Assistance Publique - Hôpitaux De Paris

This study tests a new gene therapy for children with a severe immune disorder called Artemis-SCID, where the body cannot fight infections. Doctors take the child's own blood stem cells, fix the faulty gene in a lab, and put the corrected cells back. The goal is to rebuild a work…

This trial investigates whether pioglitazone, a drug used for diabetes, can help protect the kidneys in people with ANCA-associated vasculitis—a rare autoimmune disease that causes inflammation of blood vessels, often damaging the kidneys. Participants receive either pioglitazone…

This study tests whether a simple, standardized, and repeated message from healthcare professionals can improve how well patients with chronic diseases follow their treatment plans. About 1,200 adults with chronic conditions will receive this message during regular consultations.…

This study compares IV iron to oral iron pills for treating moderate anemia after a C-section. The goal is to see if better iron levels can reduce the risk of postpartum depression. About 2,860 women will take part, and their mood will be checked 8 weeks after delivery.

This study tests whether a single dose of tocilizumab, an anti-inflammatory drug, can help children and adults with sickle cell disease recover faster from acute chest syndrome—a serious lung condition. Participants receive either the drug or a placebo, and researchers measure ho…

This trial investigates whether vagus nerve stimulation (VNS) — a device implanted in the neck that sends electrical pulses to the brain — can help people with treatment-resistant depression. About 166 adults with depression that has not responded to standard treatments will rece…

This study follows 175 adolescents and adults with monogenic obesity—a rare form caused by specific gene changes—who are taking semaglutide (Ozempic/Wegovy). Researchers will track weight and BMI changes over 4 years to see if the drug helps control weight in this group. The goal…

This study tests a cancer vaccine for people with newly diagnosed glioblastoma, a serious brain cancer. The vaccine is designed to help the immune system attack tumor cells. About 35 participants will receive the vaccine after standard treatment. The goal is to see if it is safe …

This study looks at whether giving FOLFIRINOX chemotherapy before surgery helps people with mid or lower rectal cancer that has spread to the liver. The goal is to see if both the rectal tumor and liver spots can be completely removed. About 550 adults will take part, and the mai…

This study tests whether a non-invasive ventilator (NIV) or a CPAP machine is better at preventing severe COPD flare-ups and death in people who also have sleep apnea. About 386 adults who recently survived a life-threatening breathing crisis will use one of the two machines at h…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This Phase 3 trial tests whether baricitinib, a JAK inhibitor pill, can improve symptoms of dermatomyositis (a rare autoimmune disease causing muscle weakness and skin rashes) while allowing patients to stop steroids. 62 adults with active disease will receive baricitinib or a pl…

This study tests whether ruxolitinib, a drug that blocks a specific immune signal (interferon-γ), can help people with inclusion body myositis, a rare muscle disease that causes progressive weakness. About 80 adults aged 45 and older will receive either the drug or a placebo. The…

This study compares starting with two oral medications (tadalafil and ambrisentan) versus one medication alone in people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. The goal is to see if the two-drug approach lea…

This early-stage trial tests whether a device called SonoCloud-9 can safely open the blood-brain barrier in children aged 5 to 17 with recurrent malignant brain tumors. The barrier normally blocks chemotherapy from reaching the brain. By using low-intensity ultrasound just before…

This study explores whether using connected inhalers that track medication use, combined with video doctor visits when problems arise, can manage childhood asthma as well as standard in-person care. Fifty children aged 4 to 12 with asthma will take part for 8 months. Half will us…

This phase 3 trial tests two drugs, Thymoglobulin and Grafalon, to see which one better prevents graft-versus-host disease (GVHD) in patients aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. All participants receive a stem cell transplant from a matched unrelat…

This study tests a stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that has not improved or has returned after standard drug therapy. The approach uses a special drug after transplant to lower the risk of graft-versus-host disease, a common and se…

This study tests a drug called ruxolitinib as the first treatment for children with a rare, life-threatening immune condition called primary HLH. The goal is to calm the overactive immune system and help more children survive long enough to receive a stem cell transplant. The tri…

This study tests whether adding blood thinners (anticoagulants) to standard steroid treatment is better than steroids alone for deep vein clots in people with Behçet's syndrome. About 134 adults with a first or repeat clot will be randomly assigned to one of two groups. The goal …

This study looks at whether people with active cancer who have a blood clot in their lungs (pulmonary embolism) can be safely treated at home instead of in the hospital. About 824 participants will be randomly assigned to either go home within 24 hours or stay in the hospital for…

This study tests whether a single dose of rituximab, a drug that calms the immune system, can help the heart pump better six months after a severe type of heart attack called an anterior STEMI. About 372 adults who have just had such an attack will receive either rituximab or a p…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study tests whether adding a balloon pump early to reduce pressure on the heart improves survival and recovery in 298 adults on ECMO for severe cardiogenic shock. Participants are randomly assigned to early preventive unloading or standard care with rescue unloading only if …

This Phase 3 trial tests whether giving the lungs a near-complete rest (apneic ventilation) early after starting ECMO helps people with the most severe form of acute respiratory distress syndrome (ARDS). About 280 participants will be randomly assigned to either near-apneic venti…

This study compares two oxygen therapy strategies for adults in the ICU with severe breathing failure. One group gets high-flow oxygen alone, the other gets high-flow oxygen plus CPAP sessions. The goal is to see if adding CPAP reduces the need for a breathing tube and lowers the…

This study tests whether a liver transplant after a combination of targeted internal radiation (SIRT with Yttrium-90) and chemotherapy can improve 3-year survival in people with locally advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be surgicall…

This phase 3 trial is for people with granulomatosis with polyangiitis (GPA), a rare autoimmune disease causing blood vessel inflammation, who did not get better with standard treatments. It compares three salvage therapies: rituximab plus another drug, tocilizumab, or tofacitini…

This study tests whether the drug letermovir can stop cytomegalovirus (CMV) in unborn babies better than the current treatment valaciclovir. Pregnant women with a CMV-infected fetus will take one of the two drugs daily until delivery. The goal is to see if letermovir leads to a n…

This study tests whether a drug called glycerol phenylbutyrate (RAVICTI®) can reduce fatigue and improve daily life for people with pyruvate dehydrogenase (PDH) deficiency, a rare genetic condition that affects energy production. About 15 children and young adults (ages 2 to 25) …

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard medication helps children with unstable Crohn's disease have fewer flare-ups over a year. About 120 kids aged 6-17 will be randomly assigned to either diet plus medication or medication al…

This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or med…

This study involves 792 people aged 60-80 who had a stroke linked to a patent foramen ovale (PFO), a small hole in the heart. It compares three approaches: closing the hole with a device plus antiplatelet drugs, taking newer blood thinners (apixaban, dabigatran, or rivaroxaban), …

This phase 2 trial is testing whether a combination of two drugs, atezolizumab and bevacizumab, can safely treat liver cancer that has come back after a liver transplant. The study includes 50 patients who will receive the drug combo every three weeks along with a strict immunosu…

