding alcohol to a standard numbing and steroid injection could provide better pain relief for people with sacroiliac joint pain. Fifty-four adults with chronic low back pain from the sacroiliac joint received an ultrasound-guided injection, with or wit…

This study looked at whether teaching elite volleyball players about the science of pain could help them manage chronic shoulder pain. Forty players took part, with some receiving six weeks of pain education in addition to their regular training. The results showed that those who…

This study tested whether adding ketamine or magnesium sulfate to a standard numbing medicine (levobupivacaine) can improve pain control after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons via a nerve block. The main goal was to see if …

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether wearing eye masks and earplugs at night for three nights could help prevent confusion (delirium) and reduce pain in children aged 6-12 in the pediatric intensive care unit (PICU). 74 children were randomly assigned to either wear the sleep aids or receiv…

This study looked at whether a specific nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delayed the need for extra…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study tested whether letting women listen to their own chosen music during embryo transfer could lower anxiety and pain. 42 IVF patients were randomly assigned to either listen to music through noise-canceling headphones or receive standard care. Researchers measured anxiety…

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study tested whether adding a single dose of the muscle relaxant tizanidine to a nerve block (ESP block) improves pain control after mastectomy. 90 patients were randomly assigned to receive either the nerve block alone or the nerve block plus tizanidine before surgery. The …

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for strong painkillers after a kidney transplant. Forty adults having a kidney transplant were randomly assigned to receive either the ESP block or no block. All patien…

This study tested whether putting lignocaine (a numbing medicine) inside the abdomen during gynecologic open surgery can reduce pain afterward. 112 women having surgery like hysterectomy or cystectomy took part. The goal was to see if this approach lowers pain scores and the need…

This study compared two types of nerve blocks given before hip fracture surgery to see which provides better pain relief afterward. 77 older adults received either a sacral erector spinae plane block or a supra-inguinal fascia iliaca block. Researchers measured pain scores, opioi…

This study tested two different pain-relief mixtures given as a nerve block before hip surgery. One group received nalbuphine plus bupivacaine, the other dexamethasone plus bupivacaine. The goal was to see which combination provided longer pain relief and reduced the need for ext…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block with the same numbing medicine. Researchers measured how much extra morphine …

This study tested two methods of delivering a pain-blocking injection (TAP block) after laparoscopic upper abdominal surgery: one guided by ultrasound and the other by the surgical camera. Sixty adults aged 18-70 took part, and researchers measured their pain levels and need for …

This study tested two different ultrasound-guided nerve blocks to see which provides better pain relief after breast removal surgery. Eighty-eight women received either a PECS II or MTP block before surgery, and their pain levels were tracked for 24 hours. The goal was to find a …

This study tested whether applying scents (like lavender) during heel blood collection can reduce crying, pain, and stress in newborns. 120 healthy full-term babies were randomly assigned to receive a scent or not. Researchers measured crying time, heart rate, and a standard pain…

This study looked at 90 adults having shoulder surgery to compare two types of nerve blocks for pain relief. One block targets the shoulder area directly, while the other targets a nearby muscle. The goal was to see which method provides better pain control and reduces the need f…

This study tested two drug-free methods—deep breathing and virtual reality—to see which better reduces pain and anxiety during blood draws. 264 adults were randomly assigned to one of the two techniques or standard care. The goal is to find a simple, effective option for patients…

This study tested whether Kinesio Tape, a stretchy tape applied to the skin, can reduce pain, swelling, and jaw stiffness after removing impacted lower wisdom teeth. Thirty adults were divided into three groups: one received a dexamethasone injection, one got Kinesio Tape, and on…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This study tested three different pain-blocking methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which method works best to keep kids comfortable after the operation. Researchers measured pain levels, how much extra pain medicine was needed, and any s…

This study compared two methods of pain relief after cesarean section: injecting numbing medicine into the belly and surgical wound versus giving morphine through a spinal injection. The goal was to see which approach reduces the need for extra painkillers in the first 24 hours. …

This study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…

This study tested a nerve block called the high-thoracic erector spinae plane block to see if it could reduce pain and improve diaphragm function after posterior cervical spine surgery. 50 adults undergoing this surgery received either the block or standard care. The goal was to …

This study tested whether applying ice packs over surgical incisions every 4 hours for up to 72 hours can improve patients' recovery after chest, abdomen, or groin surgery. 196 adults were randomly assigned to receive cryotherapy plus standard care or standard care alone. The mai…

