Assistance Publique - Hôpitaux De Paris

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This phase 3 trial compares a single intravenous dose of temocillin to the standard ceftriaxone shot for treating gonorrhea. The goal is to see if temocillin works just as well while having less impact on the gut's healthy bacteria, which can help prevent the rise of drug-resista…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This trial tests a gene therapy for FHL3, a rare immune disorder caused by a gene mutation. Instead of a donor stem cell transplant, patients receive their own stem cells that have been corrected with a healthy gene. The goal is to restore immune function while avoiding transplan…

This pilot study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely and effectively treat drug-resistant focal epilepsy in 13 adults. The procedure uses focused sound waves to heat and destroy small brain lesions causing seizures, without needing open su…

This phase 2 trial tests a low-dose immune drug called interleukin-2 (ILT-101) in 22 children aged 6 to 8 with moderate to severe autism whose mothers had an autoimmune condition during pregnancy. The goal is to see if the drug can increase helpful immune cells (Tregs) and improv…

This phase 3 trial tests whether a lower dose of the chemotherapy drug cyclophosphamide can reduce side effects after a half-matched stem cell transplant for blood cancers. The standard dose often causes complications, so researchers want to see if a lower dose works just as well…

This study tests whether frozen stool capsules (fecal transplants) can help children aged 8-17 with ulcerative colitis stay in remission after steroid treatment. Participants will receive either capsules or enemas containing healthy donor stool. The main goal is to see if the cap…

This early study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and might slow ALS. Twenty-three adults with ALS will receive 9 ultrasound sessions over 24 weeks. The first part checks safety; the second looks for signs of slowing the disease.

This phase II trial tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) avoid relapses and reduce steroid use. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This study tests whether giving a combination of three antibiotics to pregnant women who show signs of very early labour (between 18 and 23 weeks) can help prolong the pregnancy and reduce the risk of death or serious health problems for the baby. About 350 participants will be r…

This study tests whether adding nurse-led educational sessions helps people with tuberculosis stick to their treatment plan. About 40 adults recently diagnosed with TB will receive extra guidance from nurses. The goal is to see if this support improves treatment completion and re…

This study compares two strategies for starting the drug etoposide in adults with severe hemophagocytic lymphohistiocytosis (HLH) who are in the intensive care unit. HLH is a life-threatening overreaction of the immune system that can cause organ failure. The goal is to see if gi…

This study tests whether changing the order of steps during a Whipple surgery for pancreatic head cancer can help surgeons remove the tumor more completely and lower the chance of cancer coming back. About 150 adults with operable pancreatic cancer will be randomly assigned to ei…

This study tests a new way to use breathing machines for people with severe lung failure (ARDS). The goal is to reduce lung damage by using very gentle breaths and adding a machine that helps remove carbon dioxide from the blood. About 290 adults on breathing machines for less th…

This study tests whether giving a single unit of red blood cells to high-risk ICU patients right before removing the breathing tube can prevent the need to put the tube back in or reduce deaths within 7 days. The trial plans to enroll 800 adults who have been on a ventilator for …

This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial tha…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if it works as well as the current 18+ month regimen. About 55 adults in France will receive the shorter treatment, and their outcomes will be compa…

This study tests whether fecal microbiota transplantation (FMT) can improve liver function in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). 72 participants will receive either FMT or a sham procedure via colonoscopy and later oral capsules…

This study tests whether using a special breathing device called intrapulmonary percussive ventilation (IPV) at home can prevent hospital stays for children with multiple disabilities. About 146 children aged 1 to 16 will be randomly assigned to either standard chest therapy alon…

This study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, fix the genetic defect in the lab, and then see if these cells can help brain cells work better. The goal is to show the …

This study looks at whether giving the drug rituximab early, when signs of the disease reappear in the blood, can prevent relapses in people with certain types of vasculitis (GPA and MPA). About 70 adults who have been on maintenance rituximab for at least 18 months will be rando…

