Peripheral nervous system disorder

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This study tests an experimental drug called empasiprubart in people with a specific type of generalized myasthenia gravis (gMG) who have AChR antibodies. The goal is to see if the drug is safe and can improve symptoms like muscle weakness that affect daily activities. Participan…

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This study tests a drug called ravulizumab in 20 Chinese adults with generalized myasthenia gravis, a condition that causes severe muscle weakness. The drug is given through a vein and works by blocking a part of the immune system to reduce symptoms. Researchers will measure how …

This phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…

This phase 3 trial tests whether claseprubart (DNTH103) can improve symptoms of generalized myasthenia gravis, a condition causing muscle weakness. About 195 adults with a specific antibody type are randomly assigned to receive the drug or a placebo. The main goal is to see if th…

This study tests an experimental drug called BMS-986504 in people with a rare cancer called malignant peripheral nerve sheath tumor (MPNST) that cannot be removed by surgery. Only people whose tumors are missing a gene called MTAP can join. The drug is taken daily by mouth, and t…

This study tests a new medicine called empasiprubart in teenagers aged 12 to 17 who have a rare nerve disease called CIDP. The goal is to find the right dose and see if the drug is safe and helps control the disease. Participants will receive the drug for about 27 months and be f…

This early-phase trial tests a gene therapy called SKG0201 in 11 infants with spinal muscular atrophy (SMA) type I, a severe muscle-weakening disease. The therapy uses a harmless virus to deliver a working copy of the missing SMN1 gene. The study aims to see if it is safe and can…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether SHR-2173, added to usual care, improves symptoms of generalized myasthenia gravis (gMG) better than a placebo. About 60 adults with confirmed gMG will receive the drug or placebo for 24 weeks. The main goal is to see if daily muscle weakness and fatigue s…

This early-stage trial tests an experimental drug called empasiprubart in 60 adults with multifocal motor neuropathy (MMN), a rare condition that causes muscle weakness. The drug is given as an IV infusion, and researchers will use ultrasound to measure nerve thickness, along wit…

This study compares two types of balance training for people with diabetic neuropathy, a condition that can cause numbness and balance problems. 42 participants will be randomly assigned to do balance exercises on a firm surface or on a rolling board, three times a week for four …

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This early-stage study tests a new treatment called LVIVO-TaVec400 in 44 people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard therapies. The main goals are to check the treatment's safety and find the rig…

This study tests a combination of high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation in older adults (60+) who have been in the ICU for at least two weeks and now have muscle weakness. The goal is to see if this approach can improve …

This early study tests a new treatment called HN2301 in 6 adults with generalized myasthenia gravis, a disease that causes muscle weakness. The treatment uses the body's own immune cells to target and reduce harmful immune activity. The main goal is to check safety and see how we…

This phase 2 trial tests a combination of seven drugs (CL-Pola-R-CHP) in 28 adults aged 65 and older with double or triple-hit diffuse large B-cell lymphoma who are not eligible for transplant. The goal is to see how many patients achieve complete remission after six cycles of tr…

This study tests several experimental treatments for progressive supranuclear palsy (PSP), a rare brain disease that affects movement and thinking. About 440 people with early-stage PSP will receive one of the treatments or a placebo. The goal is to see if any of the treatments c…

This study tests a vaccine called AADvac1 in 146 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and thinking. The vaccine aims to target a protein linked to the disease and slow its progression. Participants will receive injections o…

This Phase 2 trial tests whether the drug LM11A-31 can slow the progression of Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. About 147 people with early-stage PSP will receive either the drug or a placebo twice daily for several mo…

This study looks back at how well a type of targeted radiation therapy (PRRT) works for people with advanced pheochromocytoma and paraganglioma, rare tumors of the adrenal glands. Researchers will analyze data from about 210 patients treated in Italy over 24 years. The goal is to…

This phase 2 trial is testing a daily pill called Inavolisib in about 48 people with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The drug targets that mutation to try to shrink tumors or stop them from growing. Researchers will measure how ma…

This study is testing a device called ReFeel, which is used to repair damaged nerves in the fingers. The goal is to see if it helps people recover faster and with better results, like improved feeling and less pain. Only 5 adults with a specific type of finger nerve injury will b…

This very early study will test the drug talquetamab in just 2 people with refractory generalized myasthenia gravis, a chronic autoimmune disease that causes muscle weakness. The drug is designed to help the immune system attack the cells that produce harmful antibodies. The goal…

This study looks at the long-term safety and effectiveness of a drug called rozanolixizumab for adults with ocular myasthenia gravis, a condition that causes muscle weakness in the eyes. About 100 people who have already taken the drug in a previous study will continue treatment.…

This early-stage trial tests whether two cancer drugs, cabozantinib and selumetinib, can safely shrink plexiform neurofibromas in people aged 16 and older with neurofibromatosis type 1 (NF1). About 30 participants will receive the combination daily. The study first finds the safe…

This study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, fix the genetic defect in the lab, and then see if these cells can help brain cells work better. The goal is to show the …

This study tests a drug called Telitacicept in 30 children with ocular myasthenia gravis, a condition that causes droopy eyelids and double vision. The drug aims to reduce relapses and the need for steroids. It is given as a weekly shot alongside standard care. The trial is open-…

This early-phase trial tests a single injection of gene therapy (ELP-02) into the spinal fluid of 8 children and young adults with CMT4J, a rare genetic nerve disease that causes muscle weakness. The therapy delivers a working copy of the FIG4 gene to nerve cells, potentially slo…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…

This early-phase trial will test a new treatment called QT-019C in up to 15 adults with relapsed or refractory neurological autoimmune diseases, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. The treatment uses donor-derived CAR T-cells that target two…

This early-stage trial tests whether a single infusion of ripertamab can safely improve daily living activities in 20 adults with generalized myasthenia gravis, a condition causing muscle weakness. Participants are randomly assigned to receive the drug or a placebo, and are follo…

This study compares two rehabilitation approaches—virtual reality exercises and motor-cognitive dual-task training—in 14 children aged 7-14 with brachial plexus birth injury, a condition where arm nerves are damaged during birth. Each child will do their assigned program for 12 w…