This study looked at whether showing cartoons or playing music during tooth extractions can lower pain and anxiety in children aged 6 to 12. Sixty kids were randomly assigned to watch cartoons, listen to music, or receive standard care. Researchers measured heart rate, oxygen lev…

This study compared two types of nerve blocks — the erector spinae plane block and the retrolaminar block — for controlling pain after major breast cancer surgery. Ninety women between 18 and 60 years old took part. Researchers measured pain scores and how much opioid painkiller …

This study looked at whether chewing gum (with or without sugar) can help children aged 7 to 12 feel less pain and fear during a blood draw. A total of 144 kids were randomly assigned to chew sugared gum, sugar-free gum, or no gum at all. Researchers measured pain, fear, and cryi…

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery could lower the chance of delirium (sudden confusion) in patients aged 65 and older. A total of 1500 participants were randomly assigned to receive either morphine alone or m…

This study tested whether a TENS device, which uses mild electrical pulses, can reduce pain during a prostate biopsy. 84 men were randomly assigned to receive TENS plus local anesthetic, a sham TENS device plus local anesthetic, or local anesthetic alone. Participants reported th…

This study tested whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. 70 women were randomly assigned to either use the VR headset or receive standard care. Pain and anxiety were measured right after the procedure. The goal is to find a simple…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department with common painful conditions like back pain or abdominal pain. About 290 adults were split into two groups: one received acupuncture, the other got usual care. The goal wa…

This study tested whether a nerve block called the external oblique intercostal plane block could reduce the amount of opioid painkiller needed during laparoscopic gallbladder removal. 80 adults having elective surgery received the block before the procedure. Researchers measured…

This study tested a single injection of a long-acting painkiller called SDE in 221 adults recovering from hemorrhoid surgery. Half received the drug and half a placebo. Researchers measured pain levels and how much extra pain medicine was needed over 48 hours. The goal was to see…

This study tested whether breathing exercises and using a stress ball during dressing changes can reduce pain, anxiety, and improve comfort in burn patients. 210 adults with burns on 15% or less of their body took part. Researchers measured pain, anxiety, comfort, and vital signs…

This study tested two different nerve blocks to see which one works better for pain after shoulder surgery. Sixty adults having arthroscopic shoulder surgery received either an interscalene block or a serratus posterior superior intercostal plane block. The main goal was to see h…

This study tested whether a special laser (940-nm diode) applied right after gum graft surgery can reduce pain and help the wound heal faster. 36 healthy adults received either the laser plus a protective mouth stent or just the stent alone. Researchers measured pain, painkiller …

This study tested two non-drug methods to reduce pain, fear, and anxiety in children aged 4 to 6 getting intramuscular injections in a pediatric emergency department. One method used a flat, bumpy plastic device called ShotBlocker pressed against the skin before the shot. The oth…

This study compared two types of pain-relief injections (posterior quadratus lumborum block and transversalis fascia plane block) in 54 children aged 1 to 7 years undergoing orchiopexy. Researchers measured how long it took for children to need their first painkiller after surger…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study looked at two methods to control pain after breast-conserving surgery: an ultrasound-guided nerve block (ESPB) and local wound infiltration (LWI). 66 adult women took part, and researchers measured how much morphine they needed in the first 24 hours after surgery. The …

This study tested whether an ultrasound-guided nerve block (ESP block) given before spinal surgery for scoliosis can lower pain and the need for strong painkillers after the operation. Eleven teenagers took part, with half receiving the block plus general anesthesia and half rece…

This study tested whether a combination of a specific jaw muscle technique and neck exercises could reduce pain and improve jaw function in people with temporomandibular disorder (TMD) and teeth grinding (bruxism). Sixty adults with TMD and bruxism were split into two groups: one…

This study tested whether medical hypnosis can reduce anxiety and pain in patients undergoing electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled and received either hypnosis or standard care. Researchers measured pain and anxiet…

This study tested a new type of nerve block called the PENG block in 60 adults having hip surgery. The goal was to see if it reduces pain and the need for opioid painkillers after the operation. The block targets nerves around the hip joint while avoiding leg muscle weakness.

