Kidney disorder

This early-phase study aimed to test a new vaccine called KSD-201 in people with advanced clear cell renal cell carcinoma whose cancer had stopped responding to standard treatments. The vaccine uses the patient's own immune cells to try to fight the cancer. However, the trial was…

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This study tests whether adding the targeted therapy cabozantinib to standard immunotherapy (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer. About 1,175 adults with kidney cancer that has spread will receive either the usual treatment or the usual …

This expanded access program provides tazemetostat, a drug that blocks a protein called EZH2, to adults with serious or life-threatening solid tumors that have lost the INI1 or SMARCA4 protein. Eligible patients must have tried other treatments without success and cannot join a f…

This study tests whether combining two drugs—axitinib (which blocks cancer growth) and nivolumab (which helps the immune system fight cancer)—works better than nivolumab alone for a rare kidney cancer called TFE/translocation renal cell carcinoma (tRCC). The trial includes about …

This phase 3 trial tests whether adding the immune-boosting drug nivolumab before and after kidney cancer surgery can prevent the cancer from coming back. About 819 patients with localized kidney cancer are randomly assigned to receive either surgery alone or surgery plus nivolum…

This trial compares removing a urinary catheter on day 3 versus day 6 after a living donor kidney transplant. The goal is to see if earlier removal reduces urinary tract infections within 30 days without causing more complications like urine leaks. The study involves 172 adult ki…

This phase 2 trial is testing two immunotherapy drugs, nivolumab and ipilimumab, in children and young adults with rare INI1-negative cancers that have come back or not responded to treatment. The study aims to see if the combination can shrink tumors or slow disease progression.…

This early-phase trial is testing an experimental drug called AB598, alone or with other cancer drugs, in 40 people with advanced solid tumors like lung, bladder, or breast cancer. The main goal is to check safety and find the right dose. It is not yet known if the drug helps shr…

This early-stage study is testing a new drug, AB801, alone or with other treatments, in about 91 people with advanced cancers (like lung, colon, or breast cancer) that have not responded to standard therapies. The main goal is to check the drug's safety and find the best dose for…

This study looks at the long-term safety of a drug called iptacopan for adults with a kidney disease called primary IgA nephropathy. Participants have already completed earlier studies and will continue taking the drug to monitor side effects and see if it helps slow kidney damag…

This phase 2 trial tests whether dapagliflozin, a drug already used for diabetes and chronic kidney disease, can slow kidney damage in people with lupus nephritis. Lupus nephritis is a serious complication of lupus that causes kidney inflammation and can lead to chronic kidney di…

This study tests a drug called belantamab mafodotin in people with multiple myeloma that has come back or stopped responding to treatment, and who also have kidney problems—from mild impairment to end-stage disease requiring dialysis. The drug is an antibody-drug conjugate that t…

This trial tests whether dapagliflozin (Farxiga), a drug originally developed for diabetes, can protect kidney function in people who have received a heart transplant. Kidney failure is a common and serious complication after heart transplant. The study involves 430 participants …

This study follows 205 people with solid tumors who are already taking the cancer drug avelumab. Researchers want to see how safe the drug is over the long term and how long patients live or stay cancer-free. Participants continue their current treatment or are monitored after fi…

This early-stage study tests two drugs together—linvoseltamab and dupilumab—in just 6 adults with severe food allergies. The goal is to see if the combination is safe and can lower IgE antibodies that trigger allergic reactions. Participants must have a history of anaphylaxis to …

This Phase 3 trial tests a lab-grown blood vessel (ATEV) against the standard surgically created fistula in 121 women with end-stage kidney disease who need dialysis. The goal is to see if the ATEV allows more days without a catheter and reduces infections over 12 months. If succ…

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This study looks at the long-term safety and tolerability of iptacopan in adults with paroxysmal nocturnal hemoglobinuria (PNH) who have already completed earlier phase 2 or 3 studies with the drug. About 208 participants will continue taking iptacopan and be monitored for side e…

This early-stage trial tests a new drug called remzistotug, alone or with other cancer drugs, in 152 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the right dose. It is not yet known if the drug will sh…

This phase 3 trial tests whether the drug pazopanib can delay or prevent kidney cancer from coming back in patients who have had all visible tumors removed by surgery. 129 adults with clear cell kidney cancer that had spread are randomly assigned to take either pazopanib or a pla…

This study follows 150 people who received imlifidase before a kidney transplant to see how long their new kidney works. Researchers will check for graft failure (return to dialysis, re-transplant, or kidney removal) over 5 years. A separate group of similar patients not receivin…

This study tests whether adding a radioactive drug (radium-223) to standard treatment (cabozantinib) helps people with advanced kidney cancer that has spread to the bones. About 134 participants will receive either the combination or cabozantinib alone. The goal is to see if the …

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This study tests a drug called sparsentan for people who have protein in their urine after a kidney transplant due to IgA nephropathy or FSGS. About 20 adults will take the drug once daily for 36 weeks to see if it safely reduces protein levels and protects kidney function. The g…

This study will follow 50 people with C3 glomerulopathy, a rare kidney disease, who are taking the drug Fabhalta. Researchers want to see how safe the drug is and how well it works in everyday clinical settings. They will track infections, side effects, and kidney function over t…

This phase 2 trial tests whether adding the oral drug iptacopan to standard therapy (rituximab) helps people with active ANCA vasculitis achieve and maintain remission. About 84 adults with newly diagnosed or relapsed disease will receive either iptacopan or a placebo, plus stand…

This study tests a device that uses focused sound waves (histotripsy) to break apart kidney tumors without making any cuts. About 67 adults with a single small kidney mass (3 cm or less) that hasn't spread will be treated. The goal is to see if the tumors are completely gone afte…

This early-phase trial tests a new treatment called IVS-3001, which uses a patient's own immune cells (T cells) engineered to target a protein called HLA-G found on some solid tumors. The study involves 31 adults with advanced solid tumors that have not responded to standard trea…

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

This study tests a drug called entrectinib in children with advanced solid tumors or brain tumors that have come back or haven't responded to other treatments. The trial has two parts: first finding the best dose, then seeing how well it works in children whose tumors have specif…

This study monitors about 200 adults with paroxysmal nocturnal hemoglobinuria (PNH) who are already taking iptacopan (Fabhalta). Researchers will use registry data to count infections caused by certain bacteria. The goal is to better understand the real-world safety of this medic…

This phase 3 trial tests whether a new drug, depemokimab, works as well as the current treatment mepolizumab for adults with a rare disease called EGPA, which causes inflammation of blood vessels. The study involves 163 participants and aims to see if depemokimab can help patient…

This trial tests an experimental drug called TRK-950 in combination with several standard anti-cancer treatments for people with advanced solid tumors, including colorectal, bladder, ovarian, and other cancers. The main goal is to find safe doses and understand side effects. Part…

This study compares two types of dialysis in 64 adults with end-stage kidney disease. One group gets standard hemodialysis, the other gets hemodiafiltration, which uses both diffusion and convection to remove waste. The main goal is to see if hemodiafiltration leads to less weigh…

This early-phase study tests a new treatment called NKX019 for people with lupus, an autoimmune disease. NKX019 uses specially engineered immune cells to target and calm overactive B cells. The main goal is to check safety in about 6 participants, while also looking for signs tha…

This study tests an experimental drug called APL2 for people with a kidney disease called FSGS. The goal is to see if APL2 can reduce protein in the urine, a sign of kidney damage. The trial has two parts: first, adults will receive APL2 openly; then, both adults and adolescents …

This phase 3 trial tests ravulizumab, a drug that blocks part of the immune system, against a placebo in 579 adults with IgA nephropathy—a kidney disease that can lead to kidney failure. The goal is to see if ravulizumab reduces protein in the urine and preserves kidney function …

This study tests the safety of a drug called ferric citrate in children aged 6 to 17 with chronic kidney disease who have high phosphorus levels. The drug is taken by mouth to help control phosphorus, which can cause bone and heart problems if too high. The study involves 45 chil…

This study looks at the long-term safety and effects of atacicept in people with IgA nephropathy, a kidney disease. Participants have already completed a previous trial with atacicept. Researchers will monitor side effects and measure kidney function over time to see if the drug …

This study is testing the long-term safety and effectiveness of an experimental drug called XH-S003 in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that can cause fatigue, blood clots, and other serious problems. About 26 people who have already ta…

This Phase III trial tests whether giving a highly targeted form of radiation (SAbR) before standard therapy (immunotherapy or targeted pills) helps people with kidney cancer that has spread to 2-5 spots in the body live longer. About 472 participants are randomly assigned to rec…

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this…

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This phase 2 trial is testing whether adding precise, high-dose radiation (SBRT) to standard immunotherapy (ipilimumab and nivolumab) can help people with metastatic kidney cancer live longer without their disease getting worse. About 66 participants with intermediate or poor-ris…

This phase 2 trial is testing the drug larotrectinib in children and young adults (ages 1 to 21) with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have a specific genetic change called an NTRK fusion. The cancers have either come back after treatment…

This study follows about 80 people with paroxysmal nocturnal hemoglobinuria (PNH) who have already taken danicopan in a previous trial. They will continue taking danicopan as an add-on to their standard C5 inhibitor therapy. The goal is to see if the combination remains safe and …

This study tests a drug called adavosertib in adults with advanced solid tumors that have a missing or broken SETD2 gene. The drug works by blocking enzymes that cancer cells need to grow. Researchers want to see if it can shrink tumors or keep them stable for at least 6 months.

