Radiculopathy
MONDO:0002959Disease involving a spinal nerve root (see spinal nerve roots) which may result from compression related to intervertebral disk displacement; spinal cord injuries; spinal diseases; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
Also known as: nerve root disorder
120 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Neck injection offers hope for chronic pinched nerve pain
Symptom relief CompletedThis study looked at whether a steroid injection in the neck (called cervical interlaminar epidural steroid injection) can reduce pain and disability in people with a pinched nerve in the neck (cervical radiculopathy). 98 adults with neck and arm pain that did not improve with ot…
Phase: NA • Sponsor: Saglik Bilimleri Universitesi • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Tiny camera surgery may beat standard back procedure for faster pain relief
Symptom relief CompletedThis completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…
Phase: NA • Sponsor: University of Opole • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Simple stretching technique may ease pain from pinched neck nerve
Symptom relief CompletedThis study tested whether adding a gentle nerve-stretching technique called neurodynamic mobilization to standard physical therapy helps people with cervical radiculopathy—a pinched nerve in the neck causing arm pain and weakness. Fifty adults received either standard therapy alo…
Phase: NA • Sponsor: Lebanese German University • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Neck pain relief: which exercise works better?
Symptom relief CompletedThis study compared two physical therapy approaches—McKenzie exercises and neural flossing—in 28 adults aged 25 to 60 with acute cervical radiculopathy (neck pain that travels down the arm). The goal was to see which method better reduces pain and improves daily function. Results…
Phase: NA • Sponsor: Elite College of Management Sciences, Gujranwala, Pakistan • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Core workouts may ease neck pain and improve posture
Symptom relief CompletedThis study tested whether adding core stabilization exercises to standard physical therapy helps people with cervical radiculopathy (a pinched nerve in the neck). Forty adults with neck pain and forward head posture were split into two groups: one received only standard therapy (…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Can gabapentin ease acute sciatica better than a sugar pill?
Symptom relief CompletedThis study tested whether gabapentin, a nerve pain medication, provides better short-term pain relief than a placebo for people hospitalized with acute sciatica caused by a herniated disc. 144 adults received either gabapentin or placebo on top of their usual pain treatment for t…
Phase: PHASE4 • Sponsor: Lille Catholic University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Back pain breakthrough? steroid shots may offer relief without surgery
Symptom relief CompletedThis study looked at whether steroid injections into the spine can reduce pain and improve daily function in people with lower back and leg pain from a herniated disc. 221 adults who had not improved with other treatments received the injections and were followed for three months…
Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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Stretching or nerve gliding: which eases sciatica pain better?
Symptom relief CompletedThis study tested two exercise techniques—dynamic stretching and nerve gliding—in 72 adults with lumbar radiculopathy (nerve-related back pain). Both groups also received standard physiotherapy. The goal was to see which approach better reduced pain and improved daily function ov…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Back pain breakthrough? study pits two hand therapies Head-to-Head
Symptom relief CompletedThis study tested two different hands-on treatments for people with lower back pain that shoots down the leg (lumbar radiculopathy). Twenty adults received either spinal mobilization with leg movement or nerve gliding exercises for six weeks. The goal was to see which therapy bet…
Phase: NA • Sponsor: Deraya University • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Neck pain relief: which nerve stretch works best?
Symptom relief CompletedThis study tested two types of nerve mobilization exercises—slider and tensioner—in 36 adults with chronic neck pain from cervical radiculopathy. Participants received standard care plus one of the two techniques. The goal was to see which better reduces pain, improves neck movem…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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New therapy eases chronic back and leg pain in small study
Symptom relief CompletedThis study looked at whether High Tone Power Therapy can help people with long-term lower back pain that travels down one leg. 52 adults aged 35 to 50 with a herniated disc took part. The therapy aims to reduce pain, improve movement, and boost quality of life.
Phase: NA • Sponsor: October 6 University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Back pain breakthrough? study tests combo therapy for sciatica
Symptom relief CompletedThis study looked at whether adding physical therapy (like heat, ultrasound, and TENS) to a standard steroid injection helps people with back and leg pain caused by a herniated disc. 76 adults with pain lasting more than 3 months were split into two groups: one got only the injec…
Phase: NA • Sponsor: Ankara Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Could virtual reality ease neck pain? new study tests the idea
Symptom relief CompletedThis study tested whether immersive virtual reality (VR) can help reduce pain, improve balance, and restore neck movement in people with cervical radiculopathy — a condition where a pinched nerve in the neck causes pain and numbness down one arm. 42 adults aged 35-50 took part. S…
Phase: NA • Sponsor: October 6 University • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Shocking therapy: electricity plus exercise eases stubborn neck pain
Symptom relief CompletedThis study tested whether adding electrical muscle stimulation to standard exercise therapy helps young adults with cervical radiculopathy (pinched nerve in the neck causing pain, numbness, or weakness). Fifty participants aged 18-29 did 12 sessions over 6 weeks, with one group r…
Phase: NA • Sponsor: European University of Lefke • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can remote rehab match In-Person therapy for back pain?
