Radiculopathy

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This study tests a new device called CORUS-LX for spinal fusion surgery in people with degenerative disc disease in the lower back. About 250 adults will either get the new device or standard surgery. The goal is to see if the device helps bones fuse better and reduces the need f…

This study is collecting real-world data on the Synergy Disc, an artificial disc implant for people with degenerative cervical disc disease. Researchers will follow 200 patients who have already received or will receive the implant, measuring pain and disability improvements over…

This trial tests a structured rehabilitation pathway for people having lumbar surgery for radicular pain (nerve-related back and leg pain). The pathway includes pre-surgery exercise, early movement after surgery, and active guidance to return to work. 480 participants across mult…

This study compares a new nerve monitoring device, NeuroVision®, to standard hospital monitoring during spine surgery. The goal is to see if NeuroVision® reduces the chance of nerve injury. About 148 adults having lateral spine surgery will be randomly assigned to one of the two …

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study tests whether adding a preventive procedure (bilateral foraminotomy) during standard neck decompression surgery can lower the risk of C5 palsy, a rare complication that causes arm weakness and pain. About 480 adults with cervical myelopathy (spinal cord compression) wi…

This study is following 50 people who have or will receive the Synergy Disc, an artificial disc for the neck, to treat pain from degenerative disc disease. Researchers are measuring pain levels and neck function over 12 months, and checking for any device-related problems. The go…

This study tests how well the straight leg raise test—a simple physical exam—can diagnose nerve-related leg pain caused by a slipped disc. Researchers compare the test's results to those from a diagnostic nerve block injection in 88 adults aged 18 to 65. If the leg raise test pro…

This study tests whether a special type of MRI called MR neurography can better detect pinched nerves in the neck (cervical radiculopathy) compared to standard tests. Researchers will enroll 20 adults with recent symptoms and compare imaging results with nerve tests and physical …

About 30% of people who have surgery for a herniated disc still suffer from nerve pain afterward. This study tests whether applying a gel made from the patient's own blood (platelet-rich fibrin) around the nerve during surgery can prevent that chronic pain. The trial will enroll …

This trial tests whether high-frequency electroacupuncture at specific neck points, combined with pulsed electromagnetic field therapy, can reduce pain and improve neck function better than standard electroacupuncture plus the same magnetic therapy. The study includes 104 adults …

This trial tests two hands-on therapy techniques—Mulligan Bent Leg Raise and spinal mobilization with leg movement—to see which better reduces pain, improves nerve mobility, balance, and daily function in people with lumbar radiculopathy (a pinched nerve in the lower back causing…

This trial compares two stretching techniques—myokinetic stretching and post facilitation stretching—for people with cervical radicular pain, a condition where neck pain shoots down the arm due to nerve irritation. About 40 adults aged 30 to 60 with radiating arm pain for over fo…

This trial tests whether three types of nerve-gliding exercises — called neurodynamics — can improve hamstring strength and endurance in athletes aged 18 to 30 who play organized sports or train regularly. The exercises aim to improve nerve mobility and reduce pain, and the study…

This study tests whether a specialized acupuncture technique called 'Three-Needle Dazhui' combined with electroacupuncture can reduce pain and improve daily function better than standard electroacupuncture alone. The trial will involve 74 adults with cervical spondylotic radiculo…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This study investigates whether high-power laser therapy can reduce pain, improve nerve signals, and restore daily function in people with cervical radiculopathy—a condition where a nerve in the neck is compressed. Sixty adults aged 40 to 60 with confirmed nerve compression will …

This study compares two treatments for chronic low back and leg pain caused by a herniated disc: high-intensity laser therapy and a steroid injection into the spine. About 24 adults aged 18 to 65 with pain lasting over three months will be randomly assigned to one of the two trea…

This study investigates whether wearing a virtual reality headset during epidural injections can lower pain and anxiety in people with nerve root pain (radiculopathy). Participants receive two injections, each with the headset, and researchers measure anxiety levels and pain scor…

This study tests whether describing a common pain shot (epidural steroid injection) in a very positive way helps reduce leg pain more than a neutral description. Researchers will compare three groups: positive framing of the shot, neutral framing of the shot, and neutral framing …

