Can a Weight-Loss drug shield breast cancer Survivors' hearts?
NCT ID NCT07769047
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial tests whether adding semaglutide to structured lifestyle counseling improves heart and blood vessel health in postmenopausal breast cancer survivors with obesity who are taking an aromatase inhibitor. Participants will receive either semaglutide or a placebo, along with nutrition and physical activity guidance, and researchers will measure changes in arterial stiffness and other markers over 24 weeks. The goal is to see if this approach can lower the risk of cardiovascular problems in this population.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- semaglutide
- What this could lead to
- If effective, adding semaglutide to lifestyle support could reduce cardiovascular risk in breast cancer survivors, potentially improving long-term outcomes.
- What could go wrong
- This is a small, early-phase trial, and results may not apply broadly. Semaglutide can cause gastrointestinal side effects, and the impact on heart health is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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