New hope for kidney transplant patients: experimental drug tegoprubart aims to replace tacrolimus
NCT ID NCT06126380
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a new drug called tegoprubart (AT-1501) to see if it is safe and effective for preventing kidney transplant rejection over several years. About 132 people who have already received a kidney transplant will receive either tegoprubart or the standard drug tacrolimus, along with other immunosuppressants. Researchers will monitor side effects and how well the transplanted kidney works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tegoprubart (AT-1501) plus standard immunosuppressants (mycophenolate mofetil and corticosteroids)
What this could lead to
If successful, tegoprubart could offer a safer, more tolerable alternative to tacrolimus for preventing kidney transplant rejection.
What could go wrong
This is an early-phase, open-label extension study with no placebo group, so results are preliminary. Long-term risks and benefits are still unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Augusta University
Augusta, Georgia, 30912, United States
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CHU Grenoble-Alpes - Hopital Nord Michallon
Grenoble, 38700, France
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CHU de Toulouse - Hopital de Rangueil
Toulouse, 31400, France
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Centre Hospitalier Universitaire Dupuytren
Limoges, 07042, France
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Charite Universitatsmedizin Berlin
Berlin, Germany
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory University Hospital
Atlanta, Georgia, 30322, United States
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Fiona Stanley Hospital
Perth, Western Australia, 6150, Australia
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Fundação Oswaldo Ramos - Hospital do Rim
São Paulo, 04038-002, Brazil
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Groupe Hospitalier Pellegrin
Bordeaux, France
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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Hospital Clinical de Barcelona
Barcelona, 08036, Spain
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Hospital Germans Trias i Pujol
Barcelona, 08916, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitari de Bellvitge
Barcelona, 08907, Spain
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Hospital das Clínicas da Faculdade de Medicina de São Paulo
São Paulo, 05403-010, Brazil
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Hospital del Mar - Parc de Salut Mar
Barcelona, 08003, Spain
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Jacobs Medical Center at UC San Diego Health
San Diego, California, 92037, United States
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John Hopkins University
Baltimore, Maryland, 21287, United States
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Keck School of Medicine of USC
Los Angeles, California, 90033, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55907, United States
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McGill University Health Care Centre
Montreal, Quebec, H4A 3J1, Canada
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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New York University Langone Health - Tisch Hospital
New York, New York, 10016, United States
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Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital
Oxford, OX3 9DU, United Kingdom
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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St. Paul's Hospital
Vancouver, British Columbia, V6Z IY6, Canada
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Tampa General Hospital
Tampa, Florida, 33606, United States
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Tulane Medical Center
New Orleans, Louisiana, 70112, United States
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UT Southwestern
Dallas, Texas, 75235, United States
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University of California Los Angeles
Los Angeles, California, 90024, United States
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University of California, Davis Medical Center
Sacramento, California, 95817, United States
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University of California, Irvine Medical Center
Orange, California, 92868, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45219, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Minnesota Medical Center
Minneapolis, Minnesota, 55455, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Pittsburgh Medical Center
Harrisburg, Pennsylvania, 17104, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Washington University in St. Louis
St Louis, Missouri, 63110, United States