Breast cancer

This trial is testing an experimental oral drug, LG00313112, in people with advanced solid tumors that carry a specific genetic change called TP53 Y220C. The drug aims to restore the function of the p53 protein, which normally helps stop cancer growth. The study includes adults w…

Researchers compare two radiotherapy schedules for women who had breast reconstruction after mastectomy for breast cancer. One schedule gives larger daily doses over 3 weeks; the other gives smaller daily doses over 5 weeks. The trial checks whether the shorter schedule controls …

This study provides continued access to alpelisib for people who are already benefiting from it in a previous Novartis trial. It focuses on tracking long-term safety, including any side effects, in participants with PIK3CA-related overgrowth spectrum or certain breast cancers. Pa…

This trial is for people with ER-positive, HER2-negative advanced breast cancer whose disease has started to grow in a few spots while on hormone therapy and a CDK4/6 inhibitor. It tests whether adding targeted radiation (SABR) to those spots allows patients to stay on their curr…

Researchers are testing whether women aged 65 and older with early-stage, lymph node-positive, ER+/HER2- breast cancer can safely skip chemotherapy. Participants receive CDK4/6 inhibitors, with or without endocrine therapy, after surgery. The trial tracks how many women remain fr…

Researchers are testing whether measuring specific proteins in tumors can help match patients with advanced pancreatic or breast cancer to antibody-drug conjugates that are more likely to work for them. The trial enrolls 225 adults whose cancer has progressed after prior treatmen…

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing an oral drug called AL58805, which blocks two cancer-growth proteins, PI3K and mTOR, in adults with advanced endometrial, cervical, soft tissue sarcoma, or breast cancers that have worsened after at least one standard treatment. Participants receive AL5880…

People newly diagnosed with breast, colorectal, lung, or prostate cancer often also manage other long-term conditions and take multiple medications. This pilot study tests whether a pharmacist-led medication review plus the Medisafe mobile app helps them stick to those regimens. …

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

This study tests whether a patient navigator program can help breast cancer patients with social challenges—like food, housing, or transportation issues—stay on schedule with their treatment. Participants will be contacted by a navigator every three weeks to connect them with com…

This early-stage trial tests an experimental drug called STRO-006 in adults with advanced solid tumors, including head and neck, lung, esophageal, gastric, colorectal, endometrial, bladder, and breast cancers that have not responded to standard treatments. The study has three par…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This trial tests whether a 14-week physiotherapist-led exercise program, given alongside standard pre-surgery treatment for breast cancer, improves physical fitness, muscle strength, quality of life, and the ability to complete treatment. Researchers will compare participants who…

This trial tests a cell therapy called DC-CTL, made from a patient's own immune cells, combined with standard anti-tumor treatment. The goal is to see if this approach is safe and may help control solid tumors such as colorectal, esophageal, lung, liver, and breast cancer. About …

This trial tests a type of radiation called brain-avoidant proton craniospinal irradiation (BRAVO-pCSI) in people with leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. The study includes adults with breast cance…

This phase II trial tests whether a combination of culmerciclib, letrozole, trastuzumab, and pertuzumab can shrink tumors before surgery in people with HR-positive, HER2-positive early or locally advanced breast cancer. About 33 participants who have not had prior treatment will …

This pilot trial tests whether adding the drug alisertib to usual care can help people with advanced HR+/HER2+ breast cancer whose disease has become resistant to standard treatments. Researchers want to see if alisertib can block communication between hormone receptors and HER2,…

This study tests a new treatment using specially engineered immune cells (4SCAR-T cells) that target three different markers on breast cancer cells: GD2, Her2, and CD44v6. The goal is to see if this approach is safe and can shrink tumors in people with advanced or relapsed breast…

This trial tests whether adding an experimental immunotherapy drug (QL1706) to standard hormone therapy can shrink tumors in people with a common type of breast cancer (HR-positive, HER2-negative) that did not respond well to initial chemotherapy. About 40 participants whose tumo…

This phase II trial is testing whether adding dexamethasone, a steroid, to standard hormone therapy can help people with ER+ HER2- metastatic breast cancer whose disease has progressed on the same hormone therapy. The study will enroll 80 participants and will evaluate how well t…

This trial is testing whether adding an experimental drug called JYP0035 to the standard medicine fulvestrant can help people with a certain type of advanced breast cancer. The study focuses on patients whose tumors have a PIK3CA gene mutation and who have already tried hormone t…

This trial is testing whether the drug trastuzumab deruxtecan (T-DXd) can help people with a certain type of advanced breast cancer. The study focuses on patients whose tumors were originally classified as HER2-null (no HER2 protein) but were re-scored as HER2-ultralow using arti…

This trial is investigating whether a single-port robotic system can safely and effectively perform breast cancer surgery through one small hidden incision, instead of larger cuts. The study includes women aged 18-80 with early-stage breast cancer who are candidates for either br…

This early-phase trial tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) plus a targeted drug called T-Dxd. The study aims to find the safest dose …

This trial is testing an investigational drug called SKB103 in people with advanced HER2-negative breast cancer that has not responded to standard treatments. The study has two parts: first, to find a safe dose, and second, to see how well that dose shrinks tumors. Participants r…

This trial is investigating whether cryoablation, a technique that freezes and destroys breast tumors with extreme cold, can be an effective alternative to surgery for certain patients. The study will include adults with localized breast cancer who cannot or choose not to have su…

This phase 2 trial is testing whether romiplostim, a drug that stimulates platelet production, can prevent chemotherapy-induced thrombocytopenia (low platelet counts) in breast cancer patients. The study enrolls adults aged 18 to 75 with breast cancer who experienced low platelet…

This trial tests whether adding semaglutide to structured lifestyle counseling improves heart and blood vessel health in postmenopausal breast cancer survivors with obesity who are taking an aromatase inhibitor. Participants will receive either semaglutide or a placebo, along wit…

This phase 2 trial is testing a two-step treatment approach for people with advanced HER2-positive breast cancer. First, participants receive an induction therapy with trastuzumab rezetecan. If the disease does not progress, they then move to a maintenance phase combining trastuz…

This phase III trial is testing whether adding everolimus to trastuzumab rezetecan helps people with a specific subtype of triple-negative breast cancer (called luminal androgen receptor) live longer without their disease progressing. The study enrolls adults with advanced or met…

This study compares two ways to rebuild a breast after a mastectomy for breast cancer: a newer, minimally invasive endoscopic method done through a small armpit incision, versus the traditional latissimus dorsi flap surgery (using muscle from the back, often with an implant). The…

This trial is testing whether treating only part of the breast with radiation is as effective as treating the whole breast in women with early-stage, low-risk breast cancer. Participants are women aged 40 and older who had breast-conserving surgery and did not have a sentinel lym…

This phase II trial is testing whether combining an experimental antibody called SSGJ-612 with a targeted chemotherapy (an antibody-drug conjugate) can shrink tumors in people with hormone receptor-positive, HER2-low or HER2-ultralow metastatic breast cancer. The study enrolls ab…

This phase 3 trial tests whether a combination of sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda) works better than standard chemotherapy before surgery for stage II-III triple-negative breast cancer. About 765 participants will be enrolled. The study aims to improv…

This study will compare a newer, less invasive endoscopic breast reconstruction method (direct-to-implant) with traditional flap surgery (using tissue from the abdomen) in 588 women who had a mastectomy at least one year ago. The goal is to see if the endoscopic approach leads to…

This phase 2 trial is testing whether adding an investigational drug called ivonescimab to standard chemotherapy before surgery can improve outcomes for people with triple-negative breast cancer. Ivonescimab is a bispecific antibody that works in two ways: it helps the immune sys…

This trial is testing an experimental drug called GB268, a tri-specific antibody that targets three key pathways involved in cancer growth. It is being studied alone or in combination with other treatments in people with locally advanced or metastatic breast cancer. The goal is t…

This study follows young women with hormone-sensitive breast cancer who stayed premenopausal or resumed menstruation after chemotherapy. Researchers are investigating whether adding two years of ovarian function suppression to standard tamoxifen therapy can lower the chance of ca…

This phase II trial is testing an experimental drug called SMP-656 in people with HER2-positive breast cancer that has spread or cannot be removed and has worsened after prior treatment with a specific type of antibody-drug conjugate. The study aims to see if SMP-656 can shrink t…

This trial is investigating whether women with node-positive breast cancer whose lymph nodes are cancer-free after chemotherapy can safely receive less extensive radiation. Instead of radiating the entire lymph node region, the study compares standard radiation to a more targeted…

This phase II trial is testing whether a vaccine called STEMVAC can help prevent triple-negative breast cancer from coming back after surgery. The vaccine targets proteins that cancer cells use to grow and spread, aiming to boost the immune system to destroy any remaining tumor c…

This trial tests a planned sequence of treatments for people with advanced or metastatic HER2-positive and hormone receptor-positive breast cancer. Participants first receive T-DXd (Enhertu) plus pertuzumab, then switch to a maintenance combination of palbociclib, endocrine thera…

This trial tests whether an online, personalized lifestyle program can help rural postmenopausal breast and endometrial cancer survivors lose weight and improve their health. Participants follow a tailored diet and aerobic exercise plan, with mobile health tools to track progress…

This study tests whether adding a new oral drug called fulvestaciclib to standard anti-HER2 and hormone therapy can help people with HR+/HER2+ advanced breast cancer live longer without their disease getting worse. Some participants receive the combo after initial chemotherapy, w…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This trial compares how well patients tolerate dalpiciclib versus abemaciclib or ribociclib when each is combined with standard hormone therapy for high-risk HR+/HER2- early breast cancer. About 456 patients who have completed initial local treatment will be randomly assigned to …

This trial is studying a combination of two targeted drugs, patritumab deruxtecan and trastuzumab deruxtecan, for people with a specific type of advanced breast cancer that is hormone receptor positive and has low or ultra-low levels of a protein called HER2. The study aims to fi…