This study tests a simple surgery where a piece of the patient's own vein is wrapped around a repaired nerve to reduce scarring and pain. It includes 43 adults aged 18-60 with nerve injuries below the elbow that need repair within 6 months. The goal is to see if this technique pr…

This early-stage study tests a new cell therapy called HY001N in 15 adults with relapsed or treatment-resistant autoimmune neurological diseases like neuromyelitis optica. The main goal is to check safety and side effects, while also looking for signs of improvement in disability…

This study tests a wearable device called the Leia sensory prosthesis in 80 adults with peripheral neuropathy, a condition that often causes balance problems and unsteady walking. Participants will either use the active device or a sham version for two months. The main goal is to…

This early-phase trial tests a new treatment for people with refractory myasthenia gravis, a condition causing severe muscle weakness. The treatment uses donor immune cells (CAR-NK cells) engineered to target and calm the immune system's attack on muscles. Fifteen participants wi…

This study tests whether a newer drug, efgartigimod, works better than standard intravenous immunoglobulin (IVIG) for people with myasthenia gravis who also have a thymoma tumor and need surgery. About 64 adults will receive either treatment before and after their operation to se…

This study looks at a special putty called Fibergraft used in spine surgery to help bones grow together. About 80 adults with back pain or nerve problems from spine issues will get this putty during surgery. Doctors will check how well the bones heal using CT scans and ask patien…

This study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…

This phase III trial tests a vitamin B12 injection (hydroxocobalamin chloride) in 20 children aged 6 months to 18 years with a specific type of methylmalonic acidemia (cobalamin C deficiency). The goal is to see if the injection can normalize levels of certain acids in the blood …

This study tests whether eating four GlucoBites cookies daily for 12 weeks can improve blood sugar control and reduce the risk of diabetic foot ulcers in adults with type 2 diabetes. The cookies contain an herb called Gynura procumbens. Researchers will compare blood sugar, insul…

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …

This study explores whether a painless ultrasound technique, called shear wave elastography, can detect early signs of muscle weakness in critically ill patients on breathing machines. About 98 adults will have their nerves scanned on days 1, 4, and 7 in the ICU. The goal is to s…

This study will compare a new radioactive tracer, 18F-AmBF3TATE, to the standard tracer 68Ga-DOTATATE for PET scans in people with neuroendocrine tumors. The goal is to see if the new tracer is as good or better at finding tumors. About 51 participants will receive both tracers a…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study tests whether a computer model can find signs of a heart condition called cardiac amyloidosis in bone scans that were done for other reasons. Researchers will look back at 57 patients' scans to see if the model can correctly identify those with the disease. If it works…

This study looks for early signs of a heart condition called cardiac amyloidosis in people who have had carpal tunnel surgery on both hands. Researchers will use a special heart scan to check for abnormal protein buildup. The goal is to find the disease earlier so treatment can s…

This study tests whether a special PET-CT scan using a drug called evuzamitide can detect signs of cardiac amyloidosis in people whose standard heart scans were unclear but who have high levels of a blood marker called TAD1. About 25 adults with heart failure or a genetic risk fo…

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

This study looks at whether a person's body weight affects the accuracy of ultrasound for diagnosing carpal tunnel syndrome. Researchers will measure the median nerve size with ultrasound and compare it to standard nerve tests in 120 adults. The goal is to see if weight 'masks' t…

Trigeminal neuralgia causes sudden, severe facial pain often mistaken for a toothache, leading to wrong treatments. This study tests a 15-question screening tool in 250 adults with facial pain to see if it can accurately identify possible trigeminal neuralgia before a specialist …

This study will test a new device that measures blood pressure and heart function continuously without needles. It will be used during standard autonomic function tests (like the Valsalva maneuver and tilt table) in 75 patients with orthostatic intolerance. The goal is to see if …

This study aims to see if common physical exams and diagnostic criteria can accurately identify piriformis syndrome, a cause of buttock pain. Researchers will enroll 75 adults with gluteal pain and compare exam results to an ultrasound-guided lidocaine injection into the piriform…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study aims to translate and test a diagnostic tool called CTS-6 for Turkish-speaking patients with carpal tunnel syndrome. Researchers will enroll 126 adults, including healthy volunteers, people with symptoms, and those already diagnosed. The goal is to ensure the tool is a…

This study looks at how well nerve tests and ultrasound can detect diabetic peripheral neuropathy, a common complication of diabetes that causes pain and numbness in the feet. Researchers will compare results from 75 adults with diabetes and healthy volunteers to see which tests …

This study will test whether artificial intelligence (AI) can effectively screen for diabetic retinopathy (eye damage) in 400 children with type 1 diabetes. Each child will have their eyes examined using an AI-powered camera, standard eye exams, and a detailed scan. The researche…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

This study tests a simple idea: wearing tight surgical gloves during paclitaxel chemotherapy might prevent nerve damage in the hands. About 84 breast cancer patients will be randomly assigned to either wear the gloves during treatment or receive standard care. Researchers will th…

This study tests whether two existing drugs—memantine (used for Alzheimer's) and rosuvastatin (a cholesterol-lowering statin)—can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 46 adults will receive these drugs alongside …

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This study tests whether the supplement glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine twice daily for 14 days during their treatment. Researchers will trac…

This phase 3 trial tests whether a homeopathic remedy called Stibium metallicum praeparatum 6x can prevent or reduce nerve damage caused by the chemotherapy drug paclitaxel. The study will include 120 breast cancer patients who will receive either the remedy or a placebo injectio…

This study tests whether wearing a tight surgical glove on one hand during chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. 44 participants will wear a smaller glove on their dominant hand during each chemo session, while the other hand ser…

This trial investigates whether photobiomodulation (low-level laser light) can reduce early nerve damage caused by chemotherapy. About 98 cancer patients with early signs of peripheral neuropathy will receive either light therapy or a placebo. The goal is to see if this non-invas…

This study tests whether taking a daily capsule of decaffeinated green tea extract can reduce nerve pain in people who have had cancer treatment. The trial enrolls 20 adults with stable pain who are not currently undergoing cancer therapy. Participants receive either the green te…

