New Gel-Like wrap could stop chronic pain after cancer reconstruction

NCT ID NCT07558096

Not yet recruiting Prevention Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if the matrix reduces neuropathic pain six months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Avive+ soft tissue matrix
What this could lead to: If it works, this could offer a simple way to prevent long-term nerve pain and numbness after reconstructive surgery for head and neck cancer.
What could go wrong: This is a small pilot study (80 people) that hasn't started yet. The matrix may not reduce pain better than standard closure, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER (H&N)

Contacts and locations

Locations

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

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