This trial tests a new gene therapy called DREAM01 for people with severe sickle cell disease who cannot find a matching bone marrow donor. The therapy uses the patient's own blood stem cells, modified to produce healthy hemoglobin and block the sickle cell gene. Up to 15 partici…

This study tests a drug called obinutuzumab in 33 adults with a relapsing form of granulomatosis with polyangiitis (GPA, formerly Wegener's). The goal is to see if the drug can stop disease activity and turn off the related antibody. Participants will be followed for 6 months to …

This study follows 20 adults with severe, drug-resistant Tourette syndrome who receive deep brain stimulation (DBS) targeting a specific brain region. Researchers will check tic severity, mental health, and quality of life every year for five years after surgery. The goal is to u…

This study tests a high-precision radiation treatment called SBRT for people with liver cancer who are waiting for a liver transplant but cannot have standard bridging treatments like radiofrequency ablation or chemoembolization. The goal is to see if SBRT can keep the cancer und…

This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some wil…

This study compares two types of gastric bypass surgery for people with severe obesity: the standard Roux-en-Y and a simpler omega (one-anastomosis) bypass with a shorter intestinal loop. Researchers want to see if the omega procedure is just as good at helping patients lose weig…

This phase 3 trial tests whether the drug dapagliflozin (Farxiga) can reduce deaths and heart or kidney problems in people leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support will take either the drug or a placebo daily…

This Phase 3 trial tests whether colchicine, an anti-inflammatory drug, can reduce heart scarring and prevent complications in 300 people with acute myocarditis (heart inflammation). Participants receive colchicine or a placebo for six months alongside standard care. The goal is …

This study compares two sedatives, dexmedetomidine and midazolam, in very premature babies who need a breathing tube. The goal is to see if dexmedetomidine helps them come off the ventilator sooner, which could reduce lung injury. About 380 babies born before 32 weeks will take p…

This study tests whether adding newer antibody-based drugs to standard chemotherapy can improve survival and reduce the need for stem cell transplants in adults with acute lymphoblastic leukemia (ALL). About 1,200 patients aged 18–65 with newly diagnosed ALL will be assigned to o…

This phase 3 trial tests whether giving low-dose arginine vasopressin during liver transplant surgery can prevent acute kidney injury, a common complication. Researchers will compare vasopressin to the standard drug norepinephrine in 304 adults. The goal is to see if vasopressin …

This study looks at people with colorectal cancer that spread to the liver, who had good results from chemotherapy before surgery. After removing the liver tumors, half will restart the same chemo (FOLFIRI) and half will get no further treatment. The goal is to see if the extra c…

This study tests whether an oral drug called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug for 12 m…

This study compares a new device called Endorotor to standard methods for removing dead pancreatic tissue in patients with severe pancreatitis. About 64 adults who need this procedure will be randomly assigned to one of two groups. The goal is to see if the Endorotor clears the t…

This phase 2 trial tests whether giving a short course of radiation before pancreatic surgery can prevent a common and serious complication called pancreatic fistula. About 50 patients with a high risk of this complication will receive two doses of radiation before their surgery.…

This study tests whether early, intensive day hospital treatment—with family involvement and multidisciplinary care—can improve outcomes for adolescents with anorexia nervosa compared to standard outpatient care. About 164 teens aged 12-18 with recent-onset anorexia will be enrol…

This study tests whether a drug called interferon gamma can help intensive care patients whose immune systems have shut down after a severe injury or infection. The main goal is to see if it helps them spend more days alive and off a breathing machine. About 170 adults on ventila…

This study tests whether people with heart failure whose heart function has returned to normal can safely stop taking beta-blockers. About 1,300 participants will either gradually stop their beta-blockers or continue them as usual. The goal is to see if stopping the drug leads to…

This study tests whether using chemotherapy alone before surgery works as well as chemotherapy followed by radiation for people with locally advanced rectal cancer. About 540 adults with stage T3 or node-positive rectal cancer will take part. The goal is to see if avoiding radiat…

This study looks at whether a genetic test can help choose a safer blood thinner for people who have had a heart attack. After one month on two blood thinners, some patients will switch to a single, lower-potency drug based on their genetic profile. The goal is to see if this app…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16…

This study compares two antibiotic treatments for acute kidney infection in children aged 1 month to 3 years. One group gets 3 days of IV antibiotics only, while the other gets 3 days IV followed by 7 days of oral antibiotics. The goal is to see if the shorter course works just a…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study tests whether adding letermovir to the standard drug valganciclovir works better than valganciclovir alone for treating CMV infections in kidney transplant recipients. About 80 adults who have a kidney transplant and a CMV infection will take part. The goal is to see i…

This study tests a drug called baricitinib (a JAK1 inhibitor) to see if it can shrink large inflammatory liver adenomas (a rare, non-cancerous tumor) in 25 people. The goal is to reduce tumor size enough to avoid surgery. Participants will take the drug for a short time, and doct…

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This Phase 3 trial tests whether fampridine can improve movement and vision in people with spinocerebellar ataxia SCA27B, a rare genetic condition that affects balance and coordination. About 70 adults will take either fampridine or a placebo twice daily for 12 weeks. The main go…

This study tests whether adding a protein called albumin to standard IV fluids during a major cancer surgery (cytoreduction with heated chemotherapy) can reduce complications. 140 adults undergoing this surgery will be randomly assigned to receive either standard fluids or standa…

This study looks at whether keeping patients with severe lung failure (ARDS) on their stomachs for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The g…

This Phase 3 trial tests whether a drug called obinutuzumab, combined with mycophenolate mofetil (MMF), can control lupus nephritis without the need for oral steroids. About 196 people with active lupus kidney disease will be randomly assigned to either the obinutuzumab/MMF regim…

This study tests whether giving antibiotics before burn surgery lowers the chance of infections after the operation. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics before surgery, and half will get a placebo. The goal is to …

This study tests whether itacitinib is safe and effective for adults with systemic sclerosis, a disease that causes skin thickening and organ damage. About 74 participants with early or active disease will receive the drug or a placebo for one year. The main goal is to see if it …

This study will track 16,000 children and adults who have robotic surgery to see how safe and effective it is, and how much it costs. Researchers want to know if the high-tech robots are worth the expense, especially for kids. The main focus is on complications during and after s…

This phase 3 trial is testing three different ways to give the meningococcal B vaccine to adults who have had their spleen removed. People without a spleen are at higher risk for serious infections. The study will compare how well each vaccine schedule triggers the immune system …

This early-phase trial tests whether injecting special immune progenitor cells (HTLPs) can help the immune system recover faster after a cord blood transplant in adults with blood cancers. Ten participants will receive the injection alongside their transplant. The goal is to see …

This trial tests a surgical technique to reduce severe bleeding after pancreatic head removal. In 150 high-risk patients, surgeons will either cover the exposed arteries with a flap of omental (belly) tissue or leave them uncovered. The goal is to see if the omental flap lowers t…

This study compares two treatments for long blockages (15-25 cm) in the leg's main artery. One is bypass surgery, which uses a vein or artificial tube to reroute blood flow. The other is a less invasive procedure using a balloon to open the artery, often with a stent. The trial w…