This trial investigates TQB3126, a drug designed to destroy specific proteins that help breast cancer grow. It involves adults with breast cancer whose disease has worsened after prior treatments. The study will first find the safest dose and then test how well it works, alone or…

This trial tests whether special augmented-reality goggles can help surgeons find lymph nodes that may be missed during breast cancer surgery. The goggles show a fluorescent dye that collects in lymph nodes, allowing the surgeon to re-examine the area after the planned removal is…

This study tests a combination of three drugs—tislelizumab, bevacizumab, and capecitabine—in people with advanced solid tumors. The trial focuses on two challenging groups: those whose cancers have stopped responding to immunotherapy and those with tumors that have spread to the …

This study tests whether adding lovastatin, a common cholesterol-lowering drug, can help the cancer treatment trastuzumab deruxtecan work better in people with HER2-low or ultralow advanced breast cancer. About 60 participants will receive both drugs to see if more tumors shrink …

This phase 2 trial investigates whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with early-stage hormone-receptor-positive breast cancer. Participants receive tirzepatide alone, the standard hormone therapy letrozole alone, or both t…

This trial investigates whether surgically removing the primary breast tumor, followed by standard systemic therapy, improves survival compared to systemic therapy alone in women with stage IV breast cancer that has spread only to a single bone site. The study enrolls women aged …

This Phase 3 trial compares two forms of the chemotherapy drug utidelone—a capsule taken by mouth versus an injection—both combined with another chemo drug, capecitabine, in people with HER-2 negative advanced breast cancer. The study aims to see if the oral capsule works as well…

This trial tests a 12-week program called EmpowerHer that combines home-based exercise via a mobile app with weekly in-person group sessions. It aims to improve health-related quality of life, reduce fatigue, anxiety, and depression, and increase physical fitness in breast cancer…

This study investigates cryoablation, a procedure that freezes and destroys tumor tissue, for treating the primary breast tumor in women with metastatic breast cancer. The goal is to see if this minimally invasive approach can control the local tumor for 12 months while patients …

This study tests whether high-dose radiation can control tumors in people with locally advanced or recurrent metastatic breast cancer that has not responded to systemic therapy. Participants receive radical-dose radiotherapy, and those with large tumors (5 cm or more) may get a s…

This phase 3 trial is testing a drug called trastuzumab rezetecan, alone or combined with bevacizumab, in 140 women with advanced triple-negative breast cancer that has a specific immune-suppressed pattern. The goal is to see if the combination can delay cancer growth better than…

This study is testing whether some people with early-stage breast cancer can safely skip surgery after chemotherapy and instead use only radiation. It includes 84 adults with HER2-positive or triple-negative breast cancer who have responded well to initial chemo. The goal is to s…

The SASHA trial is testing whether a single, high-dose radiation treatment delivered directly to the tumor site over one day is safe and effective for women with early-stage breast cancer. The study will enroll 134 women aged 40-85 who have already had a lumpectomy. Researchers w…

This study tests a risk-based approach to radiation after breast-conserving surgery for early breast cancer. Depending on individual risk, patients receive either whole-breast or partial-breast radiation in fewer, larger doses (hypofractionation). The goal is to maintain cancer c…

This Phase 2 trial tests BL0175, a nano-medicine that delivers cancer-fighting drugs directly into tumors. It enrolls 120 postmenopausal women with HR+/HER2- advanced breast cancer. Researchers compare different doses to find the safest and most effective one for shrinking tumors…

This phase 2 study tests whether the drug hetrombopag can prevent dangerously low platelet counts caused by chemotherapy in breast cancer patients at high risk. About 126 participants will be split into three groups: one getting no preventive drug, one taking hetrombopag continuo…

This study looks at whether people with advanced breast cancer that has spread to lymph nodes can safely have a less extensive armpit surgery after chemotherapy. Instead of removing many lymph nodes, doctors will remove only a few and then give radiation. The goal is to see if th…

This phase II trial is testing a three-drug combination given before surgery for people with intermediate-to-high risk HR-positive, HER2-low breast cancer. Participants first take dalpiciclib (a pill) plus an aromatase inhibitor (another pill) for about 4 months, followed by infu…

This study tests a drug called SHR-A1811 in 60 adults with HER2-positive advanced breast cancer who have had up to 2 prior treatments. Researchers want to see if giving the drug in different ways (like injection or infusion) can shrink tumors. The main goal is to measure how many…

This study tests whether a new drug, trastuzumab rezetecan, works as well as or better than the current drug trastuzumab deruxtecan for women with advanced HER2-positive breast cancer that has worsened after previous treatment. About 100 women will be randomly assigned to one of …

This study looks at whether a structured support program can help people with early-stage, hormone-positive breast cancer stick to their ribociclib medication (taken with an aromatase inhibitor). About 90 participants will be split into two groups: one gets standard care, the oth…

This phase 2 trial is testing a combination of three drugs—inavolisib, ribociclib, and fulvestrant—in 160 Chinese women with a specific genetic mutation (PIK3CA) in hormone receptor-positive, HER2-negative advanced breast cancer that has stopped responding to endocrine therapy. T…

This study tests a combination of two drugs, zongertinib and fulvestrant, in people with advanced breast cancer that is hormone receptor-positive and HER2-negative but has a specific HER2 gene mutation. The goal is to see if the combination shrinks tumors. About 25 adults will ta…

This study will test a device called LumiSystem that helps surgeons see if any cancer cells are left behind during breast cancer surgery. About 1500 women having a lumpectomy will be included. The goal is to see if using this imaging tool reduces the number of patients who need a…

This study tests whether giving a second, focused course of radiation to the breast is safe and effective for women whose breast cancer has returned more than a year after initial treatment. About 30 participants will receive accelerated partial breast irradiation. The goal is to…

This Phase 2 trial will enroll 100 young women (ages 18-45) with hormone receptor-positive breast cancer who are already on a 3-month GnRH injection for ovarian suppression. Half will switch to a monthly injection, while the other half stays on the 3-month schedule. The study aim…

This phase III trial is for people with HER2-positive stage IV breast cancer that has spread to a limited number of spots (oligometastatic). It tests whether adding surgery and focused radiation to standard drug therapy helps them live longer or delays cancer growth compared to d…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy as prescribed. The program includes education, reminders, and behavioral support. Researchers will measure how well participants stick with their medication and how …

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether adding 4 cycles of the targeted drug trastuzumab rezetecan (T-DXh) can eliminate residual cancer in HER2-positive breast cancer patients who still have disease after standard chemotherapy. About 59 adults will receive the drug before surgery. The main goa…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests whether placing a special amnion membrane graft under the nipple during mastectomy can prevent nipple death. The trial includes 30 people having either gender-affirming or preventive mastectomy. Half get the graft, half get standard care, and neither they nor the…

This study tests whether combining brain radiation with a targeted drug (dalpiciclib) and hormone therapy can help control breast cancer that has spread to the brain in people with HR-positive/HER2-negative disease. About 46 participants will receive the combination and be follow…

This study tests a new drug called AK138D1, given alone or with another drug (ivonescimab), in people with advanced breast cancer. The goal is to see if the treatment is safe and can shrink tumors. About 286 adults aged 18 to 75 will take part. This is an early-stage trial, so th…

This study looks at how well a drug called inavolisib works in real-world settings for people with a certain type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). About 100 participants will take inavolisib along with hormone therapy, sometimes with…

This study tests a new combination of drugs (zanidatamab, tucatinib, and chemotherapy) in people with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. The goal is to find the safest dose and see if the treatment shrinks tumors. About 24 adults…

This study tests a new type of breast-conserving surgery that uses a small camera inserted through a hidden armpit incision to remove tumors, compared to the standard open approach. About 1,366 women with early-stage breast cancer will be randomly assigned to one of the two surge…

This phase 2 trial tests whether adding a targeted drug (axatilimab) and radiation to the immunotherapy pembrolizumab can help shrink tumors in people with metastatic triple-negative breast cancer who have already tried immunotherapy. About 34 participants will receive all three …

This study tests whether a special PET scan (HER2-PET) can help doctors personalize treatment for early-stage HER2-positive breast cancer. After two cycles of standard therapy, the scan results will determine if patients need stronger or milder treatment. The goal is to improve t…

This study tests a personalized approach for people with HER2-positive breast cancer. After two cycles of standard therapy, those whose tumors shrink less than 40% will switch to a new drug combination (SHR-A1811 plus pertuzumab) for four more cycles before surgery. The goal is t…

This study tests whether a chemotherapy-free treatment using the targeted drug Dalpiciclib (a CDK4/6 inhibitor) plus hormone therapy works as well as standard chemotherapy for women with small, high-risk, hormone-receptor-positive breast cancer. About 2,288 participants will be r…

This phase 3 trial compares an injectable form of letrozole (given every 3 months) to the standard daily oral pill, both combined with ribociclib, in 300 postmenopausal women with advanced HR-positive, HER2-negative breast cancer. The goal is to see if the injection works as well…

This Phase 2 trial tests a new drug called HLX43, which is designed to seek out and destroy cancer cells in people with advanced triple-negative breast cancer (TNBC). The study will test HLX43 alone or combined with other immune-boosting drugs. About 180 adults with TNBC that has…

This study tests a freezing technique called cryoablation as a main treatment for early-stage breast cancer in adults aged 70 and older. Instead of surgery or long-term hormone pills, doctors use imaging to guide a needle that freezes and destroys the tumor. The goal is to see if…

This study will follow 500 people with HER2-positive advanced breast cancer who are starting treatment with pyrotinib, a daily oral targeted therapy. Researchers want to see how well the drug controls the cancer and what side effects occur in everyday medical practice, not just i…

This study tests whether adding the immunotherapy drug pembrolizumab to usual post-surgery treatment can help prevent breast cancer from returning in people with early-stage triple-negative breast cancer who still had cancer after initial chemo and pembrolizumab. About 1,000 adul…

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in women over 60 with early-stage, hormone-positive breast cancer. The goal is to see if cryoablation can control the disease just as well, with fewer side effects. About 938 participants w…

