New hope for advanced bile duct cancer: liver transplant after targeted radiation

NCT ID NCT06910722

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a liver transplant after a combination of targeted internal radiation (SIRT with Yttrium-90) and chemotherapy can improve 3-year survival in people with locally advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be surgically removed. The trial plans to enroll 36 participants in France. The main goal is to see if this strategy helps patients live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Yttrium-90 (radioactive beads) and chemotherapy

What this could lead to

If successful, this could offer a potential treatment path for people with advanced bile duct cancer that cannot be surgically removed, possibly improving long-term survival.

What could go wrong

This is a small, early-phase study with only 36 participants. The treatment is complex and carries risks from radiation, chemotherapy, and transplant surgery. It may not work for everyone or may not be widely available.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Beaujon

    RECRUITING

    Clichy-sous-Bois, France

    Contact Email: •••••@•••••