This study looks at whether children aged 8-13 with early onset anorexia nervosa can be treated with a shorter hospital stay followed by day treatment (going home at night) instead of staying in the hospital full-time. The goal is to see if this approach works just as well for we…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This study tests whether a blood test that measures donor DNA (dd-cfDNA) can safely guide follow-up care for kidney transplant patients, potentially reducing the need for invasive biopsies. 500 adult kidney transplant recipients will be randomly assigned to standard care or a str…

This study tests whether lowering blood pressure can slow the growth of white matter lesions in the brains of older adults (60-88) with high blood pressure and memory complaints. About 820 participants will receive either standard care or an enhanced blood pressure lowering strat…

This study tests whether a device called FibroScan, which measures liver stiffness, can quickly diagnose acute heart failure in people who come to the emergency room with shortness of breath. Researchers will enroll 100 adults and compare the FibroScan results with standard tests…

This study evaluates a rapid diagnostic test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy against standard lab methods using samples from 554 patients. The goal is to help hospitals quickly identify and …

This study tests a decision-support tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother catches it for the firs…

This study is testing whether low-dose CT scans can help find lung cancer early in people at high risk. About 20,000 adults aged 50-74 who are current or former heavy smokers will get a CT scan at the start, then again after 1 and 3 years. The goal is to see how many lung cancers…

This study is testing whether a mouthwash or a nasal swab can accurately detect pneumocystis pneumonia (PcP) in immunocompromised patients. Currently, diagnosis often requires a bronchoscopy, which is invasive and uncomfortable. Researchers will compare the new non-invasive metho…

This study is testing a new blood test that can diagnose single-gene disorders in unborn babies using a sample from the mother. The test looks at fetal DNA found in the mother's blood, which is safer than traditional invasive methods that carry a small risk of miscarriage. Resear…

This pilot study tests a new blood test that looks at markers on white blood cells to tell if a feverish baby under 3 months has a serious bacterial infection. Researchers will collect an extra small blood sample from 180 infants in the emergency department. The goal is to see if…

This study is testing whether a single trained radiologist can read low-dose CT scans for lung cancer screening as accurately as two experts. It will enroll 2,635 women aged 50 to 74 who are at risk due to heavy smoking. The goal is to see if this simpler approach can work well i…

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This study compares adding a quick MRI scan (fast-MRI) to standard ultrasound every six months for detecting early-stage liver cancer in people with cirrhosis who are at high risk. About 944 participants will be randomly assigned to either ultrasound alone or ultrasound plus fast…

This study is testing a new serious game called REALSoCog to see if it can detect social behavior problems in people with Alzheimer's, Lewy body dementia, or frontotemporal degeneration. Researchers will ask 120 patients to play the game on a laptop, which presents 16 social situ…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This pilot study tests a new cognitive test using building blocks to quickly screen for minimal hepatic encephalopathy (MHE), a subtle brain complication in people with liver disease. Researchers will compare the test's accuracy against standard methods in 100 adults with liver f…

This study tests a new technology (HD-sEMG) that monitors muscle signals to better diagnose sarcopenia—a condition where older adults lose muscle mass and strength. Researchers will enroll 846 people aged 75 and older who are hospitalized and at risk for sarcopenia. The goal is t…

This study looks at a new way to quickly figure out why someone is struggling to breathe in the emergency room. By measuring the difference between two types of carbon dioxide levels, doctors hope to tell if the cause is fluid buildup in the lungs (congestive) or something else. …

This study looks at whether automated software can consistently measure the amount of lung scarring (interstitial lung disease) on chest CT scans. Researchers will scan 150 adults with known lung scarring twice in a row to see if the measurements match. The goal is to improve the…

This study is testing whether a small, portable ultrasound probe (echOpen) can help doctors diagnose patients faster. About 100 adults who need a quick diagnosis will be included. Researchers will compare how long it takes to get a diagnosis when doctors use the probe versus when…

This study tests a new medical device called PrediMAP to see if it can accurately predict whether a pregnant woman in preterm labor will give birth within 7 days. Researchers will enroll 3,600 women visiting the emergency room with signs of preterm labor. If successful, the devic…

This study is testing whether a simple 8-item screening tool called the Autism Mental Status Exam (AMSE) can help non-specialist doctors and psychologists identify autism in adults. Currently, adults in France wait an average of 19 months for a diagnosis at expert centers, and ma…

This study is testing a new type of MRI scan called eASL that measures blood flow in the brain without needing a contrast injection. It will include 50 children with conditions like Moya-moya or sickle cell disease that affect brain arteries. The goal is to see if eASL gives clea…

This study is testing advanced lab techniques, like genetic sequencing and multiplex PCR, to improve how doctors diagnose complex eye infections such as endophthalmitis and severe corneal abscesses. Researchers will compare the new methods to standard cultures to see if they find…

This study is testing whether a simple screening test in early pregnancy (around 11-14 weeks) can predict and help prevent preeclampsia, a dangerous condition involving high blood pressure. The trial will involve 14,500 pregnant women and aims to reduce severe complications like …

This study looks at whether smokers aged 50-74 are more likely to get a low-dose CT scan for lung cancer when their family doctor recommends it. Researchers will track how many people complete the scan within one year. The goal is to catch lung cancer early in high-risk smokers.

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests a special dressing made with cinnamon to reduce bad smells from chronic or infected wounds. About 98 adults with smelly wounds will try the dressing for 14 days. The goal is to see if it improves their quality of life by cutting down on odor discomfort.

This study tests whether balance rehabilitation that changes how patients see (closing eyes, using a mask, or projecting moving dots) can improve walking stability better than standard rehab with eyes open. It includes 40 adults with chronic nerve damage who have trouble with bal…

This study tests a program that trains emergency doctors and gives patients simple educational materials to manage acute low back pain. The goal is to reduce pain and disability within a week and prevent long-term problems. About 782 adults with new or worsening back pain will ta…

This study compares two common surgical techniques used to reconnect the digestive tract after partial stomach removal for gastric cancer: Billroth II (one connection) and Roux-en-Y (two connections). The goal is to see which method leads to better quality of life one year after …

This study tests whether using a health app for follow-up after a gynecological emergency is as good as or better than traditional in-person visits. About 200 women aged 18-60 with conditions like ectopic pregnancy or miscarriage will either use the app to log symptoms and get ca…

This study looks at whether using walking sticks can help people with a forward-leaning spine (sagittal imbalance) walk longer distances. Thirty-five adults aged 50 and older who do not currently use walking sticks will test them for 3 months. Researchers will measure how far the…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either two Botox injections, one Botox and one placebo, or two placebo i…

This study tests whether automatic sound processing in cochlear implants helps children with hearing loss understand speech in noisy environments. Twenty children aged 6 to 16 who use cochlear implants will compare three different sound settings. The goal is to see which setting …

This study compares two different materials used in multifocal lenses for cataract surgery. 40 people will receive one type of lens in each eye. The goal is to see which lens provides better contrast sensitivity (ability to see differences in light and dark) 3 months after surger…