This study tests a drug called DS-8201a (trastuzumab deruxtecan) in children, teens, and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or not responded to treatment. The drug works like a smart bomb, attaching to cancer cells a…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests a new treatment called CHT105 for people with lupus nephritis that hasn't responded to standard therapies. CHT105 uses specially engineered immune cells from healthy donors to target and destroy the faulty immune cells causing kidney damage. Fourteen adults will …

This was a planned early-stage trial to test whether anti-CD19 CAR-T cells could safely help children with multi-drug resistant nephrotic syndrome, a serious kidney condition. The study was withdrawn before any patients were enrolled, so no data on safety or effectiveness were co…

This trial aimed to test whether anti-CD19 CAR-T cells could safely and effectively treat children with refractory ANCA-associated vasculitis, a rare autoimmune disease. The study was withdrawn before enrolling any participants, so no results are available. It was designed for ch…

This study looks at how well the body handles a radioactive drug (lutetium vipivotide tetraxetan) in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. Researchers want to see if different levels of kidney function change how the drug spr…

This study tracks 132 people with PNH who are taking Fabhalta to see how safe it is and what side effects occur. Researchers will monitor infections and check for serious red blood cell breakdown if the drug is stopped. The goal is to better understand the drug's risks in everyda…

This early-stage trial is testing a new treatment called KITE-363 for people with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard treatments. KITE-363 is a type of cell therapy where a patient's own immune cells are modified in a lab to t…

This phase 2 trial tests the drug cabozantinib in children and young adults with rare cancers like sarcomas, Wilms tumor, and others that have come back or not responded to treatment. Cabozantinib works by blocking enzymes that help tumors grow and form blood vessels. The study a…

This phase 2 trial is studying whether giving the drug sunitinib before surgery to remove a kidney can help control metastatic renal cell carcinoma. About 50 patients with kidney cancer that has spread will take sunitinib for 28 days, then have the affected kidney removed. Resear…

This study follows 64 Polish adults with paroxysmal nocturnal hemoglobinuria (PNH) who are taking ravulizumab as part of their routine care. Researchers will track blood markers like LDH and how many patients need blood transfusions over time. The goal is to see if the drug works…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This phase III trial tests whether adding cabozantinib to avelumab (an immunotherapy) helps keep metastatic urothelial cancer from growing after initial chemotherapy. About 654 patients will receive either the combination or avelumab alone as maintenance therapy. The goal is to s…

This study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or stand…

This study tests whether adding the chemotherapy drug eribulin to the immunotherapy atezolizumab works better than atezolizumab alone for people with advanced or spreading bladder cancer who cannot take standard cisplatin chemo. About 72 adults with recurrent or metastatic urothe…

This study looks at how safe and effective the drug everolimus is for Taiwanese adults with tuberous sclerosis complex (TSC) who have kidney tumors called angiomyolipomas. Four participants will take the drug and be monitored for side effects and tumor shrinkage. The goal is to c…

This study tests a new drug called Cetrelimab (JNJ-63723283) in 234 people with advanced solid tumors like lung, melanoma, bladder, and colorectal cancers. The drug works by blocking PD-1, a protein that stops the immune system from attacking cancer cells. The trial has two parts…

This early-stage trial tests whether the drug dexmedetomidine can reduce acute kidney injury in 78 adults undergoing ascending aortic surgery with a heart-lung machine. Half receive the drug, half get a placebo. The goal is to see if the drug's anti-inflammatory effects help prev…

This early-phase trial tests an experimental drug called HFB200603, either alone or with the immunotherapy tislelizumab, in 83 adults with advanced solid tumors (kidney, lung, melanoma, stomach, or colon cancer). The main goal is to find a safe dose and check for side effects. Re…

This study tests whether giving two drugs—nivolumab (immunotherapy) and cabozantinib (targeted therapy)—before removing the kidney can make all visible cancer disappear in people with advanced kidney cancer that has spread. About 38 adults with metastatic renal cell carcinoma wil…

This study tests whether using highly focused radiation (SBRT) on a limited number of growing cancer spots can help control the disease in patients with metastatic breast or genito-urinary cancers. Instead of switching to a new drug when some tumors start growing, doctors will ta…

This early-stage trial is testing whether amivantamab, a drug that targets specific proteins on cancer cells, can be given as a shot under the skin instead of through an IV. About 158 adults with advanced solid tumors (like lung or head and neck cancers) will receive different do…

This phase 3 trial tests whether the drug atrasentan can slow kidney function loss in people with IgA nephropathy, a disease that can lead to kidney failure. About 404 participants receive either atrasentan or a placebo, along with standard care. The main goal is to see if atrase…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study tests the safety of an antibiotic called Vabomere in children aged 3 months to 12 years who have complicated urinary tract infections, including kidney infections. The children receive the medicine through an IV while in the hospital. Researchers monitor for side effec…

This study tests a drug called CAM2029 (octreotide) given as a weekly or every-other-week shot to people with symptomatic polycystic liver disease. The goal is to see if it can shrink the liver and reduce symptoms like belly pain, bloating, and nausea. About 71 adults with an enl…

This early-phase trial is testing a new treatment called YTB323, a type of CAR T-cell therapy, in 21 adults with severe lupus that hasn't improved with standard treatments. The goal is to see if a single infusion is safe and can control the disease. Researchers will also measure …

This study tests whether the drug zanubrutinib can help people with primary membranous nephropathy, a kidney disease that causes protein leakage. About 178 participants will receive either zanubrutinib or the standard drug tacrolimus. The goal is to see if zanubrutinib reduces pr…

This early-phase study tests a new drug called JANX008 in about 130 adults with advanced solid tumors, including lung, kidney, head and neck, colorectal, pancreatic, and breast cancers. The main goal is to check safety and find the right dose. Participants must have tried all sta…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This early-phase study tests whether giving immunotherapy drugs (nivolumab alone or with bevacizumab or ipilimumab) before surgery is safe for people with advanced kidney cancer that has spread. About 104 participants will receive one of these treatments before their tumor is rem…

This study compares two types of surgery to create dialysis access in older adults (60+) with end-stage kidney disease. One method connects a vein directly to an artery (fistula), the other uses a synthetic tube (graft). The goal is to see which leads to fewer infections and more…

This study tests a drug called vonsetamig in 43 people with chronic kidney disease who are on dialysis and have very high levels of anti-HLA antibodies, making it nearly impossible to find a matching kidney donor. The drug aims to safely lower these antibodies so that a kidney tr…

This phase 2 study tests the drug atrasentan in 103 adults with various kidney diseases that cause protein leakage, including IgA nephropathy and FSGS. Participants take a daily tablet to see if it reduces protein in urine, a sign of kidney damage. The goal is to find a new way t…

This study tests whether adding an experimental drug (PF-04518600) that boosts the immune system to the standard drug axitinib can help control advanced kidney cancer better than axitinib alone. About 62 adults whose cancer has spread and who have already tried an immune checkpoi…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and resea…

This study tests a new drug called raludotatug deruxtecan (R-DXd) in 200 adults with advanced or spreading solid tumors, including certain ovarian, cervical, endometrial, bladder, and kidney cancers. The goal is to see if the drug can shrink tumors or stop them from growing. Part…

This study tests whether a two-drug combination can help the immune system attack ovarian cancer that has returned after standard treatments. The drugs are E7777, which removes certain immune cells that block the body's defenses, and pembrolizumab, which reactivates cancer-fighti…

This study looks at two drug combinations to treat BK virus infection in kidney transplant recipients. BK virus can cause the new kidney to fail. The trial compares everolimus with a lower dose of tacrolimus versus a lower dose of tacrolimus plus leflunomide in 50 adults whose vi…

This early-phase trial tests the safety of combining two cancer drugs, nivolumab and cabozantinib, in people with HIV who have advanced solid tumors. Only 8 participants were enrolled. The goal is to see if the combination is safe and can shrink or stabilize tumors.