This study tests whether a combination of three drugs (prednisone, azithromycin, and hydroxychloroquine) can slow lung function decline in adults with interstitial lung disease caused by certain gene variants. About 30 participants will receive either the triple therapy or standa…

This study tests whether adding a steroid (prednisone) to standard antibiotics can improve joint function in adults with septic arthritis, a serious joint infection. Two hundred participants will receive either prednisone or a placebo for 7 days. The main goal is to see if steroi…

This study will test whether using two OSIA bone conduction implants (one on each side) helps children with severe ear malformations hear better in noisy places compared to using just one implant. Twelve children aged 7 to 17 who already use a bone conduction device will receive …

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve alcohol withdrawal in adults aged 19-65 with alcohol use disorder. The goal is to reduce gut permeability and support recovery. Participants will provide b…

This Phase 3 trial tests whether the anti-inflammatory drug anakinra can help children with acute myocarditis (heart inflammation) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo for 7 days, alongside standard care. Th…

This study tests whether giving sepsis patients drugs tailored to their specific biological traits can improve survival and reduce the need for life support. It will enroll 2000 adults and children across multiple countries, using an adaptive platform to test several treatments a…

This Phase 2 trial is testing a combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—in 70 adults with relapsed or refractory multiple myeloma. The goal is to see if this combo can slow or stop the cancer from growing. Participants must have already tried lenali…

This phase 3 trial tests whether adding aspirin and folic acid to standard treatment can improve recovery from sudden sensorineural hearing loss. The idea is that these drugs may improve blood flow to the inner ear. The study will enroll 142 adults with recent hearing loss and tr…

This study tests whether tocilizumab, an anti-inflammatory drug already used for rheumatoid arthritis, can reduce joint pain and improve quality of life in people with chronic inflammatory calcium pyrophosphate deposition disease (CPPD) that hasn't improved with standard treatmen…

This study tests whether giving a combination of activated charcoal and polyethylene glycol (a laxative) can reduce the amount of toxic drugs absorbed in the gut for people with severe poisoning in intensive care. Two hundred adults on ventilators will be randomly assigned to get…

This study tests biologic drugs for folliculitis decalvans, a rare scalp disease that causes painful pustules and permanent hair loss. Current antibiotics only work about half the time and the condition often returns. The trial will enroll 120 adults who have already tried at lea…

This phase 2 trial tests obinutuzumab, a drug similar to rituximab but possibly stronger, in 30 adults with active cryoglobulinemic vasculitis who did not improve or could not tolerate rituximab. The goal is to see if obinutuzumab can bring the disease under control and allow pat…

This study tests a liquid material called SQUIDPERI for a procedure that blocks blood flow to the prostate (prostatic artery embolization) in men with an enlarged prostate. The goal is to see if it works better than standard particles at easing urinary symptoms like frequent or w…

This early-phase trial tests a new drug called DT-7012 for people with a rare type of skin lymphoma (CTCL) that has not responded to other treatments. The drug is an antibody designed to find and kill cancer cells in the skin and boost the immune system. About 30 adults with adva…

This study looks at whether a single, image-guided radiation implant can control advanced cervical cancer as well as the usual multiple implants. About 400 women from six French hospitals who had this single-implant treatment between 2014 and 2024 will have their medical records …

This study tests whether the steroid prednisolone can slow the decline in lung function for people with fibrotic hypersensitivity pneumonitis, a lung disease caused by inhaling certain substances. About 120 adults with mild to moderate lung impairment will receive either predniso…

This study tests whether adding visits with a nurse, dietitian, and pharmacist to standard care helps more heart attack patients reach their LDL (bad) cholesterol goals. About 230 adults who had a recent heart attack will be randomly assigned to usual follow-up or extra team-base…

This phase 3 trial tests whether the drug brentuximab vedotin can prevent relapse in people with advanced cutaneous T-cell lymphoma (CTCL) who have recently had a stem cell transplant. About 84 adults with CD30-positive CTCL will receive either the drug or a placebo every three w…

