Scientists hunt for hidden mutations behind polycystic kidney disease

NCT ID NCT03901521

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects kidney tissue from 100 adults with autosomal dominant polycystic kidney disease (ADPKD) who are already scheduled for kidney removal. Researchers will analyze the tissue for additional genetic mutations that may drive cyst formation. The goal is to better understand why the disease affects people so differently and to uncover clues for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal why some people with ADPKD get worse faster than others, pointing toward new targets for future treatments.
What could go wrong: This is an observational tissue-collection study, not a treatment trial. It may not directly lead to new therapies, and findings may take years to translate into clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant polycystic kidney disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Contacts and locations

Locations

Weill Cornell Medicine

New York, New York, 10021, United States

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