This study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This trial compares three treatments for idiopathic trigeminal neuralgia, a condition causing severe facial pain. One group gets standard carbamazepine alone, another adds the antiviral acyclovir, and the third adds the anti-inflammatory celecoxib. The goal is to see which combin…

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN). CIPN causes numbness, tingling, pain, and movement problems. The study compa…

This study tests whether a structured program of touch, temperature, vibration, and movement exercises can improve sensation and hand function in people with diabetic peripheral neuropathy. Fifty-nine adults with stable diabetes will be randomly assigned to either the active trai…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This phase 3 trial tests whether a cannabis extract called VER-01 can reduce leg pain in people with chronic nerve root compression (sciatica-like pain) who haven't gotten enough relief from standard painkillers. About 810 participants will receive either VER-01 or a placebo for …

This study tests whether TECAR therapy, a device that uses radiofrequency energy to heat tissues, can reduce pain and improve hand function in people with carpal tunnel syndrome after a burn. Fifty-two adults aged 20 to 40 with mild to moderate carpal tunnel and a history of uppe…

This study tests whether low-energy shockwave therapy can improve facial nerve function in people with chronic Bell's palsy. Forty-two adults aged 45 to 55 will receive the treatment on specific points along the facial nerve. The goal is to reduce facial muscle weakness and impro…

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This study investigates whether matrix rhythm therapy, a device that delivers gentle vibrations to the hand and arm, can reduce symptom severity and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Participants receive either active or sham therapy tw…

This study tests if a combination of manual therapy and nerve stimulation can relieve symptoms of moderate carpal tunnel syndrome as well as surgery recovery does. About 150 adults aged 30-50 with confirmed moderate carpal tunnel will be split into two groups: one gets the non-su…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether a specialized acupuncture technique called 'Three-Needle Dazhui' combined with electroacupuncture can reduce pain and improve daily function better than standard electroacupuncture alone. The trial will involve 74 adults with cervical spondylotic radiculo…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study compares two muscle energy techniques—post-isometric relaxation and reciprocal inhibition—for treating piriformis syndrome, a condition causing buttock pain and limited movement. Researchers will enroll 42 adults aged 25-40 with confirmed piriformis syndrome and modera…

This study looks at whether adding a technique called neural flossing to a standard spinal mobilization can better relieve pain and disability in people with lumbar radiculopathy (a pinched nerve in the lower back causing leg pain). Thirty-six adults aged 30-50 with radiating leg…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study looks at whether a supportive product called Neuridase can help reduce nerve damage (peripheral neuropathy) caused by a combination of two cancer drugs (enfortumab vedotin and pembrolizumab) in people with advanced bladder cancer. About 40 participants will receive sta…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests whether adding low-level laser therapy to a minor bone-poking procedure (micro-osteoperforations) can speed up tooth movement in people with braces. About 33 patients aged 12-30 will have their canine teeth retracted after premolar extraction. The goal is to shor…

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study tests whether a traditional Chinese medicine formula, Wenyang Tongbi Granules, can reduce nerve pain and numbness caused by chemotherapy. 144 adults with breast or colorectal cancer who develop hand-foot tingling or pain during chemo will receive either the herbal gran…

This study compares two injection treatments for chronic nerve pain (neuroma) after combat-related amputation. One uses platelet-rich plasma (PRP) from the patient's own blood, the other uses a standard local anesthetic. About 100 adults with persistent pain will receive an ultra…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…

This study tests whether combining a gentle electrical stimulation of the spinal cord with augmented reality exercises can improve quality of life and physical activity in people with diabetic neuropathy. About 36 adults with nerve pain will receive the treatment and be followed …

This study tests two ways to freeze painful nerve endings (neuromas) in people who lost limbs in combat. One method freezes the nerve right at the painful spot, the other freezes it further up the nerve. The goal is to see which provides better pain relief. Fifty adults with chro…

This study tests whether combining a mild electrical stimulation of the spinal cord (tSCS) with augmented reality (AR) exercises can reduce pain and improve balance in people with diabetic neuropathy. About 36 adults with moderate to severe nerve pain will receive the combined tr…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This early-phase study tests a new tablet, JMKX000189, in 18 adults with cancer who have nerve pain or numbness from chemotherapy. The main goal is to check safety and side effects, while also seeing if the drug can reduce pain and numbness. Participants must have solid tumors an…

This study tests whether a specific type of exercise, called proprioceptive neuromuscular facilitation (PNF), can improve trunk control in ICU patients who have developed muscle weakness. About 58 adults who have been in the ICU for at least 48 hours will be randomly assigned to …

This study tests a 14-day home program called BraW-Day™ that combines brain exercises (like counting backwards) with walking, delivered via a smartphone app. Researchers want to see if doing both tasks together improves thinking, balance, and mood in athletes aged 18-40 who had a…

This study tests a lidocaine spray (APC101) for people with postherpetic neuralgia, a painful nerve condition after shingles. The spray delivers pain relief without touching the sensitive skin. About 333 adults will use the spray or a placebo to see if it reduces pain over 24 hou…

This study will test whether different types of electrical acupuncture can help adults recover from Bell's palsy, a condition that causes sudden facial paralysis. One hundred participants will receive either low-frequency continuous or intermittent electrical pulses over 4 weeks.…

This study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …

This study compares two non-invasive laser treatments—high-intensity and low-level—for people with trigeminal neuralgia, a condition causing severe facial pain. About 38 adults who haven't found relief from medication or can't have surgery will receive one of the two laser therap…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This small pilot study is testing whether a non-invasive device that stimulates the vagus nerve (nVNS) can help people with long-term muscle and joint pain who also have problems with automatic body functions like blood pressure, digestion, and heart rate. Twelve adults with chro…

This study tests an experimental drug called SP-102 for people with moderate to severe sciatica (leg and back pain). About 755 adults will receive a single injection of SP-102, a placebo, or an active comparator. The goal is to see how well SP-102 reduces pain and improves daily …

This study compares a minimally invasive ultrasound-guided injection to standard open surgery for carpal tunnel syndrome. 72 adults who have not improved with conservative treatments will be randomly assigned to receive either the injection or surgery. The main goal is to see if …