This study tests a new type of day hospital for people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. In one visit, patients get blood tests, a doctor checkup, education on managing their condition, and optional workshops on diet or fatigue. Th…

This study tests whether a special 4D-flow MRI can accurately measure blood flow and pressure in the liver without needing an invasive catheter. Researchers will enroll 60 adults with cirrhosis and compare MRI results to the standard pressure test. If it works, this could make di…

This study will test whether a new, continuous method of measuring heart function (using pressure waves) matches the current standard method (thermodilution) in 43 ICU patients with septic shock. Both methods use the same catheter already placed for treatment. The goal is to see …

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

This study will develop and test artificial intelligence (AI) to automatically classify sleep stages from overnight sleep recordings (polysomnography). The goal is to see if the AI can match or beat expert manual scoring, with the aim of supporting diagnosis of chronic insomnia a…

This study looks at whether measuring a protein called S100B in the blood can help emergency doctors quickly tell if a person's fainting spell was caused by epilepsy or something else, like a heart problem. About 100 adults who come to the ER after losing consciousness will give …

This study will collect thousands of photos of mouth lesions from patients seen over 50 years at a French hospital. Experts will review each photo to confirm the diagnosis. Researchers will then use these images and patient data to train an AI system to automatically identify can…

This study will test a smartphone app that automatically measures how quickly blood returns to a fingertip after pressing on it. Researchers will compare the app's reading to measurements made by expert doctors. The goal is to see if the app can reliably monitor blood flow in 60 …

This study tests a new blood test that looks for severe genetic diseases in unborn babies using a sample from the mother. The test analyzes fetal DNA found in the mother's blood, which could avoid the need for invasive procedures like amniocentesis that carry a small risk of misc…

This study aims to improve how doctors classify colon tumors by using artificial intelligence (AI) to analyze CT scans. The AI will be trained to tell early-stage tumors from advanced ones and to detect lymph node involvement, which is key for deciding on treatments like chemothe…

This study tests whether a special PET scan using 82-Rb can tell how aggressive a kidney tumor is. Doctors will compare the scan results to the actual tumor grade after surgery. If it works, patients might avoid unnecessary biopsies or surgeries. The study involves 50 adults with…

This study will use machine learning and metabolomics (detailed analysis of blood chemicals) to improve diagnosis of hyperandrogenism, a condition causing excess male hormones in women. Researchers will analyze data from 800 women aged 16-45 to better distinguish between common c…

This study tests whether a personalized prevention plan helps female night shift workers reduce their breast cancer risk. Night shift work is linked to higher cancer risk due to disrupted sleep cycles. One hundred women at a Paris hospital will receive tailored advice on diet, ex…

This study tests whether adding backward walking exercises to standard rehabilitation can reduce falls in people over 75 who are at high risk of falling. About 300 participants in France will either receive usual care or replace part of their rehab with supervised backward walkin…

This study tests whether a smartphone app, called ICD-Shield, can help doctors adjust Parkinson's medications to prevent impulse control disorders (like compulsive gambling or shopping). About 528 people with early-stage Parkinson's will be randomly assigned to use the app or rec…

This study tests a digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients access HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts. Researchers will enroll 250 pa…

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This study tests whether adding low-dose ketamine to standard sedatives helps critically ill patients on breathing machines recover faster and spend more days alive at home. About 640 adults who need unplanned ventilation and sedation will receive either ketamine or a placebo for…

This study tests whether a smartphone app that provides personalized exercises, pain management audio, and coaching can reduce activity limitations in adults with chronic low back pain. 330 participants will either use the app or continue usual care. The main goal is to see if th…

This phase 2 trial will test whether cannabidiol (Epidyolex) can reduce severe self-injuries in 21 children aged 5 to 17 with neurodevelopmental disorders. Participants will receive increasing doses of oral cannabidiol over 28 days, then a steady dose for 35 more days. The main g…

This study tests whether personalized, automated text messages sent after in-person rehab sessions can reduce activity limitations in people with chronic low back pain. 100 participants will receive either usual follow-up or text message support for 6 months. The goal is to see i…