This study tested whether a near-infrared LED device can reduce pain, speed up tooth movement, and lower the risk of root damage in people wearing braces. Sixteen Vietnamese patients aged 11 to 30 received either the real LED device or a sham device during their orthodontic treat…

This study tested whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for fentanyl (a strong opioid) in critically ill patients on mechanical ventilators. Sixty adults were randomly assigned to receive either nefopam plus standard care or standa…

This study tested whether a nerve block called an erector spinae plane block can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. Forty-six adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The goal…

This study tested whether Emotional Freedom Techniques (EFT), a simple tapping therapy, can help first-time mothers feel safer, less anxious, and experience less pain after a planned cesarean section. Sixty women were split into two groups: one received EFT in the first 24 hours …

This study tested whether a nerve block called the anterior quadratus lumborum block, given before surgery, can reduce pain and the need for opioids in women undergoing abdominal hysterectomy. 56 participants were randomly assigned to receive either the nerve block plus standard …

This study looked at adding tramadol, nefopam, or opioids to standard painkillers (paracetamol and ketoprofene) for adults recovering from shoulder surgery. 92 patients were enrolled, and their recovery quality was measured using a survey. The goal was to find the best oral pain …

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth and aimed to help people cope with pain without medication. Researchers wanted to see if the program was acceptable an…

This study tested whether a physiotherapy technique called median nerve neural mobilization reduces pain in people with carpal tunnel syndrome better than ibuprofen or no treatment. 117 adults with confirmed carpal tunnel syndrome took part. Researchers measured pain using a stan…

This study tested two common treatments for carpal tunnel syndrome: over-the-counter ibuprofen pills and a nerve exercise called neural mobilization. 123 adults with carpal tunnel took part. The goal was to see if these treatments reduce pain and improve hand and arm function bet…

This study tested a 10-week program that combines resistance exercises with cognitive tasks (like memory games) in 38 frail older adults with chronic musculoskeletal pain. The goal was to see if the program is feasible and can improve frailty and thinking skills. Participants wer…

This study tested whether gabapentin pills or a simple physiotherapy hand stretch (nerve mobilization) can reduce pain and improve hand function in people with carpal tunnel syndrome. 126 adults with confirmed carpal tunnel took part. The goal was to see if either treatment works…

This study tested whether physiotherapy, ibuprofen arginine, or gabapentin reduces pain and improves hand function in people with carpal tunnel syndrome. 196 participants were assigned to one of these treatments or no treatment at all. The goal was to see which approach offers th…

This study tested whether a specific physical therapy technique called median nerve neural mobilization can reduce pain in people with carpal tunnel syndrome. 74 participants were randomly assigned to receive the therapy or no treatment. The main goal was to measure pain reductio…

This study tested a T-shirt printed with ceramic particles that claim to use body heat to emit far infrared radiation, potentially reducing inflammation and muscle pain. Fifty adults with chronic neck or lower back pain wore the shirt for 8 hours. Researchers measured changes in …

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested whether playing special music (solfeggio frequencies or Turkish classical tunes) during allergy skin tests could lower pain in children and anxiety in their parents. 120 children aged 2 to 17 took part. Parents reported their anxiety before and after the test, a…

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This study tested whether listening to visualized meditation sessions for three days before a colonoscopy could help reduce anxiety, pain, and improve comfort. Seventy-two first-time colonoscopy patients participated. The meditation group listened to recordings twice daily before…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested two simple distraction methods—blowing bubbles and a mental game with praise—to help children aged 7 to 12 feel less pain, fear, and anxiety during a blood draw. 207 children took part, and their pain and fear levels were measured before and after the procedure.…

This study compared two ways to manage pain after total hip replacement: a newer ultrasound-guided nerve block (PENG block) versus standard surgical infiltration. The goal was to see which method reduces the need for strong painkillers like morphine, especially in older patients …

This study tested whether adding dexmedetomidine (a sedative) to fentanyl (a painkiller) could reduce the amount of fentanyl needed for full-term newborns on breathing machines. Forty babies were given either a lower fentanyl dose plus dexmedetomidine or standard fentanyl alone. …

This study compared two types of nerve blocks—Erector Spinae Plane Block and Fascia Iliaca Compartment Block—for pain relief in adults after femur (thigh bone) surgery. 92 patients received one of the two blocks before surgery. Researchers measured how long pain relief lasted and…

This study tested two pain medicines, ketamine and dexmedetomidine, in 38 adults recovering from brain surgery in the ICU. Researchers measured pain levels using a special tool at 6, 12, and 24 hours after treatment. The goal was to see which drug provides better pain relief for …

This completed study tested whether an ultrasound-guided nerve block called RIFP can reduce pain and the need for rescue painkillers after laparoscopic gallbladder removal. 77 patients were enrolled. The block targets nerves in the upper abdomen to provide pain relief. The main g…