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This study will compare two exercise programs—the Otago program and the Beat It program—in 32 people with type 2 diabetes and nerve damage in their feet. The goal is to see which program better improves balance, walking, and quality of life. Participants will do exercises 4 times…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether papaverine, a drug that relaxes blood vessels, can relieve nerve pain and numbness caused by taxane chemotherapy. About 43 adults whose symptoms haven't improved with standard treatments will receive daily infusions of papaverine for up to three weeks. Th…

This study will compare two exercise programs—qigong (a gentle movement practice) and Otago (a standard balance and strength program)—in 44 adults with diabetic neuropathy (nerve damage from diabetes). The goal is to see which one better improves agility, balance, walking, and qu…

This study tests whether a 15-minute hand and foot exercise routine can reduce nerve pain caused by Taxane chemotherapy in cancer patients. Fifty-eight adults with mild nerve symptoms will either do the exercises plus standard care or receive standard care alone. Researchers will…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with Bell's palsy recover facial movement and reduce symptoms like drooping. About 111 adults who have had Bell's palsy for 3 weeks to 6 months will receive either real o…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This study compares two non-invasive nerve stimulation techniques—TENS (electrical pads on the skin) and rTMS (magnetic pulses on the scalp)—for reducing pain and improving function in people with cervical radiculopathy (a pinched nerve in the neck causing arm pain). Fifty adults…

This study tests a new ankle orthosis (brace) in 4 people with chronic ankle injuries or nerve damage that limits ankle movement. Participants will wear the new brace for one month and compare it to their usual brace or no brace. The goal is to see if the new device improves ankl…

This study tests whether a program combining exercise and mindfulness-based therapy can reduce nerve pain and emotional distress in cancer patients who have nerve damage from chemotherapy. About 40 adults with early-stage cancer and chemotherapy-induced peripheral neuropathy will…

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to r…

This study tests whether low-frequency electroacupuncture can reduce pain and numbness in people with diabetic peripheral neuropathy (DPN). 92 adults with DPN will receive either real or sham electroacupuncture for 6 weeks. Researchers will measure nerve function, pain levels, an…

This pilot study will test whether a device that sends magnetic pulses to the arm can reduce pain in people with tennis elbow, golfer's elbow, or carpal tunnel syndrome. About 40 adults will receive either real or fake (sham) stimulation over two days. Researchers will measure pa…

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study tests whether Tecar therapy, a non-invasive device that delivers high-frequency electromagnetic energy to deep tissues, can reduce pain and disability in people with lumbar radiculopathy (sciatica). Ninety adults with recent-onset symptoms will be randomly assigned to …

This study tests whether adding EMG-triggered electrical stimulation to standard physiotherapy can help people regain hand function after median or ulnar nerve repair. The stimulation activates wrist and finger extensor muscles weakened by post-surgery immobilization. Twenty-six …

This study aims to see if a stress management program can help adults with myasthenia gravis feel less anxious and stressed, and improve their quality of life. About 62 participants will take part in an 8-session program and report their symptoms before and after. The goal is to …

This study tests whether standing on a vibrating platform (whole body vibration) for 15 minutes, three times a week for eight weeks, can improve balance, reduce fear of falling, and enhance quality of life in people with nerve damage from chemotherapy. Thirty adults aged 30-60 wi…

This study looks at whether ziconotide, a drug given through a pump in the spine, can reduce nerve pain caused by chemotherapy. Researchers will track pain levels and daily function in 24 adults over 24 months. The goal is to see if this already-approved pain treatment can help p…

This study will compare three different injections—glucocorticoid, ozone, and 5% dextrose—to see which provides the best pain relief for people with mild to moderate carpal tunnel syndrome. Researchers will enroll 105 adults aged 18 to 65 who have not responded to conservative tr…

This study looks at whether different doses of steroid injections work equally well for treating sciatica (nerve pain in the lower back and leg). About 150 adults with MRI-confirmed lumbar radiculopathy who have not had back surgery will receive one of several doses of either tri…

This trial compares surgery to physiotherapy for people with persistent median nerve compression in the upper arm. 160 adults will be randomly assigned to either a nerve release operation or guided stretching exercises. The main goal is to see which treatment leads to better symp…

This study tests whether hyaluronic acid injections work as well as standard steroid shots for mild to moderate carpal tunnel syndrome. Sixty adults will receive one type of injection under ultrasound guidance, and researchers will track symptom changes and nerve function for thr…

This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…

This study compares three different wrist splint positions (flexed, neutral, and extended) worn at night for eight weeks in 108 adults with mild to moderate carpal tunnel syndrome. All participants also receive education and exercises. The goal is to see which position best reduc…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study will test whether a gentle nerve-sliding technique can reduce pain, improve function, and help balance in people with chronic leg pain from a pinched nerve in the lower back (lumbar radiculopathy). Twenty-eight adults with symptoms lasting 3 to 18 months will receive e…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. 126 participants will either get real electroacupuncture or a sham version, while continuing …

This study tests whether low-frequency magnetic field therapy (magnetotherapy) can reduce pain and improve function in people with mild-to-moderate carpal tunnel syndrome. Sixty adults will be randomly assigned to receive either active magnetotherapy, a placebo device, or standar…

This study tests whether adding nerve gliding exercises to standard rehab can reduce pain and improve neck movement, grip strength, and quality of life in people with cervical radiculopathy (a pinched nerve in the neck). The trial plans to enroll 28 adults with disc bulges at spe…

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing drug (bupivacaine) can provide longer pain relief after thoracoscopic thymectomy in people with myasthenia gravis. Sixty patients will be randomly assigned to one of three groups. The main goal…

This study tests whether a dietary supplement called Cronilief (palmitoylethanolamide) can reduce nerve pain in people with diabetes when added to their usual treatment. Seventy adults with moderate nerve pain will take either the supplement or a placebo for 8 weeks. The goal is …

This study tests whether a continuous nerve block placed by the surgeon during back surgery can reduce pain and the need for opioids afterward. One hundred adults having lumbar spine surgery will be randomly assigned to receive either the nerve block with a numbing medicine or a …