This study tests a special exercise program (neuromuscular re-education) against standard therapy for people with cervical radiculopathy, a condition causing neck pain, numbness, and weakness in one arm. Researchers will measure pain, neck movement, and daily function in 52 adult…

This trial tests if using ultrasound to guide a nerve root injection works as well as the standard X-ray method for treating lower back and leg pain from irritated nerves. Sixty-four adults aged 18 to 75 will receive one injection of steroid and numbing medicine, then be followed…

This study tests whether a hands-on technique that releases the diaphragm can reduce neck pain and improve movement in people with cervical radiculopathy (a pinched nerve in the neck). Forty adults with neck pain for at least two months will receive either standard physical thera…

This study compares a targeted nerve block injection to usual pain treatment for people with sudden sciatica in the emergency department. About 100 adults will be randomly assigned to receive either the nerve block or standard care. Researchers will measure pain levels and walkin…

This study tests a non-invasive treatment called ultrasound-guided transcutaneous pulsed radiofrequency (TCPRF) for people with cervical radiculopathy, a condition causing neck, shoulder, and arm pain. Thirty-two adults with symptoms lasting over six weeks will receive either TCP…

This study tests whether adding mechanical lumbar traction to a specific spinal mobilization technique (SMWLM) provides better pain relief and function than the mobilization alone for people with lumbar radiculopathy (sciatica). Thirty-two adults with a confirmed disc bulge will …

This study tests whether an intensive five-day neck traction program reduces pain and disability from cervical radiculopathy (a pinched nerve in the neck) better than a placebo traction. 206 adults with the condition will be randomly assigned to real or placebo traction. The goal…

This study looks at whether adding a short course of dexamethasone (a steroid) to standard ibuprofen treatment can improve pain and disability in people with acute radicular low back pain (pain that shoots from the back down the leg). About 132 adults visiting the emergency depar…

This study looks at whether adding an eight-week home exercise program after a steroid injection helps people with long-term neck and arm pain more than the injection alone. About 60 adults with chronic cervical radiculopathy will be randomly assigned to one of two groups. The go…

This early-stage study tests a single injection of C-1101 into the spine area for people with long-term sciatica (leg pain from a pinched nerve). The main goal is to check if the treatment is safe and tolerable compared to a saltwater placebo. Only 24 adults with pain that hasn't…

This study tests whether a specific type of gentle neck movement (Mulligan mobilization) combined with stretching can reduce pain and disability in people with cervical radiculopathy — a condition where a pinched nerve in the neck causes pain, numbness, or weakness down the arm. …

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study looks at whether using a nerve stimulator in short bursts (30 seconds on, 90 seconds off) can provide the same or better pain relief as continuous stimulation. It involves 30 adults who have had a dorsal root ganglion stimulator for at least a year and report at least …

This study compares two physical therapy techniques—ELDOA (a sustained stretching method) and Spinal Mobilization with Limb Movement (SMWLM)—for treating lumbar radiculopathy, commonly known as sciatica. Thirty-six adults aged 30-50 with mild disc herniation will receive one of t…

This study looks at whether a steroid injection into the spine can improve how well people with chronic neck pain sense their arm movements. Researchers will give the injection to 46 adults with a pinched nerve in the neck and measure arm position accuracy before and after. The g…

This study tests a remote program called Move-MORE for people with sciatica (nerve pain from the lower back into the leg). The program combines mindfulness, gentle movement, and motivational coaching to help manage pain and improve daily function. Researchers will enroll 32 adult…

This study tests whether focused shock wave therapy can reduce pain and improve nerve function in people with cervical radiculopathy (pinched nerve in the neck). Eighty adults aged 36 to 46 with confirmed disc problems and active trigger points will receive either real or sham sh…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study looks at whether people who use AI symptom-checking tools (like ChatGPT) before a spine physical therapy appointment have different experiences than those who don't. Researchers will compare shared decision-making, how soon patients seek care, and whether their expecte…

This study examines whether three specific signs seen on CT scans — nerve-root swelling, tissue infiltration around the nerve, and increased density of the nerve — can identify the exact nerve root causing sciatica. Researchers reviewed planning CT scans from 400 adults with low-…

This study looks at how well people with cervical radiculopathy (a pinched nerve in the neck) can sense where their arm is in space. Researchers will compare 58 patients to healthy volunteers using a reaching test on a wall chart. The goal is to see if nerve compression affects a…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…