This phase 2 trial will test a combination of two drugs—serplulimab (an immunotherapy) and SHR-A1811 (a targeted chemotherapy)—given before surgery to women with early-stage triple-negative breast cancer. The main goal is to see how many patients have no cancer left at the time o…

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants will receive a combination of hormone therapy and a targeted drug (abemaciclib) based on their tumor's gene test res…

This early-phase trial tests a new type of cell therapy for people with metastatic HER2-positive breast cancer that has worsened after standard treatment. Researchers take a patient's own immune cells (T cells), add new genes to help them recognize and attack cancer cells, and re…

This early-phase trial tests whether combining the targeted drug trastuzumab deruxtecan (T-DXd) with precise radiation (SRS) is safe for people with HER2-positive breast cancer that has spread to the brain. Up to 20 participants will receive the drug by IV every three weeks along…

This early-phase trial will test the safety and tolerability of combining a CDK4/6 inhibitor (abemaciclib) with radiation therapy after surgery in 30 women with HR+/HER2- high-risk breast cancer. The study aims to find the highest safe dose of the drug when used alongside radiati…

This phase 2 trial tests a combination of two drugs—entinostat and oral paclitaxel—in 50 people with HR-positive, HER2-negative advanced breast cancer who have already tried 2 to 4 prior treatments. The goal is to see if the combo can delay cancer growth. Participants take both d…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study looks at whether a combination of ribociclib (a targeted drug) and hormone therapy can be as effective as chemotherapy followed by the same combo for people with a common type of early breast cancer (HR+/HER2-). Only patients whose blood tests show no signs of cancer D…

This phase 2 trial tests whether a new drug, trastuzumab-rezetecan, works as well as the established drug T-DXd in shrinking HER2-positive breast tumors before surgery. About 68 women with early or locally advanced breast cancer will receive one of the two drugs for 8 cycles, the…

This study tests whether taking two drugs (imlunestrant and abemaciclib) before surgery can shrink tumors in people with a common type of breast cancer (ER+/HER2-). About 189 women aged 18-75 with early-stage breast cancer will join. The treatment is guided by a marker called Ki6…

This study tests a surgical technique called lymphaticovenous bypass (LVB) to prevent lymphedema (arm swelling) in 400 breast cancer patients whose cancer has spread to lymph nodes. During standard lymph node removal, doctors will also reroute lymph vessels to veins, hoping to re…

This study compares a new drug, SHR-A1811, with a standard combination therapy (pyrotinib plus capecitabine) in 100 adults with advanced HER2-positive breast cancer that did not respond to the first-line treatment trastuzumab. The goal is to see which approach better delays cance…

This pilot study tests whether a daily grape polyphenol concentrate can reduce heart damage in women receiving certain chemotherapies for breast cancer. 120 women at high risk of heart problems will take either the supplement or a placebo for three months. Researchers will measur…

This study tests a new drug called SYS6010 against standard chemotherapy in people with a specific type of advanced breast cancer (HER2-negative, EGFR-positive) that has come back or spread. About 400 adults who have already tried 1-2 chemotherapy treatments will be randomly assi…

This study is for people with HER2-negative breast cancer whose tumors did not shrink after initial chemotherapy. Researchers are testing whether adding an immunotherapy drug (toripalimab) and targeted radiation before and after surgery can improve outcomes. About 110 participant…

This phase 3 trial will test if women with intermediate-risk breast cancer can safely skip radiation to the lymph nodes after surgery. About 3,142 participants will be randomly assigned to receive either standard radiation to the breast or chest wall plus lymph nodes, or radiatio…

This study tests whether adding famitinib to SHR-A1811 works better than SHR-A1811 alone for people with a certain type of advanced breast cancer (HR+/HER2-) that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will take part. The goal is to see if the combina…

This Phase 2 trial tests a new antibody drug (QL1706) combined with chemotherapy in 40 people with early triple-negative breast cancer. The treatment is tailored based on how the tumor responds after initial cycles, with the goal of avoiding certain heart-damaging drugs if possib…

This study looks at two powerful drugs, sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd), for people with a certain type of advanced breast cancer (HER2-low/TROP2-high). The goal is to find out which drug works best when given first and how to switch if the first sto…

This study tests whether a drug called RC48, combined with chemotherapy, works better than standard treatments for women with advanced HER2-positive breast cancer whose disease has progressed after prior therapy. About 268 participants will be randomly assigned to receive either …

This phase 2 trial tests whether adding the drug fluzoparib to standard treatment after surgery can help prevent breast cancer from coming back in women with certain inherited gene mutations (HRR). About 334 women with early breast cancer will be randomly assigned to receive eith…

This study compares two shortened radiation therapy schedules for breast cancer patients after surgery: one lasting 2 weeks and another lasting 3 weeks. The goal is to see which schedule better controls the cancer and causes fewer skin side effects. About 70 women who have had br…

This phase 2 trial tests a combination of three drugs (neratinib, fulvestrant, and eribulin) in 35 women with a specific type of advanced breast cancer (HR+/HER2+) that has stopped responding to the drug trastuzumab deruxtecan. The goal is to see if this new combination can shrin…

This study tests a new two-drug combination (JSKN016 plus D-0502) in 60 people with advanced hormone receptor-positive, HER2-negative breast cancer whose disease worsened after standard hormone therapy. The goal is to see if the combination is safe and shrinks tumors. Participant…

This phase II trial tests whether adding the drugs SHR-A1811 and/or adebrelimab to standard chemotherapy can improve outcomes for people with HR-positive, HER2-low early-stage breast cancer. About 249 participants will receive either chemo alone, chemo plus adebrelimab, or a sequ…

This study looks at 4,000 women aged 50 or younger with a common type of early breast cancer. Researchers want to see if hormone therapy plus ovarian function suppression works as well as chemotherapy for those with certain genetic test scores. The goal is to find out who can saf…

This study tests a new drug combination (SHR-A1811 plus pertuzumab) given before surgery to women with early or locally advanced HR-positive, HER2-positive breast cancer. The goal is to see if this treatment can eliminate all cancer cells in the breast and lymph nodes by the time…

This Phase 2 trial tests a new drug called SHR-A1811, alone or with hormone therapy (letrozole), against standard chemotherapy in 120 women with early-stage HR-positive, HER2-low breast cancer. The goal is to see if these combinations can shrink tumors before surgery more effecti…

This study tests whether a combination of two drugs (fulvestrant and ribociclib) works better than standard treatments for people with a certain type of advanced breast cancer (HR+, HER2-). The cancer has returned after the patient finished a prior course of CDK4/6 inhibitors. Ab…

This phase 2 trial is testing the drug sacituzumab govitecan (Trodelvy) as a first treatment for people with advanced triple-negative breast cancer who haven't had prior therapy for advanced disease. Researchers want to see if the drug can shrink tumors or slow the cancer's growt…

This phase 2 trial tests a personalized approach for women with early-stage HR+/HER2+ breast cancer. After two cycles of standard therapy, patients who respond well continue the same treatment, while those who do not switch to a combination of targeted therapy and hormone-blockin…

This study is testing a combination of four drugs (trastuzumab, pertuzumab, palbociclib, and exemestane) given before surgery to 90 people with early-stage triple-positive breast cancer. The goal is to see if this treatment can completely eliminate cancer cells in the breast and …

This study tests whether monitoring tumor DNA in the blood (ctDNA) and treating with abemaciclib can prevent breast cancer from coming back. 30 people with HR+/HER2- breast cancer who have finished standard treatment will be followed. If ctDNA is detected, they will receive abema…

This phase II trial tests a combination of targeted drugs and hormone therapy given before surgery for a specific type of breast cancer (ER-positive, HER2-positive). The goal is to shrink tumors without using standard chemotherapy. The study will enroll 42 women and measure how m…

This early-stage trial tests whether fecal microbiota transplants (FMT) from healthy donors can safely be added to standard chemotherapy and immunotherapy for triple-negative breast cancer. About 125 patients will take part, first in an observation phase and then in a treatment p…

This phase 3 trial tests whether placing tiny radioactive seeds in breast tumors before chemotherapy can help eliminate cancer more completely. About 194 women with early or locally advanced breast cancer will either get standard chemo alone or chemo plus seed placement. The goal…

This study tests a therapy that takes a patient's own immune cells, grows and strengthens them in a lab, and then gives them back to fight cancer. It is for people with advanced lung, liver, colorectal, or breast cancer that has spread. The goal is to see if this approach is safe…

This study reviews 150 breast cancer patients who had a delayed breast reconstruction using a new endoscopic technique through a small armpit incision, at least 6 months after their mastectomy. The goal is to see if this method leads to better patient satisfaction and fewer compl…

This study looks at whether time-restricted eating (eating only during certain hours) can improve heart and brain health in 152 women aged 60-85 who finished chemotherapy for early-stage breast cancer at least a year ago. Participants will get counselling on when to eat and how t…

This phase 2 trial tests whether adding trilaciclib to the chemotherapy drug eribulin can protect bone marrow in people with advanced triple-negative breast cancer who have already tried at least two chemotherapies. The study will enroll 29 participants and measure how often seve…

This phase 2 trial tests whether adding the drug inavolisib to a standard pre-surgery regimen (pertuzumab, trastuzumab, and nab-paclitaxel) can improve outcomes for people with a specific genetic mutation (PIK3CA) in HER2-positive early breast cancer. About 164 participants will …

This study looks at whether taking a thin layer of tissue from around the removed tumor (cavity shaving) is a safe and effective way to ensure all cancer is removed during breast-conserving surgery. It compares this method to the standard frozen section analysis. The goal is to s…

This study tests whether a combination of targeted drugs and hormone therapy can replace chemotherapy for people with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread). About 1,500 participants will receive either the standard chemo p…

This study tests whether a 6-month supervised exercise program can improve blood flow to the brain and thinking skills in women who had breast cancer 5-10 years ago. Participants will be randomly assigned to either the exercise program or usual care. The goal is to see if exercis…