This study tests whether hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will…

This study looks at whether laser acupuncture can help reduce carpal tunnel syndrome symptoms in breast cancer patients who take aromatase inhibitors. Fifty-four women aged 40-60 will be split into two groups: one gets laser acupuncture plus standard physical therapy, the other g…

This study tests if taking fish oil by mouth can prevent or lessen nerve damage (peripheral neuropathy) caused by the chemotherapy drug bortezomib in people with multiple myeloma. Researchers will compare nerve health in 200 patients who take fish oil versus those who don't. The …

This study looks at people with a single herniated disc in the lower back who are getting laser disc surgery. Some will also receive a steroid injection during the same procedure. Researchers will track pain, daily function, and need for more treatments to see if the extra inject…

This study looks at whether exercise can lessen nerve damage caused by certain chemotherapy drugs. About 140 people with colorectal or gynecologic cancer will either exercise or receive usual care. Researchers will measure nerve function, blood markers, and quality of life to see…

This study compares two non-invasive treatments—high-power laser and pulsed electromagnetic therapy—for reducing pain and improving nerve function in people with lumbar radiculopathy (sciatica from a herniated disc). Sixty participants aged 55-68 will receive one of the therapies…

This study tests whether acupressure—a non-invasive therapy using finger pressure on specific body points—can reduce nerve pain, improve balance confidence, and lessen fear of falling in adults aged 65+ with painful diabetic peripheral neuropathy. 76 participants will be randomly…

This study tests whether 4-aminopyridine, a drug already approved for other nerve conditions, can improve symptoms of carpal tunnel syndrome or delay the need for surgery. Researchers will give 160 adults either the drug or a placebo for 6 weeks and track symptom changes using ha…

This study will test whether applying neck traction at different angles, combined with gentle nerve mobilization exercises, can reduce pain and improve function in people with cervical radiculopathy (a pinched nerve in the neck). Forty-five adults aged 30 to 45 with confirmed ner…

This study tests if a special balance training program can help cancer patients who have numbness, tingling, and walking problems caused by chemotherapy. 70 adults aged 30-60 with breast, rectal, or stomach cancer will be randomly assigned to either standard physical therapy or s…

This study tests whether high-power laser therapy can reduce itching, pain, and improve quality of life in people with notalgia paresthetica, a chronic nerve condition. Forty adults will be randomly assigned to receive either real laser or sham treatment over four weeks. The goal…

This study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…

This study tests whether a non-invasive brain stimulation device can reduce the persistent nerve pain that sometimes follows a shingles infection. Researchers will compare real stimulation to a sham (fake) procedure in 94 adults who have had pain for at least 3 months. Participan…

This study looks at whether adding special hand exercises (nerve gliding or bone mobilization) to a standard wrist splint helps people with mild-to-moderate carpal tunnel syndrome more than using the splint alone. About 93 adults will be assigned to one of three groups and treate…

This study looks at whether leaving out bicarbonate from the numbing medicine (lidocaine with adrenaline) affects how well people recover the day after hand or foot surgery. About 150 adults having common procedures like carpal tunnel release or bunion surgery will be randomly as…

This study looks at whether taking magnesium by mouth or soaking feet in a magnesium solution can help colorectal cancer patients who are on chemotherapy. The goal is to see if these simple treatments can reduce nerve damage (pain, tingling) and improve sleep quality. About 75 ad…

This study tests whether dexamethasone palmitate, a steroid, can better relieve shingles pain and prevent long-term nerve pain compared to standard care. About 954 adults with shingles rash and severe pain will receive the drug by injection or infusion. Researchers will track pai…

This study looks at whether combining kinesio tape with specific neck exercises can improve how well people with cervical radiculopathy sense their neck position, and whether it also reduces pain and improves function. Sixty adults aged 35-50 with chronic neck pain and nerve symp…

This study tests whether a special type of horseback physiotherapy can improve movement, posture, breathing, and quality of life in children with spinal muscular atrophy (SMA). Twenty children aged 2 to 9 years will receive both the horse therapy and standard physiotherapy in ran…

This study tests whether a non-invasive magnetic stimulation device (rPMS) can reduce pain and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Forty participants will receive either real or sham stimulation plus standard exercises over two weeks. Res…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests if a gentle, non-invasive electrical stimulation on specific acupoints can reduce nerve pain caused by chemotherapy in children aged 10-17 with acute lymphoblastic leukemia. The treatment is given for 8 weeks, and researchers will check if it helps with pain, mov…

This study compares an 8-week versus a 12-week supervised exercise programme in 50 colorectal cancer patients receiving chemotherapy. The goal is to see if exercise can reduce chemotherapy-induced peripheral neuropathy—nerve damage causing tingling, numbness, and pain—and improve…

This early study tests a brain stimulation device for people with long-term nerve pain that hasn't responded to other treatments. The device is surgically placed to send mild electrical pulses to specific brain areas. The main goal is to see if the procedure is feasible and accep…

This study tests two types of pulsed radiofrequency treatments for people with severe trigeminal neuralgia, a condition causing intense facial pain. 62 adults who haven't found relief from medication will receive either a standard or a new irregular-pulse technique. The goal is t…

This study tests an injectable supplement that combines B vitamins with an energy molecule (ATP) to treat painful diabetic nerve damage. Two hundred adults with diabetes and nerve pain will receive either the ATP-enhanced shot or a standard B vitamin shot for 12 weeks. Researcher…

This study tests whether TECAR therapy, a deep heat treatment using radiofrequency, can improve proprioception (body awareness) in people with cervical radiculopathy. Eighty adults aged 30-40 with confirmed nerve root compression will be randomly assigned to real or sham TECAR. T…

This study compares two types of exercise programs—Modified Otago Exercises and Dynamic Neuromuscular Stabilization Exercises—to see which better improves balance and daily living activities in older adults with diabetic peripheral neuropathy. The trial will involve 36 participan…

This study looks at whether doing foot and ankle exercises at home can help people with diabetic nerve pain feel better. The exercises are done twice a day, three days a week, for eight weeks. Researchers will measure pain, sleep quality, and depression in 70 adults with diabetic…