This study tests whether workshops and exchange groups can improve quality of life for people who have had their larynx removed due to cancer. Researchers will compare quality-of-life scores between 50 participants who join the program and a control group. The goal is to see if g…

This study looks at whether a cochlear implant can help children aged 4 to 6 who have severe hearing loss in one ear but normal hearing in the other. The implant is compared to a special hearing aid (CROS or BiCROS). The main goal is to see if the implant improves the child's abi…

This study tests whether a nasal spray of fentanyl or ketamine can relieve moderate to severe pain from limb injuries in children (ages 2-17) faster than oral morphine. About 300 children in the emergency room will be randomly assigned to one of the three medicines. The goal is t…

This study tests whether immersive virtual reality (IVR) can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). 35 participants will try both a VR session based on medical hypnosis and a music therapy session. …

This study compares two approaches for treating newly diagnosed Alzheimer's disease: the drug donepezil versus a non-drug approach using cognitive stimulation or remediation. Researchers will measure changes in thinking and memory over 6 months in 240 participants aged 50 and old…

This study looks at whether shiatsu, a type of Japanese bodywork, can improve symptoms and quality of life in people with cardiac amyloidosis, a serious heart condition. Researchers will compare targeted shiatsu to comfort-focused shiatsu and no shiatsu in 108 adults. They will m…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study tests a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease better understand what day, month, or season it is. Twenty participants will use the tool during their hospital stay to see if it improves their time orientation. The goal is…

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This phase 3 trial is testing whether metformin, a common diabetes drug, can improve muscle function in adults with myotonic dystrophy type 1 (Steinert's disease). The study will enroll 142 participants who will receive either metformin or a placebo for 6 months. Researchers will…

This study tests whether using a connected exercise bike at home, along with usual care, can improve daily activities for people with lumbar spinal stenosis—a condition that causes leg and back pain when walking. About 302 adults aged 50 and older with confirmed spinal narrowing …

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of inflammatory arthritis affecting the spine and pelvis. Seventy-two participants will attend group sessions twice a week for ten weeks. The goal is to see if yoga…

This study compares different visual keyboard layouts to see which helps people with complex sensorimotor disabilities type faster and with less fatigue. Twelve adults who already use a virtual scanning keyboard will test each layout. The goal is to find the best design to improv…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cravings in people addicted to nicotine. One hundred daily smokers who are highly dependent will receive tDCS sessions. The goal is to see if this painless, mild electrical stimulation can …

This Phase 3 trial tests whether adding intravenous ketamine to the antidepressant venlafaxine can relieve severe depression faster than venlafaxine alone. Sixty hospitalized adults with major depression will receive either ketamine or placebo infusions over one week. The goal is…

This study looks at 50 children (over 1 year old) in intensive care who are on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers want to see if two methods can reliably measure airway opening pressure, which could help doctors personalize ventilati…

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This study looks at how well hospitals manage severe oxygen deprivation (asphyxia) in newborns at or near full term. Researchers will review care given during labor and after birth to find where improvements can be made. The goal is to help doctors and nurses provide better, fast…

This study at Necker Hospital in Paris is checking how well patients with inherited metabolic diseases follow their daily oral medication routines. About 200 patients (children aged 7 and up, teens, and adults) will fill out a questionnaire during a regular visit. The goal is to …

This study looks at the bacteria, fungi, and viruses living on the skin, in the gut, and in the mouth of people with Netherton syndrome, a rare condition that damages the skin barrier and often causes allergies. Researchers will compare these microbes to those of healthy voluntee…

This study follows 300 adults aged 30–60 with genetically confirmed familial hypercholesterolemia, a condition causing very high cholesterol. Researchers use CT scans to see how coronary artery plaques change over 5 years. The goal is to better understand disease progression and …

This observational study will follow 800 adults with IgA nephropathy, a common kidney disease, to see how well current treatments control protein in the urine and preserve kidney function over 12 months. Researchers want to understand why some patients do not respond to standard …

This study is collecting joint fluid and tissue samples from 50 adults with inflammatory or non-inflammatory bone and joint diseases. Researchers will use both standard and advanced lab techniques to find new biomarkers that could help diagnose rheumatic diseases more accurately …

This study looks at how parents and doctors handle the moment a newborn is diagnosed with phenylketonuria (PKU) through routine screening. Researchers will interview 80 parents and medical staff to understand the emotional impact and find ways to improve how the diagnosis is shar…

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study follows 200 children with growth hormone deficiency for three years. Researchers will measure body composition, including muscle and fat, in kids taking either daily or long-acting growth hormone. The goal is to understand why some children gain weight on long-acting f…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study surveys 200 adult women with primary immune deficiency diseases about their use of intrauterine devices (IUDs), tampons, and menstrual cups. Researchers want to see if these products lead to infections like pelvic inflammatory disease or toxic shock syndrome. By collec…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study uses a one-time survey to learn about the eye and body symptoms of people with congenital aniridia, a rare genetic condition that affects the iris. Researchers want to see how much patients understand about their own disease. About 100 patients of all ages will take pa…

This study looks back at the medical records of 150 patients who died in intensive care between 2018 and 2022 after being treated for a joint prosthesis infection. The goal is to understand what went wrong and identify patterns that could help doctors better manage similar cases …

This study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study collects blood, spinal fluid, and brain tissue from 400 people with severe seizures (status epilepticus) or epilepsy linked to brain inflammation (dysimmune encephalitis), plus control patients. Researchers aim to find antibodies and markers of nerve cell death that co…

This study monitors immune function in 200 intensive care patients after severe trauma, high-risk surgery, or respiratory distress. Researchers use a simple, automated blood test to measure interferon-gamma levels, which indicate immune strength. The goal is to identify when pati…

This study aims to better understand why some patients with ARDS (a severe lung condition) get very sick while others recover. Researchers will collect blood and lung fluid from 50 ICU patients to study their immune cells and inflammation patterns. The goal is to identify differe…

This study is collecting detailed information from 180 people with Susac syndrome, a rare condition that affects the brain, hearing, and vision. Researchers want to learn more about the symptoms, possible causes, and how the disease progresses over time. The goal is to improve di…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study looks at whether private practice doctors can safely give children with suspected mild delayed allergies to beta-lactam antibiotics (like amoxicillin) a direct oral challenge. The challenge involves giving the child a small dose of the antibiotic and watching for a rea…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study looks at how the brain and lungs communicate in patients with severe breathing failure who are getting high-flow oxygen. Researchers will use brain wave monitors (EEG), oxygen sensors (NIRS), and muscle activity sensors (EMG) before and after starting oxygen therapy. T…

This study looks at whether a specific gut bacterium, Akkermansia muciniphila, can predict how well men with advanced prostate cancer respond to a common hormone therapy (abiraterone acetate). Researchers will collect stool and blood samples from 52 men over three months to track…

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see how many develop joint damage and what factors predict it. Researchers will use X-rays and other data to identify early signs of aggressive disease. The goal is to help doctors decide wh…