This study tests a new drug called obinutuzumab in 100 children aged 1-18 with refractory nephrotic syndrome, a kidney condition causing swelling and protein loss. The drug targets immune cells to reduce disease flares and dependence on steroids and other medications. Researchers…

This study tests a new medicine, NS-229, in 45 adults with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA), which causes inflammation in blood vessels. The goal is to see if NS-229 can help patients achieve remission while lowering their daily steroid d…

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lu…

This early-phase trial is testing whether a ketogenic diet (low carbs, high fat) can safely help immunotherapy drugs work better in people with advanced melanoma or kidney cancer. About 60 participants will follow the diet while receiving standard immunotherapy. The main goals ar…

This study tests a combination of two drugs, nivolumab and axitinib, in people with advanced kidney cancer. The goal is to find the safest dose and see how well the drugs shrink tumors. About 98 participants will take part, including those who have had prior treatment and those w…

This phase 3 study tests whether combining two drugs (savolitinib and durvalumab) works better than the standard drug sunitinib for people with a rare, advanced kidney cancer called papillary renal cell carcinoma that has a specific genetic change (MET-driven). About 148 adults w…

This early-stage trial tests a new drug called LY4101174 in people with advanced solid tumors, including bladder, breast, and lung cancers. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The study will check if the drug is safe, tolerable, and ef…

This phase 3 trial tests whether adding ianalumab (a biologic injection) to standard therapy helps control active lupus nephritis, a serious kidney complication of lupus. About 452 adults with active lupus nephritis are receiving either ianalumab every 4 or 12 weeks or a placebo,…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This early-stage trial tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in people whose prostate, bladder, or kidney cancer has spread. The main goals are to find the safest dose and see what side effects occur. About 65 participants will receive both drugs t…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 28 adults with advanced clear cell kidney cancer that worsened after initial immunotherapy. The goal is to see if the combo can shrink tumors or slow disease progression. Participants receive treatment un…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This clinical trial is testing several new combinations of drugs for people with advanced kidney cancer that has spread. The study includes about 400 participants who have not had any prior treatment for their advanced disease. The goal is to see if these combinations are safe an…

This study is testing whether eating Brazil nuts can reduce inflammation and oxidative stress in people with chronic kidney disease. Fifty patients will take Brazil nut supplements for six months while researchers measure changes in blood and gut bacteria. It is a small, early-st…

This study compares two procedures for removing 1-2 cm kidney stones from the lower part of the kidney. One method uses a thin tube with a camera through the urinary tract, while the other makes a small incision in the back. The goal is to see if the less invasive approach works …

This study tests a new medicine, crovalimab, for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease that destroys red blood cells. It involves healthy volunteers and people with PNH to check safety and how well the drug works. The goal is to control the disease, not …

This phase 3 trial tests whether the drug povetacicept can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a kidney disease. About 605 participants will receive either the drug or a placebo by injection. The study is active but not recruit…

This phase II trial tests whether adding the immunotherapy drug atezolizumab to the standard drug cabozantinib helps people with advanced papillary kidney cancer live longer without their disease getting worse. About 200 participants will receive either cabozantinib alone or cabo…

This early-phase trial is testing a combination of two drugs—erdafitinib and enfortumab vedotin—in 24 people with advanced bladder cancer that has spread and has specific FGFR2/3 gene changes. Erdafitinib blocks a faulty protein that helps cancer grow, while enfortumab vedotin de…

This early-phase trial tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and ziv-aflibercept (which cuts off blood supply to tumors)—in people with advanced solid tumors like melanoma, colorectal, ovarian, and kidney cance…

This phase 3 trial tests whether adding belzutifan to standard pembrolizumab after kidney cancer surgery can delay or prevent the cancer from coming back. About 1800 participants with clear cell renal cell carcinoma are randomly assigned to receive either belzutifan plus pembroli…

This early-phase study tests a combination of two or three drugs (cabozantinib, nivolumab, and sometimes ipilimumab) in people with advanced genitourinary cancers that have spread. The main goals are to find the safest doses and understand side effects. About 152 adults with vari…

This study looks at whether a combination of nurse health coaching, doctor training, and subsidies for a kidney-protecting drug can help slow the worsening of chronic kidney disease. About 724 adults with moderate-to-severe kidney disease in Singapore will be randomly assigned to…

This phase 3 trial compares the experimental drug belzutifan to the standard drug everolimus in 755 people with advanced kidney cancer that has worsened after prior treatments. The goal is to see if belzutifan can better delay cancer growth and improve survival. Participants take…

This study looks at whether taking cinnamon supplements for three months can lower inflammation and improve gut health in people with chronic kidney disease. Thirty patients will take either cinnamon capsules or a placebo. Researchers will measure markers of inflammation and oxid…

This study tests a combination of two drugs (fruquintinib and serplulimab) as the first treatment for people with a rare type of kidney cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors or slow the disease. About 39 adults will t…

This study tests whether adding an SGLT2 inhibitor to standard ARB therapy better reduces protein in the urine (a sign of kidney damage) in diabetic patients without high blood pressure. Sixty adults aged 30-60 with diabetes and microalbuminuria will receive either ARBs alone or …

This study tests two immunotherapy drugs, tiragolumab and atezolizumab, in children and adults with rare cancers that have come back or not responded to treatment. These cancers lack certain genes (SMARCB1 or SMARCA4), making them hard to treat. The goal is to see if the drug com…

This Phase 3 trial tests whether adding zibotentan to the standard drug dapagliflozin can better protect kidney function in people with chronic kidney disease and high proteinuria. About 1,800 adults are taking either the combo or dapagliflozin alone. The main goal is to see if t…

This study tests a drug called obinutuzumab for people with lupus nephritis, a kidney disease caused by lupus. About 271 participants receive either the drug or a placebo, added to their usual treatment. The goal is to see if the drug helps achieve complete kidney response, meani…

This phase 3 trial tests crovalimab in about 50 people with PNH who have not used similar drugs before. PNH causes red blood cells to break apart, leading to fatigue, pain, and need for transfusions. Crovalimab is given as an IV infusion and then as injections under the skin to b…

This study tests whether a lower dose of the steroid prednisone can treat relapses of nephrotic syndrome in children as effectively as the standard dose. Fifty children aged 1 to 18 with active relapses will be randomly assigned to either the reduced-dose or standard-dose regimen…

This study tests whether a newer drug, benralizumab, works as well as the current standard, mepolizumab, for people with a rare disease called EGPA that inflames blood vessels. About 140 adults with active EGPA will receive either drug for a year, along with their usual steroids.…

This study is testing a new combination of two immunotherapy drugs (BGB-A445 and tislelizumab) in about 113 people with advanced bladder, kidney, or skin cancer that has spread. The goal is to see if the combo can shrink tumors and how safe it is. Participants must have already t…

This study tests whether combining newer immunotherapy drugs with a standard targeted therapy (axitinib) can safely control advanced kidney cancer. About 199 adults with untreated, advanced clear-cell renal cell carcinoma will receive one of three drug combinations. The main goal…

This early-phase study tests a new immune therapy for people with advanced kidney or bladder cancer. Researchers take a person's own natural killer cells, train them in the lab to better recognize cancer, and give them back along with a protein that boosts immune activity. The ma…

This study tests whether a standardized care plan can help chronic kidney disease patients better control high potassium levels while optimizing their RAASi medications. About 1,000 participants will receive the care plan, which includes doctor training and patient education. The…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This phase 2 trial is testing whether the drug cabozantinib can shrink tumors in 22 people with advanced kidney cancer before they have surgery. The goal is to see if the drug reduces tumor size enough to improve surgical outcomes and delay cancer return. Participants take caboza…