This study tests whether injecting a larger or smaller amount of fluid around the median nerve in the wrist better relieves pain from carpal tunnel syndrome. 35 adults with mild to moderate carpal tunnel will receive either 8 ml or 3 ml of dextrose, or a steroid injection. The go…

This study tests whether gentle electrical stimulation on acupoints or acupressure on the ear can reduce nerve pain caused by chemotherapy in children with leukemia. 132 children aged 8-17 will be randomly assigned to one of three groups: electrical stimulation, acupressure, or s…

This study compares two minimally invasive treatments for carpal tunnel syndrome: pulsed radiofrequency (using heat pulses) and hyaluronidase hydrodissection (injecting a fluid to free the nerve). About 56 adults with mild to moderate carpal tunnel will be randomly assigned to on…

This study tests whether aromatherapy foot massage can reduce neuropathic pain in people with type 2 diabetes. 78 participants will massage their feet for 10 minutes, three times a week for 4 weeks. Researchers will compare the effects of an aromatherapy oil versus a plain oil to…

This study compares two non-drug treatments—light therapy (photobiomodulation) and electrical stimulation—to see which better helps people with Bell's palsy regain facial movement. About 34 adults with moderate to severe facial weakness will receive one of the treatments along wi…

This study tests whether doing exercises in a heated pool (hydrotherapy) can reduce pain, improve balance, and boost quality of life for people with diabetic peripheral neuropathy. Thirty-four adults with type 2 diabetes and nerve damage will be randomly assigned to either hydrot…

This study tests whether dipping the hand and forearm in warm paraffin wax for 20 minutes can immediately reduce muscle stiffness and pain in people with carpal tunnel syndrome. Twenty-four adults with the condition will be randomly assigned to either the wax treatment or rest. R…

This study tests whether doctors can safely perform ultrasound-guided pain procedures, like nerve blocks, at home for patients with chronic or cancer pain. It includes 100 adults already receiving home hospital care. The goal is to see if this approach reduces pain, cuts down on …

This study tests whether a simple breathing exercise, called inspiratory muscle training, can improve the body's stress response and reduce symptoms like pain, fatigue, and sleep problems in women with fibromyalgia. Fifty-one women will be randomly assigned to real training, a sh…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study looks at whether a single 20-minute warm whirlpool bath can quickly reduce muscle stiffness and pain in the forearm and hand for people with carpal tunnel syndrome. About 24 adults with the condition will either take the bath or rest. Researchers will measure muscle st…

This phase 2 trial tests whether low sodium oxybate (Xywav) can reduce nighttime cluster headache attacks in people with chronic cluster headache. About 52 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug lowers the number o…

This study tests a minimally invasive procedure to release a trapped median nerve at the elbow (lacertus syndrome) using ultrasound guidance. Instead of a large cut, doctors make a tiny incision and cut the tight band pressing on the nerve. The goal is to reduce pain, improve han…

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study tests whether a gentle, hands-on movement technique applied to the non-painful side can reduce pain and disability in people with cervical radiculopathy (nerve pain in the neck and arm). It includes 40 adults who will receive a single session of this technique. The goa…

This study tests whether taking N-acetylcysteine (NAC), a common supplement, before and after hand or foot surgery can reduce pain and the need for opioid painkillers. About 80 adults will be randomly assigned to take NAC or a placebo for 14 days. Researchers will track pain, fun…

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

This study will test three approaches to reduce painful nerve damage in people with type 2 diabetes. Sixty adults aged 35-85 with moderate to severe neuropathy will receive either a special massage-like therapy (INF), a diet guided by a food sensitivity test (NVIf), or both toget…

This study compares two types of pulsed radiofrequency treatments for postherpetic neuralgia, the long-lasting nerve pain that can follow a shingles infection. One hundred adults whose pain has not responded to standard care will receive either the regular or a new 'STP' irregula…

This study tests whether a 12-week exercise program that works the trunk, hips, knees, and ankles can reduce symptoms and improve quality of life in people with diabetic peripheral neuropathy. Sixty-four adults with type 2 diabetes and nerve damage will be randomly assigned to ei…

This study tests whether carpal tunnel release surgery actually works better than a placebo surgery for carpal tunnel syndrome. 96 adults with confirmed CTS will be randomly assigned to real surgery or a sham procedure, and neither they nor their doctors will know which they rece…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This study tests whether using an immersive virtual reality headset during physical therapy can improve satisfaction and recovery for patients in the intensive care unit. Ninety adult ICU patients will be randomly assigned to either traditional rehab or rehab with VR. The goal is…

This Phase 2 trial tests an experimental oral drug called HL-1186 for diabetic peripheral neuropathic pain—a common, painful nerve condition caused by diabetes. About 180 adults with type 1 or type 2 diabetes will receive either HL-1186 or a placebo for 12 weeks. The main goal is…

This study tests a home-based tele-rehabilitation program for people who have thinking and movement problems after chemotherapy. Sixty adults who finished chemo will be split into two groups: one gets 15 sessions of personalized cognitive and motor exercises via a tablet and remo…

This study tests whether acupuncture can safely reduce arm pain caused by cervical spondylotic radiculopathy, a condition where a nerve in the neck is compressed. Researchers will compare real acupuncture to a sham version in 168 adults over 6 weeks, then follow them for 6 months…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study investigates sexual and urinary problems in people with generalized myasthenia gravis, an autoimmune disease that causes muscle weakness. While visible symptoms like droopy eyelids are well-known, issues like sexual dysfunction and bladder problems are often ignored. R…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study will observe 30 children with type I or type II spinal muscle atrophy who are taking risdiplam. Researchers will track motor function improvements over 24 months using standard tests. The goal is to see how well the drug works in everyday medical practice.