This study tests whether wearing a custom-made back brace, along with standard care like physical therapy, can reduce low back pain in adults with degenerative scoliosis (a curved spine that causes pain). About 130 people aged 40 to 75 with moderate to severe pain will be randoml…

This study tests whether a smartphone app called MAELA® can help people recover better after surgery for digestive cancers. About 555 adults will use the app to report symptoms for 90 days after surgery, while doctors monitor alerts. The goal is to see if the app reduces serious …

This study looks at whether a functional restoration program—a mix of exercise, education, and support—can help people with chronic low back pain who are unable to work. The goal is to see if the program improves quality of life, reduces healthcare use, and helps people return to…

This phase 3 trial will compare methoxyflurane (Penthrox®), a painkiller gas patients inhale themselves, against standard morphine injections for chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be enrolled in pre-hospital setti…

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This study tests whether having a child shake a maraca in the arm opposite to where a blood draw happens can reduce pain. Researchers will compare this playful distraction plus usual care against usual care alone in 160 children aged 1 to 3 years. The goal is to see if active mov…

This study tests whether restoring airflow to the nose can reduce breathlessness in patients who breathe through a tracheostomy tube and rely on a ventilator. Researchers will compare three non-drug methods: continuous nasal airflow, nasal sprays, and a fan blowing toward the fac…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This study tests whether wearable body sensors can help doctors better adjust medication for people with Parkinson's disease who experience motor fluctuations. 218 participants will wear the sensors for 7 days before each visit, and only the experimental group's data will guide t…

This study looks at whether a special education program and a check-in on caregivers' own needs can boost the quality of life for people caring for someone with multiple myeloma. About 27 caregivers will take part. The goal is to see if this extra support helps them feel better a…

This study tests whether adding a device that turns body movements into sound can help people with acute stress disorder (ASD) feel more connected to themselves. Thirty adults who recently experienced a traumatic event will receive standard therapy plus this 'movement sonificatio…

This study compares carbon fiber ankle braces to standard plastic ones in 38 children with cerebral palsy aged 8-15. Each child will try both braces for 4 weeks to see which one improves walking, running, and jumping. The goal is to find out which brace helps kids be more active …

This study tests a personalized self-rehabilitation program designed to help people with chronic stroke improve their ability to perform daily living activities. Researchers will enroll 158 participants who had a stroke more than 6 months ago. The program involves following a tai…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This study tests whether awake prone positioning (lying on the stomach while awake) can help sickle cell patients with severe acute chest syndrome in the ICU. The approach aims to improve oxygen levels and breathing by evening out air flow in the lungs. Fifteen adults will be enr…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study uses blood tests (liquid biopsies) to track how small cell lung cancer changes during chemotherapy and immunotherapy. Researchers will analyze DNA from blood samples taken before, during, and after treatment in 50 patients. The goal is to understand why some cancers be…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

This study follows 100 adults diagnosed with skull base osteomyelitis, a rare and serious bone infection near the ear and skull base. Researchers will track how often the infection returns or leads to death within 12 months. The goal is to gather real-world data to help standardi…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study will look at medical records of 350 children with sickle cell disease in France who had serious bacterial infections between 2020 and 2025. The goal is to find out which bacteria are causing these infections today, especially with new vaccines available. The results co…

This study will follow 473 women with polycystic ovary syndrome (PCOS) and a control group to understand what affects their ability to get pregnant. Researchers will look at medical history, hormone levels, and lifestyle factors to see which ones help or hinder natural or assiste…

This study looks at how safe surgery is for a rare condition called functional popliteal artery entrapment, which causes leg pain in young athletes during exercise. Researchers will track 138 adults who have the surgery to see how many need to return to the hospital within 30 day…

This study looks at whether certain natural chemicals in vaginal fluid can predict if labor induction will work in first-time mothers. Researchers will collect a swab from 190 women before induction and track whether they go into active labor. The goal is to find a way to avoid f…

