New trial aims to boost survival in HER2+ breast cancer by adding surgery and radiation to drug therapy
NCT ID NCT07578116
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase III trial is for people with HER2-positive stage IV breast cancer that has spread to a limited number of spots (oligometastatic). It tests whether adding surgery and focused radiation to standard drug therapy helps them live longer or delays cancer growth compared to drug therapy alone. About 562 participants will be randomly assigned to receive either standard systemic therapy alone or standard therapy plus locoregional treatment (surgery and radiation) and metastasis-directed radiation. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Surgery, radiation therapy, and stereotactic body radiation therapy (SBRT)
What this could lead to
If it works, this could show that adding focused treatments like surgery and radiation to standard drug therapy helps people with HER2+ breast cancer that has spread to a few spots live longer or keep the cancer from growing.
What could go wrong
This is a large phase III trial, but it hasn't started yet. Adding surgery and radiation may not improve survival over standard therapy alone, and these procedures carry risks like infection, pain, or damage to nearby tissues.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.