This study follows 500 adults who received a stem cell transplant at least 10 years ago to see if iron buildup in the body raises the risk of liver problems. Researchers will use blood tests and a special liver scan (FibroScan) to check for damage. The goal is to understand wheth…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on a severe genetic disease but did not have a baby from it. Researchers want to know how many later have a healthy child naturally, through other treatments, or decide to s…

This study looks at how blood clotting works differently in the liver's portal vein compared to the rest of the body in people with liver cirrhosis. Researchers will take blood samples from 45 patients during a routine procedure called TIPS, which helps relieve high blood pressur…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study looks at whether ICU staff with minimal training can measure stroke volume (a key sign of blood flow) as accurately as expert doctors, using an AI-guided ultrasound tool. About 100 critically ill patients who need fluids will be enrolled. The goal is to see if AI can m…

This study looks at how the hepatitis B vaccine triggers T cells, a key part of the immune system. Researchers will test blood from 115 healthy adults 5 to 10 weeks after vaccination to see if they have T cells that recognize the hepatitis B virus. The goal is to understand why s…

This study looks at young adults with chronic inflammatory rheumatic diseases who are moving from pediatric to adult healthcare. Researchers want to see if a structured program that includes education workshops and joint doctor visits helps patients manage their own care better. …

This study looks at how antibiotic-resistant bacteria move between people and their pet dogs. Researchers will follow 525 dog owners and their dogs for three months, collecting samples to track bacterial changes. The goal is to create better strategies to prevent the spread of th…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This study will survey 2,000 medical residents in Paris hospitals about their physical and mental health, including anxiety, depression, burnout, and sexual health. Researchers aim to find out how many residents have health issues and how well they access care. The goal is to imp…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study will use pelvic ultrasound to check for endometriosis and adenomyosis in 400 women aged 29–37 who are freezing their eggs for non-medical reasons. Researchers will compare imaging findings with symptoms, anxiety, depression, and quality of life. The goal is to understa…

This study aims to better understand how children aged 8 to 16 with neurodevelopmental disorders (like autism or ADHD) process social information. Researchers will use a new set of tests to measure skills like recognizing emotions and understanding others' thoughts. The goal is t…

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study looks at slow brain waves during sleep and wakefulness in 90 people: young adults, healthy seniors, and early-stage Alzheimer's patients. Researchers will measure these waves and test memory and attention. They will also play sounds during sleep to see if it boosts mem…

This study aims to understand how to better coordinate care for people with multiple sclerosis (MS). Researchers will hold focus groups with patients, carers, and healthcare professionals to identify what works and what doesn't in current care pathways. The goal is to propose imp…

This study takes skin biopsies and blood samples from people with ALS, healthy carriers of ALS-related gene mutations, and control subjects. Researchers will grow skin cells in the lab to study how the disease works at a cellular level. The goal is to better understand ALS, not t…

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans to see how these beliefs change after a single dose of ketamine. The goal is to understand why some depressed patients hold onto negative tho…

This study tests a standardized health program for children under 5 who are in child protective services. It compares their mental and physical health over 2 years to children receiving usual care. The goal is to see if the program improves emotional development and overall well-…

This study looks at whether people with disorders of consciousness (like coma or minimally conscious state) can form and recall memories. Researchers will use brain wave (EEG) and skin sensors to detect memory activity that can't be seen through behavior alone. The goal is to bet…

This study in France tests whether having the national health insurance pay for vaccines during outpatient visits increases how many people get vaccinated. Researchers will compare vaccination rates for pneumococcal infections and whooping cough (pertussis) before and after the f…

This study follows 1,600 advanced practice nurses (APNs) in France to see how their role grows and works in real healthcare settings. Researchers will use surveys and interviews over several years. The goal is to learn what helps or hinders APNs from being fully used in patient c…

This study tests a new questionnaire that measures how well patients stick to a bowel management technique called transanal irrigation. The method helps people with bowel movement or leakage problems, but many stop using it over time. Researchers will enroll 100 adults who have u…

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study looks at 1,200 children and young adults (ages 1-20) with suspected sleep-disordered breathing to see if their sleep test results match up with problems in thinking, mood, and behavior. Participants will complete sleep studies, questionnaires, and thinking tests. The g…

This study looks at 200 highly myopic adults in France, the Netherlands, and Spain to understand why some develop a condition called posterior staphyloma, where the back of the eye bulges outward. Researchers will analyze blood samples and eye images to find genetic and molecular…

This study aims to bring molecular markers into routine care for patients with rare adrenal cancers. Researchers will collect blood, urine, and tumor samples from 450 patients before and after surgery to see if these markers can guide treatment decisions. The goal is to make thes…

This study looks at how women with a severe form of congenital adrenal hyperplasia (classic 21-hydroxylase deficiency) become pregnant and what happens during their pregnancies. Researchers will collect information from medical records and phone interviews with 200 adult women. T…

This study is for 244 people with early-stage Alzheimer's disease. Researchers want to find new blood markers that show why some people's brains are more resilient to the disease. Participants will give blood samples and take memory tests over time. No new treatment is being test…

This study looks at DNA methylation patterns (chemical tags on DNA) in fetuses with rare genetic diseases. Researchers will analyze DNA from amniotic fluid and tissue samples to create reference signatures. The goal is to improve diagnosis of these conditions before birth. The st…

This study is testing whether a special physiotherapy assessment, called the EPIC Assessment, can predict which patients in the intensive care unit will have trouble after their breathing tube is removed. About 330 adults on ventilators for more than 48 hours will be evaluated. T…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study compares 3D models of children's pelvic and retroperitoneal tumors to standard 2D scans to see if they help surgeons plan better. About 60 children and their surgeons will answer questions about the images. The goal is to improve surgical precision, not to test a new t…

This study looks at children born with a lung spot (congenital lung malformation) and compares those who had surgery to those who didn't. The main goal is to see how the decision affects parents' anxiety levels when the child is 6 to 9 years old. Researchers will also track how m…

This study aims to find new biomarkers to better screen and monitor Activated PI3K Delta Syndrome (APDS), a rare immune disorder. Researchers will collect blood, urine, and stool samples from 14 APDS patients over two years to analyze changes in immune cells and other markers. Th…

This study follows 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will track survival and complications like bleeding or infections to learn how to improve patient care. The goal is to collect data and samples to better understand…

This study looks at why some kidney transplant rejections don't respond to treatments that target B cells. Researchers will collect blood, stool, and kidney tissue from 45 patients to study B cell behavior and antibody reactions. The goal is to uncover the hidden triggers of reje…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …

This study will use eye tracking to measure how children with Angelman syndrome look at social and non-social images. Researchers hope to identify abnormalities in social perception that could serve as a biomarker for future treatment trials. The study includes 40 children with A…

This study looks at how gut bacteria change the energy use of immune cells in people with inflammatory bowel disease (IBD) and healthy adults. Researchers will give healthy volunteers a short course of antibiotics to alter their gut bacteria, then measure immune cell metabolism u…

This study is looking at a genomic test called EndoPredict that analyzes tumor genes to predict the risk of breast cancer returning. The goal is to see if women with a low-risk score can safely skip chemotherapy and only take hormone therapy. Researchers will follow 1,000 patient…