This study looks back at data from 562 people who received a liver transplant for liver cancer (hepatocellular carcinoma) at hospitals in France, Canada, and Belgium. The goal is to create a better scoring system that considers tumor shrinkage before transplant, cancer growth whi…

This study looks at whether sending a neonatal transport team to be present before birth (antenatal) versus after birth (postnatal) improves survival and brain development in extremely premature babies (23-28 weeks) born at hospitals without a specialized intensive care unit. Res…

Denys-Drash syndrome is a rare genetic condition that causes kidney failure in early childhood, often requiring a transplant. Past research suggests these children have a much higher chance of developing a type of lymphoma after transplant compared to other kids. This study will …

This study looks at 2,500 people newly diagnosed with hepatitis C in France. Researchers will use existing medical data to map the different virus types and subtypes, including rare ones. The goal is to understand which types are most common and why some treatments fail, helping …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This large French study will follow 1,810 adults receiving their first liver transplant to see if the way the donor liver is removed affects outcomes. The main focus is on avoiding artery and bile duct complications for three years after transplant. The goal is to identify the be…

This study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive DNA markers are…

This study will test whether ultrasound measurements of the diaphragm can estimate a standard breathing effort test (P0.1) in 40 intubated patients. During a spontaneous breathing trial, researchers will compare diaphragm movement and thickness with the P0.1 reading. If the ultra…

Severe preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these fac…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

This study looks at whether certain gut bacteria help the remaining intestine absorb nutrients better after surgery for short bowel syndrome. Researchers will follow 15 adults who are having surgery to reconnect their small intestine and colon. They will measure how well the inte…

This study looks at how a new type of heart ablation (pulsed-field ablation) changes the heart's structure in people with atrial fibrillation. Researchers will use MRI scans before and 4 months after the procedure to measure scarring and function. About 39 adults with persistent …

This study tests whether speech can be decoded from brain activity recorded during awake brain tumor surgery. Twenty adult patients will have a special graphene electrode grid placed on their brain surface for up to two hours while they name pictures. Researchers will use machine…

This study explores whether testing hospital wastewater can reliably track the spread of multidrug-resistant bacteria, instead of using uncomfortable rectal swabs on patients. Researchers will compare bacteria and resistance genes found in the sewage of a single hospital building…

This study aims to understand the biological causes of autism by growing tiny 3D brain models called organoids from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to see how genetic differences affect brain cell develop…

This study aims to better understand a condition called multilocus imprinting disorder (MLID), where multiple genes are affected by abnormal chemical marks. Researchers will test a new technique to detect these marks in 96 people, including those with known imprinting disorders a…

This study will follow 5,000 adults with immune system problems to see if certain blood cell mutations (called clonal hematopoiesis) are linked to their condition. Researchers will track new cases of immune-related diseases over time. No treatments or drugs are tested—this is pur…

This study looks at whether a simple blood test can track how well treatment is working in children with acute lymphoblastic leukemia (ALL). Currently, doctors must take bone marrow samples to check for leftover cancer cells, which is invasive and painful. The researchers will co…

This study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…

This study looks at how male hormones (androgens) influence the immune cells around glioblastoma tumors, the most common and aggressive brain cancer in adults. Researchers will collect blood, saliva, and stool samples from 40 newly diagnosed patients before and after standard che…

This study looks at the healthcare path of 36 young people aged 12 to 25 who have somatic symptom disorder—physical symptoms like pain or fatigue that doctors can't explain with a standard medical condition. Researchers will interview participants and their parents to map every d…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study aims to translate and adapt the COMFORTneo pain assessment scale into French for newborns. Researchers will work with 50 healthcare professionals from French neonatal units to ensure the translated items are accurate and easy to understand. The goal is to provide a rel…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This observational study will monitor brain activity (EEG) in 330 people during anesthesia or sedation to see how it relates to drug levels and patient factors. It includes children with and without autism, adults over 70, and adults having sedation for endoscopy. The goal is to …