This study looked at whether adding a numbing injection into the wound and a steroid medication during a planned C-section could lower the number of women experiencing severe pain after surgery. The researchers compared pain scores before and after making this change in 100 women…

This study compares two types of ultrasound-guided nerve blocks for controlling pain after mastectomy: the standard paravertebral block and a newer proximal intercostal block. Researchers want to see if the newer block offers better needle visibility, faster procedure time, and i…

This study tested two different nerve block techniques to control pain after shoulder arthroscopic surgery. Fifty adults were randomly assigned to receive either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary nerve blocks. The…

This study tested three different nerve blocks to control pain after video-assisted chest surgery. Sixty adults received one of the blocks, and researchers measured how long they could go before needing morphine. The goal is to find the best way to reduce pain and the need for st…

This study tested two common painkillers, ketamine and lidocaine, to see which works better for pain after gallbladder removal. 76 adults were randomly assigned to receive one of the drugs right after surgery. Researchers measured their pain levels over the next 24 hours. The goa…

This study tested three different numbing injections (nerve blocks) to see which one provides the best pain relief after a type of chest surgery called thoracoscopic sympathectomy. Sixty adults took part, and researchers measured how long it took before they needed morphine for p…

This study looked at whether giving children stickers during an IV insertion can lower their pain and anxiety. 72 children aged 5 to 10 took part. The idea is that stickers can distract kids and make the experience less scary.

This study tested two common drugs, lidocaine and magnesium sulfate, to see which one works better for pain after gallbladder removal surgery. 168 adults received one of the two drugs during surgery, and their pain levels were checked at several points over 24 hours. The goal was…

This study tested a 6-week online pain management program for breast cancer survivors who still have bothersome pain after treatment. The program included education, exercises, and psychological strategies to cope with pain. Researchers wanted to see if it helps reduce pain's imp…

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days.…

This study tested whether using heat or cold packs during childbirth can lessen perineal pain after delivery. 115 women having their first vaginal birth took part. Researchers measured pain levels and healing. The goal was to find a simple, drug-free way to improve comfort after …

This study tested whether interacting with a live parrot, a robotic parrot, or a picture of a parrot could reduce pain during blood draws in 240 adults with chronic diseases. Participants were randomly assigned to one of the three groups, and their pain was measured using a stand…

This study looked at whether acupuncture can reduce pain and anxiety in men undergoing a prostate biopsy. 72 men were randomly assigned to receive either real acupuncture or a sham (fake) version before the procedure, in addition to standard numbing medicine. The main goal was to…

This pilot study tested a dietary supplement made from parsley, rosemary, selenium, and vitamins in 36 women with endometriosis. The goal was to see if it could reduce pain and the need for NSAIDs. The supplement was taken daily for a period, and pain levels were measured using a…

This study tested whether a pain medicine called oxycodone causes fewer side effects than morphine after hip replacement surgery. About 246 adults took part. The goal was to see if oxycodone reduces problems like nausea, vomiting, itching, and breathing trouble by half. The resul…

This study tested whether wearing virtual reality (VR) glasses during a leg artery procedure (angioplasty) can lower patients' pain and anxiety. 52 adults having elective angioplasty were randomly assigned to either use VR or standard care. Researchers measured pain and anxiety l…

This study compared two types of nerve blocks—Quadroiliac Plane Block and PENG Block—for pain relief after femur fracture surgery. 52 adults were randomly assigned to receive one of the blocks. Researchers measured pain scores and how much opioid painkiller patients needed in the…

This study tested four different nerve blocks (erector spinae, retrolaminar, serratus anterior, and pectoral nerve block) to see which one provides the longest pain relief after breast cancer surgery. 188 women aged 18 to 65 took part. The main goal was to measure how long it too…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested whether using virtual reality (VR) at home can help people with long-term low back pain feel better and move more. Over 400 participants used one of three VR programs (skills-based, distraction, or sham) along with a Fitbit to track activity. The goal was to see…

This study tested whether a lower dose (15 mg) of the painkiller ketorolac works as well as a higher dose (60 mg) for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one injection of either dose. The results showed that t…

This study tested whether using a virtual reality headset during cancer surgery under local anesthesia can reduce pain and anxiety. 42 adults with cancer were randomly assigned to receive either local anesthesia alone or local anesthesia plus VR. The VR used hypnosis and relaxati…

This study tested whether a small device called TENS, which sends mild electrical pulses to the skin, could reduce leg pain during walking in people with peripheral artery disease (PAD). It also looked at adding a patient education program to encourage more physical activity. The…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block leads to less pain, less …

