Teaching the brain about pain may boost relief from diabetic nerve damage
NCT ID NCT07695181
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This study tests whether adding pain neuroscience education — simple lessons and metaphors about how pain works — to nerve mobilization exercises provides more relief than exercises alone. About 40 adults with type 2 diabetes and long-term leg nerve pain will be randomly assigned to one of the two approaches. Researchers will measure pain intensity, physical function, quality of life, and signs of central sensitization over six weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pain neuroscience education plus neural mobilization exercises
- What this could lead to
- If effective, this combined approach could offer a simple, drug-free way to better manage diabetic nerve pain and improve daily function.
- What could go wrong
- This is a small, early-stage trial with only 40 participants, so results may not apply widely. The added benefit of education over exercises alone may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions Exclusion Criteria: Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Positive Solution Clinic, Wah Cantt
Rawalpindi, Punjab Province, 46000, Pakistan
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