This early-stage trial tests a drug called sacituzumab govitecan combined with hormone therapy in 12 people with HR-positive, HER2-negative metastatic breast cancer that has worsened after CDK4/6 inhibitor treatment. The main goal is to check safety and side effects, while also l…

This study tests a new drug called CVL006 combined with standard chemotherapy or other targeted drugs in people with advanced solid tumors that have not responded to previous treatments. The trial has two phases: first, to find the safest dose, and second, to see if the combinati…

This study tests whether a shorter course of hormone therapy (2-3 years) works as well as the standard longer treatment for women with a very low-risk, early-stage breast cancer. About 2,900 women will be randomly assigned to either the shorter or standard treatment. The goal is …

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

This study is testing a new blood test that looks for specific DNA changes (called epigenetic changes) to help diagnose breast cancer. Researchers will collect blood samples from 450 people, including those with breast cancer, healthy volunteers, and others, and follow them for a…

Researchers are testing whether an artificial intelligence model can spot breast cancer on chest CT scans that women already receive during routine health exams. The study includes a retrospective phase to validate the AI on existing images and a prospective phase where the AI re…

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This study tests whether combining two lymph node biopsy methods, sentinel lymph node biopsy and wire localized lymph node biopsy, can accurately identify breast cancer patients with only limited lymph node spread. The goal is to see if these patients can safely skip a more invas…

This trial tests a handheld device called the ZedScanner, which measures how breast tissue stores electrical energy—a property that differs between healthy, benign, and cancerous tissue. Around 220 women attending a breast clinic will get an extra, non-invasive scan after routine…

This study will test an artificial intelligence system that screens for breast, liver, kidney, and bladder cancers using standard CT scans taken for other reasons. Researchers plan to enroll 100,000 participants to see if the AI can catch tumors earlier and help doctors reduce mi…

This study tests a special PET scan that uses a radioactive tracer to track a protein called HER2 in the body. It aims to see if this imaging can predict how well a targeted cancer drug (T-DXd) works in 30 people with advanced breast cancer. The goal is to potentially replace inv…

This trial is testing whether a breath analysis device can detect unique chemical patterns—called volatile organic compounds—that may signal the presence of cancer. Researchers will collect breath samples from 1,000 people with various cancers and 1,000 healthy volunteers, then u…

This study tests a new type of breast imaging called upright breast CT (UBCT) that creates a 3D picture without compressing the breast like a mammogram. It uses a low radiation dose similar to standard mammography. The goal is to see if this device can help doctors detect breast …

This early-phase study tests a new imaging agent that targets a protein called TROP2, found on many cancer cells. About 40 adults with metastatic bladder, breast, or lung cancer will receive the agent to see where it goes in the body. The goal is to see if this tracer can help do…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study investigates whether offering regular breast ultrasound screening to women aged 65 to 80 can increase the rate of early-stage breast cancer detection compared to routine health check-ups. Over 82,000 women from communities in China will be assigned to either receive st…

This study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…

This study tests whether augmented-reality goggles, combined with a special dye called indocyanine green (ICG), can accurately identify cancerous lymph nodes during breast cancer surgery. Two hundred adults with breast cancer will take part. The goggles use near-infrared light to…

This study will test if a microwave imaging device can detect breast implants in 10 women who have had implants for at least 6 months. Researchers want to see if the scanner can create clear images of the implants and compare the left and right breasts. The goal is to explore a s…

This early-phase study will test two radioactive tracers designed to light up certain solid tumors on scans. Twenty adults with breast, head and neck, pancreatic cancer, or glioma will receive an injection of the tracers and then undergo PET/CT and SPECT/CT imaging. The goal is t…

This study tests whether a vacuum-assisted biopsy can accurately tell if breast cancer has been completely eliminated by chemotherapy, compared to the standard surgical removal. About 100 women with breast cancer who have finished chemotherapy will receive the biopsy, and results…

This study tests whether a special ultrasound technique (super-resolution imaging) can predict if breast cancer will completely respond to chemotherapy after just one cycle. Researchers will enroll 150 women with invasive breast cancer scheduled for chemotherapy. The goal is to s…

This study looks at two ways to train non-radiologist doctors and nurses in rural Rwandan hospitals to perform breast ultrasound. The goal is to help women get diagnosed with breast cancer earlier, without having to travel to a big city hospital. About 1,792 women will take part,…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study tests a new radioactive tracer called 68Ga-MY for PET scans. It targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will get both a standard FDG scan and a 68Ga-MY scan. Researchers will compare the…

This study aims to see if a less invasive biopsy method, using ultrasound guidance, can accurately detect whether breast cancer has spread to nearby lymph nodes. Researchers will enroll 200 adults with newly diagnosed breast cancer. The goal is to find the best way to identify su…

This study compares a new type of PET scan (FAPI) to the standard PET scan (FDG) in 15 people with metastatic invasive lobular breast cancer. The goal is to see if the new scan finds more cancer spots. Each participant will get both scans within a few weeks, and doctors will comp…

This study will compare two types of scans—PET/CT and CT—to see which is better at finding distant spread of breast cancer. About 97 patients with advanced breast cancer will receive both scans within a few weeks. The goal is to improve early staging and guide treatment to improv…

This study tests a new type of PET/CT scan that targets a protein called FAP, which is found in many breast cancers. The goal is to see if this scan can find cancer spread more accurately than current scans, helping doctors plan better treatment. About 65 adults with newly diagno…

This study looks at whether combining a special 3D mammogram (wide-angle tomosynthesis) with an AI tool helps doctors diagnose breast cancer more accurately and confidently. About 1,400 women with breast symptoms or who were called back after a screening mammogram will take part.…

This study tests whether a new MRI contrast agent, gadopiclenol, can detect brain metastases earlier than standard methods in 180 patients with advanced lung, breast, or skin cancer. Participants will receive screening brain MRIs to compare diagnosis timing and accuracy. The goal…

This study will test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can accurately measure the size of breast tumors in people with ductal carcinoma in situ (DCIS). Twelve participants will receive both a standard MRI and an FCI scan before surgery. The results…

This trial tests whether using more sensitive imaging (like MRI or contrast mammograms) based on a woman's personal risk can detect breast cancer recurrences earlier than standard mammograms. It will involve 2,300 women who had breast-conserving surgery and are at higher risk of …

This study will test an AI-enhanced ultrasound system to see if it can detect breast biopsy markers placed during standard care. About 100 adult women scheduled for breast tumor removal will have a short ultrasound scan. The AI software will try to locate the marker, but results …

This study will test whether AI-enhanced 3D and 2D echocardiography (heart ultrasound) can detect chemotherapy-related heart damage as accurately as cardiac MRI. Researchers will compare these new imaging methods with standard ultrasound and MRI in 120 adults who have received po…

This study will check if standard mammogram and ultrasound images can accurately predict the molecular subtype of breast cancer. Researchers will compare imaging features to lab results from biopsies in 122 women with suspected or confirmed breast cancer. If imaging can reliably …

This pilot study will test a device called the Histolog Scanner in 20 women having breast-conserving surgery for breast cancer. The scanner uses special microscopy to check if all cancer has been removed while the patient is still in the operating room. The goal is to see if this…

This study tests a new type of PET scan using a tracer called 68Ga-FAPI-46 to find cancer that has spread in patients with lobular breast cancer. Standard scans often miss these metastases. The trial will enroll 45 adults whose standard PET scan was negative or unclear, and see i…

This study tests a new device called VTM that uses infrared light to look for early signs of breast cancer, possibly before a lump appears. Researchers will compare VTM scans with standard mammograms in 120 women with breast cancer. The goal is to see if VTM can find tumors and b…

This study tests a new handheld scanner that gives surgeons a real-time, close-up view of the surgical area to see if any cancer cells remain after removing a breast tumor. Current methods can take time and may miss some cancer cells, sometimes requiring a second surgery. The sca…

This study will test whether artificial intelligence can analyze non-contrast breast MRI scans to detect cancer early, avoiding the need for contrast agents that can be costly and risky. Researchers plan to enroll 30,000 women aged 30-70 and compare AI readings to standard radiol…

This study compares a new DNA sequencing platform (MGI) against the current standard (Illumina) for diagnosing hereditary cancers like breast and ovarian cancer, Lynch syndrome, and intestinal polyposis. Researchers will analyze 248 patient samples using both platforms to see if …

Trastuzumab deruxtecan (T-DXd) treats metastatic breast cancer but can cause interstitial lung disease (ILD), a form of lung inflammation that sometimes forces patients to stop treatment. Researchers are testing whether giving dexamethasone before each T-DXd infusion lowers the c…

Researchers test a hybrid breast cancer education program for women aged 20 to 65 who visit an obstetrics and gynecology clinic. The program combines a face-to-face session using a breast model with four weeks of educational messages and reminders sent through a mobile app. The t…

This phase 3 trial tests whether a homeopathic remedy called Stibium metallicum praeparatum 6x can prevent or reduce nerve damage caused by the chemotherapy drug paclitaxel. The study will include 120 breast cancer patients who will receive either the remedy or a placebo injectio…

Doxorubicin is a common chemotherapy for breast cancer, but it can damage the heart. This trial compares two diabetes drugs, empagliflozin and metformin, to see if either can protect heart function in women receiving doxorubicin-based treatment. About 150 women with breast cancer…

Researchers are testing a digital program that educates women about the connection between alcohol and breast cancer risk. The study enrolls women aged 40 and older who drink alcohol regularly and are attending a routine breast cancer screening visit. Participants use the program…

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This pilot study tests whether a compression sleeve with a built-in sensor can prevent lymphedema in breast cancer survivors who already have mild arm swelling. About 40 women who had lymph node removal will wear the sleeve to see if it stops the swelling from getting worse. The …

This study tests whether providing online webinars, digital tools, and a logbook can help adults at high risk for breast cancer become more physically active. Participants (200 women aged 30-69) will either receive the full motivation package or just standard activity recommendat…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study tests a personalized program supported by a mobile app to prevent heart damage caused by breast cancer treatments. Researchers will enroll 102 women recently diagnosed with early-stage breast cancer who are at risk for heart side effects. The program uses artificial in…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study tests a simple idea: wearing tight surgical gloves during paclitaxel chemotherapy might prevent nerve damage in the hands. About 84 breast cancer patients will be randomly assigned to either wear the gloves during treatment or receive standard care. Researchers will th…