This study looks at the long-term safety of a drug called sibeprenlimab for people with IgA nephropathy, a kidney disease. About 600 adults who completed earlier trials of this drug will continue receiving it for up to 2 more years. Researchers will track side effects and measure…

This early-stage trial tests a new drug called VSA012 in about 50 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that destroys red blood cells. The study includes people who have not used complement inhibitors before or who still have low hemoglobin …

This pilot study tested whether adding low-dose radiation (brachytherapy) to standard immunotherapy could help shrink tumors in people with advanced melanoma, kidney cancer, or urothelial cancer. Only 5 participants were enrolled, and the main goal was to see how many responded t…

This phase 3 trial compares a combination of two drugs, belzutifan and lenvatinib, against the standard drug cabozantinib in 747 people with advanced kidney cancer that has worsened after initial treatment. The goal is to see if the combo can better slow cancer growth or improve …

This early-phase study tests whether a single infusion of special immune cells (regulatory dendritic cells) from the kidney donor can help the recipient's body accept the new kidney with fewer side effects. 14 first-time kidney transplant recipients will receive the cells one wee…

This study tests if adding another drug (belzutifan or quavonlimab) to a standard two-drug treatment can help people with advanced clear cell kidney cancer live longer or stop their cancer from growing. About 1,650 adults who have not had prior treatment for advanced disease will…

This study tests an experimental drug called Auxora in 150 adults with acute kidney injury and breathing failure. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive, breathe without a machine, and avoid kidney dial…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assi…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This phase 2 trial tests whether giving heated chemotherapy directly into the abdomen during surgery can help people with a rare and aggressive adrenal cancer that has spread within the belly. About 30 participants will have surgery to remove visible tumors, followed by a wash of…

This study is testing experimental combinations of drugs for people with advanced kidney cancer (clear cell type) that has gotten worse after initial treatment. The goal is to see if these combinations are safe and can shrink tumors. About 370 participants will be enrolled in thi…

This pilot study tests whether adding a special type of dialysis (peritoneal dialysis) between regular hemodialysis sessions can remove extra sodium and fluid from the body. Ten adults on hemodialysis will receive this extra treatment twice a week for three weeks. Researchers wil…

This study tests whether empagliflozin, a drug used for diabetes, is safe and tolerable for people with autosomal dominant polycystic kidney disease (ADPKD). About 50 adults with moderate kidney function will receive either the drug or a placebo for 12 months. Researchers will mo…

This early-phase trial is testing a new drug called NTX-1088, which targets a protein on cancer cells, either alone or combined with the immunotherapy pembrolizumab. The study involves 90 people with advanced solid tumors that have spread or cannot be removed. The main goals are …

This study tests a combination of two experimental drugs, pozelimab and cemdisiran, for people with PNH, a rare blood disease that destroys red blood cells. The goal is to see if this combo works better and is safer than current standard treatments (ravulizumab and eculizumab). A…

This phase 3 trial compares crovalimab, a new injectable drug, to eculizumab in about 190 people with paroxysmal nocturnal hemoglobinuria (PNH) who are already on complement inhibitors. The study aims to see if crovalimab is as safe and effective, with a focus on side effects and…

This phase 2 trial tests whether theophylline, a drug used for asthma, can help people with pseudohypoparathyroidism lose weight and improve blood sugar control. The study includes 29 obese participants aged 13 and older. Researchers will measure changes in body mass index and gl…

This early-phase study tests a new gene therapy for people with advanced clear cell kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better attack cancer, and return them to the body. The main goals are to check safety and see if tumors shr…

This study tests whether crovalimab works as well as eculizumab for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. About 210 adults who have not had prior complement inhibitor therapy will receive either drug. The main goals are to see if crovalimab…

This study tests a new device called STARgraft-3, a tube used for dialysis in people with end-stage kidney disease. The goal is to see if it stays open longer and resists infection better than standard grafts. About 21 adults will be followed for up to a year to check how well th…

This study tests a drug called tezepelumab in 42 adults with EGPA, a rare disease that causes inflammation in blood vessels and can damage organs. The goal is to see if the drug helps patients reach remission, meaning no active disease and low steroid use. Participants receive ei…

This study tests a special dialysis fluid containing amino acids (protein building blocks) to see if it can improve the nutritional status of adults with end-stage kidney disease who are on peritoneal dialysis. About 50 participants will replace one daily dialysis bag with this s…

This study tests whether theophylline, a drug used for asthma, can help children and young adults with pseudohypoparathyroidism—a rare genetic condition causing early obesity, hormone problems, and short stature. Researchers will check for weight loss, better blood sugar control,…

This phase 2 trial tests theophylline, a drug used for asthma, in 34 children aged 2 to 12 with pseudohypoparathyroidism, a genetic condition causing obesity, short stature, and hormone resistance. The study aims to see if theophylline can help with weight loss, slow bone growth …

This phase 2 trial tests whether adding evolocumab (a cholesterol-lowering drug) to nivolumab (an immunotherapy) can help control metastatic kidney cancer that has not responded to prior treatments. Only 10 participants are enrolled, and the main goal is to check safety and side …

This study tests an inhaled form of interleukin-2 (IL-2), a protein that boosts the immune system, in people whose cancer has spread to the lungs. The goal is to find the best dose and see if it can shrink lung tumors. About 70 adults with cancers like melanoma, sarcoma, or kidne…

This study tests whether motivational interviewing, a counseling style that encourages patients to find their own reasons for change, can help African American adults on hemodialysis attend all their sessions. 176 participants will either receive the coaching or standard care, an…

This study tests a drug called ceralasertib, alone or with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors by blocking enzymes that help cancer grow.…

This Phase 3 trial tests sparsentan, a new drug, against irbesartan (a standard treatment) in 406 adults with IgA nephropathy, a kidney disease. The goal is to see if sparsentan better protects kidney function over about 2 years. Participants must have significant protein in thei…

This study tests a minimally invasive procedure that blocks blood flow to kidney angiomyolipomas (non-cancerous tumors). The goal is to shrink the tumors and stop bleeding while preserving kidney function. Researchers will follow 50 patients for one year to check safety and effec…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can b…

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with locally advanced kidney cancer that hasn't spread to other organs. About 18 participants will receive the combination for 12 weeks before their operation. The go…

This study aimed to see if a special blood filter (Seraph 100) could reduce BK virus levels in kidney transplant patients with high viral loads. It planned to enroll adults with a BK virus level of 10,000 IU/mL or higher who already had dialysis access. However, the trial was wit…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This study tests whether combining two treatments—thermal ablation (using heat to destroy tumor cells) and stereotactic radiosurgery (precise, high-dose radiation)—can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with vari…

This early-phase trial tests whether adding camu camu, a prebiotic fruit, to standard immunotherapy (nivolumab and ipilimumab) is safe and can improve treatment for advanced kidney cancer. About 31 people with metastatic clear-cell or sarcomatoid kidney cancer will receive the co…

This phase 2 trial tests whether high-precision radiation (SBRT) can control kidney cancer that has spread to a few spots in the body. The goal is to see if radiation alone can delay or replace the need for systemic drug therapy. The study involves 123 participants and includes b…

This study tests whether giving estrogen through a vein during kidney transplant surgery can reduce damage to the new kidney. It includes 30 women who need dialysis and are getting a kidney from a deceased donor. The goal is to see if estrogen helps the kidney work better right a…

This study tests whether the drug finerenone can lower protein levels in the urine of people with chronic kidney disease who are not taking certain blood pressure medications. About 180 adults will receive either finerenone or a placebo for 6 months. The goal is to see if fineren…

This study looks at how well surgery works for people with kidney cancer that has spread to other parts of the body. About 86 patients will have the cancer removed by a surgeon. The goal is to see if this surgery helps them live longer without the cancer coming back.