Symptom relief CompletedThis study compared hybrid tele-rehabilitation (online sessions via Zoom) to standard clinic-based therapy for 32 adults with lumbar radiculopathy (sciatica from a slipped disc). Participants did exercises like lumbar stabilization and nerve mobilization. The trial measured pain,…
Phase: NA • Sponsor: Ahmed Adel Eid • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Gentle back therapy may improve walking in nerve pain patients
Symptom relief CompletedThis study tested whether a gentle hands-on therapy called Maitland mobilization, added to standard physical therapy, can improve walking patterns in people with lumbosacral radiculopathy (nerve pain in the lower back and leg). 46 adults aged 35-45 with chronic pain took part. Re…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Simple neck exercises show promise for pinched nerve pain
Symptom relief CompletedThis study looked at whether combining McKenzie exercises with nerve-gliding moves could help people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. 46 adults aged 35-50 with a bulging disc in the lower neck took part. Over 4 weeks, they did these exerci…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Back pain breakthrough? simple moves may fix spinal shift
Symptom relief CompletedThis study tested two physical therapy approaches for people with chronic low back pain caused by a pinched nerve, where the spine also shifts to one side. 28 adults aged 30-60 took part. The goal was to see if the McKenzie method (a specific exercise technique) works better than…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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New study tests Scope-Based back pain treatment in surgery and Non-Surgery patients
Symptom relief CompletedThis study looked at a procedure called epiduroscopic adhesiolysis, which uses a tiny camera to see inside the spine and break up scar tissue, for people with long-term back and leg pain. Researchers compared results in 141 adults who had prior back surgery and those who did not.…
Phase: NA • Sponsor: EPC Education s.r.o. • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Steroid shot during back surgery may ease pain, small trial suggests
Symptom relief CompletedThis study tested whether giving a steroid (dexamethasone) during minimally invasive back surgery reduces pain and disability afterward. 90 adults with a herniated disc in the lower back took part. Half received the steroid during surgery, half got a saltwater placebo. Researcher…
Phase: NA • Sponsor: Centro Hospitalar De São João, E.P.E. • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Simple head exercises may ease chronic neck pain and dizziness
Symptom relief CompletedThis study looked at whether a set of head and neck exercises (called Cawthorne-Cooksey exercises) can improve neck awareness and daily function in people with long-term neck pain from a pinched nerve. 54 adults aged 30-45 with mild to moderate neck disability and dizziness took …
Phase: NA • Sponsor: German International University • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Magnetic pulses plus massage ease sciatica pain in small trial
Symptom relief CompletedThis study tested whether adding a painless magnetic stimulation treatment to standard manual therapy (like massage and stretching) helps people with sciatica caused by a herniated disc. Forty adults were split into two groups: one got manual therapy alone, the other got manual t…
Phase: NA • Sponsor: International Hellenic University • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Safer injection for neck pain? study tests new Ultrasound-Guided method
Symptom relief CompletedThis study compared two injection treatments for neck pain caused by cervical radiculopathy. Seventy adults who did not get better with standard care were randomly assigned to receive either an ultrasound-guided retrolaminar block or a fluoroscopy-guided epidural injection. The g…
Phase: NA • Sponsor: Istanbul Medeniyet University • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New disc injection shows promise for sciatica relief
Symptom relief CompletedThis early-stage study tested whether an injection called STA363 is safe for people with sciatica from a herniated (slipped) disc. Twenty-five adults received either the study drug or a placebo injection into the disc. Researchers checked for side effects and measured changes in …
Phase: PHASE1 • Sponsor: Stayble Therapeutics • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New Non-Opioid drug VX-548 tested for chronic leg nerve pain
Symptom relief CompletedThis completed Phase 2 trial tested the drug VX-548 (Suzetrigine) in 218 adults with painful lumbosacral radiculopathy, a condition where a pinched nerve in the lower back causes leg pain. The study compared the drug to a placebo to see if it safely reduces leg pain and improves …
Phase: PHASE2 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Laser light could ease sciatica pain without surgery
Symptom relief CompletedThis study tested whether high-power laser therapy can reduce pain and disability in people with sciatica caused by a herniated disc. Thirty-six adults with at least 12 weeks of symptoms received either real or sham laser treatments. The goal was to see if the laser improves pain…
Phase: NA • Sponsor: Iran University of Medical Sciences • Aim: Symptom relief
Last updated Jun 26, 2026 17:55 UTC
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Can a simple quiz improve back pain care for troops?