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests a gel called TAR-0520 to see if it can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. About 25 people with breast or colorectal cancer will apply the gel to their hands twice daily for 12 weeks. Their feet will n…

This study tests whether two types of diabetes medications—SGLT2 inhibitors and DPP-4 inhibitors—can prevent heart damage caused by the chemotherapy drug doxorubicin in women with breast cancer. About 150 Egyptian women will be randomly assigned to receive one of the drugs or sta…

This study tests a surgical technique done at the same time as breast cancer lymph node removal to prevent arm lymphedema (chronic swelling). The procedure uses a small flap of tissue from the side of the chest to rebuild the armpit area and support fluid drainage. One hundred hi…

This study tests whether telmisartan, a blood pressure medication, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 36 newly diagnosed women and measure changes in heart function and injury markers. If effecti…

This study tests whether taking rosuvastatin, a cholesterol-lowering drug, can prevent heart damage caused by anthracycline chemotherapy in women with breast cancer. Four hundred participants will receive either rosuvastatin or a placebo daily for 12 months. The main goal is to s…

Researchers are testing a five-session meaning-centered psychotherapy called CASA in Puerto Rican patients with Stage III or IV breast cancer and their caregivers. The trial compares CASA with usual care in about 114 people to see whether the therapy reduces psychological distres…

Many people treated with aromatase inhibitors for early-stage breast cancer develop joint pain and stiffness that can make it hard to continue the therapy. This Phase II pilot study tests whether hydroxychloroquine, an anti-inflammatory drug often used for inflammatory joint cond…

Researchers are testing whether an intravenous lidocaine infusion works as well as a thoracic paravertebral nerve block for helping women recover after breast cancer surgery. The trial enrolls 112 adults scheduled for mastectomy or breast-conserving surgery. Participants receive …

This study looks at whether an 8-week aerobic exercise program can improve blood vessel function in women who have finished chemotherapy for non-metastatic breast cancer. Forty women will exercise three times a week for 30 minutes at a moderate pace. Researchers will measure arte…

Researchers at City of Hope test whether a prehabilitation program is practical for breast cancer patients receiving chemotherapy before surgery. The program includes aerobic exercise, nutrition guidance, and education, all led by a physiatry team. Twenty participants will be ask…

This study looks at two ways to improve sleep after breast cancer surgery: a nerve block injection or a mild ear stimulation device. About 136 women will be randomly assigned to one of the two treatments. Their sleep will be tracked with a wrist monitor and questionnaires for the…

The PRISM trial compares two radiation approaches after breast-conserving surgery for early-stage breast cancer. One approach treats only the area around the original tumor, while the other treats the whole breast. Both use the same short schedule of five radiation treatments. Re…

This study tests a virtual group program called Breath-Body-Mind (BBM) that uses slow breathing and gentle movements to help young breast cancer survivors (ages 18-50) cope with psychological distress. Thirty participants will be randomly assigned to either the BBM program or a g…

This study looks at whether a long-acting G-CSF called telpegfilgrastim causes less bone pain than other long-acting G-CSFs in breast cancer patients receiving chemotherapy. About 132 patients will be divided into two groups based on which G-CSF their doctor prescribes. Researche…

This study tests whether adding low-level red-light therapy to the standard hair-loss treatment minoxidil helps breast cancer patients regrow hair lost during chemotherapy. About 50 adults with stage I-IV breast cancer who lost at least half their scalp hair after chemo will be e…

This trial tests an AI chatbot that guides breast cancer survivors through a six-week program of mindfulness, compassion, and body-mind-spirit techniques. The goal is to see if using the chatbot improves holistic well-being, reduces depressive symptoms, and enhances coping skills…

This study tests whether using a special heating device on the breast before mastectomy and reconstruction is practical and helpful. Forty adult patients will either use the device for one or three cycles, or receive no treatment. The main goal is to see if patients can follow th…

This study looks at whether adding the drug bupropion (Wellbutrin) to standard hormone therapy can help women with early-stage breast cancer who have lost interest in sex. About 100 women will be randomly assigned to receive either their usual hormone therapy alone or with buprop…

This study tests a group therapy program called LiveWell mBC for women with metastatic breast cancer who are feeling distressed. The program uses adapted Dialectical Behavioral Therapy (DBT) skills to help manage emotions and uncertainty. 48 women will be randomly assigned to eit…

This pilot trial tests an artificial intelligence-based platform designed to help breast cancer survivors manage lingering symptoms like fatigue, pain, and insomnia after finishing treatment. Thirty-six women who have completed primary treatment within the past two years will be …

This study looks at whether a 6-week home program combining exercise and a limited eating window is practical and helpful for breast cancer survivors who are on hormone therapy and feel fatigued. Twenty participants will follow a plan to increase their steps, do resistance band e…

This trial tests whether a supervised exercise program is practical and safe for women with early-stage breast cancer receiving chemotherapy before surgery. Participants either join a supervised aerobic and strength training program twice a week during chemo, or receive usual car…

This trial asks whether a single nerve block can match the pain relief of multiple nerve blocks after breast cancer surgery. Women aged 18-65 scheduled for breast cancer surgery will receive either one or several injections of a local anesthetic near the spine. The study measures…

This phase III trial is testing whether adding aromatherapy—using lemon, lavender, and peppermint essential oils—to standard anti-nausea medication can better prevent nausea and vomiting in breast cancer patients receiving highly emetogenic chemotherapy. About 374 patients will b…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This trial tests whether mind-body practices like breathwork, meditation, and gentle yoga can improve quality of life, stress, and sleep in people who have recently finished cancer treatment. Participants will practice these techniques weekly for six weeks while wearing an activi…

This trial tests whether a structured education program, given to both breast cancer patients and their primary caregivers together, can improve self-care behaviors and reduce anxiety for patients, while also easing caregiver anxiety and burden. The program involves four weekly s…

This trial compares two ultrasound-guided nerve blocks for pain after modified radical mastectomy: the newer serratus posterior superior intercostal plane block (SPSIPB) and the established serratus anterior plane block (SAPB). Seventy women undergoing mastectomy will receive one…

This trial tests whether a 12-week structured exercise program, called "Exercise for Muscle Health," can improve muscle mass, strength, and physical function in breast cancer survivors who have sarcopenia—a condition of muscle loss and weakness. About 104 women who have finished …

This trial tests whether self-guided digital programs can reduce both insomnia and depression in breast cancer survivors. Participants use an online insomnia program or a mental health program, either alone or in sequence, to see which approach works best. The goal is to find a s…

This trial investigates whether a daily supplement of Channa striata (snakehead fish) and curcuma (turmeric) can improve nutritional status, reduce inflammation, and enhance quality of life in women with breast cancer undergoing chemotherapy. Over one month, 76 participants will …

This study tests whether a 24-week, remotely supervised exercise program combining aerobic intervals and resistance training can improve physical health and quality of life in women with breast cancer undergoing chemotherapy. Participants, aged 30-65 with stage II-III breast canc…

This study tests whether taking a high dose of whey protein after each workout helps breast cancer survivors gain more muscle and lose more fat compared to exercise alone. Participants are women aged 20 to 89 who have completed treatment for breast cancer and are prescribed exerc…

This study tests a digital behavioral program called The-Optimal-Lymph-Flow (TOLF Self-Care) for breast cancer survivors who experience lymphatic pain—a common, often painful condition that can lead to chronic lymphedema. The program teaches self-care skills to promote lymph flow…

This study tests whether acupuncture can help breast cancer survivors who are on hormone therapy and still dealing with pain, fatigue, and poor sleep. Researchers will give a standardized acupuncture treatment and measure changes in these symptoms. The goal is to find out if acup…

This study tests two types of theta burst stimulation, a non-invasive brain stimulation technique, to relieve chronic nerve pain caused by chemotherapy in breast cancer survivors. Forty participants will receive both types of stimulation at different times, with brain scans used …

This study tests a device called ORASIS, which helps keep the surgical area clean during DIEP flap breast reconstruction. The device automatically removes fluid and smoke, so the surgeon can work without pausing. The trial will include 30 women who have had a mastectomy and are g…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study compares three techniques—ultrasound, wire, and magnetic seed—to help surgeons remove non-palpable breast tumors more accurately during breast-conserving surgery. About 1,300 adult women with early-stage breast cancer will be randomly assigned to one of the three metho…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This study compares a physical activity program to a health education program for improving memory and attention in Hispanic women aged 50 and older who have been treated for early-stage breast cancer. Researchers want to see if aerobic exercise can help with cognitive problems l…

This study will test a structured early rehabilitation program for women who have had breast cancer surgery. The program includes education, gentle exercises starting the day after surgery, and home-based workouts with monitoring. Researchers want to see if it is safe and helps w…

This study tests whether an artificial intelligence-powered digital education program can reduce the severity of radiodermatitis (skin irritation from radiation) and improve quality of life in women with breast cancer. 38 patients will be randomly assigned to either receive the A…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study tests whether a 16-week supervised exercise program can help breast cancer survivors improve their body's ability to switch between burning carbs and fats for energy. Researchers will enroll 44 women aged 18-70 who completed chemotherapy within the last 6 months and ar…

This pilot study tests a program called COPE (Creating Opportunities for Personal Empowerment) in 40 women with stage I-III breast cancer who are starting their first treatment. Participants will either receive the 7-week COPE sessions plus standard care, or standard care alone. …

This study compares two types of nerve blocks to see which one provides better pain relief after breast cancer surgery. About 70 women will receive either a newer block (SPSIP) or a standard block (SAP) before surgery. The goal is to reduce pain and the need for strong painkiller…

This study tests whether applying topical oxygen or LED light therapy can help heal nipple cracks in breastfeeding mothers. About 51 mothers with cracked nipples will be split into three groups: one gets oxygen, one gets LED light, and one gets standard care. The goal is to see i…

