New Non-Opioid drug VX-548 tested for chronic leg nerve pain

NCT ID NCT06176196

Completed Symptom relief Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested the drug VX-548 (Suzetrigine) in 218 adults with painful lumbosacral radiculopathy, a condition where a pinched nerve in the lower back causes leg pain. The study compared the drug to a placebo to see if it safely reduces leg pain and improves sleep. Results will show whether this non-opioid option might help people with chronic nerve pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

VX-548 (Suzetrigine) tablets

What this could lead to

If successful, this could lead to a new non-opioid painkiller for nerve-related leg pain, offering relief without addiction risks.

What could go wrong

This is an early Phase 2 trial with only 218 people, so results may not apply to everyone. The drug might not reduce pain better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAINFUL LUMBOSACRAL RADICULOPATHY

Contacts and locations

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Locations

AES Dallas Forth Worth

Dallas, Texas, 75234, United States
AES New York

New York, New York, 10017, United States
AMR Las Vegas (Clinical Research Consortium)

Las Vegas, Nevada, 89119, United States
AMR Norfolk

Norfolk, Virginia, 23502, United States
AMR Norman

Norman, Oklahoma, 73069, United States
AMR Wichita East, KS

Wichita, Kansas, 67207, United States
ARSN-Brain and Spine Institute

Port Orange, Florida, 32127, United States
Accel Research Site - St. Petersburg/Largo

Seminole, Florida, 33777, United States
Accel Research Sites - Neurostudies

Decatur, Georgia, 30030, United States
Albany Medical Center

Albany, New York, 12208, United States
Arizona Research Center

Phoenix, Arizona, 85053, United States
Atlanta Center for Medical Research

Atlanta, Georgia, 30331, United States
Be Well Clinical Studies - Austin

Round Rock, Texas, 78681, United States
Be Well Clinical Studies, LLC

Lincoln, Nebraska, 68516, United States
Brigham and Women's Hospital (BWH)

Boston, Massachusetts, 02115, United States
Center for Pain Management and Rehab

Stockbridge, Georgia, 30281, United States
ClinCept Clinical Research

Columbus, Georgia, 31904, United States
Clinical Investigations LLC.

Edmond, Oklahoma, 73034, United States
Clinical Trials of South Carolina - Charleston

Charleston, South Carolina, 29406, United States
Convenient Medical Research

Hialeah, Florida, 33013, United States
Essential Concepts Research Solutions

Palos Hills, Illinois, 60465, United States
Expert Pain

Houston, Texas, 77079, United States
Fleming Island Center for Clinical Research

Fleming Island, Florida, 32003, United States
Healthcare Research Network

Hazelwood, Missouri, 63042, United States
Healthcare Research Network II, LLC

Flossmoor, Illinois, 60422, United States
Hope Research Institute

Phoenix, Arizona, 85018, United States
JBR Clinical Research

Salt Lake City, Utah, 84107, United States
JY Research Institute

Cutler Bay, Florida, 33189, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
L&C Professional Medical Research Institute

Miami, Florida, 33144, United States
Lubbock Spine Institute

Lubbock, Texas, 79410, United States
META Medical Research Institute

Dayton, Ohio, 45432, United States
MedVadis Research Coorporation

Waltham, Massachusetts, 02451, United States
Medical Research of Westchester

Miami, Florida, 33165, United States
Nature Coast Clinical Research - Crystal River

Crystal River, Florida, 34429, United States
NexGen Research

Lima, Ohio, 45805, United States
Pacific Sports and Spine

Eugene, Oregon, 97404, United States
Pain Management and Injury Relief

Thousand Oaks, California, 91320, United States
Probe Clinical Research

Riverside, California, 92501, United States
St. Louis Pain Consultants

Chesterfield, Missouri, 63017, United States
Synexus Clinical Research - Henderson

Henderson, Nevada, 89052, United States
Trovare Clinical Research

Bakersfield, California, 93301, United States
Velocity Clinical Research - Banning

Banning, California, 92220, United States
Velocity Clinical Research - Boise

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Cincinnati

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - Grants Pass

Grants Pass, Oregon, 97527, United States
Velocity Clinical Research - Hampton

Hampton, Virginia, 23666, United States
Velocity Clinical Research - Portsmouth

Portsmouth, Virginia, 23703, United States
Velocity Clinical Research - Providence

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research - Rockville

Rockville, Maryland, 20854, United States
Velocity Clinical Research - San Diego

La Mesa, California, 91942, United States
Velocity Clinical Research - Savannah

Savannah, Georgia, 31406, United States
Velocity Clinical Research - Savannah Neurology Specialists

Savannah, Georgia, 31406, United States
Visionary Investigators Network

Aventura, Florida, 33180, United States