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This pilot study will test whether eye-tracking and balance tests can help identify early signs of ADHD in children aged 3 to 5. Researchers will compare 30 children with ADHD symptoms to 30 healthy children of the same age. The goal is to develop a platform for earlier detection…

This study looks at how a person's genes affect their response to the heart drug mavacamten for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see which genetic types respond best. The goal is to improve dosing safety and effect…

This study will test whether a mobile app called Resilience PRO can help monitor symptoms and quality of life in 80 adults with IDH-mutated glioma who are starting a new systemic treatment. Participants will use the app to report side effects and complete questionnaires every two…

This study looks at how sepsis changes the RNA in white blood cells over time. Researchers will follow 200 sepsis patients, 50 other critically ill patients, and 40 healthy people to map these changes. The goal is to understand why some people have long-term immune problems after…

This study looks at how surgery for a rare brain tumor called craniopharyngioma might change what foods people like, especially fatty and sugary ones. Researchers will compare food preferences of 346 adults who had this surgery with two other groups: people who had a different pi…

This study gathers information from 5,000 adults with hypertrophic cardiomyopathy, a condition where the heart muscle is too thick. Researchers will use heart MRI scans to look for scarring and build a better way to predict who is at risk of dying from the disease. The goal is to…

This study looks at whether measuring the stapedius reflex (a tiny ear muscle reflex) can help program cochlear implants in children aged 0 to 7. Currently, programming relies on behavioral responses, which can be hard to get from very young kids. The researchers will test the re…

This study follows 1,000 patients with rare, life-threatening skin and soft tissue infections who are treated through a special care network in the greater Paris area. Researchers will track survival rates, long-term complications, and quality of life to understand what factors a…

This study will test whether a new 3D ultrasound method, combined with artificial intelligence, can better detect early brain injury in very preterm infants (born before 30 weeks). Researchers will scan 360 babies at several time points and compare the results with brain MRIs and…

This study watches how the lungs work during surgery in 34 adults under general anesthesia. It uses special monitors to measure lung pressure and air distribution during a routine breathing technique called alveolar recruitment. The goal is to see if these monitors can help docto…

This study aims to find out whether some women diagnosed with polycystic ovary syndrome (PCOS) actually have a rare genetic condition causing severe insulin resistance. Researchers will compare 25 women with a known LMNA gene mutation (linked to lipodystrophy) to 50 women with cl…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study will interview 63 people, including patients with prosthetic joint infections, their family members, and healthcare professionals, to understand their experiences. The goal is to use this information to create a therapeutic education program that helps patients manage …

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study follows 30 women aged 18-80 who are getting an artificial urinary sphincter to treat severe urine leakage. Researchers want to see if the surgery changes their sexual quality of life. Participants will fill out questionnaires 6 and 12 months after the procedure.

This study aims to create a 3D model of the bile ducts using MRI and CT scans, along with an AI tool to help doctors guide a camera during a procedure called ERCP. The goal is to improve safety and accuracy. The study will use existing medical images from 100 adult patients who h…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study will collect data from 5,000 adults with acute myocarditis (heart muscle inflammation) across France. Researchers will analyze heart MRI scans to see if certain patterns can predict who is at risk for serious complications like death, heart failure, or dangerous heart …

This study aims to create a new lab model of human diaphragm muscle cells using tissue from women undergoing surgery for diaphragmatic endometriosis. Researchers will compare these cells to arm muscle cells to understand what makes the diaphragm unique. The goal is to provide a t…

This study checks if a new French questionnaire accurately measures how the look of your smile affects your daily life. Researchers will ask 120 adult dental patients to fill out the survey twice to see if the results are consistent. The goal is to give dentists a reliable way to…

This study looks at whether objective measurements, like the stapedius reflex, can help doctors program cochlear implants more precisely. Currently, tuning relies on patients describing what they hear, which can be subjective. Researchers will test 60 adults with severe hearing l…

This study looks at whether nerve ultrasound can help doctors tell the difference between genetic and acquired forms of sensory neuronopathy, a rare nerve condition. Researchers will review ultrasound images and medical records from about 50 adults. The goal is to see if nerve si…