This study tests a small, wearable device that gently stimulates a nerve in the ear to reduce joint pain and stiffness caused by common breast cancer hormone pills (aromatase inhibitors). About 60 women with breast cancer who have joint pain will use either the active device or a…

This study will test whether a 16-week Pilates program can improve quality of life, reduce pain and fatigue, and boost emotional well-being in 50 women currently undergoing breast cancer treatment. Participants will do light-to-moderate Pilates exercises twice a week. The goal is…

This study tests whether a gentle electrical stimulation on the ear (called taVNS) can reduce joint and muscle pain caused by aromatase inhibitors, a common breast cancer treatment. 216 women with hormone-positive breast cancer will receive either real or sham stimulation daily f…

This study compares a new breast reconstruction method done in one surgery through a small armpit incision to the standard two-stage expander-to-implant approach. About 412 women who had a mastectomy at least a year ago will take part. The goal is to see which method has fewer co…

This study tests whether moderate aerobic exercise, done during breast cancer radiotherapy, can reduce inflammation and improve physical fitness and quality of life. Forty women with early-stage breast cancer will either do supervised exercise sessions or receive usual care. Rese…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests whether training doctors in shared decision-making and giving patients educational materials improves treatment conversations for HER2-negative metastatic breast cancer. 120 patients starting first-line therapy will be randomly assigned to receive the program or …

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that also removes lymph nodes. Sixty women aged 18-65 will receive one of the two blocks before surgery. Researchers will measure pain levels, opioid use, and side e…

This study tests whether a simple, video-guided mindfulness breathing program can improve quality of life and mental well-being in people with breast cancer. Fifty participants who have completed chemotherapy will either practice daily 5-minute breathing exercises for 6 weeks or …

This study tests whether a short psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can help chemotherapy work better in women with locally advanced breast cancer. Fifty-four participants will either receive standard chemotherapy alone or with Brief-…

This study tests whether a continuous nerve block using the numbing drug ropivacaine can reduce pain, inflammation, and opioid use in women undergoing mastectomy for breast cancer. Forty women will be randomly assigned to receive the nerve block or standard pain care. Researchers…

This study tests a decision aid called BCT Aid for women newly diagnosed with breast cancer. The tool helps patients understand their surgical options and what matters most to them. Researchers will compare women who use the aid to those who get usual care, looking at decision co…

This study tests whether foot reflexology, a gentle foot massage technique, can help reduce nausea and vomiting caused by chemotherapy in breast cancer patients. Fifty women receiving chemotherapy will be split into two groups: one gets standard care plus foot reflexology, the ot…

This study tests whether a system combining a smartphone app, a special pill bottle that records when it's opened, and a Fitbit can help breast cancer survivors take their long-term hormone therapy more consistently. Fifteen survivors aged 21-70 will use the system for six months…

This study tests whether a low-level laser applied to specific points on the ear can improve sleep in women with breast cancer who have insomnia. Seventy participants will receive either real or sham laser acupuncture twice a week for five weeks. Sleep quality, fatigue, and mood …

This study develops and tests a support program for cancer survivors who worry about their cancer returning. 150 adults who finished treatment for breast, head and neck, colon-rectal, or prostate cancer will join. Depending on their level of fear, they will receive education, psy…

This study tests a new surgical approach for women with early breast cancer who need a nipple-sparing mastectomy. If cancer is found in the nipple during surgery, doctors will remove the nipple but try to save the pigmented skin around it (the areola) and rebuild a new nipple rig…

This study compares two types of radiation therapy—proton and photon—given after breast cancer surgery to see which causes fewer side effects. Researchers will track 750 women for one year, monitoring heart, lung, skin, and lymph node problems. The goal is to find a gentler treat…

This study looks at whether adding psychosocial support to standard chemotherapy helps breast cancer patients feel better and respond better to treatment. About 160 Palestinian women with early-stage breast cancer will take part. Half will get usual care, and half will also recei…

This study will test whether hyaluronic acid injections in the face can improve appearance and quality of life in women who have completed breast cancer treatment. The researchers plan to enroll 22 women aged 18 to 50 who became menopausal due to chemotherapy or hormone therapy. …

This study tests a special scanner that lets surgeons check, in real time during breast cancer surgery, whether all cancer has been removed. The goal is to reduce the need for a second operation. About 228 women with certain high-risk breast cancer types will take part. The scann…

This study compares two ways of giving a large-volume subcutaneous injection of targeted therapy (pertuzumab and trastuzumab) to 40 women with HER2-positive breast cancer. Each patient will receive one injection by a nurse using a stopwatch to mimic a steady speed, and another in…

This study tests whether Baduanjin, a gentle exercise, can improve arm and shoulder function in breast cancer survivors. About 76 women who have finished surgery and other treatments will practice this exercise and report how they feel. The goal is to see if it reduces disability…

This study tests whether a whole food, plant-based diet combined with behavioral education can improve quality of life and diet adherence in 60 women with metastatic breast or endometrial cancer. Participants are randomly assigned to either the plant-based diet with support or a …

This study tests an educational program called SHARE-MC designed to help women with metastatic breast cancer address sexual health issues. About 96 women will take part in group video sessions or receive an informational booklet. The goal is to see if the program improves sexual …

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests whether a supervised exercise program, started two weeks before chemotherapy and continued for 16 weeks during treatment, can help adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemotherapy better. The goal is to see if participants can receive…

This study will test a culturally tailored online peer-support program for Korean-speaking breast cancer survivors and patients. Over 12 weeks, mentors (survivors) and mentees (patients in treatment) will interact through a bilingual platform. Researchers will measure whether the…

This study is testing a smartphone-based system that gives personalized advice to breast cancer patients going through chemotherapy. The system uses a knowledge graph to combine medical guidelines and patient-reported symptoms. Thirty patients and their nurses will use the system…

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study aims to find the best combination of three support strategies—priority coaching, education, and guided goal-setting—to help people who finished early-stage breast cancer treatment return to work, social life, and daily activities. About 352 participants will try one of…

This study tests whether a specific set of shoulder and scapular exercises can reduce pain, improve range of motion, and lessen disability in women who have had a mastectomy. 33 women aged 30-65, 4-12 weeks post-surgery, will be randomly assigned to either the exercise program or…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study looks at whether breast cancer patients can safely stop taking allergy-preventing medications before weekly paclitaxel after two doses without a reaction. Researchers want to see if stopping these drugs improves quality of life, since they can cause side effects like i…

This pilot study tests a device called BLOOM43 that warms the breast skin the night before reconstructive surgery after mastectomy. The goal is to see if preconditioning reduces skin necrosis (tissue death) and improves healing. Sixty women undergoing immediate breast reconstruct…

This study compares a plyometric strength-endurance exercise program to conventional strength training in 51 women who are breast cancer survivors or currently undergoing treatment. Over 12 weeks, participants will attend supervised 60-minute sessions twice a week. Researchers wi…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study will test if a specific exercise program can improve forward head posture and shoulder movement in women who have had a mastectomy. Sixty women aged 45-65 with upper cross syndrome will participate. The program focuses on exercises to correct posture and increase range…

This study tests whether adding magnesium to standard nerve blocks can better control pain after breast removal surgery. Sixty women scheduled for a mastectomy will receive either the standard nerve block or one with added magnesium. The goal is to see if the magnesium helps redu…

This study tests whether an online sexual health video series can help women newly diagnosed with breast cancer feel more confident talking to their doctors about sexual health. About 200 women will be randomly assigned to watch the videos or receive usual care. Researchers will …

This study tests whether a gentle exercise routine called Shangshou Daoyin can improve sleep and quality of life in breast cancer patients with insomnia. 76 women who completed cancer treatment at least 3 months ago will either do the exercises three times a week or receive stand…

This study tests whether a simple home exercise program done for at least three weeks before breast cancer surgery can help women recover better. 54 women with early-stage breast cancer will be randomly assigned to either the exercise program or usual care. Researchers will measu…

This study looks at whether adding magnesium sulfate to a standard nerve block can better control pain after a mastectomy. One hundred women having breast cancer surgery will be randomly assigned to receive the nerve block with or without magnesium. The main goal is to see if it …

This study looks at whether doing shoulder exercises before a mastectomy can lower inflammation, reduce pain, and improve shoulder function and quality of life in women with advanced breast cancer. Half of the 52 participants will do structured shoulder exercises for 6-8 weeks be…

This study compares two types of nerve blocks for pain after modified radical mastectomy. One block is placed under the chest muscle, the other above it, and a third combines both. The goal is to see which approach reduces opioid use and pain scores most effectively. Sixty women …

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…

This study tests whether a personalized diet can improve quality of life in 100 women with advanced gynecologic or breast cancer who are receiving antibody-drug conjugate therapy. Participants will either follow a diet tailored to their needs or receive general Mediterranean diet…

This study tests whether hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study looks at whether laser acupuncture can help reduce carpal tunnel syndrome symptoms in breast cancer patients who take aromatase inhibitors. Fifty-four women aged 40-60 will be split into two groups: one gets laser acupuncture plus standard physical therapy, the other g…

This study tests a 6-month online program for women with newly diagnosed breast cancer. The program includes daily exercise, mindfulness, and support via email and optional group sessions. Researchers want to see if it reduces psychological distress and improves well-being compar…

This study tests whether giving a mild electrical stimulation to the nerves during mastectomy surgery can help restore sensation to the breast and nipple. Thirty women having both breasts removed and reconstructed will receive the stimulation on one breast only, and their sensati…

This study tests whether a traditional Chinese herbal formula called Qibei Jiedu can prevent or ease the painful skin rash (radiation dermatitis) that often occurs during breast cancer radiotherapy. Sixty women with early-stage breast cancer will receive either the herbal drink o…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This Phase 3 trial tests whether taking creatine supplements daily can prevent or reduce the memory and thinking problems that often come with chemotherapy. About 227 women with early-stage breast cancer will receive either creatine or a placebo, starting before chemo and continu…