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This study looks at whether a painless ultrasound scan of the sciatic nerve and a blood test for a specific protein can help detect diabetic peripheral neuropathy (nerve damage) earlier than current methods. Researchers will measure nerve size and blood flow in 120 people with ty…

This study looks at 70 adults with sensory neuronopathy, a rare nerve condition that causes balance and coordination problems. Researchers will test several clinical scales over 12 months to see which one best tracks how the disease changes over time. The goal is to find a reliab…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study is a registry that will collect health information from 1,000 people who carry the gene for hereditary amyloidosis, including those with and without symptoms. Researchers will track who develops the disease and how it progresses, including the need for heart transplant…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study follows 150 adults who had a traumatic arm or leg amputation to see if a stump infection increases the risk of long-term pain. Researchers will check pain levels at 3 and 6 months after surgery. The goal is to understand if preventing infections could reduce chronic pa…

This study will interview 15 parents or guardians of children with spinal muscular atrophy type 1 to learn about their daily challenges with feeding and communication. Even though newer treatments have improved survival, their impact on swallowing and speech is not well understoo…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study will use wearable activity trackers to measure how much people with Charcot-Marie-Tooth disease type 1A (CMT1A) move at home. Researchers want to see if sensor data matches standard clinical tests. The goal is to improve patient follow-up and support future trials of n…

This study looks at 300 adults with a brain bleed from a ruptured aneurysm. It tests a non-invasive headband to monitor brain blood flow and two nerve treatments (a neck injection and ear stimulation) to see if they improve brain function. The goal is to find better ways to preve…

This study looks at whether the way health information is presented can help people with diabetes better understand their risk of developing foot ulcers. Researchers will compare two types of messages—one focusing on the benefits of good foot care, the other on the risks of negle…

This study will check if an artificial intelligence (AI) system can accurately measure facial paralysis in people with Bell's palsy. Currently, doctors use subjective scales that can vary between observers. The AI analyzes facial movements using a camera and compares its scores t…

This observational study will follow 40 adults with thymic abnormalities or myasthenia gravis (MG)-related antibodies to better understand how the disease develops and progresses. Researchers will analyze blood, thymus tissue, and muscle samples, along with clinical assessments, …

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year, using surveys and a pressure gauge. The goal is to build an AI system that can predict who is at risk for long-term pain,…

This study looks at how inflammation in the nervous system affects pain and recovery after elbow fractures or dislocations. Researchers will take blood samples from 60 adults before and after surgery to measure specific inflammatory markers. The goal is to better understand why s…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at bone health in children with spinal muscular atrophy (SMA), a condition that causes muscle weakness. Researchers want to find out how common fractures are and whether newer SMA treatments affect bone strength. They will review medical records from about 550 ch…

This study will test a wearable device called Syde® in 30 people with progressive supranuclear palsy (PSP-R). The device tracks movement and activity during daily life. Researchers want to see if patients find it easy to use and if the data matches standard clinic tests. The goal…

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study aims to find blood markers that can predict which cancer patients will develop chronic nerve pain from chemotherapy. Researchers will collect blood samples and perform neurological exams on 192 patients over 6 months. The goal is to use this information to personalize …

This study follows 60 adults with hand or upper limb injuries to see if improvements in the first weeks of rehab can predict function months later. A digital tool created by a therapist tracks progress and patient feedback. The goal is to help clinicians make better, data-driven …

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This observational study looks at 85 adults with Bell's palsy to see if worse facial muscle function is linked to higher anxiety, depression, and lower self-esteem. Researchers will measure facial movement and muscle activity, then compare those results with participants' answers…

This study will test whether a 12-week progressive resistance training program can improve brain health in people with relapsing-remitting multiple sclerosis. Researchers will measure brain volume and a nerve damage marker in the blood. The trial involves 26 participants and aims…

This study will analyze blood samples from 90 people — 30 healthy, 30 with diabetes but no nerve issues, and 30 with diabetic peripheral neuropathy (nerve damage causing pain). Researchers will look for unique molecules in the blood that could serve as early warning signs. The go…

This study uses ultrasound to measure the size and blood flow of the median nerve in people with carpal tunnel syndrome. Researchers will compare findings between diabetic and non-diabetic patients to see if diabetes affects nerve changes. The goal is to better understand the con…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This study will compare two methods for locating the ulnar nerve in the wrist: using ultrasound imaging versus measuring physical landmarks. Researchers will enroll 40 healthy adults to see which technique is more reliable for placing stimulating electrodes. The goal is to improv…

This study will enroll 200 patients scheduled for surgery to remove rare adrenal tumors called pheochromocytomas or paragangliomas (PPGL). Before surgery, researchers will use a model to predict the risk of severe blood pressure swings during the operation. During surgery, a real…

This study looks at how diabetic polyneuropathy (nerve damage from diabetes) changes responses to common dental pulp tests like electric and cold stimuli. Researchers will compare people with mild neuropathy, severe neuropathy, and healthy controls to see if nerve damage leads to…

This study will follow 120 adults receiving a steroid injection for lower back and leg pain caused by a slipped disc. Researchers want to see how factors like anxiety, pain during the procedure, and sedation affect how satisfied patients feel one hour after the injection. The goa…

This study will interview 30 children aged 6-17 who are undergoing chemotherapy for cancer, along with their parents, to understand how they deal with changes in taste, smell, and food texture. The goal is to learn what coping strategies families use at home and in the hospital t…

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are …

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This observational study will follow 3000 adults having oral surgery to see how often complications like infections or nerve damage occur. Researchers will collect patient and surgery details, plus surgeon predictions, to build an AI tool that might one day help prevent these pro…

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study looks at two ways to help people with Charcot-Marie-Tooth disease (CMT) walk better. One group gets foot surgery followed by rehabilitation, the other gets only physical therapy. Researchers will track walking speed and endurance for up to two years to see which approa…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This pilot study looks at fatigue in people with Charcot-Marie-Tooth type 1A (CMT1A), a nerve disorder affecting arms and legs. Researchers will compare 22 patients with 22 healthy volunteers to measure how fatigue affects walking and balance. They use tests like muscle strength …

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study watches 15 adults with severe cancer pain who are getting a procedure called cordotomy to block pain signals. Researchers will use MRI scans to check for swelling in the spinal cord right after and one month later. The goal is to see if swelling relates to how well the…

This study will check if doing a heart procedure through the wrist artery can hurt nearby nerves. About 100 adults will get nerve tests before and after the procedure. The goal is to find out how often nerve injury happens and how serious it is.

