Freezing, not cutting: new study tests cryoablation for breast cancer in seniors

NCT ID NCT07398118

Not yet recruiting Disease control Sponsor: St. Antonius Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a freezing technique called cryoablation as a main treatment for early-stage breast cancer in adults aged 70 and older. Instead of surgery or long-term hormone pills, doctors use imaging to guide a needle that freezes and destroys the tumor. The goal is to see if this less invasive approach is safe and effective, potentially offering a quicker recovery with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoablation (freezing procedure)
What this could lead to: If successful, cryoablation could offer a less invasive, single-session treatment option for older adults with early-stage breast cancer, avoiding surgery or long-term hormone therapy.
What could go wrong: This is a small, early feasibility study (61 participants) with no control group. The procedure may not fully destroy the tumor, requiring additional treatment, and long-term outcomes are unknown.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER EARLY STAGE BREAST CANCER (STAGE 1-3) BREAST CANCER STAGE I

Contacts and locations

Locations

Amphia Hospital

Breda, North Brabant, 4818 CK, Netherlands
Antoni van Leeuwenhoek - Nederlands Kanker Instituut

Amsterdam, North Holland, 1066 CX, Netherlands
Rijnstate Hospital

Arnhem, Gelderland, 6836 BH, Netherlands

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