This study tests whether two immunotherapy drugs, nivolumab and relatlimab, can shrink or control a rare and aggressive kidney cancer called renal medullary carcinoma (RMC). The trial includes 30 adults whose cancer has spread or cannot be removed by surgery. The goal is to see h…

This phase 3 study compares a new drug, savolitinib, to the standard drug sunitinib in 60 people with a specific type of advanced kidney cancer called MET-driven papillary renal cell carcinoma. The goal is to see if savolitinib is better at stopping the cancer from growing and to…

This study follows 9 people with Fanconi Anemia who already received a gene therapy that adds a working FANCA gene to their blood stem cells. Researchers will check their health and blood counts for 15 years to see if the treatment remains safe and keeps working. No new treatment…

This phase 2 trial is testing a daily pill called belzutifan in 50 people with VHL disease who have kidney cancer. The goal is to see if the drug can shrink tumors. Researchers are also monitoring how long any tumor shrinkage lasts and checking for side effects.

This study tests whether adding entinostat to high-dose aldesleukin (interleukin-2) can help shrink tumors in people with metastatic kidney cancer. About 47 adults with clear cell renal cell carcinoma that has spread will receive both drugs. The goal is to find the safest dose an…

This early-phase trial tests two drugs together—MK-2206 and hydroxychloroquine—in people with advanced solid tumors, melanoma, kidney, or prostate cancer. The goal is to find the safest dose and see how the combination affects cancer cell growth. About 62 participants will take b…

This study tests whether pentoxifylline, a medicine used since 1984 for leg blood vessel problems, can slow kidney damage and delay death in people with diabetic kidney disease. About 2,376 participants with type-2 diabetes and moderate-to-severe kidney decline are being followed…

This registry follows 750 patients with small kidney tumors who are not good candidates for surgery. They receive either cryotherapy (freezing) or radiofrequency ablation (heating) to destroy the tumor. Researchers will track survival, kidney function, and complications over time…

This study tests whether ambrisentan, a drug approved for lung blood pressure, can help patients with hepatorenal syndrome—a serious kidney problem that can occur in advanced liver cirrhosis. About 54 hospitalized adults will receive either ambrisentan or the standard drug terlip…

This study tests a combination of three drugs—tazemetostat, nivolumab, and ipilimumab—in children with rare tumors that lack the INI1 or SMARCA4 proteins. The goal is to find a safe dose and see if the drugs can shrink tumors. About 49 children with specific tumor types are being…

This study tests a drug called atacicept given once a month to people with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if monthly dosing lowers harmful antibodies and reduces protein in the urine, which are signs of kidney damage. About 9…

This Phase 3 trial is testing whether a monthly injection of ziltivekimab can reduce the risk of heart attacks and strokes in 6,200 people who already have heart disease, chronic kidney disease, and signs of inflammation. Participants receive either the drug or a placebo for up t…

Some people waiting for a kidney transplant have immune systems that reject most donors, leading to years of waiting. This study tests whether two drugs—carfilzomib (used for multiple myeloma) and belatacept (an immune-suppressing drug)—can reduce that sensitivity. About 21 parti…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study tests a drug called obinutuzumab against a standard treatment (tacrolimus) in 142 adults with primary membranous nephropathy, a kidney disease that lets protein leak into urine. The goal is to see if obinutuzumab can bring about complete remission (no protein in urine)…

This study tests a new two-drug combination (cadonilimab plus axitinib) as a first treatment for people with advanced or spread kidney cancer of rare types. About 37 participants will receive the drugs until their disease gets worse or side effects become too severe. The goal is …

This phase II trial tests the immunotherapy drug pembrolizumab in 39 people with advanced adrenocortical carcinoma that cannot be removed by surgery. The study aims to see if the drug can shrink or control the cancer. Participants receive pembrolizumab and are monitored for tumor…

This study tests the safety and how the body processes migalastat in 14 adults with Fabry disease who have severe kidney impairment or are on dialysis. Participants take migalastat capsules, and researchers measure drug levels in blood and dialysate. The goal is to ensure proper …

This study aimed to see if the drug mitapivat could help people with sickle cell disease who also have kidney damage. It planned to measure changes in a key kidney marker over six months. However, the trial was withdrawn before enrolling any participants, so no results are availa…

This study tests the long-term safety and effectiveness of pegcetacoplan in 100 people with two rare kidney diseases, C3 glomerulopathy and IC-MPGN. Participants previously completed a one-year trial and saw benefit from the drug. The goal is to see if pegcetacoplan can keep redu…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This study tests a device called GPX that blocks blood flow to tumors or other targeted areas. About 114 adults with conditions like kidney tumors or bone tumors will receive the treatment. The goal is to see if the device is safe and works well at reaching and blocking small blo…

This study explores whether eating alkalizing fruits and vegetables, delivered to your home, can help manage metabolic acidosis in people with chronic kidney disease. The usual treatment, sodium bicarbonate, often causes side effects and doesn't always work. The trial will see if…

This phase 3 study tests BION-1301 (Zigakibart) in 383 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants receive either the drug or a placebo as a shot every 2 weeks for 2 years. The main goal is to see if the drug helps preserve kidney f…

This early-stage trial tests a new drug called BAY2965501, which boosts the immune system to fight cancer. It is given alone or with other drugs like pembrolizumab and chemotherapy. The study includes about 284 people with advanced solid tumors (skin, kidney, stomach, or lung can…

This study looks at whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease. About 92 participants with moderate kidney disease will receive either the active beetroot ju…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This study tests whether adding a special filter (hemoperfusion) to regular dialysis can better remove waste products like beta-2 microglobulin, parathyroid hormone, and C-reactive protein from the blood. About 410 adults with end-stage kidney disease on maintenance dialysis will…

This study tests whether combining two drugs—serplulimab and fruquintinib—can prevent kidney cancer from returning after surgery in people with a rare, aggressive type called non-clear cell renal cell carcinoma. About 40 adults at high risk of recurrence will receive both drugs f…

This study tests a new medicine called AK112 (Yivoximab) for people with advanced kidney cancer that has spread. The drug works in two ways: it helps the immune system attack cancer cells and blocks blood vessels that feed tumors. About 60 participants will receive the drug every…

This study looks at whether people with ANCA vasculitis who have reached end-stage kidney disease can safely stop taking immunosuppressive medications. The goal is to see if stopping these drugs lowers the risk of serious infections and other side effects without causing dangerou…

This study looks at whether people with advanced bladder cancer can stop taking immunotherapy drugs (like pembrolizumab or nivolumab) after about a year instead of continuing indefinitely. The goal is to see if stopping early leads to similar survival rates while reducing side ef…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study compares two drugs, mannitol and nitroglycerin, given during robotic prostate or bladder surgery to prevent acute kidney injury. The surgery can reduce blood flow to the kidneys, and these drugs may help protect them. 90 adults with normal or mildly reduced kidney func…

This study is tracking over 1,000 Japanese patients with chronic kidney disease who are taking JARDIANCE® (empagliflozin) daily for a long period. Researchers are monitoring side effects and whether the drug helps slow kidney decline in real-world conditions. The goal is to see i…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests a drug called ARGX-117 in people who get a kidney from a deceased donor and are at risk for delayed graft function (when the kidney takes time to start working). About 103 participants will receive either the drug or a placebo by IV. The goal is to see if the dru…

This early-phase study tests a new treatment called Prula-cel for people with autoimmune diseases like lupus, scleroderma, and vasculitis. Prula-cel uses donor immune cells engineered to target and destroy faulty immune cells that attack the body. The goal is to find a safe dose …

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This early-phase trial tests a new type of cell therapy for children and young adults with solid tumors that have come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are trained in the lab to recognize and attack multiple cancer…

This study looks at whether canagliflozin, a drug used for diabetes, can safely reduce protein in the urine (a sign of kidney damage) in people with advanced chronic kidney disease (CKD), including those on dialysis. About 35 adults with CKD stage 4 or 5 will take the drug for up…

This study compares two methods for placing peritoneal dialysis catheters in adults with advanced chronic kidney disease. The Moncrief-Popovich technique buries the catheter under the skin before use, while the conventional method places it directly. Researchers will track how lo…

This study planned to test a material called PuraBond that helps stop bleeding during robotic surgery for kidney cancer. The goal was to see if it works safely and helps the kidney heal. However, the study was withdrawn before any participants were enrolled.

