Could a placental graft keep nipples alive after mastectomy?

NCT ID NCT06073808

Not yet recruiting Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether placing a special amnion membrane graft under the nipple during mastectomy can prevent nipple death. The trial includes 30 people having either gender-affirming or preventive mastectomy. Half get the graft, half get standard care, and neither they nor their doctors know who got what.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dehydrated human amnion/chorion membrane allograft (AmnioFix)
What this could lead to: If it works, this could offer a way to reduce nipple loss after mastectomy, improving cosmetic outcomes and patient satisfaction.
What could go wrong: This is a very small early trial with only 30 people, so results may not apply widely. The graft might not improve healing or could cause complications like infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast fibrocystic disease breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENIGN BREAST CONDITION GENDER AFFIRMATION SURGERY MASTECTOMY NIPPLE SPARING MASTECTOMY PROPHYLACTIC MASTECTOMY

Contacts and locations

Locations

Division of Plastic & Reconstructive Surgery

Palo Alto, California, 94304, United States

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