New trial aims to boost survival in HER2+ breast cancer by adding surgery and radiation to drug therapy
NCT ID NCT07578116
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase III trial is for people with HER2-positive stage IV breast cancer that has spread to a limited number of spots (oligometastatic). It tests whether adding surgery and focused radiation to standard drug therapy helps them live longer or delays cancer growth compared to drug therapy alone. About 562 participants will be randomly assigned to receive either standard systemic therapy alone or standard therapy plus locoregional treatment (surgery and radiation) and metastasis-directed radiation. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Surgery, radiation therapy, and stereotactic body radiation therapy (SBRT)
- What this could lead to
- If it works, this could show that adding focused treatments like surgery and radiation to standard drug therapy helps people with HER2+ breast cancer that has spread to a few spots live longer or keep the cancer from growing.
- What could go wrong
- This is a large phase III trial, but it hasn't started yet. Adding surgery and radiation may not improve survival over standard therapy alone, and these procedures carry risks like infection, pain, or damage to nearby tissues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANATOMIC STAGE IV BREAST CANCER AJCC V8 are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Digital therapy aims to tame the fear that haunts cancer survivors
- Engineered immune cells join chemo and antibody to attack Hard-to-Treat breast cancer
- Can couples coping together ease the burden of advanced cancer?
- Blood test could track breast cancer in real time
- Wheat germ supplement studied for immune boost in advanced cancer
- Could red light help breast cancer survivors regrow hair after chemo?