This study tests an oral drug called vadadustat (Vafseo) for treating anemia in people with end-stage kidney disease who are on hemodialysis. About 2,200 adults will be randomly assigned to take vadadustat three times a week or continue standard injectable treatments. The goal is…

This study planned to test a device called RetroPerc that helps doctors reach and remove large kidney stones. It was designed for adults with kidney stones larger than 10 mm. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study tests whether a 6-month exercise and personalized diet plan can help patients with obesity (BMI 40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as 'inactive' due to their weight will follow a fitne…

This large global trial is testing whether two experimental drugs—volrustomig (an immunotherapy) and casdatifan (a pill)—work better than the current standard immunotherapy combination for people with advanced clear cell kidney cancer. About 1,100 participants who have not had pr…

This study looks at whether losing weight with a special very low-calorie diet (Optifast) can lower oxalate levels in urine for obese adults who have had calcium oxalate kidney stones. Fourteen participants will eat a low-oxalate diet and provide urine samples before and after th…

This study tests whether adding tocilizumab (a drug used for arthritis) to standard immunotherapy can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive all three drugs. The goal is to see if the combina…

This early-phase trial is testing whether giving two immunotherapy drugs (durvalumab and tremelimumab) before surgery can help patients with aggressive bladder cancer who cannot take standard chemotherapy. The study involves 54 participants and primarily looks at safety and how t…

This phase II trial tests whether adjusting doses of two drugs—pembrolizumab (Keytruda) and axitinib (Inlyta)—based on tumor response can better control advanced kidney cancer. The study aims to enroll 75 adults with clear cell renal cell carcinoma that has spread. The trial is c…

This early-phase trial is testing whether adding a probiotic called CBM588 to the standard combination of cabozantinib and nivolumab can improve treatment for advanced or metastatic kidney cancer. The probiotic is designed to restore helpful gut bacteria that may help the immune …

This study tests two different drug treatments in people with advanced kidney cancer that has spread and continued to grow despite prior immunotherapy. About 90 participants will receive either a combination of lenvatinib and everolimus or cabozantinib alone. The goal is to see w…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study tests whether a drug called finerenone can reduce scarring and fat buildup in the heart muscle of people with diabetic kidney disease and heart failure. About 40 adults will take the pill daily for 6 months and get advanced heart scans to see if their heart structure i…

This study tests two drugs, pazopanib and bevacizumab, given one after the other in people with advanced kidney cancer that has spread. The goal is to find the best dose and see how well the combination works. About 51 patients who have not had prior treatment will take part. The…

This early-phase study tests a new drug called E7386 in about 70 people with advanced solid tumors, including colorectal cancer. The main goal is to check safety and find the right dose. Participants have tumors that no longer respond to standard treatments.

This study tests a 6-month digital care program for adults aged 50+ with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online education, phone support, a mobile health app, home visits, and personalized c…

This was a planned phase 2 study testing nipocalimab, an experimental drug, in adults with active lupus nephritis (kidney inflammation caused by lupus). The trial aimed to see if adding nipocalimab to standard treatment could improve kidney function. However, the study was withdr…

This phase 2 trial is testing a radioactive drug called 177Lu-PSMA-617 (Pluvicto) in 24 people with advanced clear cell kidney cancer that shows a specific marker (PSMA). The drug is given by IV and aims to shrink tumors. Researchers are measuring how many patients respond and tr…

This study tests a new pill, vadadustat, taken three times a week, against the usual injected medicine for anemia in people with kidney failure who are on dialysis. About 350 adults will take part to see if the pill can safely keep their red blood cell levels in a healthy range. …

This study tested two drug combinations (lenvatinib plus everolimus or pembrolizumab) against the standard drug sunitinib in people with advanced kidney cancer. The goal was to see if the combinations could delay cancer growth better than sunitinib alone. About 1,069 adults with …

This phase 3 study tests anifrolumab, an IV drug, against placebo in 359 adults with active lupus nephritis (kidney inflammation from lupus). The main goal is to see if more patients achieve complete kidney response, meaning better kidney function and less protein in urine. The t…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study follows 50 adults with PNH who take danicopan along with their usual medication (eculizumab or ravulizumab). Researchers track serious side effects and infections over time to see if the combination is safe for long-term use. Participants are already in a PNH registry …

This study compares two schedules for shockwave lithotripsy (ESWL) to treat kidney stones 8-15 mm. 600 participants will receive two ESWL treatments either in the same week or three weeks apart. Researchers will measure how quickly stones clear, complication rates, and patient qu…

This study looks at the long-term safety of danicopan when added to standard treatments (Soliris or Ultomiris) for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Researchers will analyze data from 50 adult patients in an international registry, trac…

This phase 2 trial is testing whether adding propranolol, a common blood pressure drug, to standard immunotherapy can help control advanced bladder cancer. The study enrolled 6 adults with urothelial carcinoma that has spread or cannot be removed by surgery. Researchers are prima…

This early-stage trial is testing a new treatment called KYV-101 for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis. The treatment involves taking a patient's own immune cells, modifying them to target and destroy faulty B cells, and giving them ba…

This study planned to test whether adding acarbose, a drug normally used for diabetes, could improve standard immunotherapy for advanced kidney cancer. The goal was to see if the combination was safe and affected gut bacteria. However, the trial was withdrawn before enrolling any…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study aimed to see if an ultrasound score called VEXUS could help detect acute kidney injury in adults after heart surgery. About 20% of patients develop this complication, which raises the risk of death. However, the study was withdrawn before enrolling any participants, so…

This study planned to test a special PET-CT scan (68Ga-PSMA) in people newly diagnosed with advanced kidney cancer. The goal was to see if it could find small cancer spots that standard scans miss. However, the trial was withdrawn before any patients were enrolled, so no results …

This program gives patients with kidney masses access to a radioactive tracer called 89Zr-DFO-girentuximab, which is used with a PET/CT scan to detect clear cell renal cell carcinoma (a common kidney cancer) without surgery. The tracer attaches to a protein (CAIX) often found on …

This study looks at whether a substance called UDP-glucose in urine can help doctors find kidney injury earlier in children after heart surgery. Current tests often miss early signs, delaying treatment. About 305 children under 8 years old having heart surgery will provide urine …

This study tests whether a special MRI can tell the difference between harmless and cancerous kidney growths when standard CT scans cannot see fat. About 44 adults with kidney masses that have no visible fat on CT will get this advanced MRI. The goal is to see if the MRI can iden…

This study tests whether a special type of scan called SPECT/CT can help doctors make better decisions about treating kidney tumors. The scan uses a radioactive tracer to see how tumors behave. Researchers will check if the scan changes what doctors recommend for 102 patients wit…

This study tests a new type of MRI that uses a natural substance (pyruvate) to see how active a kidney tumor is. The goal is to find out if the scan can tell the difference between harmless tumors, slow-growing cancers, and fast-growing cancers without needing a needle biopsy. Ab…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care or …

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which is thought to damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This study looks at whether eating a diet high in magnesium can help prevent low blood magnesium levels in women with ovarian cancer who are receiving carboplatin chemotherapy. Low magnesium is a common side effect of this treatment. The study enrolled 26 participants and will me…

This study tests whether wearing bright light glasses during dialysis can reduce severe fatigue in people with end-stage kidney disease. Sixty adults on hemodialysis will use the glasses for one hour, three times a week, for four weeks. The goal is to see if this simple, non-drug…

This study tests whether a 9-week tele-nursing program—including education, phone or online check-ins, and counseling—can improve quality of life and health outcomes for people with stage 3 or 4 chronic kidney disease who are not yet on dialysis. Researchers will compare 66 parti…

This study compares two laser methods for breaking up kidney and ureteral stones during surgery. One method uses standard laser pulses, the other uses a newer 'Moses 2.0' pulse mode. Researchers want to see if the newer mode reduces surgery time and improves stone clearance. Abou…

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study compares two drugs—methocarbamol and oxybutynin—to see which works better for pain and discomfort caused by a ureteral stent placed after kidney stone surgery. About 126 adults aged 18 to 80 who have the surgery will take one of the study drugs along with standard pain…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study tests a new surgical technique for removing large kidney stones (2 cm or bigger). Doctors will use a flexible scope and a special suction tube to break up and remove the stones. The goal is to see if this method is safe and can clear all stones in one procedure. Thirty…

This study tests whether a combination of IV acetaminophen and ketorolac can manage pain during kidney stone shockwave treatment as well as the standard opioid-based regimen. About 266 adults will be randomly assigned to receive either the non-opioid or opioid pain medicines. The…