Knowledge-focused CompletedThis study tested whether using a screening questionnaire called the STarT Back Tool helps doctors tailor low back pain treatment for military members. 290 adults aged 18-50 with low back pain were randomly assigned to either risk-stratified care or usual care. The goal was to se…
Phase: NA • Sponsor: Brooke Army Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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VR training boosts precision in tricky back injections, study finds
Knowledge-focused CompletedThis study tested whether letting doctors practice on a 3D virtual reality model of a patient's spine before a real injection makes the procedure faster and safer. Thirty adults with difficult-to-treat back pain took part. The main goal was to see if VR training reduced procedure…
Phase: NA • Sponsor: Korea University Anam Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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Pelvic tilt linked to poor hip sense in back pain patients
Knowledge-focused CompletedThis study looked at 64 adults with lower back and leg pain caused by a herniated disc. Researchers measured how well participants could sense their hip joint position and compared it to any pelvic asymmetry. The goal was to understand the connection between pelvic alignment, bod…
Sponsor: Noura ahmed ibrahim hendy • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Spine procedure safe: no extra disc damage after 10 years
Knowledge-focused CompletedThis study followed 50 people with chronic low back pain for 10 years after they had a procedure that punctured a spinal disc. Researchers used MRI scans to check if the punctured disc wore out faster than expected. The main goal was to see if the puncture itself caused extra dam…
Sponsor: SRH Gesundheitszentrum Bad Herrenalb • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Back to work after back surgery: surgeons share their advice in new survey
Knowledge-focused CompletedThis study surveyed 54 Belgian spinal surgeons about how they advise patients on returning to work after lumbar surgery for leg pain caused by nerve compression. The goal was to understand current practices, barriers, and what helps surgeons give good return-to-work guidance. The…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Can we predict who will benefit from neck steroid shots?
Knowledge-focused CompletedThis study reviewed records of 107 adults who received steroid injections in the neck for arm and neck pain caused by a pinched nerve. The goal was to find out which patient traits or injection details were linked to better pain relief at 6 months. By identifying these predictors…
Sponsor: Mersin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC
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Blood test may predict pain treatment success
Knowledge-focused CompletedThis study looked at 264 people with chronic lower back and leg pain caused by a pinched nerve. Researchers wanted to see if routine blood test results could predict who would get good pain relief from a combination of two treatments: a nerve block and a short electrical pulse to…
Sponsor: Ankara Etlik City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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MRI clues may predict who gets pain relief from neck injection
Knowledge-focused CompletedThis study looked back at the medical records of 90 adults with neck and arm pain caused by a pinched nerve. Researchers wanted to see if MRI scans could predict who would get good pain relief from a procedure called a stellate ganglion block, where numbing medicine is injected n…
Sponsor: Asan Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Magnesium levels may predict back pain injection success
Knowledge-focused CompletedThis study looked at whether having low magnesium in the body makes steroid injections for back pain less effective. Researchers followed 118 people with back pain who received these injections and measured their pain and disability levels. The goal was to see if magnesium defici…
Sponsor: Kanuni Sultan Suleyman Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Blood flow measure may predict neck pain block success
Knowledge-focused CompletedThis completed study with 92 people tested whether a measure called perfusion index (a way to check blood flow) can predict how well a nerve block (erector spinae plane block) relieves chronic neck pain from conditions like herniated discs or spinal narrowing. Researchers tracked…
Sponsor: Keimyung University Dongsan Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Showing patients their spine images after injections may boost satisfaction
Knowledge-focused CompletedThis study tested whether doctors reviewing post-procedure X-ray images with patients after spine injections improves satisfaction. 141 adults with leg pain from pinched nerves participated. Two weeks later, patients filled out surveys about their care experience and how much the…
Phase: NA • Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:38 UTC
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Study links neck disability to limited motion in pinched nerve patients
Knowledge-focused CompletedThis study looked at 80 adults with cervical radiculopathy (a pinched nerve in the neck) to see how their level of neck disability relates to their ability to move their neck in different directions. Researchers measured range of motion in six directions and compared it to disabi…
Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:58 UTC