This study compared two types of nerve blocks—erector spinae plane (ESP) and rhomboid intercostal (RIB)—for managing pain after breast surgery. 84 patients received one of the blocks before their operation. Researchers measured how much morphine they needed afterward and their pa…

This study looked at whether a special nerve block called PENG can reduce pain when positioning patients with hip fractures for spinal anesthesia. Sixty adults having hip fracture surgery were randomly assigned to receive the block or not. The main goal was to see if the block ma…

This completed study looked at how well a long-acting painkiller called ERDS works for pain after surgery. Researchers followed 634 adults who received an ERDS injection after anesthesia. They measured pain levels and how much extra pain medicine was needed over five days. The go…

This study looked at whether a single injection of numbing medicine between the ribs (rhomboid intercostal block) can lower the chance of chronic pain after mastectomy. 254 women having breast cancer surgery were split into two groups: one got the block, the other did not. Resear…

This study tested two different knee injections for people with knee osteoarthritis. One injection was a common steroid (triamcinolone), and the other was a long-acting anti-inflammatory (tenoxicam). The goal was to see which one reduced pain and improved knee function better, wh…

This study compared two pain-blocking techniques—epidural block and erector spinae plane block—in 71 patients undergoing open gynecologic cancer surgery. Researchers measured pain scores, opioid use, and how quickly patients could move after surgery. The goal is to find which met…

This study tested whether adding a nerve block to a standard hematoma block reduces pain better during wrist fracture realignment. 180 adults with displaced wrist fractures were randomly assigned to receive either a hematoma block alone or a hematoma block plus a median nerve blo…

This study looked at whether giving ketamine during anesthesia can reduce the need for morphine and lower pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps avoid morphine's side effects.

This completed study looked at how different amounts of chiropractic care affect chronic low back pain in 766 veterans. In the first phase, participants received either 1-5 or 8-12 visits over 10 weeks. Then, some continued with monthly maintenance visits for 10 months. The goal …

This study tested whether using augmented virtual reality (AVR) during chemotherapy can help reduce pain, stress, and anxiety while boosting self-confidence. 150 adult cancer patients in the West Bank were split into two groups: one received standard care, and the other used AVR …

This study tested whether a long-acting painkiller called Exparel (liposomal bupivacaine) can control pain better after open or laparoscopic hernia repair. Nineteen adults having hernia surgery received Exparel along with standard care. Researchers measured patient satisfaction w…

This completed study looked at whether giving a spinal painkiller (morphine) before robotic hysterectomy helps reduce pain after surgery. Researchers reviewed records from 100 patients who had the procedure. The main goal was to see if this approach lowers pain scores, which coul…

This study tested whether hypnosis or virtual reality can reduce pain during repeated medical procedures like wound dressing. 52 patients received standard pain care, standard care plus hypnosis, or standard care plus virtual reality in a random order. The goal was to see if thes…

This study tested whether using a sonic device (EDDY) during root canal treatment in children's baby molars reduces pain afterward. Thirty children aged 5-8 with tooth infections received either sonic-activated cleaning or standard cleaning. Pain was measured using a face scale a…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors received counseling and the medication varenicline (Chantix). The goal was to see if the program was practical and helpful, not yet to prove it works.

This study looked at 75 women who had planned cesarean deliveries to see if different pain relief methods affect how soon they start breastfeeding and whether they breastfeed exclusively. The researchers compared standard pain management with TAP blocks, a type of abdominal nerve…

This study surveys intensive care unit (ICU) doctors and nurses across Europe and Israel about their understanding of palliative care and local laws regarding end-of-life decisions. The goal is to measure how aware clinicians are of palliative care practices and the legal framewo…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study is testing a new wearable device that uses focused ultrasound to stimulate nerves in the arms and legs. Researchers want to see if it's comfortable and easy to use in 15 healthy adults aged 20-40. Participants will complete nine sessions involving cold water and pressu…

This study looked at how patients view the routine pain checks they receive after planned surgery. Researchers surveyed and interviewed 312 adults to understand whether these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain.…

This completed study tested an oral form of the painkiller nalbuphine, called PHN131, in 16 healthy adults. The goal was to see how the body absorbs and processes the pill compared to the injected version. Researchers also monitored safety by checking vital signs like blood press…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study looked at whether a genetic marker called COMT can predict how well a person responds to hypnosis for pain after surgery. Researchers tested a new, faster method to read this gene from saliva or blood samples. The goal is to one day use a simple genetic test to persona…