This phase 2 study looks at whether people with certain cancers (non-small cell lung cancer, kidney cancer, or melanoma) prefer getting the drug pembrolizumab as a quick shot under the skin instead of a longer IV infusion. About 147 participants will try both methods and then say…

This study looks at two ways to give radiation to brain tumors in people who are also receiving immunotherapy for cancers like lung, breast, kidney, or melanoma. The standard approach gives one high dose of radiation, while the experimental approach gives smaller doses over sever…

This study tests whether adding mindfulness (guided meditation) to a group exercise program during dialysis can improve safety, adherence, and quality of life for people with chronic kidney disease. Thirty participants will be split into two groups: one doing exercise plus mindfu…

This study is testing whether a smartphone app that teaches mindfulness can help people with advanced kidney cancer cope with their illness. The trial will enroll 21 patients who are already receiving immunotherapy and have moderate to high fear of their cancer returning. The mai…

This study tests whether a live, online exercise program can improve physical function in adults waiting for a kidney transplant. Eighty participants will either join twice-weekly virtual exercise sessions or a health education class. The main goal is to see if they can stand up …

This study tests whether using a smaller ureteral stent (4.8 Fr instead of 7 Fr) reduces pain and discomfort after kidney stone surgery. About 100 adults who need a stent after surgery will be randomly assigned to one of the two sizes. Patients will report their pain daily until …

This study tests whether a 6-month program of aerobic and resistance exercises, done during dialysis sessions, can improve body composition, muscle oxygen levels, and physical function in 40 adults with chronic kidney disease. Participants are randomly assigned to either the exer…

This study tests whether a 5-week virtual reality program that teaches positive thinking skills can help reduce depression and improve quality of life in people on hemodialysis. Sixty-one adults with end-stage kidney disease and mild-to-moderate depressive symptoms will either re…

This study tracks people who have had or will have a procedure called ablation to destroy kidney tumors. Researchers want to see how effective the procedure is and whether it improves patients' quality of life. Participants fill out questionnaires about their health and well-bein…

This study tests a special needle with a tiny tracking device inside, like a mini GPS, to help doctors find tumors that are hard to see on CT scans. About 3,900 adults with certain cancers or growths will have their biopsy or ablation procedure done using this smart needle. The g…

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…

This study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This study tracks how 150 patients in Belgium use the drug cabozantinib (Cabometyx), alone or with nivolumab, for advanced or metastatic kidney cancer. It looks at real-world dosing, treatment changes, and quality of life. The goal is to understand how these treatments are actual…

This study observes 224 adults with advanced or metastatic kidney cancer who are taking cabozantinib alone or with nivolumab as their first treatment. Researchers track how often doses are reduced, paused, or stopped due to side effects in everyday medical practice. The goal is t…

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This observational study collects extra tumor tissue from 416 people with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) during routine biopsies. The goal is to develop and train a 'live tumor diagnostic platform' that can predict whe…

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This long-term study follows over 5,000 people with chronic kidney disease to learn how the condition affects the heart and blood vessels. Researchers are tracking kidney function, heart events like heart attacks and strokes, and various risk factors. The goal is to find better w…

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

Hispanic/Latino and American Indian patients are less likely to get kidney transplants, even though they have higher rates of kidney failure. This study compares two methods to help them complete the transplant evaluation process: a fast-track evaluation done in one day or within…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This study follows thousands of critically ill adults in intensive care units across China to better understand acute kidney injury (AKI), a common and dangerous complication. Researchers will collect medical data, images, and biological samples to build a large database. The goa…

This study investigates whether a single infusion of L-arginine, an amino acid, can reduce abnormally high sympathetic nerve activity in people with chronic kidney disease (CKD). High nerve activity is linked to increased cardiovascular risk in CKD patients. Researchers will meas…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study was designed to see if different types of anesthesia could help a surgically created blood vessel connection (called a fistula) work better for dialysis patients. The plan was to compare three methods: a nerve block in the armpit, a nerve block in the neck, and local a…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study tests two ways to help older adults with kidney failure make informed choices about their care. One approach offers education and decision aids; the other adds a supportive care program for those who choose non-dialysis options. Researchers will compare how many patien…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study tests a questionnaire called NECPAL to see if it can spot patients with serious long-term illnesses like cancer, heart failure, or kidney disease who might benefit from palliative care. Researchers will check 200 adults in the hospital or day clinic to see how many are…

This study was designed to see if a new method of measuring the visual field—by projecting vision zones on the ground—helps people with retinitis pigmentosa understand their remaining sight and improve their walking rehabilitation. The trial was withdrawn before enrolling any par…

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key component of kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to understa…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how die…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study looks at how canagliflozin (Invokana), a diabetes drug, protects the kidneys in people with type 2 diabetes. Researchers will use advanced imaging, kidney biopsies, and function tests to uncover the mechanisms. The trial involves 45 adults and aims to explain the drug'…

The APOLLO study looks at how variations in the APOL1 gene, common in people of African ancestry, affect kidney transplant outcomes. Researchers are testing DNA from 5,000 kidney donors and recipients to see if certain gene variants lead to faster kidney failure or harm living do…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study tests whether a special type of CT scan (DCE-CT) can help doctors see if targeted therapy drugs for advanced kidney cancer are working. About 120 adults with metastatic renal cell carcinoma will get these scans before and shortly after starting treatment. The goal is t…

This study follows 28 kidney transplant recipients who are switching from one anti-rejection drug (anticalcineurin) to another (belatacept). Researchers want to see how this change affects the immune system's ability to fight the common CMV virus. Participants will have blood tes…

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is…

This study examines stored tumor samples from 15 people with kidney or bladder cancer who initially responded to immune checkpoint therapy but later developed new tumors. Researchers will compare the genetic and tissue features of the original and new tumors to understand how the…

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

This study looks at whether low levels of pyrophosphate, a natural substance that prevents mineral buildup, can predict artery hardening in people with moderate chronic kidney disease. Researchers will measure pyrophosphate in blood samples from 242 patients and track artery chan…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This research study collects tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early, especially in …

This study looks at whether people who received a kidney transplant later regret their choice. Researchers will survey 250 patients one year after their transplant to measure feelings of regret and quality of life. The goal is to understand how common regret is and help doctors s…

This study aims to understand why kidney tumors in people with VHL syndrome can be different from each other. Researchers will use advanced imaging, multiple biopsies, and lab-grown tumor models to map these differences. The goal is to learn more about the disease, not to test a …

This study looks at how robotic surgery for prostate, bladder, or kidney cancer affects patients' finances. Researchers will ask 120 people who had surgery in the last year to fill out questionnaires about their medical costs, travel expenses, and support needs. The goal is to un…

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study planned to test whether giving doctors machine-learning alerts about patient risks after surgery could reduce serious complications like kidney injury or unplanned ICU stays. It was designed for high-risk patients, but the study was withdrawn before enrolling anyone, s…

This study tests a web-based tool called WellPrept that gives patients clear information before their urology procedures. Researchers want to see if it helps patients feel more confident and understand their condition better, and if it shortens clinic visits. About 300 men and wo…

This study is testing whether a detailed MRI scan can provide better information about chronic kidney disease (CKD) than standard tests. Researchers will scan 486 adults with CKD and track their health over time to see if the MRI can predict which patients will get worse. The goa…

This study was designed to see how a new experimental drug for chronic kidney disease, nurandociguat, affects the way the body processes two common medicines: rosuvastatin (a cholesterol drug) and dabigatran (a blood thinner). Healthy adults would have taken these drugs alone and…

This study explores whether having kidney cancer patients report their side effects weekly through a short survey can help doctors manage those side effects better. The surveys ask about symptoms like nausea and fatigue and are sent directly to the care team, who then follow up i…

This study was designed to track the long-term health of hospitalized patients in China who develop acute kidney injury (AKI). Researchers planned to monitor kidney function decline, new heart problems, and death rates over time. However, the study was withdrawn before any partic…

This study is not testing a new drug, but rather doing the early science needed to develop one. Researchers are looking for the right targets (antigens) on adrenocortical carcinoma cells and studying how the tumor suppresses the immune system. The goal is to find a way to create …

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. No new treatme…

This study follows 400 people with adrenocortical carcinoma who are taking mitotane as their first treatment. The goal is to carefully record all side effects, including ones that are not well understood. By collecting this data, researchers hope to improve how side effects are m…

