Radiation before pancreatic surgery may prevent dangerous leaks

NCT ID NCT07370987

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether giving a short course of radiation before pancreatic surgery can prevent a common and serious complication called pancreatic fistula. About 50 patients with a high risk of this complication will receive two doses of radiation before their surgery. Researchers will then track how many patients avoid a fistula within 90 days after the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stereotactic radiotherapy
What this could lead to: If it works, this could reduce a serious complication after pancreatic surgery, making recovery safer for patients.
What could go wrong: This is a small, early-phase trial with only 50 participants and no comparison group, so results may not be conclusive. Radiotherapy also carries risks like radiation toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pancreatic Fistula

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC FISTULA PANCREATICODUODENECTOMY

Contacts and locations

Locations

Department of HPB Surgery, Hospital Pitié Salpétrière
RECRUITING

Paris, 75013, France

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