This study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pa…

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main go…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This completed study with 120 adults undergoing brain surgery tested whether brain wave patterns and vital signs like blood pressure can show pain from skull pin fixation. Researchers compared three pain management methods: a scalp nerve block, IV opioids, and a local anesthetic …

This early-stage study tested a new drug called CG001419 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for pain relief. Participants took single or multiple doses, and some took it with food to check for effects. The study is…

This study looked back at the medical records of 134 adults with chronic cancer pain to see how well different pain management strategies worked. Researchers measured pain severity using a standard 0–10 scale and noted the types of pain and treatments used. Because it was a revie…

This study looked back at records of 126 people who had total knee replacement and received nerve blocks for pain. The goal was to compare different nerve block techniques to see which one provides better pain relief, fewer complications, and faster recovery. The findings could h…

This study tested whether a 3D-printed model of pain biochemistry helps nursing students understand pain mechanisms and stay motivated. 90 students were split into two groups: one used the 3D model, the other used standard PowerPoint slides. Researchers measured knowledge and mot…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study explored whether a parent's anxiety before their child's surgery influences the child's own anxiety and pain after the operation. Researchers measured anxiety in 81 parents and their children aged 2-6 undergoing groin surgery. The goal was to see if easing parental wor…

This study asked over 1,000 emergency doctors in Europe what they would prescribe for a patient with sudden belly pain. The patient's race was changed to see if it affected the doctor's choice to give morphine. The goal was to understand if racial bias plays a role in pain manage…

This study tested two different tablet forms of an experimental pain drug (LTG-001) in 14 healthy adults to see how well each is absorbed. Participants took single doses of each version, and researchers measured drug levels in the blood. The goal was to find which formulation wor…

This study looked at 52 adults having cosmetic breast surgery to see if things like self-esteem, anxiety, and personality traits affect how much pain they feel afterward. Before surgery, participants filled out questionnaires about their mental state and pain expectations. After …

This study looked at 50 older adults (65+) having major surgery to see if using a computer-controlled sedation method (target-controlled infusion, or TCI) helps protect thinking and memory after the operation. Participants were split into two groups: one received TCI and the othe…

This study looked at how two common steroids, methylprednisolone and dexamethasone, affect the time it takes for children to recover from muscle relaxants used during surgery. Sixty children aged 5 to 12 received one of the steroids or a placebo before their operation. The goal w…

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study looked at 142 people with hard-to-treat high blood pressure who had a procedure called renal denervation, which uses energy to calm overactive kidney nerves. Researchers compared two types of sedation—dexmedetomidine versus a fentanyl-propofol combination—to see which …

This study tested how well BD NRFit spinal needles and syringes work in real-world medical settings. A total of 161 patients receiving anesthesia or pain relief procedures were included. Researchers measured successful needle placement, syringe function, and safety issues like he…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study tested whether a single 70-minute Pain Neuroscience Education session could improve pain knowledge and attitudes in 155 undergraduate physiotherapy students. The session covered pain neurophysiology, chronic pain mechanisms, and biopsychosocial factors. Students comple…

This study tested whether daily phone calls after day surgery help patients control pain better than a single call the next morning. 280 adults having hernia repair, gallbladder removal, hemorrhoid surgery, or knee/shoulder arthroscopy took part. The goal was to see if more frequ…

This study looked at whether specially trained anesthesia nurses can safely manage sedation for digestive endoscopy, with an anesthesiologist available if needed. Over 18,000 people took part to compare safety and satisfaction. The goal was to see if this nurse-led model could be…

This study looked at how different nerve blocks numb the skin for breast cancer surgery. Thirty-six patients received one of three types of nerve blocks before surgery. Researchers mapped the numb area and checked if it covered the surgical incision. The goal is to help doctors c…

This study looked at how much lidocaine and ropivacaine stay in the blood when both are used for pain control during major abdominal surgery. It involved 51 adults having open abdominal surgery. The goal was to understand if combining these drugs is safe and how their levels chan…

This study looks at how disrupted sleep changes the way common drugs (like painkillers, stimulants, and sedatives) work in the body. Researchers will disturb the sleep of 148 healthy adults in a lab and then measure how their brains respond to these drugs, including pain relief a…

This study looked at 150 adults who came to the emergency room with sudden low back spasms. Researchers compared those who got only standard pain medication to those who also received physiotherapy, including manual therapy and TENS. The goal was to see if adding physiotherapy im…