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Brain surgery pain showdown: which drug wins?

NCT ID NCT07254936

Symptom relief Sponsor: Universitas Sumatera Utara Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two pain medicines, ketamine and dexmedetomidine, in 38 adults recovering from brain surgery in the ICU. Researchers measured pain levels using a special tool at 6, 12, and 24 hours after treatment. The goal was to see which drug provides better pain relief for these patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Mar 2025

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years and older. * Intubated post-craniotomy patients in the ICU. * Glasgow Coma Scale (GCS) score of 8-15 pre-operatively. Able to provide informed consent (either personally or through family/legal representative). Exclusion Criteria: * Hypersensitivity to ketamine or dexmedetomidine. * Renal failure (elevated serum creatinine and BUN). * Heart failure (EF \<40%, elevated BNP/NT-proBNP, abnormal ECG). * Hepatic failure (elevated AST/ALT, bilirubin, prolonged PT/INR). * Patients with severe bradycardia, hypotension, or hallucinations due to study drugs. * Death during the study period. * New critical illness (e.g., sepsis, stroke). * Withdrawal of consent by the patient or family. * Incomplete data or ICU discharge before 24-hour follow-up.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ketamine VS dexmedetomidine for pain relief Pain control in icu Post-craniotomy Post-craniotomy pain management

Contacts and locations

Locations

  • H. Adam Malik General Hospital, Hajj General Hospital, and TK II Putri Hijau Army Hospital

    Medan, North Sumatra, 20155, Indonesia

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