Cystinuria drug trial pulled before it even started

NCT ID NCT04147871

Terminated Disease control Sponsor: Advicenne Pharma Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study was designed to test whether ADV7103, a combination of potassium citrate and potassium bicarbonate, could help people with cystinuria by making their urine less acidic. The goal was to see if it could raise urine pH to 7.0 or higher, which might reduce kidney stone formation. However, the trial was withdrawn before enrolling any participants, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ADV7103 (a mix of potassium citrate and potassium bicarbonate)
What this could lead to: If it had worked, this could have pointed toward a better way to manage cystinuria by controlling urine acidity to prevent kidney stones.
What could go wrong: The trial was withdrawn before enrolling anyone, so no results are available. Even if run, it was an early-stage study with a short 7-day treatment period, so long-term benefits and safety would remain uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTINURIA

Contacts and locations

Locations

CHRU Lille

Lille, Lille, 59000, France
CHU Grenoble

Grenoble, Grenoble Cedex, 38043, France
CHU Pitié-Salpétrière

Paris, Paris, 15013, France
CHU Purpan

Toulouse, Toulouse Cedex 9, 31059, France
CHU Reims

Reims, Reims, 51100, France
Centre Hospitalier Universitaire de Lyon - Hôpital Femme Mère Enfant

Bron, 69500, France
Cliniques Universitaires Saint-Luc

Brussels, Brussels Capital, Belgium
Hôpital Américain CHU de Reims

Reims, Reims, 51092, France
Hôpital Necker AP-HP

Paris, Paris, 75015, France
Hôpital Necker Enfants Malades

Paris, Paris, 75015, France
Hôpital Ténon - Explorations fonctionnelles Mutlidisciplinaires et INSERM UMR S 1155

Paris, Paris, 75020, France
UZ Leuven, Gasthuisberg Hospital

Leuven, Leuven, Belgium

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