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give th…

This study will check if a standard jaundice test (a light meter on the skin) works equally well for newborns of all skin colors. About 510 babies will have their skin color classified and their jaundice levels measured both with the meter and a blood test. The goal is to see if …

This study looks at people with Enamel Renal Syndrome, a rare genetic condition that causes calcium deposits in the body, leading to kidney and blood vessel problems. Researchers will measure kidney function and test how the body handles calcium, phosphate, water, and acid. The g…

This study interviews 15 people who have donated a kidney to understand their feelings about receiving a symbolic token of gratitude, like a commemorative medal. Researchers want to learn if such recognition could improve donors' experience and encourage more donations. The study…

This study will test a new markerless motion capture system that uses only four cameras to analyze how children walk. Researchers will enroll 125 healthy children aged 6 to 17. The goal is to see if this simpler setup can provide useful information about walking patterns, which c…

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study watches for thinking and memory issues in 90 adults with early-stage, operable lung cancer. Researchers will track complaints like forgetfulness or trouble focusing before, during, and after treatment using simple questionnaires. The goal is to understand when these pr…

This study aims to find biological markers in blood and urine that could explain congenital central hypoventilation syndrome (CCHS), a rare disorder where the brain fails to control breathing during sleep. Researchers will collect samples from 40 adults with CCHS and healthy volu…

This study tests a new rapid diagnostic system that can tell doctors which antibiotic will work against a blood infection in 4-6 hours, instead of the usual 18-24 hours. Researchers want to see if this faster information helps ICU doctors change to a better antibiotic sooner. The…

This study looks at tiny particles in the blood, called extracellular vesicles, to see if they can predict serious liver problems like liver failure or liver cancer. Researchers will collect blood samples from 845 people, including healthy volunteers, diabetes patients, and those…

This study will test whether a mobile app called EPIDAY can predict the daily risk of epileptic seizures in 50 adults with focal epilepsy. Participants will use the app to report symptoms and track seizures for three months. The goal is to see if machine learning can turn these r…

This observational study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers—such as gut bacteria patterns—that predict disease progression and complications. Researchers will collect blood, stool, saliva, and tissue samples during ro…

This study will analyze videos of developing embryos from 1,500 IVF cycles to see if a computer algorithm can predict which ones will successfully implant in the womb. Researchers will combine embryo growth patterns with patient health data to train the algorithm. The goal is to …

This study looks back at medical records of 150 children who had surgery for neuroblastic tumors in the lower chest. Some had a special X-ray (arteriography) before surgery to map a key spinal artery, while others did not. Researchers want to see if the imaging helps prevent spin…

This study will collect information from 100 people in France with SITRAME syndrome, a rare autoinflammatory disease. Researchers want to learn about the disease's symptoms, treatments, and outcomes. No new treatments are being tested; the goal is simply to better understand the …

This study will review medical records of 300 immunocompromised adults hospitalized with COVID-19 in France between June 2023 and April 2024. Researchers want to see how well antiviral drugs like nirmatrelvir/ritonavir and remdesivir work in these patients. The goal is to track t…

This study will review medical records of 60 people treated for brain nocardiosis, a rare infection. Researchers want to see how brain lesions change on MRI or CT scans during treatment and whether those changes relate to patient outcomes. The goal is to better understand what re…

This study looks at how CMV (a common virus) changes the immune system in people who have had a kidney transplant. Researchers will take blood samples from 60 patients to compare immune responses in those with and without CMV infection. The goal is to understand why CMV may incre…

This study will collect blood, saliva, urine, and stool samples from 500 adults with systemic histiocytosis—a group of rare inflammatory disorders. Researchers aim to identify biomarkers that could improve diagnosis, predict disease progression, and enable less invasive monitorin…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…

This study will gather and combine medical and genetic data from 2,000 children with acute myeloid leukemia (AML) across France. The goal is to find hidden patterns that predict which patients are most likely to relapse. By creating a large, shared database, researchers hope to i…