This study tests whether giving atropine before treatment can prevent diarrhea in people with advanced breast cancer receiving the drug sacituzumab govitecan. About 30 participants will receive atropine alongside their cancer therapy. The goal is to improve treatment tolerance an…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study will compare two surgical techniques for nipple-sparing mastectomy in 170 women with early breast cancer: the traditional open surgery and a newer endoscopic method using small hidden cuts. The main goal is to see which approach leads to better recovery of breast skin …

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study looks at whether wellness coaching, delivered through a mobile app or in a group, can help women recently diagnosed with breast cancer adjust emotionally and feel better overall. About 124 women will take part, answering surveys before and after an 8-week program. The …

This study tests if a traditional Chinese medicine hand and foot bath can help control nerve pain and numbness caused by chemotherapy in breast cancer patients. About 78 adults will either receive the herbal bath or a standard vitamin treatment. The goal is to see which approach …

This study tests whether adding Huaier Granule to standard care can reduce proteinuria (excess protein in urine) in breast cancer patients who developed it as a side effect of immunotherapy or anti-angiogenic therapy. About 120 women will be randomly assigned to receive either st…

This study looks at whether melatonin or vitamin D can help prevent heart damage in breast cancer patients receiving the chemotherapy drug doxorubicin. About 90 women will be randomly assigned to take melatonin, vitamin D, or a placebo alongside their cancer treatment. The goal i…

This study tests whether a special skin-like sheet (SureDerm) placed during breast-conserving surgery can improve how the breast looks and feels afterward. About 116 women with breast cancer will be randomly assigned to get the implant or standard surgery alone. Researchers will …

This study tests a 6-week support program for young and middle-aged women with breast cancer who are raising children. The program includes counseling and parenting guidance to help reduce anxiety about parenting. Researchers will enroll 20 participants to see if the program is a…

This study tests whether reconnecting nerves during breast reconstruction can improve sensation and quality of life. Twenty-eight women who had a mastectomy will be randomly assigned to receive either standard reconstruction or reconstruction with a nerve graft. Researchers will …

This study tests whether using a virtual reality headset for 30 minutes during chemotherapy can reduce pain and anxiety in breast cancer patients. Fifty participants will either receive standard care or standard care plus VR. Researchers will measure pain and anxiety levels using…

This study tests whether a single injection of liposome bupivacaine, a long-acting anesthetic, into the chest wall can reduce pain sensitivity and prevent chronic pain after radical mastectomy. 120 breast cancer patients will receive the nerve block during surgery, and their pain…

This study tests whether adding logotherapy—a type of counseling that helps people find meaning in their struggles—to standard support can reduce anxiety and depression in women newly diagnosed with breast cancer. Sixty-six women will be randomly assigned to receive either standa…

This phase 3 trial tests whether CBD oil can reduce joint pain caused by aromatase inhibitors, a common hormone therapy for early breast cancer. About 130 participants will receive either CBD or a placebo for 12 weeks, then switch treatments. The study measures pain interference …

This study tests whether a combination of two anti-nausea drugs (NEPA plus megestrol acetate) works better than the standard regimen (NEPA plus dexamethasone) for preventing nausea and vomiting in breast cancer patients receiving T-DXd therapy. 120 participants will be randomly a…

This study tests two different ultrasound-guided nerve blocks to see which one provides better pain relief after breast cancer surgery. 70 adults aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce the need for strong painkillers and impro…

This study compares removing drainage tubes earlier versus later after a specific type of nipple-sparing mastectomy with immediate breast implant reconstruction. About 379 women aged 18–70 with breast cancer or those having preventive mastectomy will take part. The goal is to see…

This study compares two types of nipple-sparing mastectomy: one done with a robotic arm through a small side incision, and the standard open surgery. Researchers want to see if the robotic method improves women's satisfaction, body image, and recovery over 12 months. The trial wi…

This study tests a simple home questionnaire for women with HR+HER2- advanced breast cancer who are taking CDK4/6 inhibitors and hormone therapy. The goal is to see if the questionnaire can accurately identify which patients truly need to come to the hospital for a check-up, pote…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This study will test SerenApp, a smartphone app designed with input from patients and doctors to help breast cancer survivors cope with anxiety, depression, and stress. 90 women who have finished primary treatment will use the app for 8 weeks. Researchers will measure changes in …

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

This pilot study will test whether a 4-week Mediterranean diet program is practical and acceptable for women newly diagnosed with breast cancer before they have surgery. Twenty post-menopausal women with stage I-III breast cancer will receive all their meals and snacks. The main …

Many breast cancer survivors struggle with arm and shoulder problems long after treatment ends. Researchers at Pamukkale University are measuring muscle oxygen levels in the upper arm using a light-based sensor, along with arm strength and daily function, in 80 women who finished…

This study looks at how financial stress from cancer treatment affects quality of life in breast cancer survivors, and whether personal strengths like resilience and posttraumatic growth can soften that blow. About 160 women will fill out surveys before, during, and after chemoth…

This pilot study is testing whether wearable patch monitors can help detect heart problems early in adults undergoing treatment for breast cancer, blood cancers, or multiple myeloma. Participants will wear two patches—one that tracks heart rhythm continuously and another that rec…

This study looks at whether radiation therapy for breast cancer affects the thymus, a small gland in the upper chest that helps produce immune cells. Researchers will collect blood samples from young women aged 18 to 50 who are receiving radiation after breast cancer surgery, as …

Researchers are testing whether the format of a breast cancer risk estimate affects how much women believe it. Women aged 39 to 74 will receive a personalized risk estimate online, with some seeing risk over 5, 10, or 30 years, and others seeing it out of 100 or 1,000 women. Some…

This study surveys 240 breast cancer patients to understand how they use herbs and supplements alongside standard treatments like chemo or hormone therapy. Researchers want to see if ethnicity influences which products people take. The goal is to gather information, not to test a…

This study follows 200 adults with stage 4 breast cancer that has spread to the brain or spinal lining. Participants fill out questionnaires about their symptoms, thinking abilities, and physical function over time. The goal is to track how symptoms change and how treatments affe…

This study explores whether a large language model (AI) can generate personalized exercise prescriptions for people recovering from breast cancer surgery. Researchers will collect health and fitness data from 40 postoperative patients and use the AI to create exercise plans. Expe…

This study tests whether a culturally tailored program can help Black women keep their mammogram appointments. About 176 women aged 40 and older who are scheduled for a screening mammogram will take part. The goal is to find better ways to reduce racial disparities in breast canc…

This study looks at breast cancer tumors to understand HER2 levels, including low and ultra-low expressions, which may affect treatment choices. Researchers will examine tissue samples from 100 patients diagnosed in Sohag, Egypt, and compare HER2 status with other tumor features …

This study is testing whether a six-gene risk score, calculated from a tumor tissue sample, can predict which women with early-stage breast cancer are more likely to develop lung metastasis. Researchers will follow 330 women aged 18 to 70 for up to 120 months, tracking lung metas…

This observational study looks at whether different molecular subtypes of breast cancer—like Luminal A, HER2-enriched, and triple-negative—show distinct patterns of bone metastasis on bone scans. Researchers will compare imaging results from 100 adults with breast cancer to see i…

This observational study examines long-term quality of life and aesthetic outcomes in women who underwent breast reconstruction using a PAP flap — a technique that uses tissue from the inner thigh. Researchers will survey participants and analyze photos to understand satisfaction…

This observational study is testing whether a blood test called a liquid biopsy can provide useful information for people with early-stage breast cancer who are about to start treatment before surgery. The test looks for tiny fragments of tumor DNA circulating in the blood. Resea…

This study will enroll 235 women with hormone receptor-positive, HER2-negative breast cancer who are taking abemaciclib after surgery. Researchers want to see if higher levels of the drug in the blood are linked to severe diarrhea, a common side effect. By understanding this link…

This study enrolls 1,000 adults with solid tumors, including breast cancer, who receive an AI-based pathology test as part of their routine care. Researchers will link the AI test results with short- and long-term health outcomes to see how well the scores predict prognosis and t…

This study looks at how different types of bilateral breast reconstruction affect women's quality of life and satisfaction. Researchers will compare women who had preventive mastectomy (due to high risk) with those who had therapeutic mastectomy (due to cancer), and also consider…

This study observes people with a common type of advanced breast cancer (HR+/HER2-) who are already on standard hormone therapy. Researchers use simple blood tests to look for changes in the ESR1 gene, which can make the cancer stop responding to treatment. By tracking these muta…

This pilot study looks at how different resistance training routines change levels of myokines—molecules released by muscles during exercise—in women who have finished breast cancer treatment. Participants will be assigned to one of three exercise regimens (conditioning, strength…

This study is developing an AI tool that analyzes tumor images, proteins, and patient data to predict whether a person with advanced HER2-positive or low-expression breast cancer will benefit from the targeted drug T-DXd. The goal is to avoid giving ineffective treatment, which c…

This study looks at how well a chemotherapy and immunotherapy combination works for early triple-negative breast cancer when the usual anthracycline drugs are left out. The researchers are focusing on patients who cannot take anthracyclines due to previous treatment, older age, o…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at whether breast-conserving surgery (removing only the tumor, not the whole breast) is safe for women diagnosed with multifocal or multicentric breast cancer—meaning they have two or more tumors in one breast. Researchers will follow 100 adult women for at least…

This study follows 100 women whose breast cancer has come back after a mastectomy. Researchers will track their health for at least three years to understand what factors affect survival and how different standard treatments work. No experimental drugs are given; the goal is to l…

This study looks at whether tracking tumor DNA in the blood (ctDNA) can help doctors see how well breast cancer treatment is working before surgery. It will include 186 people with stage II-III HER2-positive or triple-negative breast cancer. Researchers will take blood samples at…

This study looks at how common stigma is for breast and cervical cancer patients, caregivers, and community health workers in Rwanda. It also tests a program called RISE that includes resilience training, support groups, and videos of cancer survivors to see if it can reduce stig…

