New hope for kidney transplant patients: experimental drug tegoprubart aims to replace tacrolimus

NCT ID NCT06126380

ENROLLING_BY_INVITATION Disease control Sponsor: Eledon Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new drug called tegoprubart (AT-1501) to see if it is safe and effective for preventing kidney transplant rejection over several years. About 132 people who have already received a kidney transplant will receive either tegoprubart or the standard drug tacrolimus, along with other immunosuppressants. Researchers will monitor side effects and how well the transplanted kidney works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tegoprubart (AT-1501) plus standard immunosuppressants (mycophenolate mofetil and corticosteroids)
What this could lead to: If successful, tegoprubart could offer a safer, more tolerable alternative to tacrolimus for preventing kidney transplant rejection.
What could go wrong: This is an early-phase, open-label extension study with no placebo group, so results are preliminary. Long-term risks and benefits are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT REJECTION

Contacts and locations

Locations

Augusta University

Augusta, Georgia, 30912, United States
CHU Grenoble-Alpes - Hopital Nord Michallon

Grenoble, 38700, France
CHU de Toulouse - Hopital de Rangueil

Toulouse, 31400, France
Centre Hospitalier Universitaire Dupuytren

Limoges, 07042, France
Charite Universitatsmedizin Berlin

Berlin, Germany
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Fiona Stanley Hospital

Perth, Western Australia, 6150, Australia
Fundação Oswaldo Ramos - Hospital do Rim

São Paulo, 04038-002, Brazil
Groupe Hospitalier Pellegrin

Bordeaux, France
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hospital Clinical de Barcelona

Barcelona, 08036, Spain
Hospital Germans Trias i Pujol

Barcelona, 08916, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitari de Bellvitge

Barcelona, 08907, Spain
Hospital das Clínicas da Faculdade de Medicina de São Paulo

São Paulo, 05403-010, Brazil
Hospital del Mar - Parc de Salut Mar

Barcelona, 08003, Spain
Jacobs Medical Center at UC San Diego Health

San Diego, California, 92037, United States
John Hopkins University

Baltimore, Maryland, 21287, United States
Keck School of Medicine of USC

Los Angeles, California, 90033, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55907, United States
McGill University Health Care Centre

Montreal, Quebec, H4A 3J1, Canada
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
New York University Langone Health - Tisch Hospital

New York, New York, 10016, United States
Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital

Oxford, OX3 9DU, United Kingdom
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
St. Paul's Hospital

Vancouver, British Columbia, V6Z IY6, Canada
Tampa General Hospital

Tampa, Florida, 33606, United States
Tulane Medical Center

New Orleans, Louisiana, 70112, United States
UT Southwestern

Dallas, Texas, 75235, United States
University of California Los Angeles

Los Angeles, California, 90024, United States
University of California, Davis Medical Center

Sacramento, California, 95817, United States
University of California, Irvine Medical Center

Orange, California, 92868, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Minnesota Medical Center

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Pittsburgh Medical Center

Harrisburg, Pennsylvania, 17104, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

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