Two-Drug combo takes on painful NF1 tumors in early trial
NCT ID NCT06502171
First seen Nov 01, 2025 · Last updated May 11, 2026 · Updated 27 times
Summary
This study tests whether combining two drugs, cabozantinib and selumetinib, can safely shrink plexiform neurofibromas in adults and teens (16+) with neurofibromatosis type 1. About 30 participants will receive the drugs in escalating doses to find the best balance of safety and effectiveness. The goal is to reduce tumor size by at least 20% within a year.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 34294, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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