This study uses a special PET-MRI scan to measure brain inflammation in people with multiple sclerosis (MS). Researchers will scan 41 adults with active MS and compare the results to healthy volunteers. The goal is to better understand inflammation patterns and improve how we pre…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand its features and causes. Researchers will use imaging, vision tests, and quality-of-life surveys to track the disease over time. They will also analyze DNA to find…

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study uses advanced MRI scans to measure how well the brains of children with multiple sclerosis (MS) can repair myelin, the protective coating around nerve cells. Researchers will compare these repair levels with thinking and memory test scores. The goal is to understand if…

This study looks at different types of neutrophils (a kind of immune cell) in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to tumor growth and resistance to immunotherapy. They will compare blood samples from 100 lung cancer…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study looks at people with a rare condition called cerebral folate deficiency, where the brain lacks enough folate. Researchers think the problem may be in the choroid plexus, a part of the brain that helps control what goes in and out of brain fluid. They will use MRI scans…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study follows 1,000 children and teens with rare epilepsies (like West and Dravet syndromes) to see how different treatments affect their seizures and thinking skills. Researchers will compare care across hospitals to find what works best. The goal is to give families cleare…

This study monitors brain blood flow in 92 ICU patients during routine blood pressure adjustments. Using non-invasive tools like ultrasound and brain wave monitors, researchers aim to find the safest blood pressure range for sedated patients. The goal is to prevent brain injury b…

This study follows 250 adults with gout to see how long it takes for urate crystals in the joints to dissolve when uric acid levels are kept below 40 mg/L. Participants will have regular ultrasounds of their feet and knees to track crystal disappearance. The goal is to identify f…

This study is creating a large collection of leftover blood, urine, and other samples from 800 hospitalized patients. The samples will be stored with medical data to help researchers develop and evaluate rapid diagnostic tests for emerging infectious diseases and biological threa…

This study follows 800 people who carry a mutation in the PRSS1 gene, which causes hereditary pancreatitis. Researchers will collect health data and questionnaires to track how often pancreatic cancer develops and how the disease progresses over time. The goal is to better unders…

This study is following 1,200 people from two memory clinics in Paris to see how sleep patterns, daily routines, and other personal factors relate to different types and stages of dementia. Participants will wear an activity tracker, answer questionnaires, and have cognitive test…

This study follows 480 children born to mothers who received either nifedipine or a placebo after early rupture of membranes (22-33 weeks). Researchers will assess the children at age 6 for cerebral palsy, coordination, language, behavior, and thinking skills using parent questio…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study aims to establish normal scores for four paper-and-pencil tests that detect spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking adults aged 20 to 89, divided by age and sex. The results will help doctors know what…

This study aims to validate French versions of two short screening questionnaires: the PHQ-4 for anxiety and depression, and the PC-PTSD-5 for post-traumatic stress disorder. Researchers will enroll 90 adults, both outpatients and hospitalized, to see if these tools work as well …

This study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …

This study follows 50 children and young adults with Dravet syndrome caused by SCN1A gene mutations over four years. Researchers will use standard tests to measure changes in thinking, movement, and daily skills. They will also look for chemical markers in the blood that might re…

This study looks for substances in the blood that might be linked to fatigue in people with low platelet counts (thrombocytopenia). Researchers think a protein called BDNF, which is stored in platelets, could play a role. They will measure BDNF levels in 280 patients and healthy …

This study follows 140 people who were first hospitalized for early-onset anorexia nervosa between 2016 and 2021. Researchers will check their physical and mental health 4 to 9 years later using questionnaires and medical records. The goal is to understand long-term recovery and …

This study looks at how the adrenal glands work in patients who develop dangerously low blood pressure after heart surgery. Researchers will take blood samples from 200 adults to measure stress hormones. The goal is to better understand this complication, not to test a new treatm…

This study follows 150 adults with cirrhosis who are waiting for a liver transplant. Researchers will use questionnaires and blood tests to measure sexual function before and one year after the transplant. The goal is to understand how transplantation changes sexual health and wh…

This study is following 200 children and teens (ages 7-20) who have experienced psychosis to see if they fall into distinct subgroups. Researchers will use interviews, brain scans, and genetic tests to classify participants. The goal is to see if these subgroups predict how well …

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. Over half of right-stroke patients have trouble with prosody, which can affect social interactions and quality of life. Researchers will test 150 participants…

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study aims to better understand periodontitis and peri-implantitis by analyzing biological samples like plaque, saliva, and gum fluid from 219 participants. Researchers will compare samples from people with severe gum disease to those with healthy gums. The goal is to identi…

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-shrinking procedure called endoscopic sleeve gastroplasty. Researchers will follow 205 obese adults for 12 months, measuring weight, blood markers, and gut bacteria changes…

This study is testing whether a simple blood test (called a liquid biopsy) can better predict relapse in children and young adults with classical Hodgkin lymphoma. Researchers will track 400 patients under 25 to see if tumor DNA in the blood can catch early signs of relapse or tr…

This study looks at whether cancer patients do better when they go to an emergency room at their own cancer hospital versus a regular hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital…

This study looks at whether removing surgical dressings the day after abdominal surgery is as safe as keeping them on for about a week. About 1,288 adults having planned abdominal surgery will be randomly assigned to stop dressings on day 1 or day 6. The main goal is to see if ea…

This study looks at how different ventilator modes affect lung volume changes during chest physiotherapy in 40 ICU patients on breathing machines. Researchers will compare two common ventilator settings to see which one helps the lungs expand more after chest compressions. The go…

This study follows 540 adults admitted to the intensive care unit (ICU) to see how their immune and inflammatory responses relate to their recovery. Researchers will collect extra blood samples at several time points over one year to measure immune cells and inflammation markers.…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study follows 250 atrial fibrillation patients who received a left atrial appendage closure device to prevent strokes. The procedure blocks a small pouch in the heart where clots often form, allowing patients to avoid long-term blood thinners. Researchers will track how many…

This observational study tracks 200 adults with severe burns (over 30% of body surface) to see if giving albumin in the first 24 hours after injury improves outcomes. Researchers will measure death rates, kidney failure, and severe lung problems within 28 days. The goal is to gat…

This study tests whether a rapid nose swab test that detects three common respiratory viruses (COVID-19, flu, and RSV) can help doctors avoid prescribing antibiotics when they aren't needed. About 2,000 people with respiratory symptoms will be enrolled. Doctors will either prescr…

This study aims to find immune system markers that can predict how well a cancer patient responds to radiotherapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize future cancer tr…

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study looks at people with a mechanical heart valve who hear a clicking noise from it. Researchers want to know if remembering information given before surgery about this noise affects their quality of life afterward. About 180 participants will answer questionnaires over th…

This study looks at why a numbing injection in the thigh (adductor canal block) works so well for knee surgery pain. Researchers think the medicine may spread to the sciatic nerve, but they want to measure how often this happens. About 70 adults having knee surgery will be tested…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study aims to understand how adolescents with post-traumatic stress disorder (PTSD) experience psychotherapy. Researchers will interview 65 teens aged 12-18, along with their parents and therapists, to explore what helps them feel better. The goal is to learn more about the …

