Ozone treatment eases mouth pain for head and neck cancer patients
NCT ID NCT07199712
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days. The main goal was to see how quickly sores healed and pain decreased. The research aims to find a simple supportive care option to improve comfort and keep cancer treatment on track.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ozone therapy (professional ozone gas treatment and home ozonated toothpaste, mouthrinse, and gel)
- What this could lead to
- If it works, this could offer a simple, drug-free way to reduce mouth sore pain and speed healing during cancer treatment, improving quality of life.
- What could go wrong
- This is a small, completed trial with no control group, so results may not be definitive. Ozone therapy is generally safe but may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Lombardy, 27100, Italy
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Other studies related to the condition(s) this trial covers.
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