This study tests a new type of nerve block catheter designed to stay in place better than current ones. Researchers will place the catheter near a nerve in the leg a few days before a scheduled amputation and check if it moves. The study involves 15 adults and aims to see if the …

This observational study will test whether computer analysis of voice recordings can detect a deep type of exhaustion called central fatigue in people with generalised myasthenia gravis. 240 adults in the US and UK will record themselves speaking twice daily, twice a week for 4 w…

This study looks at how chemotherapy for breast cancer affects the sense of arm position (proprioception). Researchers will compare three groups: breast cancer patients who had chemotherapy, those who had surgery only, and healthy volunteers. Using robotic tasks and video trackin…

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Pa…

This study creates a large international database to monitor how well spinal cord stimulation and similar nerve therapies work for people with chronic nerve pain. Researchers will collect real-world data from 1,000 patients across multiple countries to track safety, quality of li…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study looks at how Gamma Knife radiosurgery affects brain connections in people with severe facial pain called trigeminal neuralgia. About 28 adults will get brain scans before treatment and at 1, 3, and 12 months after. The goal is to see if changes in brain wiring match pa…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study looks at how two types of peripheral neuropathy—hereditary and inflammatory—affect daily life and well-being. Researchers will ask 60 adults to fill out questionnaires about their functioning, independence, and quality of life. No treatments are given; the goal is to b…

This study will analyze blood samples from 24 adults with generalized myasthenia gravis who are being treated with ravulizumab. Researchers will look for changes in thousands of proteins over 26 weeks to find markers that show how well the treatment is working and whether the ner…

This study looks at how neck pain and muscle strength relate to walking symmetry in 61 adults aged 40-50 with cervical radiculopathy (a pinched nerve in the neck). Researchers will measure pain, disability, muscle strength, and walking patterns using special mats and devices. The…

This study explores whether a smartphone app called MyoSense 360 can help track changes in generalized Myasthenia Gravis (gMG) symptoms over 12 months. About 100 adults with gMG will use the app at home to collect data. The goal is to see if the app can detect when symptoms get b…

This study looks at how neck muscle endurance relates to the ability to sense head position in people with cervical radiculopathy (a pinched nerve in the neck causing pain and arm symptoms). Researchers will test 80 adults aged 20-60 using a device to measure neck movement accura…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This study will assess physical function in 80 people with chemotherapy-induced peripheral neuropathy (CIPN) using tests like balance, walking, and grip strength. Researchers will compare these objective measures with patients' own symptom reports to develop better ways to track …

This study looks at whether a protein called neurofilament light chain (NfL) in the blood can help measure brain injury in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by lack of oxygen at birth. Researchers will measure NfL levels at several time point…

This study tests how stimulating the vagus nerve at different frequencies affects heart rate, blood pressure, and breathing in 36 healthy adults. Participants will receive five different stimulation frequencies (including a sham) in random order. The goal is to find which frequen…

This study will check how well standard X-rays and MRIs can spot common spinal bone variations (transitional vertebrae) and correctly identify the disc that is causing pain. Researchers will look at scans from 250 adults with back and leg pain to see if routine imaging alone is a…

This study looks at 700 adults with trigeminal neuralgia who had a balloon compression procedure to relieve facial pain. Researchers will use machine learning to analyze past patient data and create a model that predicts if pain will come back. The goal is to identify key factors…

This study looks at how forward head posture relates to trunk muscle strength and body awareness in people with cervical radiculopathy—a condition where a pinched nerve in the neck causes pain that travels down the arm. Researchers will measure head angle, trunk strength, and bal…

This study will measure vitamin D and nerve growth factor levels in 57 men with type 2 diabetes and nerve damage, comparing them to diabetic men without nerve damage and healthy men. Researchers will also test nerve function using electrical studies. The goal is to see if low vit…

This study tests whether wearable sensors and smartphone apps can accurately track symptoms of generalized myasthenia gravis (gMG) in 25 people starting treatment with VYVGART. Participants wear sensors to measure activity, speech, and fatigue over 16 weeks. The goal is to see if…

This study explores whether wearable sensors can effectively monitor symptoms of myasthenia gravis, a condition causing muscle weakness. Fifty adults will wear devices that track physical activity, speech, and other health signals over 12 months. The goal is to see if these digit…

This study looks at people who had surgery for a severe facial pain condition called trigeminal neuralgia. Researchers want to know if dental treatments or other mouth stimulation after surgery can make the pain come back. About 100 participants will answer surveys about their pa…

This study looks at how parents feel after their newborn is screened for spinal muscular atrophy (SMA). Researchers will interview 36 parents in two French regions to understand their anxiety, stress, and support needs. The goal is to improve how screening results are shared and …

This study will look at medical and lab factors that influence how children with Guillain-Barré syndrome recover. Researchers will follow 80 children to see which ones fully recover within 3 months. The goal is to create better ways to predict outcomes and guide treatment.

This study aims to find biological markers in blood and urine that could explain congenital central hypoventilation syndrome (CCHS), a rare disorder where the brain fails to control breathing during sleep. Researchers will collect samples from 40 adults with CCHS and healthy volu…

This study will follow 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will use questionnaires and exams before treatment and one year later. The goal is to better understand these side effects in…

This study will compare two surgical techniques for treating pain after a finger amputation: reconnecting the nerve (microanastomosis) versus cutting and burying it (traction neurectomy). Researchers will track pain levels and hand function in 50 adults over six months. The goal …

This study looks back at medical records of 150 children who had surgery for neuroblastic tumors in the lower chest. Some had a special X-ray (arteriography) before surgery to map a key spinal artery, while others did not. Researchers want to see if the imaging helps prevent spin…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…

This pilot study will test whether combining movement imagery techniques (like watching or imagining movements) with nerve stretching exercises can improve how the median nerve responds to pressure and stretch. Ten healthy volunteers will receive both the combined treatment and n…

This study will follow 460 diabetes patients who take semaglutide to see if those with nerve damage (neuropathy) are more likely to develop stomach retention, where food stays in the stomach too long. Participants will have a stomach exam to check for retained food or liquid. The…