This study aims to understand brain differences in people with autism spectrum disorder. Researchers will use MRI scans and eye-tracking to see how the brain works and how people with autism process social information. The study involves 160 participants, including children and y…

This study follows 700 women who have had three or more early miscarriages or repeated implantation failures. Researchers will collect medical history, run tests, and track outcomes to find immune and genetic factors that may cause these losses. The goal is to better understand w…

This study looks at how losing all your teeth and getting dentures affects your sense of taste, touch in the mouth, and food likes. Researchers will compare 40 people who have worn dentures for at least a year with 40 people who still have their natural teeth. The goal is to unde…

This study aims to find better ways to detect acute mesenteric ischemia, a condition where blood flow to the intestine is blocked, causing severe pain and damage. Researchers will analyze blood samples and CT scans from 556 adults with sudden abdominal pain to identify early biom…

This study is for people aged 70 and older with early-stage lung cancer who are scheduled for surgery. Researchers want to see if markers of aging (like changes in DNA and cell health) can help predict who will have complications or need unplanned hospital stays. The goal is to u…

This study is for adults with advanced liver cancer who are starting a common immunotherapy combination (Atezolizumab and Bevacizumab). Researchers want to see if levels of a protein called Glypican-3 in the blood can help predict how well the treatment works. About 240 participa…

This study follows 130 adults with hypophosphatasia, a rare bone disorder, to understand how they are diagnosed and what symptoms they have. Researchers hope to find ways to reduce the long delay between first symptoms and diagnosis. No treatment is being tested; this is purely a…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study looks at whether special brain scans (MRI and PET) can predict how multiple sclerosis (MS) will affect a person's disability over many years. Researchers will follow 80 adults with MS who were in earlier studies to see if certain brain changes can forecast worsening sy…

This study aims to create and test a better way to measure breathing difficulty (dyspnea) in children aged 6 to 17. Researchers will use special questionnaires to see if they can accurately describe the symptom, which could lead to improved treatment and follow-up for kids with l…

This study aims to understand why blood vessels become leaky during severe inflammation (SIRS), a condition common in sepsis and shock. Researchers will measure certain proteins in the blood and lung fluid of 180 ICU patients and see how they relate to fluid balance and organ fun…

This study looks at how early menopause (premature ovarian insufficiency) affects the heart's electrical signals, which can raise the risk of dangerous heart rhythms. Researchers will compare 120 women with and without this condition, and also check how hormone replacement therap…

Acute alcoholic hepatitis is a serious liver condition with a high risk of death, but current prediction tools are limited. This study will analyze data from 1,400 patients to find more accurate markers of prognosis. By integrating clinical, lab, and tissue information, researche…

This study tests whether providing gentle nasal airflow to sedated, intubated patients with low oxygen levels can improve brain activity and lung function. Researchers will measure brain waves, blood flow, and lung ventilation under different airflow settings. The goal is to unde…

This study looks at 120 people with various immune deficiencies to see if a chronic gut virus infection is tied to liver or digestive problems. Researchers will collect blood, stool, urine, and biopsy samples to screen for enteric viruses. The goal is to identify which patients a…

This study talks to siblings aged 9 to 18 whose brother or sister is in the pediatric intensive care unit (PICU). Researchers want to learn about the siblings' needs and how this experience affects their daily life. They will interview each sibling twice: once during the hospital…

This study tests whether a bedside bone biopsy, done in the patient's room, works as well as the usual surgical or radiology-guided biopsy to diagnose bone infection in diabetic foot ulcers. The trial will include 320 adults with diabetes and signs of foot bone infection. If the …

This study examines how the community of bacteria in the lungs (the microbiome) affects how well pneumonia patients respond to antibiotics. Researchers will follow 300 adults with pneumonia, taking samples from the mouth, rectum, and lungs over 90 days. The goal is to see if the …

This study looks at whether people with a staph bloodstream infection and a low risk score (VIRSTA score less than 3) can safely avoid a routine heart ultrasound. About 700 participants will be randomly assigned to either get the ultrasound or not. The goal is to see if skipping …

This study looks at whether a sleep breathing test done at home can help doctors check how well a nighttime breathing machine is working for people with neuromuscular diseases. The goal is to see if the test is practical and gives useful information to adjust the machine settings…

This study looks at the link between gut bacteria and mental health symptoms like anxiety and depression in people with anorexia nervosa. Researchers will compare 120 participants (patients with severe anorexia and healthy volunteers) to see if changes in gut bacteria, intestinal…

This study aims to find genetic differences that make some cancer patients more likely to develop a rare but life-threatening heart inflammation (myocarditis) from immune checkpoint inhibitors. Researchers will compare the DNA of 100 patients who had this side effect with 400 who…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand how certain immune cells (called T cells) stop working properly, leading to the disease. The goal is to gat…

This study is testing whether adding fetal MRI to standard ultrasound can help doctors better see and diagnose congenital anomalies in unborn babies. Researchers will enroll 1500 pregnant women with single or twin pregnancies between 16 and 36 weeks. The goal is to see if MRI can…

This study aims to improve how doctors assess movement in infants with spinal muscular atrophy (SMA), a severe muscle-weakening disease. Researchers will use sensors to measure babies' movements in a special bathtub, where water helps reduce gravity's effects. The goal is to crea…

This study is testing whether mathematical models can help doctors choose the best dose of anti-infective drugs for hospitalized patients, especially those with sepsis. Researchers will analyze drug levels and patient data from 60 adults to understand how factors like organ funct…

This study is looking at how anti-infective drugs work in critically ill children. The goal is to find the right doses for each child to improve treatment and reduce risks. Researchers will collect blood samples and health data from 3000 children in intensive care or immuno-hemat…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study looks at how often young children (ages 1 to 6) with inherited metabolic diseases develop eating disorders when they are on special diets. Researchers will use a feeding scale to measure eating problems in 200 children. The goal is to understand the link between these …

This study monitors the immune system of 20 adults with serious mold infections (like Aspergillus) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy to standard antifungal drugs. Researchers will measure immune checkp…

This study follows 700 patients with infective endocarditis, a serious heart infection, to gather real-world data on complications and outcomes. Researchers aim to improve treatment guidelines, which currently rely on expert opinion due to limited evidence. No new drug or treatme…

This study looks at whether using a standardized checklist (AnesList) when anesthesiologists hand over patient care in the operating room can reduce serious problems like death, major complications, or return to the hospital within a month after major surgery. About 1,120 adults …

This study is testing a new cell therapy in the lab for people with Merkel cell carcinoma, a rare skin cancer linked to a virus. Researchers will take immune cells from 15 patients and try to train them to attack the cancer in a test tube. The goal is to see if this approach work…

This study looks at whether a new 3D ultrasound method can measure heart muscle stiffness in people with a leaky mitral valve (mitral regurgitation). The goal is to see if these measurements match findings from MRI scans that show scarring in the heart. About 40 adults with diffe…

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health problems, such as heart disease and thinking issues, that survivors face. By an…