This study looks at whether SGLT2 inhibitors, a type of diabetes drug, can help prevent or manage anemia in people with chronic kidney disease. Researchers will analyze data from 15,000 patients in Japan to see how these drugs affect anemia rates, treatments, and costs. The goal …

This study is creating a registry of 5,000 adults with chronic kidney disease (CKD) to collect information on their health, treatments, and outcomes. Researchers aim to understand how the disease progresses, identify risk factors, and see how well current treatments match guideli…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This observational study follows 25 people with end-stage kidney disease who are receiving a living donor kidney transplant. Researchers want to see how protein in the urine (proteinuria) relates to blood flow in the native kidneys before and after transplant. They also check for…

This study looks at whether losing weight over two years can improve how the kidneys use oxygen and how the body responds to insulin in people with autosomal dominant polycystic kidney disease (ADPKD) who are overweight. Researchers will use PET scans and insulin tests to measure…

This study looks at whether a 12-week survivorship program for men with advanced prostate, kidney, bladder, testicular, or penile cancer can be successfully added to their regular follow-up care. Researchers will measure how feasible and acceptable the program is using questionna…

This study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study tests a special PET/CT scan that uses a radioactive tracer to see if it can predict how kidney cancer patients will respond to immunotherapy. The trial involves 46 participants with either localized or advanced kidney cancer. Researchers will compare scan results with …

This study looks at whether high-intensity cycling during hemodialysis can protect the heart from damage that dialysis sometimes causes. Fifteen adults on dialysis will exercise at different intensities during their sessions. Researchers will use echocardiograms to measure heart …

This study looks at 1000 people who had a first arteriovenous fistula (AVF) created for dialysis. Researchers want to know how many are actually being used for dialysis two years later, and why some are not. The goal is to understand what prevents these fistulas from being used.

This study looks at 401 people with autosomal dominant polycystic kidney disease (ADPKD) to see how different versions of the PKD1 gene relate to patient traits like age at diagnosis and body size. Researchers are not testing any treatment—they are simply gathering information to…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study looks at data from 3,500 kidney transplant patients to understand if a technique called normothermic machine perfusion (NMP) improves outcomes. NMP keeps donated kidneys warm and oxygenated before transplant, but there is no registry field to track it. Researchers will…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study planned to monitor tiny bits of tumor DNA in the blood of people with early breast cancer. Researchers wanted to see how these DNA levels change during treatment and follow-up. The study was withdrawn before any participants were enrolled, so no results are available.

This small phase II trial is studying whether specific gene mutations (ARID1A and KDM6A) and a protein called CXCL13 can predict how well patients with advanced bladder cancer respond to the immunotherapy drug nivolumab. Six participants with metastatic urothelial cancer whose tu…

This study looks at how certain blood chemicals and blood vessel function relate to kidney disease severity in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers will measure homocysteine levels and blood vessel health in 80 participants age…

This study tests a new tool that personalizes lab results for older adults (65+) with chronic kidney disease. Researchers want to see if the new reports help patients better understand their results and feel less anxious. About 255 participants will review different report design…

This study follows about 793 people with chronic kidney disease who previously took part in a program designed to help them talk to doctors and family about kidney transplants. Researchers want to see if the program's effects last over time, including whether patients start trans…

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study is testing a new blood and urine test to see if it can find kidney cancer early and track how well treatment is working. Researchers will compare test results from healthy people, patients with early-stage kidney cancer, and patients with advanced kidney cancer. The go…

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or fluid overload and are treated with the Carpediem continuous renal replacement therapy system. Researchers will track survival, kidney recovery, and hospital stay lengths to see how well the d…

This study explores the experiences of young adults aged 16 to 30 who receive haemodialysis in a hospital or clinic. Researchers want to understand what makes social interaction difficult and how to reduce loneliness. Through surveys, interviews, and workshops, they aim to create…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This observational study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) develops during a hospital stay. Researchers will also compare death rates and readmission rates between patients who develop AKI and those who do not…

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study looks at whether a biomarker test (NGAL) can help doctors better manage fluids and dialysis in children with acute kidney injury in the pediatric ICU. Researchers will follow 420 children at risk for kidney problems to see if the test helps make faster, safer treatment…

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers to find markers t…

This study reviews medical records of 50 adults who received a simultaneous liver-kidney transplant between 2015 and 2020. Researchers want to find out how many of them developed BK virus in their blood, which can harm the new kidney. The goal is to better understand this risk in…

This study is looking at two substances in the blood, called MMP2 and MMP9, to see if they can predict how well certain drugs work for people with advanced kidney cancer. Researchers will measure these markers in 50 patients who are starting treatment with Sunitinib or Pazopanib,…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study uses health records from 17,000 Canadian adults to understand why some people switch from peritoneal dialysis (done at home) to hemodialysis (done in a clinic). Researchers will look at how often this happens, what predicts it, and what happens to patients after the sw…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This study looks at how being obese might increase the amount of oxalate your body makes, which can lead to kidney stones. Researchers will give 40 adults (half obese, half not) a special diet and measure their urine oxalate levels. The goal is to understand the link between obes…

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study follows 1,600 people with chronic kidney disease for 10 years to see how different types of exercise affect harmful toxins in the blood, physical fitness, and overall health. Participants include those in early stages, on dialysis, or with a kidney transplant. The goal…

This study looks at how older adults (65+) with cancer understand their illness and what they value in life before and after a major operation. Researchers will interview 100 patients to learn about their awareness, expectations, and decision-making. No new drug or treatment is b…

This study tests whether a video decision aid helps older adults with advanced kidney disease plan their future medical care. About 456 patients aged 65 and older will watch a video explaining dialysis, non-dialysis management, and CPR, then record their preferences. The goal is …

This study compares a proactive, prescription-based fluid management plan to usual care in 150 critically ill patients who need kidney replacement therapy (dialysis). The goal is to see if a standardized daily prescription can help achieve a neutral or negative fluid balance, pre…

This study aimed to compare costs and health outcomes for heart surgery patients who developed acute kidney injury versus those who did not. Researchers planned to review medical records from UK hospitals over a 10-year period. The study was withdrawn before enrolling any partici…

This study looks back at medical records from 1,000 people with adrenocortical carcinoma (ACC), a rare and serious cancer. Researchers want to see how factors like age, sex, race, and tumor burden relate to survival and treatment response. No new treatments are given; instead, th…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study looks at how to improve dialysis for children with kidney failure. Researchers will measure how well different dialysis settings remove waste from the blood while also tracking how much water is used. The goal is to find the best balance between cleaning the blood and …

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will give 22 calcium oxalate stone formers a controlled low-oxalate diet and a special tracer to measure oxalate absorption, kidney handling, and natural…

This study looks at 475 people on hemodialysis to find better markers for bone disease and blood vessel hardening. Researchers are checking if new markers can predict heart attacks, strokes, and death better than current tests. The goal is to improve monitoring and care for dialy…

This study is investigating whether a substance called copeptin, which is a stable marker of the hormone vasopressin, is linked to blood pressure changes that happen during hemodialysis. Researchers will measure copeptin levels in routine blood samples from 71 adults on chronic d…

This study examines how end-stage renal disease (ESRD) impacts recovery after pancreatic surgery. Researchers will review medical records of 100 patients to compare complication rates, hospital stays, and costs based on kidney function and dialysis use. The goal is to provide cle…

This study looks at how the complement system, a part of the immune system, may contribute to kidney damage in people with diabetes. Researchers will measure complement proteins in blood and urine from 90 participants to see if they are linked to kidney disease severity and blood…

This study tests whether a tele-health navigator program can help more kidney transplant candidates find living donors. About 347 adults with end-stage kidney disease will either get the navigator support or standard care. The goal is to see if remote guidance increases donor scr…

This study was designed to measure how often urine flows backward from the bladder into the ureter after placing a special stent (RELIEF) in people with kidney stones. Researchers planned to use bladder X-rays to check for reflux and track any symptoms. However, the study was wit…

This study follows 468 people with metastatic kidney cancer to see how their treatment and quality of life change over time in real-world clinics. Researchers will track medication adherence, symptoms, and well-being using patient questionnaires. The goal is to understand what ac…

This study looked at 122 adults who received a kidney from a living donor. Researchers wanted to see if the amount of fluids given in the first 4 hours after surgery affected how well the new kidney worked. They measured kidney function and complications in the first week and fir…