This study looks at whether changes in gut bacteria are linked to cancer-related weight and muscle loss (cachexia) in women with breast cancer who receive care at home. About 140 participants will provide blood, stool, and urine samples and answer questionnaires. Some will take a…

This study will enroll 56 women with breast cancer to see if two different regional anesthesia techniques (paravertebral block vs. erector spinae plane block) cause different immune responses during surgery. Participants will receive one of the two blocks along with general anest…

This study tests whether taking omega-3 supplements before surgery can change the types of fats found in breast tumors. About 35 adults with early-stage breast cancer will take the supplement for 4 to 28 weeks while also receiving standard cancer treatments. The goal is to see if…

This study aims to see if taking PET/CT scans later after injection of a special tracer (18F-Fluoroestradiol) can better detect breast cancer that has spread to the liver or abdomen. Researchers will use a new, more sensitive scanner that allows for later imaging, which may impro…

This study aims to use MRI and 3D images from 25 women who have had or will have a mastectomy (breast removal) to develop a computer model for a customizable breast implant called MyBREAST One. The goal is to create implants that are tailored to each person's body. This is an ear…

This study is testing a new tool to help older adults (65+) with metastatic breast cancer and their care partners make treatment decisions together. Researchers want to see if the tool is acceptable, appropriate, and practical for use. The study involves 150 participants and focu…

This study looks at tumor samples from 55 women with early-stage breast cancer to find early signs of whether chemo-immunotherapy is working. By analyzing individual cells before, during, and after treatment, researchers hope to identify markers that predict response or resistanc…

This study aims to understand why breast cancer in young women is often more aggressive. Researchers will look at how pregnancy and breastfeeding might influence the disease. They will collect information from 1,000 women aged 45 or younger (and a comparison group aged 55+) with …

This study aims to find the best score on a simple, self-administered questionnaire to identify mild nerve damage caused by chemotherapy in breast cancer survivors. About 28 women who have completed taxane-based chemotherapy and radiation will participate. The goal is to improve …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study looks at two ways to rebuild a breast after mastectomy for breast cancer: one-step with a permanent implant, or two-step using a temporary expander first. Researchers will compare complication rates in 276 women to see which method works better. The goal is to help doc…

This study will review medical records of about 240 adults in Kazakhstan with HER2-positive metastatic breast cancer to see how they were treated and how well they did. Researchers will look at treatments given in routine care (except one specific drug) and track outcomes like ho…

This pilot study tests whether a biology-guided therapy recommendations report can help doctors choose treatments for advanced hormone receptor-positive breast cancer that cannot be removed by surgery or has spread. Researchers will analyze tumor tissue from 20 patients to create…

This study will follow 2,200 young women (aged 40 or younger) who had breast cancer and carry a mutation in a breast cancer gene other than BRCA1/2. Researchers want to see if getting pregnant after diagnosis affects the cancer's return. The study does not test any drug or treatm…

This study checks if a new set of thinking and memory tests can better detect cognitive problems in breast cancer survivors who had chemotherapy. Researchers will compare results from 200 survivors and healthy volunteers to see if the tests are accurate. The goal is to improve di…

This early-stage study looks at whether taking oral paclitaxel with encequidar on an empty stomach or after a meal changes how much drug gets into the body. About 46 adults with advanced solid tumors (like breast, lung, or stomach cancer) will take the drugs in different sequence…

This study monitors 1,500 adults with breast cancer who receive LUMISIGHT during lumpectomy surgery. Researchers will track how often serious allergic reactions occur within 60 minutes of injection. No new drug is being tested; the goal is to better understand the safety of this …

This study looks at how gut bacteria affect diarrhea and other stomach issues in people with HR+/HER2- breast cancer taking the drug abemaciclib. In the first part, researchers will collect stool samples to track bacteria changes. In the second part, a small group will try eating…

This study will look at a specific genetic marker called PCGEM1 in blood and tissue samples from 90 newly diagnosed breast cancer patients. The goal is to learn more about how breast cancer develops and find possible targets for new treatments. No extra procedures are needed beyo…

This study looks at women with a very early form of breast cancer called DCIS. It uses a special test to find those at low risk of the cancer coming back. The goal is to see if these low-risk women can skip radiation therapy after their lump-removal surgery without a meaningful i…

This study looks at whether a blood test can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, ovarian, or pancreatic cancer. Researchers will collect blood and tumor samples from 300 adults to analyze cancer cells and their DN…

This study looks at whether a color Doppler ultrasound feature called the 'twinkling artifact' can make breast tissue marker clips easier to see. These clips are placed to mark suspicious areas in the breast or lymph nodes. The study will review past images from about 86 women wi…

This study will use a special PET/CT scan after proton radiation therapy for breast cancer to see how accurate the proton beam is. The goal is to link any beam errors with side effects like lung inflammation or rib fractures. By understanding these errors, doctors hope to improve…

This study looks back at medical records of 2000 women with HER2-positive early breast cancer who still had cancer after initial treatment. Researchers want to see which follow-up drug regimen—trastuzumab plus pertuzumab or T-DM1—leads to better long-term outcomes. The goal is to…

This study tests a simpler way to check for cancer spread after chemotherapy in women with node-positive breast cancer. Doctors will use a blue dye called methylene blue to find and remove a wider area of lymph nodes, instead of the standard method. The goal is to see if this app…

This study will take tumor samples from 40 women with locally advanced breast cancer and grow them in the lab as 3D 'mini tumors' called organoids. Researchers will test how these organoids respond to chemotherapy and compare the results to how the patients actually responded. Th…

This study looks at whether tiny particles called exosomes, released by breast cancer cells, contain genetic material (microRNA) that can predict how well chemotherapy will work before surgery. Researchers will collect tumor tissue and blood samples from 60 women with breast canc…

This observational study will follow 300 women aged 45-55 with hormone receptor-positive breast cancer to see if changes in a hormone called AMH can predict when they will reach menopause. Researchers will collect blood samples at seven time points and track menstrual patterns. T…

This study looks at 150 breast cancer patients starting T-DXd, a drug that often causes nausea, vomiting, and weight loss. Researchers will measure blood levels of a hormone called GDF-15 before and during treatment to see if changes in GDF-15 are linked to these side effects. If…

This study will follow 81 people with early-stage, hormone-positive breast cancer who are at high risk of the cancer coming back. Researchers want to see how often patients take their prescribed CDK4/6 inhibitor pills (abemaciclib or ribociclib) alongside standard hormone therapy…

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study will compare two different tissue expanders used in breast reconstruction after mastectomy in 80 women. Some participants will also receive radiation therapy, which is not typically recommended with these devices. Researchers will evaluate aesthetic outcomes, patient s…

This study looks at whether doing broad gene testing early, instead of later, helps find more effective treatments for people with advanced pancreatic, liver, or triple-negative breast cancer. About 360 adults with poor-prognosis cancers will be randomly assigned to early or stan…

This study tests whether special PET/MRI scans can predict how well breast cancer treatments work. 300 women will get scans before and after two cycles of therapy. The goal is to find which scan patterns match good or poor responses, helping doctors choose the right treatment for…

This study looks at whether chemicals called endocrine disruptors (found in plastics, food, and everyday items) are linked to breast cancer. Researchers will measure these chemicals in urine, hair, and breast fat from 42 women scheduled for breast lesion surgery. The goal is to u…

This study will track gut microbiome changes in 12 women with hormone receptor-positive breast cancer starting Verzenio (abemaciclib) therapy. Participants will take either a resistant potato starch supplement or a placebo, and provide stool samples and symptom questionnaires rem…

This study will use MRI scans and artificial intelligence to predict the type and aggressiveness of breast cancer without needing a biopsy. Researchers will analyze images from 400 patients to see if computer models can identify HER2 status and other key features. The goal is to …

This study will track 827 people with early breast cancer who had breast surgery but no armpit (axillary) surgery. The goal is to see if skipping armpit surgery is safe and how it affects quality of life. Researchers will monitor for cancer coming back in the armpit over three ye…

This study looks at whether women identified as having a higher risk of breast cancer will attend additional breast imaging appointments. About 3,000 women in Norway who either have very dense breasts or had a false-positive screening result will be invited for extra scans. The g…

This study looks at how chemotherapy for breast cancer affects the sense of arm position (proprioception). Researchers will compare three groups: breast cancer patients who had chemotherapy, those who had surgery only, and healthy volunteers. Using robotic tasks and video trackin…

This study will check if people with metastatic breast or colon cancer have antibodies that might also attack the heart. Researchers will collect blood samples and ECGs from 196 participants over 12 months. The goal is to see if these antibodies raise the risk of dangerous heart …

This study tests a structured education program to help women learn and practice breast self-exams. 76 women aged 20-69 will be randomly assigned to receive the program or not. Researchers will measure changes in self-exam behavior, breast cancer knowledge, awareness, and fear le…

This study looks at how often women with early-stage breast cancer experience taste changes during chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect nutrition and quality o…

This study will analyze medical records from 100,000 people in Korea who had early-stage hormone receptor-positive, HER2-negative breast cancer and received surgery followed by other treatments. The goal is to see how often the cancer comes back and what factors might affect that…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study aims to see if MRI can measure breast tumor volume more accurately than the usual one-dimensional ruler method. About 59 women with suspicious or confirmed breast cancer will get an MRI before surgery, and the MRI-based tumor volume will be compared to the actual tumor…

This study looks at whether a blood test for circulating tumor DNA (ctDNA) can detect leftover cancer after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 participants will give blood samples before and after standard treatments. No new treat…

This study looks at bacteria living inside breast tumors and compares them to bacteria in the gut and urine of 240 women undergoing breast cancer surgery. Researchers want to see if these microbes differ across cancer subtypes and if they relate to tumor features. The goal is to …

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…

This study compares two types of scans—standard CT and bone scans versus PET-CT—to see which better evaluates how well the drug trastuzumab deruxtecan (T-DXd) works in people with HER2 low metastatic breast cancer. About 262 participants will be split into two groups and scanned …