This study tests whether a non-invasive digital cuff can accurately measure blood pressure continuously during carotid endarterectomy surgery, compared to the standard invasive arterial catheter. The goal is to see if the cuff can provide the same vital information without the ri…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study follows 643 children who were born before 32 weeks of pregnancy and whose mothers received either a full or half dose of betamethasone before birth. Researchers will test the children's thinking skills, memory, and social behavior at age 5 to see if the lower dose is j…

This study collects blood samples from 100 people with rare brain diseases like adrenoleukodystrophy and metachromatic leukodystrophy. Researchers will study immune cells called macrophages to see if they affect how the disease progresses. No treatment is given; the goal is to le…

This study is testing a new blood test that looks for kidney-specific DNA to detect injury or rejection after a kidney transplant. Researchers will measure these DNA markers before and after surgery in 30 patients with end-stage kidney disease. The goal is to see if the test can …

This study is looking at people with a rare type of digestive system cancer called GEP-NET who are receiving a targeted radiation therapy (PRRT). Researchers will use special PET-MRI scans and artificial intelligence to find patterns that predict how well the treatment works. The…

This study follows 80 obese patients who are planning to have bariatric surgery. Researchers will measure back pain, spine alignment, and spinal fat before and after significant weight loss. The goal is to understand how losing a lot of weight affects the spine and whether it hel…

This study looks at whether a connected scale can help monitor blood cancer patients (with lymphoma or myeloma) during chemotherapy. Thirty patients will weigh themselves daily for about 7 weeks, and their data will be sent to their medical team. The goal is to see if this approa…

This study compares cognitive function in 180 adults aged 45-64 with severe hearing loss to those with normal hearing. Participants take memory, attention, and thinking tests. The goal is to see if hearing loss is linked to mild cognitive impairment earlier in life.

This study aims to better understand how the spleen filters and responds to abnormal blood cells in various diseases. Researchers will collect spleen tissue and blood from 100 adults undergoing planned splenectomy. By perfusing the spleen in the lab, they hope to uncover its role…

This study looks at whether children and young adults (ages 12-20) with osteogenesis imperfecta, also known as brittle bone disease, have problems with their hearing and balance. Participants will undergo hearing tests and special balance assessments, and some may get CT or MRI s…

This study looks at whether tiny particles from blood vessels, found in urine, can help predict which pregnant women with high blood pressure will develop a dangerous condition called pre-eclampsia. Researchers will measure these particles in 110 pregnant women at two points duri…

This study tests whether a small recording device called LENA can help speech therapists guide parents to improve their child's language environment. Thirty children with profound congenital deafness who received a cochlear implant before 18 months old will wear the recorder at h…

This study explores whether using emotional sounds—like a patient's own name spoken by a family member—can improve brain wave tests that help predict recovery in people with disorders of consciousness. Researchers will compare brain responses to familiar versus unfamiliar voices …

This study looks at how multifamily therapy—where several families meet together—helps teenagers with anorexia nervosa. Researchers will interview teens, parents, and siblings who took part in the therapy at a Paris hospital. The goal is to understand how the therapy affects eati…

This study is collecting blood and joint fluid samples from 300 children and young adults with juvenile idiopathic arthritis (JIA) to see if certain markers can predict how severe the disease will become. Researchers will track participants' symptoms, treatments, and joint damage…

This study uses placentas donated after childbirth to measure how drugs pass from mother to fetus. Researchers will perfuse the placenta in a lab to calculate drug transfer rates. The goal is to fill a gap in knowledge about medication safety during pregnancy, since pregnant wome…

This study investigates whether serotonin, a chemical in the body, affects symptoms of oculocutaneous albinism in children. Researchers will measure serotonin levels in 160 children with and without albinism. The goal is to better understand the condition, not to test a new treat…

This study uses interviews to learn how adolescents with anorexia nervosa, their parents, and healthcare professionals experience psychotropic drugs. Researchers will talk to 90 participants to uncover their thoughts and feelings. The goal is to better understand the personal imp…

This study looks at how blood flows in the brains of children who have been on ECMO, a machine that helps the heart and lungs. Researchers will use MRI scans and computer models to compare two ways of repairing the carotid artery after ECMO is removed. The goal is to understand w…

This study looks at children aged 9 to 15 who were hospitalized for a serious suicide attempt. Researchers will use questionnaires to assess psychiatric disorders, neurodevelopment, and attachment issues. The goal is to better understand what leads to these severe attempts and fi…

This study looks at fetal cells that remain in a mother's blood after pregnancy, called fetal microchimeric cells, in women with chronic skin ulcers like venous or diabetic ulcers. Researchers will analyze these cells' genetic activity to see if they might help with wound healing…

This study looks at 840 people in Paris whose hearts stopped and didn't restart with standard CPR. They received a special life-support machine called ECMO to keep blood flowing. Researchers will track how many survive for one year and how well their brains recover. The goal is t…

This study is following 670 adults with vasculitis, a rare blood vessel disease, for up to 5 years. Researchers will collect medical data and blood samples to see how the disease starts, how it is treated, and what long-term problems may arise. No new treatments are being tested—…

This study tests whether measuring a tiny ear muscle reflex (the stapedial reflex) can help doctors set the right volume levels on cochlear implants for children. Currently, kids must describe how loud sounds feel, which can be tricky. The researchers will compare reflex measurem…

This registry will enroll 450 adults with tic disorders to study how tic severity relates to quality of life, and whether this relationship differs between men and women. Participants will complete questionnaires about tics, mood, and daily functioning. The goal is to better unde…

This study follows 180 people who had a benign thyroid nodule treated with radiofrequency heat ablation three years ago. Researchers will use ultrasound and a fine-needle biopsy to see how the nodule looks and whether any cells have changed. The goal is to create a better way to …

This study aims to find noninvasive biomarkers—like substances in urine, blood, or saliva—that can accurately detect active eosinophilic esophagitis in children. Currently, diagnosis and monitoring require repeated endoscopies with biopsies under anesthesia. Researchers will coll…

This study looks at how common ICU treatments—like fluids, blood pressure drugs, or heart medications—affect blood flow to the skin in patients with acute circulatory failure. Researchers will measure skin blood flow and capillary refill time in 180 intensive care patients. The g…

This study collects tumor samples from 50 lung cancer patients whose disease has worsened while on immunotherapy. The goal is to analyze the tissue for clues about why the treatment stopped working. No new drug is being tested; instead, researchers hope to better understand resis…

This study examines how different surgical methods for removing lung cancer affect a patient's posture and breathing. Researchers will compare traditional open surgery with minimally invasive techniques using video or robotic assistance. By measuring changes in spine alignment an…

This study looks at people with autoinflammatory diseases or AA amyloidosis who have genetic changes that are hard to interpret. Researchers want to understand if these changes actually cause the disease. The goal is to improve diagnosis and knowledge, not to test a new treatment…

This study looks at whether CAR-T cell therapy, a new immunotherapy for blood cancers like leukemia and lymphoma, can cause early heart problems. Researchers will measure heart function with ultrasound before and a few days after treatment in 60 patients. The goal is to find out …